Acta Chromatographica最新文献

Determination of four dry cough medications in fixed dose form by developed stability indicating liquid chromatography-photodiode array detection 用已开发的稳定性指示液相色谱-光电二极管阵列检测法测定四种固定剂型的干咳药物

IF 1.7 4区化学

Acta Chromatographica Pub Date : 2024-08-08 DOI: 10.1556/1326.2024.01238

J. Saroja, K. Jagadeesh, B. N. Suresh Varma Dendukuri, Rama Swamy Guttula, B. Leela Kumari, C. Chandrashekar

{"title":"Determination of four dry cough medications in fixed dose form by developed stability indicating liquid chromatography-photodiode array detection","authors":"J. Saroja, K. Jagadeesh, B. N. Suresh Varma Dendukuri, Rama Swamy Guttula, B. Leela Kumari, C. Chandrashekar","doi":"10.1556/1326.2024.01238","DOIUrl":"https://doi.org/10.1556/1326.2024.01238","url":null,"abstract":"This study deals with the development of HPLC assay method for the determination of guaifenesin (GUF), bromhexine (BRH), chlorpheniramine (CHP), and dextromethorphan (DEE) in bulk and Leekuf tablets. Column C18 Aligent eclipse was used to analyse GUF, BRH, CHP and DEE. The H3PO4 (0.01%) and methanol combined in 70:50 (vol/vol) parts was used as mobile phase. The HPLC assay method was validated in accordance with the ICH prerequisite and was capable of providing accurate (99.90% recovery for BRH, 99.40% recovery for CHP, 100.00% recovery for GUF and 99.50% for DEE) and precise (0.160–0.805% RSD range for GUF, BRH, CHP and DEE) quantitative results under slight variations in chromatographic circumstances in the range of quantities 25–150 μg mL−1 (GUF), 2–12 μg mL−1 (BRH), 0.5–3 μg mL−1 (CHP) and 2.5–15 μg mL−1 (DEE). These results concluded that HPLC assay method developed was beneficial for the evaluation of GUF, BRH, CHP and DEE simultaneously in commercial tablet dose. The degradants eluted are well resolved from the GUF, BRH, CHP, and DEE peaks, showing that the process is stability indicating.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Method development and validation of Metformin HCL and Dapagliflozin by using RP-HPLC 采用 RP-HPLC 法开发和验证二甲双胍盐酸盐和达帕格列净的方法

IF 1.7 4区化学

Acta Chromatographica Pub Date : 2024-07-10 DOI: 10.1556/1326.2024.01226

Waqar Siddique, Zulcaif, Hassaan Umar, Sufyan Junaid Usmani, Muhammad Waqas, Maria Gul, Mubashra Gul

{"title":"Method development and validation of Metformin HCL and Dapagliflozin by using RP-HPLC","authors":"Waqar Siddique, Zulcaif, Hassaan Umar, Sufyan Junaid Usmani, Muhammad Waqas, Maria Gul, Mubashra Gul","doi":"10.1556/1326.2024.01226","DOIUrl":"https://doi.org/10.1556/1326.2024.01226","url":null,"abstract":"The prevalence of diabetes is increasing day by day as per a report by the year 2045, 1 out of every 8th individuals may suffer from diabetes. This research article focuses on developing and validating Metformin and Dapagliflozin in combination by using high-pressure liquid Chromatography (RP-HPLC). The validation of the method was followed as per the guidelines provided by the International Conference on Harmonization (ICH) and United States Pharmacopeia (USP). Separation of both drugs takes place in less than 4 min. This separation takes place using Phosphate buffer (pH 6.8) and acetonitrile in a 45:55 (v/v) ratio at a 1.0 mL min−1 flow rate. Furthermore, studies on both drugs were conducted by using the bulk and pharmaceutical dosage forms (Tablets). The developed method was accurate as drug recoveries in both cases of Metformin, and Dapagliflozin ranged between (100.8, 99.6, 98.8%) to (100.8, 99.3, and 101.5%) respectively having a concentration range of solutions between 70, 100 and 130 μg mL−1 dilution. The recommended method for simultaneous quantification of Metformin and Dapagliflozin was established and validated and no excipient interactions were found.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of fraxetin, fraxin and dimethylfraxetin in rat plasma by UPLC-MS/MS 利用 UPLC-MS/MS 法测定大鼠血浆中的 fraxetin、fraxin 和 dimethylfraxetin

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-05-24 DOI: 10.1556/1326.2024.01220

Qing Jia, Ziyue Wang, Shuqian Wang, Shunjun Ma, Xueqi Qiao, Xueli Huang, Xianqin Wang, Congcong Wen, Xia-yin Zhu

