Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi最新文献

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Asthma, infection and antibiotic. 哮喘,感染和抗生素。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2008-01-01 DOI: 10.7097/APT.200802.0001
Ping I. Lee
{"title":"Asthma, infection and antibiotic.","authors":"Ping I. Lee","doi":"10.7097/APT.200802.0001","DOIUrl":"https://doi.org/10.7097/APT.200802.0001","url":null,"abstract":"","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89978367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory myofibroblastic tumor presenting as acute abdomen: report of one case. 以急腹症为表现的炎性肌成纤维细胞瘤1例报告。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0337
Hsiu-Huei Wen, Kui-Lin Cheng, Yau-Kan Hung, P. Chang
{"title":"Inflammatory myofibroblastic tumor presenting as acute abdomen: report of one case.","authors":"Hsiu-Huei Wen, Kui-Lin Cheng, Yau-Kan Hung, P. Chang","doi":"10.7097/APT.200712.0337","DOIUrl":"https://doi.org/10.7097/APT.200712.0337","url":null,"abstract":"Inflammatory myofibroblastic tumor (IMT) is a very rare benign tumor composed of myofibroblastic spindle cells of uncertain etiology, which can occur at any age and affect any organ system. More and more cases of IMT in children have been described in pediatric literature in recent years. However, this tumor occurring intraabdominally in children has rarely been reported in Taiwan. Here we present a 1-year-9-month-old boy who had fever and abdominal pain only for 2 days, symptoms mimicking acute abdomen. After imaging study, a huge tumor nearly 10 cm in diameter was incidentally found over the right abdomen with unknown origin and nature. After surgical removal of the tumor, IMT was confirmed by the pathological findings. It is very difficult to make an accurate preoperative diagnosis on this tumor according to past experience, so the role of pathological diagnosis with immunohistochemical study becomes important. This case illustrates that IMT should be considered as a possible cause of intra-abdominal mass in children who have fever of unknown origin.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73145803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy. 接受卡马西平或丙戊酸单药治疗的儿童骨密度的评价。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0317
I. Chou, K. Lin, Huei-Shyong Wang, Chao-jan Wang
{"title":"Evaluation of bone mineral density in children receiving carbamazepine or valproate monotherapy.","authors":"I. Chou, K. Lin, Huei-Shyong Wang, Chao-jan Wang","doi":"10.7097/APT.200712.0317","DOIUrl":"https://doi.org/10.7097/APT.200712.0317","url":null,"abstract":"BACKGROUND\u0000Antiepileptic drugs have been shown to be associated with a lowering of bone mineral density in childhood and adolescence, which are critical periods of skeletal mineralization. A lower peak bone mass attained at the end of adolescence is associated with greater involutional osteoporosis and risk for fracture in the elderly. Our purpose was to evaluate the effects of carbamazepine and valproate monotherapy on bone mineral density in children in Taiwan.\u0000\u0000\u0000METHODS\u0000From November 1995 to April 2005, forty-two children with uncomplicated epilepsy, who were treated with either carbamazepine (n=21) or valproate (n=21) monotherapy for more than 6 months, were enrolled in this study. All subjects were 5 to 18 years of age, seizure-free for 5 months or more, with normal daily activity, and normal diet. Lumbar bone mineral density of L1 to L4 was measured by dual-energy X-ray absorptiometry.\u0000\u0000\u0000RESULTS\u0000The mean serum levels of carbamazepine and valproate were 5.12 +/- 2.15 mcg/ml and 49.61 +/- 20.84 mcg/ml, respectively. Treatment durations were 37.05 +/- 31.11 months and 22.86 +/- 18.84 months, respectively. The serum levels of calcium and phosphate in both groups were within therapeutic range. The serum level of alkaline phosphatase was significantly higher in the carbamazepine group (264.71 +/- 66.91, U/L) than in the valproate group (179.48 +/- 79.37, U/L). Three patients (140%) had bone mineral density Z-score of -2.0 or lower in the carbamazepine-treated group, but none in the valproate-treated group (p=0.232). Comparing the Z-score in carbamazapine- and valproate-monotherapy children, 7 (33%) had Z-score of -1.5 or lower in the carbamazepine-treated group, and none in the valporate-treated group had Z-score of -1.5 or lower (p=0.009). Four (57%) patients in the 7 carbamazepine-treated children with Z-score of -1.5 or lower had serum drug level lower than therapeutic range.\u0000\u0000\u0000CONCLUSIONS\u0000Children receiving carbarmazepine monotherapy had increased frequency of lower bone density than children receiving valproate monotherapy.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73359949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Cri-du-chat syndrome. Cri-du-chat综合症。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0328
Chia-Ying Chang, Shuan-Pei Lin, Hsiang-Yu Lin, Yen‐Jiun Chen, H. Kao, C. Yeung, Chyong-hsin Hsu, H. Chi
