嘌呤能信号:卵巢功能的新调节剂

M. Díaz-Muñoz, A. Campos-Contreras, Patricia Juárez-Mercado, E. Velázquez-Miranda, F. Vázquez-Cuevas
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引用次数: 0

摘要

嘌呤能信号是一个复杂的系统,其中ATP和相关分子作为细胞间信使。当ATP被释放到细胞外空间时,它会激活属于P2家族的特定受体。与此同时,外核酶转化ATP的去磷酸化代谢物,包括腺苷,刺激P1受体。这两种受体的活性影响各种细胞过程。此外,代谢条件与嘌呤信号相关联,以符合一个动态和连续的信息网络。嘌呤能信号在卵巢细胞中的作用已被研究,例如,已知符合卵泡表达功能受体的细胞调节基本细胞过程,如增殖、诱导凋亡细胞死亡和类固醇生成。在本章中,我们回顾了嘌呤能在卵巢细胞生理学中的作用的当代信息,并说明其在这一领域的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Purinergic Signaling: A New Regulator of Ovarian Function
Purinergic signaling is a sophisticated system of elements in which ATP and related molecules function as intercellular messengers. When ATP is released into the extracellular space, it activates specific receptors that belong to the P2 family. In parallel, ectonucleotidases transform ATP in its dephosphorylated metabolites including adenosine, which stimulates P1 receptors. The activity of both receptors influences various cellular processes. Moreover, metabolic conditions are concatenated with purine signaling to conform a dynamic and continuous informational network. The role of purinergic signaling in ovarian cells has been investigated, for instance, it is known that cells conforming the follicle express functional receptors that modulate basic cellular process such as proliferation, induction of apoptotic cell death, and steroidogenesis. In this chapter, we review contemporary information on purinergic action in ovarian cell physiology and state its relevance in this field.
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