{"title":"Determination of fraxetin, fraxin and dimethylfraxetin in rat plasma by UPLC-MS/MS","authors":"Qing Jia, Ziyue Wang, Shuqian Wang, Shunjun Ma, Xueqi Qiao, Xueli Huang, Xianqin Wang, Congcong Wen, Xia-yin Zhu","doi":"10.1556/1326.2024.01220","DOIUrl":"https://doi.org/10.1556/1326.2024.01220","url":null,"abstract":"The levels of fraxetin, fraxin, and dimethylfraxetin in rat plasma to be measured using an ultra-performance liquid chromatography tandem mass-spectrometry (UPLC–MS/MS) technique and applied to their pharmacokinetics and bioavailability.The protein precipitation technique was applied to the plasma preparation using acetonitrile and methanol (9:1, v/v). At a flow rate of 0.4 mL min−1, the elution time was 6 min. The mobile phase consisted of acetonitrile-water with 0.1% formic acid, and the chromatographic column was UPLC HSS T3 (50 mm × 2.1 mm, 1.8 μm). Quantitative analysis was conducted using multiple reaction monitoring (MRM) mode and detection was performed using electrospray ionization (ESI) positive ion mode. In each group, six rats were treated with fraxetin, fraxin, and dimethylfraxetin either orally (5 mg kg−1) or intravenously (1 mg kg−1).The calibration curves showed good linearity in the range of 2–4,000 ng mL−1, where r was greater than 0.99. The bioavailability of dimethylfraxetin, fraxin, and fraxetin was determinated to be 19.7, 1.4, and 6.0%.The established UPLC-MS/MS method for determining the levels of these three compounds in rat plasma was successfully applied to the pharmacokinetics of dimethylfraxetin, fraxin, and fraxetin, and the bioavailability was calculated.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an HPLC-UV method for the simultaneous determination of allantoin and D-panthenol in cosmetic products containing Aloe vera extracts 建立同时测定含芦荟提取物的化妆品中尿囊素和 D-泛醇的 HPLC-UV 方法

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-05-21 DOI: 10.1556/1326.2024.01216

Burhan Ceylan, Ş. E. KEPEKÇİ TEKKELİ

{"title":"Development of an HPLC-UV method for the simultaneous determination of allantoin and D-panthenol in cosmetic products containing Aloe vera extracts","authors":"Burhan Ceylan, Ş. E. KEPEKÇİ TEKKELİ","doi":"10.1556/1326.2024.01216","DOIUrl":"https://doi.org/10.1556/1326.2024.01216","url":null,"abstract":"A simple, fast and selective analytical method has been developed for the simultaneous determination of allantoin and D-panthenol in cosmetic products containing Aloe vera extracts. The proposed method depends on reversed-phase liquid chromatography with isocratic flow profile of the mobile phase composed of acetonitrile–10 mM phosphoric acid (pH 2.5) (85:15, v/v), with a C18 column at 30 °C. The analytes were detected with UV–vis. detector at 210 nm. The injection volume was 20 μL. The linearity ranges were found to be 0.2–20 and 0.1–10 μg mL−1 for allantoin and D-panthenol, respectively. LOD values were found to be 0.07 μg mL−1 and 0.03 μg mL−1, LOQ values were found to be 0.2 and 0.1 μg mL−1 for allantoin and D-panthenol, respectively. No interference was observed from concomitants. The developed method was applied to the analysis of 10 different type cosmetic products. It is foreseen that the method will be able to be used in order to carry out routine analysis, quality control and standardization in cosmetic products containing allantoin and D-panthenol.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141116088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A simple, rapid, and green method for determination of three cholic acids in bio-transformed Jindanfen by HPLC-MS 利用 HPLC-MS 测定生物转化金丹芬中三种胆酸的简单、快速、绿色方法

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-05-08 DOI: 10.1556/1326.2024.01209

Zhengming Qian, Qi Huang, Feng Wang, Qing-Qing Lei, Zhuobin He, Qilong Wu, Menghua Wu, Jin Gao

