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Adenosine Triphosphate in Health and Disease最新文献

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Phosphorylation of NF-κB in Cancer NF-κB在肿瘤中的磷酸化作用
Adenosine Triphosphate in Health and Disease Pub Date : 2019-04-24 DOI: 10.5772/INTECHOPEN.83650
Mat Martin, Antja-Voy Hartley, J. Jin, Mengyao Sun, T. Lu
{"title":"Phosphorylation of NF-κB in Cancer","authors":"Mat Martin, Antja-Voy Hartley, J. Jin, Mengyao Sun, T. Lu","doi":"10.5772/INTECHOPEN.83650","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.83650","url":null,"abstract":"The proinflammatory transcription factor nuclear factor- κ B (NF- κ B) has emerged as a central player in inflammatory responses and tumor development since its discovery three decades ago. In general, aberrant NF- κ B activity plays a critical role in tumorigenesis and acquired resistance to chemotherapy. This aberrant NF- κ B activity frequently involves several post-translational modifications of NF- κ B, including phosphorylation. In this chapter, we will specifically cover the phosphorylation sites reported on the p65 subunit of NF- κ B and their relationship to cancer. Importantly, phosphorylation is catalyzed by different kinases using adenosine triphosphate (ATP) as the phosphorus donor. These kinases are frequently hyperactive in cancers and thus may serve as potential therapeutic targets to treat different cancers. κ B solid and hematological malignancies.","PeriodicalId":7175,"journal":{"name":"Adenosine Triphosphate in Health and Disease","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73307060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Clinical Evaluation of Adenosine Triphosphate Disodium Hydrate (ATP-2Na) for Asthenopia 三磷酸腺苷水合二钠(ATP-2Na)治疗弱视的临床评价
Adenosine Triphosphate in Health and Disease Pub Date : 2019-04-24 DOI: 10.5772/INTECHOPEN.80288
Yo Nakamura, Yu Ban, Yoko Ikeda, H. Higashihara, S. Kinoshita
{"title":"Clinical Evaluation of Adenosine Triphosphate Disodium Hydrate (ATP-2Na) for Asthenopia","authors":"Yo Nakamura, Yu Ban, Yoko Ikeda, H. Higashihara, S. Kinoshita","doi":"10.5772/INTECHOPEN.80288","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80288","url":null,"abstract":"To investigate the effect and the safety of Adenosine triphosphate disodium hydrate (ATP-2Na) for asthenopia. 40 subjects [35 females and 5 males, 25~87 years old (average: 62.5 years old)] with asthenopia ingested 200~300 mg/day ATP-2Na for 3 months. Before and after 1 and 3 months ingestion, subjects completed a questionnaire to determine their asthenopia symptom and fatigue symptom by visual analog scale (VAS). The scores were compared between before and after ingestion. 31 subjects completed a questionnaire for 1 month. The scores of asthenopia symptom before ingestion, 1 and 3 months were 4.05 ± 3.22, 2.67 ± 2.19 and 2.41 ± 2.16, respectively. The scores of fatigue symptom were 4.76 ± 3.05, 3.08 ± 2.93 and 3.10 ± 3.19, respectively. Both scores were significantly decreased (p < 0.005) at 1 month compared before ingestion. Three subjects had side effects (diarrhea for two, nausea for one), and all subjects improved by oral discontinuation. These results suggest that ATP-2Na is relatively early effective in improving asthenopia and accompanying fatigue symptoms.","PeriodicalId":7175,"journal":{"name":"Adenosine Triphosphate in Health and Disease","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74888818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introductory Chapter: From Adenosine Triphosphate to Basic and Clinical Research in Light of First and Second Messenger Systems to Cellular Energetical and Other Regulatory Functions of Cells in Animals and in Humans (with a Sample of Peptic Ulcer Disease 导论章:从三磷酸腺苷到第一和第二信使系统的基础和临床研究，到动物和人类细胞的能量和其他调节功能(附消化性溃疡疾病样本)
Adenosine Triphosphate in Health and Disease Pub Date : 2019-03-08 DOI: 10.5772/INTECHOPEN.84990
G. Mózsik
{"title":"Introductory Chapter: From Adenosine Triphosphate to Basic and Clinical Research in Light of First and Second Messenger Systems to Cellular Energetical and Other Regulatory Functions of Cells in Animals and in Humans (with a Sample of Peptic Ulcer Disease","authors":"G. Mózsik","doi":"10.5772/INTECHOPEN.84990","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.84990","url":null,"abstract":"","PeriodicalId":7175,"journal":{"name":"Adenosine Triphosphate in Health and Disease","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74105392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature-Dependent Effects of ATP on Smooth and Skeletal Muscles ATP对平滑肌和骨骼肌的温度依赖性作用
Adenosine Triphosphate in Health and Disease Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80794
A. U. Ziganshin, S. N. Grishin
{"title":"Temperature-Dependent Effects of ATP on Smooth and Skeletal Muscles","authors":"A. U. Ziganshin, S. N. Grishin","doi":"10.5772/INTECHOPEN.80794","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80794","url":null,"abstract":"ATP acting via different subtypes of P2X and P2Y receptors induces contractions or relaxation of mammalian smooth muscles, while in skeletal muscles, ATP can pre- and postsynaptically modulate effect of acetylcholine. It was shown that effects of ATP on both types of the muscle are significantly changed when the temperature shifts from physiological condition. For example, contractile responses of rodent urinary bladder and vas deferens mediated by P2X receptors are markedly increased with the decrease of the temperature. Similarly, in frog skeletal muscles, ATP-induced inhibition of acetylcholine release became more pronounced at low temperatures. In case of mammalian skeletal muscle, effect of temperature on ATP-induced responses depends on the type of muscle—slow and fast. In this chapter, we will discuss temperature-dependent effects of ATP on different muscle contractility and their possible mechanisms.","PeriodicalId":7175,"journal":{"name":"Adenosine Triphosphate in Health and Disease","volume":"301 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75444877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Purinergic Signaling: A New Regulator of Ovarian Function 嘌呤能信号:卵巢功能的新调节剂
Adenosine Triphosphate in Health and Disease Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.80756
M. Díaz-Muñoz, A. Campos-Contreras, Patricia Juárez-Mercado, E. Velázquez-Miranda, F. Vázquez-Cuevas
{"title":"Purinergic Signaling: A New Regulator of Ovarian Function","authors":"M. Díaz-Muñoz, A. Campos-Contreras, Patricia Juárez-Mercado, E. Velázquez-Miranda, F. Vázquez-Cuevas","doi":"10.5772/INTECHOPEN.80756","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.80756","url":null,"abstract":"Purinergic signaling is a sophisticated system of elements in which ATP and related molecules function as intercellular messengers. When ATP is released into the extracellular space, it activates specific receptors that belong to the P2 family. In parallel, ectonucleotidases transform ATP in its dephosphorylated metabolites including adenosine, which stimulates P1 receptors. The activity of both receptors influences various cellular processes. Moreover, metabolic conditions are concatenated with purine signaling to conform a dynamic and continuous informational network. The role of purinergic signaling in ovarian cells has been investigated, for instance, it is known that cells conforming the follicle express functional receptors that modulate basic cellular process such as proliferation, induction of apoptotic cell death, and steroidogenesis. In this chapter, we review contemporary information on purinergic action in ovarian cell physiology and state its relevance in this field.","PeriodicalId":7175,"journal":{"name":"Adenosine Triphosphate in Health and Disease","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75249940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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