Acta physiologica latino americana最新文献

Glucose and orthophosphate incorporation and lactate release in the perfused hind limb of the rat during lactic acidemia. 乳酸性酸血症大鼠后肢灌注后葡萄糖和正磷酸盐的掺入及乳酸的释放。

Acta physiologica latino americana Pub Date : 1983-01-01

F De Venanzi, R L de Wikinski, F Peña Perelli, E de D'Andrea

{"title":"Glucose and orthophosphate incorporation and lactate release in the perfused hind limb of the rat during lactic acidemia.","authors":"F De Venanzi, R L de Wikinski, F Peña Perelli, E de D'Andrea","doi":"","DOIUrl":"","url":null,"abstract":"A perfused preparation of the hind limb of normal and diabetic rats was used to study the effects of lactic acidosis, alone or associated with hypoinsulinemic diabetes, on the incorporation of glucose and inorganic orthophosphate (Pi) into the skeletal muscle. A well oxygenated perfusate was recirculated for ninety minutes during which the lactic acid accumulated into the medium with the ensuing pH drop. The perfusions were practiced in the hind limb of alloxanized diabetic rats, in the hind limb of diabetic rats with perfusate containing 200 microU of insulin/ml, in the hind limb of 24 hour fasted rats, and on the hind limb of fed rats, and they were compared to similar groups with normalized pH perfusate with a sodium bicarbonate infusion. In the diabetic perfusions with lactic acidemia, it was observed that the addition of insulin increased the uptake of Pi and of glucose, and reduced the release of Pi by the muscular tissues. A smaller release of Pi by the preparations obtained from fed rats was observed when compared to the hind limb preparations of fasted rats. The diabetic preparations showed an increased glucose uptake when the pH was normalized, and a decrease of Pi released by the muscles, even in the absence of insulin, and at the same time, the administration of insulin associated with the normalization of pH increased the uptake of Pi and of glucose, and decreased the Pi released by the muscles. In all the groups, the administration of sodium bicarbonate significantly increased the lactate release into the medium. It was also found that the lactic acidosis reduced the uptake of Pi by the preparations inducing hyperphosphatemia. According to these results, muscular tissue plays a role in the hypophosphatemia that has been reported in the insulin treated diabetic ketoacidosis by increasing the incorporation of Pi and reducing its release by the same tissue.","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 2","pages":"121-37"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17725650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth of the functional components of the rat skull in protein deficiency. 蛋白质缺乏对大鼠颅骨功能成分生长的影响。

Acta physiologica latino americana Pub Date : 1983-01-01

A C Barceló, R M Alippi, H M Pucciarelli, M E Río, C E Bozzini

引用次数: 0

Development of pancreatic hydrolases in inbred mice. 近交系小鼠胰腺水解酶的研究进展。

Acta physiologica latino americana Pub Date : 1983-01-01

L I de Caboteau, E L Calvo, A J Maillie, M I Vaccaro, O H Pivetta

引用次数: 0

Presence of 5-hydroxy-indolacetic acid in Diloboderus abderus larvae without monoamine-oxidase-like activity. 无单胺氧化酶样活性的阿derderus幼虫体内存在5-羟基吲哚乙酸。

Acta physiologica latino americana Pub Date : 1983-01-01

M C Rubio, C G Bonelli, I O Mastronardi, D C Rondina, J A Izquierdo

引用次数: 0

[Inhibition by propranolol of the ouabain binding to myocardium]. [心得安对瓦阿因与心肌结合的抑制作用]。

Acta physiologica latino americana Pub Date : 1983-01-01

O A Gende

引用次数: 0

Production of plasminogen activator in a melanoma cell line. 黑色素瘤细胞系纤溶酶原激活剂的产生。

Acta physiologica latino americana Pub Date : 1983-01-01

O Matsuo, T Sakai, C Matsuo, Y Nishida, K Akazawa, H Mihara

引用次数: 0

Analysis of urinary steroid profiles of women with Cushing's syndrome by computerised gas chromatography-mass spectrometry. 计算机气相色谱-质谱法分析库欣综合征女性尿液类固醇谱。

Acta physiologica latino americana Pub Date : 1983-01-01

M E de Pedrazzini, O D Bruno, E G Gros

{"title":"Analysis of urinary steroid profiles of women with Cushing's syndrome by computerised gas chromatography-mass spectrometry.","authors":"M E de Pedrazzini, O D Bruno, E G Gros","doi":"","DOIUrl":"","url":null,"abstract":"Urinary steroidal profiles were studied in five women with Cushing's syndrome and in two normal women that were chosen as controls, by means of gas chromatography and gas chromatography-mass spectrometry. Four patients presented ACTH-dependent adrenal hyperplasia and the last patient had an adrenocortical carcinoma. Steroids were analyzed in urinary extracts, as their respective trimethylsilyloximes and/or trimethylsilylderivatives. Qualitative and quantitative data about 36 urinary steroids were obtained. Three pituitary patients showed a well defined picture of \"5-ene pathway\" in adrenal function. The fourth patient depicted some primary deficiencies of corticosteroid biosynthesis that overshadowed most biochemical expressions of Cushing's disease. The patient with adrenal carcinoma developed a steroidal pattern resembling autonomous functioning of adrenal cortex inner zones, showing both \"5-ene pathway\" and \"4-ene pathway\" increase. This patient also had an unexpected excretion of a major metabolite of 18-hydroxycorticosterone, that did not correlate with parameters of aldosterone production. Tetrahydro-6-hydroxy-cortisol was determined in urine of two patients and original data about urinary cortoic acids in Cushing's syndrome are given. Peripheral reductive metabolism played the most important role in almost all patients. In turn, some oxidative metabolic pathways for cortisol were not specifically favoured in the cases of Cushing's disease here reported.","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 3","pages":"243-52"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17727339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of plasminogen activator in ovulation. 纤溶酶原激活剂在排卵中的作用。