{"title":"A simple, rapid, and green method for determination of three cholic acids in bio-transformed Jindanfen by HPLC-MS","authors":"Zhengming Qian, Qi Huang, Feng Wang, Qing-Qing Lei, Zhuobin He, Qilong Wu, Menghua Wu, Jin Gao","doi":"10.1556/1326.2024.01209","DOIUrl":"https://doi.org/10.1556/1326.2024.01209","url":null,"abstract":"A simple, rapid, and green high-performance liquid chromatography-mass spectrometry (HPLC-MS) method was developed for determination of tauroursodeoxycholic acid (TUDCA), taurocholic acid (TCA), and taurochenodeoxycholic acid (TCDCA) in bio-transformed Jindanfen (BTJDF), which is obtained from chicken bile through a bioconversion process. The sample was prepared using water. The HPLC separation was operated on a poroshell 120 EC-C18 column with a 2.0 min gradient elution procedure. Detection was performed on a single quadrupole mass spectrometer in negative mode with selected ion monitoring mode (SIM). This developed HPLC-MS method presented good linearity (r > 0.997) and sensitivity (limit of quantification, 30.0–80.0 pg) for three analytes. The relative standard deviations (RSDs) for precision, repeatability, and stability were all below 3.00%. The matrix effects and average recoveries of three analytes were 91.2–97.9% (RSDs < 1.50%) and 95.4–103% (RSDs < 3.00%), respectively. The average contents of TUDCA, TCA, and TCDCA in ten batches of samples were 33.8, 13.2, and 20.5%, respectively. Finally, the greenness of the developed method was validated by Analytical Eco-Scale and Complex-GAPI. The developed method was proved to be an eco-friendly, effective, and reliable approach for assaying the three cholic acids in BTJDF, which is help to improve the quality evaluation level of the BTJDF industry.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and structural characterization of potential degradation products of baricitinib using liquid chromatography combined with quadrupole time-of-flight mass spectrometry 利用液相色谱法结合四极杆飞行时间质谱法鉴定巴利替尼的潜在降解产物并确定其结构特征

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-04-12 DOI: 10.1556/1326.2024.01212

Eleni Kakouri, Konstantinos Gkountanas, C. Kanakis, P. Tarantilis, Y. Dotsikas

{"title":"Identification and structural characterization of potential degradation products of baricitinib using liquid chromatography combined with quadrupole time-of-flight mass spectrometry","authors":"Eleni Kakouri, Konstantinos Gkountanas, C. Kanakis, P. Tarantilis, Y. Dotsikas","doi":"10.1556/1326.2024.01212","DOIUrl":"https://doi.org/10.1556/1326.2024.01212","url":null,"abstract":"Baricitinib (BRT) is a drug substance with potent anti-inflammatory activity indicated in rheumatoid arthritis, atopic dermatitis, severe alopecia areata and recently for the treatment of Covid-19. Process impurities of the drug during its formulation are quite known, however studies regarding its degradation products (DPs) under stress conditions are limited. In this study, the drug was subjected to forced degradation under various degradation conditions, including acidic hydrolysis, alkaline hydrolysis, oxidative and thermal, to determine its inherent stability. To this purpose, a novel HPLC method was developed for the determination of degradation impurities of BRT. Alkaline hydrolysis test showed a selectivity towards breaking C–C bonds. This resulted to five DPs formed by chain scission reactions occurred at the pyrrolo-pyrimidine group between C6–C10 and C8–C9. Also, the ethylsulfonyl-azetidin-ylidene group was subjected to C–C bond cleavage at C12–C15 and C16–C18. Degradation products were further characterized with the use of liquid chromatography quadrupole time of flight tandem mass spectrometry (LC-Q-TOF-MS/MS).","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140708742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodology for high-performance liquid chromatography detection of latanoprost and latanoprost free acid 高效液相色谱法检测拉坦前列腺素和拉坦前列腺素游离酸的方法

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-04-08 DOI: 10.1556/1326.2024.01206

Ashleigh M. Jankowski, Camila Vardar, Matthew V. Talarico, Liana D. Wuchte, Mark E. Byrne

{"title":"Methodology for high-performance liquid chromatography detection of latanoprost and latanoprost free acid","authors":"Ashleigh M. Jankowski, Camila Vardar, Matthew V. Talarico, Liana D. Wuchte, Mark E. Byrne","doi":"10.1556/1326.2024.01206","DOIUrl":"https://doi.org/10.1556/1326.2024.01206","url":null,"abstract":"A gradient high-performance liquid chromatography (HPLC) method has been developed to determine the concentrations of latanoprost (LP) and latanoprost free acid (LPA) in aqueous solutions. It is novel due to a combination of its simplicity, speed, and detection capability in aqueous solutions for both active drug (LPA) and prodrug (LP). This method is applicable for the research and development of novel drug delivery devices and quality control assays for experimental and commercial laboratory settings, as it allows for a high sample throughput. Samples were chromatographed across a C18 + 2.7 µm 4.6 × 7.5 mm reversed-phase column with gradient elution using a mobile phase of aqueous acetic acid (pH 3.1) and acetonitrile with 0.1% acetic acid. UV spectrophotometry was used to monitor the eluents at 210 nm. Drug concentrations from 1.0 to 150 μg mL−1 were tested, with good linearity observed across the range. LPA had a signature peak at approximately 4.82 min (SD < 0.08) and LP at 9.27 min (SD < 0.07). For both drug and pro-drug, LOD and LOQ were 1.0 and 2.5 μg mL−1, respectively. This assay which accurately measures both prodrug and drug in a single injection, has significant applicability in determining the release kinetics of novel LP drug delivery systems.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140731771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical and numerical solutions of linear and nonlinear chromatography column models 线性和非线性色谱柱模型的分析和数值解决方案