{"title":"Cri-du-chat syndrome.","authors":"Chia-Ying Chang, Shuan-Pei Lin, Hsiang-Yu Lin, Yen‐Jiun Chen, H. Kao, C. Yeung, Chyong-hsin Hsu, H. Chi","doi":"10.7097/APT.200712.0328","DOIUrl":"https://doi.org/10.7097/APT.200712.0328","url":null,"abstract":"BACKGROUND\u0000Cri-du-chat syndrome is a genetic disorder associated with various sized deletions of the short arm of chromosome 5. There are typical physical features, but individual phenotypes vary considerably.\u0000\u0000\u0000METHODS\u0000The records of 23 patients with cri-du-chat syndrome admitted to Mackay Memorial Hospital from June 1984 to February 2006 were retrospectively reviewed. Data abstracted from the records included abnormal facial features and physical findings, results of echocardiography, bronchoscopy, auditory evoked potential, visual evoked potential, brain ultrasonography, and karyotype. We examined the various clinical phenotypes to see if there was an association with specific karyotypes.\u0000\u0000\u0000RESULTS\u0000Among congenital heart conditions, atrial septal defect (8/15, 53%) was the most common, followed by ventricular septal defect (4/15, 26%), tricuspid regurgitation (4/15, 26%) and patent ductus arteriosus (3/15, 20%). Laryngomalacia was the most frequent airway problem (8/23, 34%) and strabismus the commonest visual disorder (1/23). A high percentage of patients had impaired hearing (5/23, 21%). There was no clear relationship found between deletion size and major clinical manifestations in this study.\u0000\u0000\u0000CONCLUSIONS\u0000Karyotype is not a reliable indicator of specific organ involvement in cri-du-chat syndrome. However, karyotyping is still useful, particularly if parental translocation are found to be involved. It helps for prenatal diagnosis of next pregnancy.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74080421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Effects of perfluorochemicals for intrapulmonary vancomycin administration and partial liquid ventilation in an animal model of meconium-injured lungs. 全氟化学物质对肺内万古霉素给药和部分液体通气的影响
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0309
M. Jeng, Yu-Sheng Lee, W. Soong
{"title":"Effects of perfluorochemicals for intrapulmonary vancomycin administration and partial liquid ventilation in an animal model of meconium-injured lungs.","authors":"M. Jeng, Yu-Sheng Lee, W. Soong","doi":"10.7097/APT.200712.0309","DOIUrl":"https://doi.org/10.7097/APT.200712.0309","url":null,"abstract":"BACKGROUND\u0000Acute lung injury, such as meconium aspiration syndrome in neonates, may present with exacerbated ventilation and perfusion abnormalities. This can impair the efficacy of intravenous antibiotic therapy in treating pulmonary infection. Intrapulmonary administration via perfluorochemical as a vehicle may adequately deliver drugs, such as the poorly pulmonary-penetrative antibiotic vancomycin, to affect lung regions while maintaining gas exchange and non-toxic serum level.\u0000\u0000\u0000METHODS\u0000Twelve newborn piglets were injured with intra-tracheally installed human meconium, and randomly grouped into intravenous group (intravenous injection with vancomycin 15 mg/kg, followed by conventional gas ventilation) or intrapulmonary group (intrapulmonary instilled with vancomycin 15 mg/kg and perfluorochemical emulsion, followed by partial liquid ventilation). Blood samples were obtained to check vancomycin serum concentrations (0-240 mins). Lung tissues were tested for vancomycin contents.\u0000\u0000\u0000RESULTS\u0000Intrapulmonary group animals had significantly lower vancomycin serum levels than the intravenous group, but vancomycin contents (198.9 +/- 72.5 microg/g dry tissue) in lung tissues was significantly higher than in the intravenous group (134.9 +/- 39.1 microg/g dry tissue) (p < 0.05). Gas exchange and lung compliance in the intrapulmonary group were also significantly better than in the intravenous group.\u0000\u0000\u0000CONCLUSIONS\u0000Perfluorochemical is a good vehicle to deliver vancomycin and maintains gas exchange in severe meconium-injured lungs.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86076552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Eicosanoids in asthma. 哮喘中的类二十烷酸。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0299
K. Wan, Wei-Fong Wu
{"title":"Eicosanoids in asthma.","authors":"K. Wan, Wei-Fong Wu","doi":"10.7097/APT.200712.0299","DOIUrl":"https://doi.org/10.7097/APT.200712.0299","url":null,"abstract":"Eicosanoids belong to a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. They are the key mediators of the pathobiology of asthma. Among the eicosanoids, lipoxins (LXs) were the first agents to be identified and recognized as potential anti-inflammatory endogenous lipid mediators. Lipoxins are biosynthesized in vivo at inflammation sites. They result mainly from the interaction between 5 and 15-lipoxygenases (LOs), which are distinct from leukotrienes (LTs) and prostaglandins (PGs) in structure and function. Leukotrienes are potent proinflammatory mediators and directly and indirectly stimulate fibroblast chemotaxis, proliferation, and collagen synthesis. Prostaglandins have both bronchoconstrictive and bronchoprotective effects and the bronchoconstriction mediated by PGD2 and PGF2alpha is only occurred in asthmatic patients but not in healthy subjects. Lipoxins counter-regulate the proinflammatory actions of LTs and activate resolution of the inflammatory response. At least two classes of receptors, CysLT1 receptors and Asprin-triggered lipoxin A4 (ALX) receptors, can interact with lipoxin A4 (LXA4) and LXA4 analogs to mediate their biologic actions. Allergen challenge initiates airway biosynthesis of LXA4 and increases expression of its receptor. In addition, LXA4 affects the release of interleukin-8 by blood mononuclear cells, and ALX affects calcium influx into epithelial cells. Therefore, the pivotal role of LXs is mediating airway homeostasis, and LXs may be part of a novel, multipronged approach for treating human asthma.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89153032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Bone mineral density of Taiwanese children. 台湾儿童骨矿物质密度。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0297