Acta physiologica latino americana Pub Date : 1983-01-01

K Akazawa, O Matsuo, T Kosugi, H Mihara, N Mori

{"title":"The role of plasminogen activator in ovulation.","authors":"K Akazawa, O Matsuo, T Kosugi, H Mihara, N Mori","doi":"","DOIUrl":"","url":null,"abstract":"The role of plasminogen activator in ovulation was investigated using the inhibitor, trans-aminomethylcyclohexane carboxylic acid (t-AMCHA). In the regular cycle rat, the plasminogen activator activity of the follicles increased from the diestrus to the estrus phase. In the latter phase, a proteolytic enzyme which was not inhibited by t-AMCHA appeared. After ovulation, the plasminogen activator activity decreased. When ovulation was induced in immature rats by pregnant mare serum gonadotrophin and human chorionic gonadotrophin, remarkable fibrinolytic activity appeared in the ovaries immediately before ovulation. When t-AMCHA was given in the ovulation-induced rats, the fibrinolytic activity of the ovaries was suppressed, the number of ovulated ova decreased and the timing of ovulation was delayed. When t-AMCHA solution was given to rats in the proestrus phase, ovulation was almost completely suppressed, but aprotinin solution exerted no effect on ovulation. These results suggest that plasminogen activator is a key enzyme in ovulation, and that the chain reaction from plasminogen activator to proteolytic enzyme (including collagenase) is of greater importance than that of plasminogen activator to plasmin.","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 2","pages":"105-10"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17482163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating immune complexes and peripheral B lymphocytes in non insulin dependent diabetic patients. 非胰岛素依赖型糖尿病患者的循环免疫复合物和外周血B淋巴细胞。

Acta physiologica latino americana Pub Date : 1983-01-01

R I Barañao, P A Tesone, N A Chasseing, M Mendelson, L S Rumi

{"title":"Circulating immune complexes and peripheral B lymphocytes in non insulin dependent diabetic patients.","authors":"R I Barañao, P A Tesone, N A Chasseing, M Mendelson, L S Rumi","doi":"","DOIUrl":"","url":null,"abstract":"Serum circulating immune complexes (CIC) were measured in 27 patients with non insulin dependent diabetes (NIDD). This was done by measuring the degree of binding to human red blood cells by the C3b complement fraction. At the same time, the percentage of B lymphocytes in peripheral blood was evaluated by means of the direct immunofluorescence technique for surface IgG and EAC rosettes for cells with receptors to C3b complement fraction. Twenty normal control subjects were simultaneously studied by the same methodology. An increase in serum CIC was observed in NIDD patients, as compared to healthy subjects. Values were 35.8 +/- 3.2 and 25.6 +/- 2.1 micrograms/ml, respectively. The percentage of cells with surface IgG was 10.2 +/- 0.8 in diabetic patients; this value was significantly higher than that found in the control group (6.0 +/- 0.8). No significant quantitative difference in the percentage of EAC binding cells was found between NIDD patients and the control group. When NIDD patients were divided into two groups, those with and those without microvascular complications, neither differences in CIC levels nor in the percentage of B lymphocytes were found. Nor any correlation could be found between the highest individual CIC levels and the highest percentage of lymphocytes with surface IgG. These data show an increase of CIC levels and of cells with surface IgG in NIDD patients who had not received insulin at least not in a constant or prolonged therapy. This could allow us to suspect the existence of antigen-antibody complexes different to insulin-antiinsulin CIC found in insulin dependent diabetes.","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 2","pages":"111-6"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17293234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sympathetic superior cervical ganglia as "little neuroendocrine brains". 交感颈上神经节是“小神经内分泌脑”。

Acta physiologica latino americana Pub Date : 1983-01-01

D P Cardinali, M I Vacas, P V Gejman, M A Pisarev, M Barontini, R J Boado, G J Juvenal

{"title":"The sympathetic superior cervical ganglia as \"little neuroendocrine brains\".","authors":"D P Cardinali, M I Vacas, P V Gejman, M A Pisarev, M Barontini, R J Boado, G J Juvenal","doi":"","DOIUrl":"","url":null,"abstract":"The superior cervical ganglia (SCG) provide sympathetic innervation to the pineal gland, cephalic blood vessels, the choroid plexus, the eye, carotid body and the salivary and thyroid glands. Removal of the ganglia brings about several neuroendocrine changes in mammals, including the disruption of water balance in pituitary stalk-sectioned rats and the alteration of normal photoperiodic control of reproduction and thyroid function in hamsters, ferrets, voles, rams and goats. These effects are commonly attributed to pineal denervation. However, pinealectomy does not always mimic ganglionectomy in its neuroendocrine sequelae. This paper discusses several examples illustrating the differences in ganglia and pineal removal, including the acute and chronic effects of ganglionectomy on the control of thyroid response to TSH in rats. A functionally relevant link between SCG and the hypothalamus occurs in rats, inasmuch as ganglionectomy depresses norepinephrine uptake and increases the number and responses of alpha-adrenoceptors in medial basal hypothalamus. Lastly the SCG are active points of concurrency for hormone signals, as revealed by the metabolic changes induced by steroid and anterior pituitary hormones in these structures, even in the absence of intact preganglionic connections, as well as by the existence of putative receptors for some of the hormones, namely estradiol, testosterone and corticosteroids. The SCG appear to constitute a peripheral neuroendocrine center.","PeriodicalId":7131,"journal":{"name":"Acta physiologica latino americana","volume":"33 3","pages":"205-21"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17385391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0