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-03-27 DOI: 10.1556/1326.2024.01199

Krzysztof Kaczmarski, M. Szukiewicz

引用次数: 0

Development and validation of an analytical method for acetamiprid determination in plant protection products using HPLC-DAD 利用 HPLC-DAD 开发和验证测定植保产品中啶虫脒含量的分析方法

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-03-25 DOI: 10.1556/1326.2024.01214

Patrycja Marczewska, Joanna Rolnik, T. Stobiecki, M. Sajewicz

{"title":"Development and validation of an analytical method for acetamiprid determination in plant protection products using HPLC-DAD","authors":"Patrycja Marczewska, Joanna Rolnik, T. Stobiecki, M. Sajewicz","doi":"10.1556/1326.2024.01214","DOIUrl":"https://doi.org/10.1556/1326.2024.01214","url":null,"abstract":"Plant protection products (PPP), crucial for agricultural production, are experiencing increased global demand, particularly with the growing need for food production. To meet this demand, robust analytical methods are essential for confirming the presence and determining active substance concentrations in PPP. This study introduces an analytical method utilizing high-performance liquid chromatography with a diode array detector (HPLC-DAD) for determination of acetamiprid in water-soluble powder formulations. The method, validated according to SANCO/3030/99 rev.5, demonstrated exhibited adequate accuracy and precision, with repeatability expressed as the ratio of the standard deviation (% RSD) to the relative standard deviation (% RSDr) being lower than 1. Recoveries for the active substance at concentrations above 10% ranged from 97% to 103%. The developed method is also characterized by suitable linearity, confirmed by a correlation coefficient >0.99. Specific chromatographic profiles were generated, and acetamiprid content in 180 formulations was analyzed, including reference products. The developed method aligns with “green chemistry” principles, minimizing solvent use and emphasizing energy efficiency. Overall, it offers a comprehensive approach for qualitative and quantitative analysis, ensuring the reliability of PPP quality control.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140383680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly determine venetoclax in plasma sample using an LC-MS/MS method and apply it in TDM for acute leukemia children patient 利用 LC-MS/MS 方法快速测定血浆样本中的 Venetoclax，并将其应用于急性白血病儿童患者的 TDM 中

IF 1.9 4区化学

Acta Chromatographica Pub Date : 2024-02-26 DOI: 10.1556/1326.2023.01192

Yanni Zhang, Ning Sun, Dong Mei, Feng Yu

{"title":"Rapidly determine venetoclax in plasma sample using an LC-MS/MS method and apply it in TDM for acute leukemia children patient","authors":"Yanni Zhang, Ning Sun, Dong Mei, Feng Yu","doi":"10.1556/1326.2023.01192","DOIUrl":"https://doi.org/10.1556/1326.2023.01192","url":null,"abstract":"Venetoclax is the first oral Bcl-2 inhibitor with high affinity targeting tumor cell apoptosis mechanism. In this study we developed a simple, sensitive and reliable LC–MS/MS method to determine venetoclax in children's hemolytic or lipemic samples. The method utilized an electrospray ion source and operated in multiple reaction monitoring mode. Venetoclax-d8 was used as an internal standard. Plasma samples were precipitated by acetonitrile containing 10% dimethyl sulfoxide and were separated by a Hypersil GOLD column (2.1 mm × 150 mm, 5 μm). The mobile phase consisted of acetonitrile-2 mM ammonium acetate (30:70, v/v) containing 0.4% formic acid. The quantification for venetoclax and venetoclax-d8 were m/z 868.1 → 636.1, m/z 876.1 → 644.1, respectively. The linear range was 10–2,000 ng mL−1 for venetoclax. The matrix in normal plasma, hemolytic or lipemic plasma had no significant effect on the detection results. The specificity, recovery and stability also met the acceptance criteria of guiding principles for the validation of biological sample quantitative analysis presented in the Chinese Pharmacopoeia (2015). As a result, this method is particularly suitable for determining venetoclax in hemolytic or lipemic samples from children with acute myeloid leukemia. The method, with the application of monitoring drug concentrations in pediatric patients, was successful.","PeriodicalId":7130,"journal":{"name":"Acta Chromatographica","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140430354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0