Chii-Jeng Lin
{"title":"Bone mineral density of Taiwanese children.","authors":"Chii-Jeng Lin","doi":"10.7097/APT.200712.0297","DOIUrl":"https://doi.org/10.7097/APT.200712.0297","url":null,"abstract":"","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76034546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermittent small doses of propofol for sedation of pediatric patients undergoing magnetic resonance imaging. 间歇小剂量异丙酚对接受磁共振成像的儿科患者的镇静作用。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0305
Ying-Lun Chen, C. Chen
{"title":"Intermittent small doses of propofol for sedation of pediatric patients undergoing magnetic resonance imaging.","authors":"Ying-Lun Chen, C. Chen","doi":"10.7097/APT.200712.0305","DOIUrl":"https://doi.org/10.7097/APT.200712.0305","url":null,"abstract":"BACKGROUND\u0000Sedation of children is always necessary for magnetic resonance imaging (MRI). General anesthesia may be recommended for infants and small children to protect the airway or in children who have previously failed sedation. Our practice has been to use intermittent administration of small doses of propofol.\u0000\u0000\u0000METHODS\u0000We retrospectively reviewed the anesthesia records of all children who underwent sedation for MRI between March 2004 and March 2007.\u0000\u0000\u0000RESULTS\u0000A total of 120 children underwent sedation for MRI. Few adverse events (respiratory 3%, movement 8%) and no complications occurred during sedation. Almost all of the procedures (99%) were completed successfully.\u0000\u0000\u0000CONCLUSIONS\u0000Our experience demonstrates that intermittent administration of small doses of propofol by experienced personnel for MRI can be used safely and effectively in pediatric patients.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87981498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bone mineral density and correlation factor analysis in normal Taiwanese children. 台湾正常儿童骨矿物质密度及相关因素分析。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0323
S. Shu
{"title":"Bone mineral density and correlation factor analysis in normal Taiwanese children.","authors":"S. Shu","doi":"10.7097/APT.200712.0323","DOIUrl":"https://doi.org/10.7097/APT.200712.0323","url":null,"abstract":"Background: Our aim was to establish reference data and linear regression equations for lumbar bone mineral density (BMD) in normal Taiwanese children. Several influencing factors of lumbar BMD were investigated. Methods: Two hundred fifty-seven healthy children were recruited from schools, 136 boys and 121 girls, aged 4-18 years were enrolled on a voluntary basis with written consent. Their height, weight, blood pressure, puberty stage, bone age and lumbar BMD (L2-4) by dual energy x-ray absorptiometry (DEXA) were measured. Data were analyzed using Pearson correlation and stepwise regression tests. Results: All measurements increased with age. Prior to age 8, there was no gender difference. Parameters such as height, weight, and bone age (BA) in girls surpassed boys between ages 8-13 without statistical significance (p≥0.05). This was reversed subsequently after age 14 in height (p<0.05). BMD difference had the same trend but was not statistically significant either. The influencing power of puberty stage and bone age over BMD was almost equal to or higher than that of height and weight. All the other factors correlated with BMD to variable powers. Multiple linear regression equations for boys and girls were formulated. Conclusions: BMD reference data is provided and can be used to monitor childhood pathological conditions. However, BMD in those with abnormal bone age or pubertal development could need modifications to ensure accuracy.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78388629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Harlequin ichthyosis: report of one case. 丑角鱼鳞病1例报告。
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi Pub Date : 2007-12-01 DOI: 10.7097/APT.200712.0342
Peck-Foong Thien, W. Soong, Ping-Yao Wang, Ting-Rong Hsu
{"title":"Harlequin ichthyosis: report of one case.","authors":"Peck-Foong Thien, W. Soong, Ping-Yao Wang, Ting-Rong Hsu","doi":"10.7097/APT.200712.0342","DOIUrl":"https://doi.org/10.7097/APT.200712.0342","url":null,"abstract":"Harlequin ichthyosis (HI) is the most devastating form of skin disorder, which is inherited as autosomal recessive trait related to consanguineous marriage. Although prenatal examination has become scheduled and convenient throughout Taiwan, an unexpected case of HI in a male premature infant born at 32 weeks of gestation was presented. The parents were healthy, neither relatives nor having history of congenital abnormality. We report our management and the massive impact left on both parents. We believe this is an extremely rare case in Taiwan.","PeriodicalId":7156,"journal":{"name":"Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2007-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73408357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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