Acta geneticae medicae et gemellologiae最新文献_第6页

Correlation of antepartum uterine activity and cervical change in twin gestation. 双胎妊娠产前子宫活动与子宫颈变化的关系。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000702

R B Newman, J M Ellings, M M O'Reilly, B C Brost, M C Miller, D Gates

{"title":"Correlation of antepartum uterine activity and cervical change in twin gestation.","authors":"R B Newman, J M Ellings, M M O'Reilly, B C Brost, M C Miller, D Gates","doi":"10.1017/s0001566000000702","DOIUrl":"https://doi.org/10.1017/s0001566000000702","url":null,"abstract":"Objective: To determine the correlation between quantitative measurements of antepartum uterine activity and cervical change twin gestations.Methods: Forty women from our Twin Clinic constituted the study group. Participants had a cervical examination each week between 20 and 37 weeks gestation and a cervical score (CS) was calculated as follows: CS = cervical length (cms)-cervical dilation (cms) at the internal os. The women also performed blinded home uterine activity monitoring (HUAM) for a mean of 7.0 + 3.0 hrs/wk (+SD). Uterine activity was expressed as mean number of contractions/hour/week gestation based on the average of three independent reviewers. CS was determined by a single clinician unaware of the HUAM recordings. A significant change in the CS was defined as a reduction of at least 0.5 from the preceding week. Correlation coefficients were used to determine the association between uterine activity and change in the cervical score.Results: Twin pregnancy was characterized by a rise from 0.2 + .03 contractions/hr at 20 weeks to 3.2 + 2.4 contractions/hr at 37 weeks gestation. CS fell from a mean of 2.6 + 0.2 at 20 weeks to -2.1 + 0.9 at 37 weeks gestation. There was a significant negative correlation (-0.317, p < .0001) between increasing uterine activity and decreasing CS. There were significantly more (p < .002) contractions during the 7 days preceding a significant reduction in CS (3.3 + 3.5 contractions/hr) than when the CS was unchanged (1.6 +/- 1.5 contractions/hr).Conclusions: In twin gestations, an increasing frequency of uterine contractions is strongly correlated with quantifiable cervical change between 20-37 weeks gestation. Persistent daytime contraction frequencies of > 3/hr represent a risk factor for cervical dilation and/or effacement.","PeriodicalId":7118,"journal":{"name":"Acta geneticae medicae et gemellologiae","volume":"46 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s0001566000000702","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20239669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Twin zygosity diagnosis by mailed questionnaire below age twelve months. Le Groupe Romulus. 通过邮寄问卷对12个月以下的双胞胎合子进行诊断。罗穆卢斯集团。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000568

C Charlemaine, M Duyme, J T Aubin, F Guis, N Marquiset, I de Pirieux, N Strub, Y Brossard, G Jarry, R Frydman, J C Pons

引用次数: 8

From genetic research into clinical practice. 从基因研究到临床实践。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000556

B Dallapiccola, I Torrente, R Mingarelli, G Novelli

{"title":"From genetic research into clinical practice.","authors":"B Dallapiccola, I Torrente, R Mingarelli, G Novelli","doi":"10.1017/s0001566000000556","DOIUrl":"https://doi.org/10.1017/s0001566000000556","url":null,"abstract":"The present genome era is characterized by speedy progress and prompt transfer of results into clinical practice. This creates the need for rapid disclosure of results and renewal of laboratory's protocols. Molecular cytogenetics has provided and increased ability to identify chromosomes, correlate chromosome structure with gene location, find out cryptic aberrations, and detect specific DNA sequences. These advances have allowed the confident discovery of a number of contiguous gene syndromes. The positional cloning and positional candidate strategies have greatly expedited the search process of disease genes, and become relevant methods for genes' discovery. Understanding the molecular basis of diseases has shown an unpredicted wide genetic heterogeneity, which has splitted single disorders into many clinically similar conditions, and added complexity to the nosology of human diseases. The opposite process, allelism, where clinical diversity results from allelic mutations, has lumped together many distinct disorders, by showing that different clinical entities are not necessarily due to mutations in different genes. Dynamic mutations have provided the molecular understanding of interindividual and intrafamilial variability including anticipation, in a number of diseases. The discovery of distinct correlations between the molecular pattern and disease severity is providing a unique opportunity for using molecular results to assess the clinical outcome. Diagnostic, presymptomatic and predictive molecular testing are becoming widely used and provide enormous opportunities for improving the lot of our patients.","PeriodicalId":7118,"journal":{"name":"Acta geneticae medicae et gemellologiae","volume":"46 3","pages":"139-46"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s0001566000000556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20563066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioethical considerations on cloning and twinning. 克隆和双胞胎的生物伦理考虑。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000544

M Milani-Comparetti

引用次数: 1

High rate of twins among offspring of mothers with the Järvi-Hakola-Nasu disease and with comments on disorders associated with twinning. 患有Järvi-Hakola-Nasu疾病的母亲的后代双胞胎率高，并对与双胞胎有关的疾病发表评论。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000738

H P Hakola, A W Eriksson

引用次数: 0

Case of gastroschisis of the surviving fetus in monochorionic twin pregnancy. 单绒毛膜双胎妊娠存活胎儿胃裂1例。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000647

W Malinowski, I Biskup

引用次数: 1

Prevalence and correlates of susceptibility to motion sickness. 晕车的患病率及其易感性。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000660

K Sharma, Aparna

{"title":"Prevalence and correlates of susceptibility to motion sickness.","authors":"K Sharma, Aparna","doi":"10.1017/s0001566000000660","DOIUrl":"https://doi.org/10.1017/s0001566000000660","url":null,"abstract":"Data on susceptibility to motion sickness were collected on a sample of 535 individuals divided into eight groups. The prevalence of motion sickness among Tibetans and Northeast Indians (28%) was slightly higher than Northwest Indians (26%). Generally speaking, females (27.3%) were more susceptible than males (16.8%). Among different groups, the highest incidence of susceptibility to motion sickness (SMS) was recorded in schizophrenic patients (30%), while the lowest in rowers (zero percent). Ears and eyes are the most potent receptors of provocative motion that causes sickness. Individuals with greater spatial and motor control, reflected in sports like rowing, athletics and professions like armed and paramilitary forces, were less susceptible to motion sickness. The SMS was significantly higher in individuals who suffered from spatial disorientation (35.05%), migraine (26.31%), gastrointestinal disorders (26.82%) and those who were more sensitive to unpleasant odours (24.64%) and preferred sweet flavours (24.48%) than their counterparts. These correlates have been utilized to explain the genesis of sickness using threshold model. Genetic and environmental pathways are strongly advocated. Past episodes of motion sickness acted as a strong psychological attribute in determining further episodes. The roadway buses and trucks proved more effective passive transportation types that caused sickness. The voluntary stabilization of the head and neck movements and gaze control proved very effective natural measures adopted by 38% subjects to avoid or limit motion sickness. About 50% of susceptible individuals became less susceptible or fully acclimatized to motion sickness due to habituation. The mean age at acclimatization was 21.98 +/- 5.93 years.","PeriodicalId":7118,"journal":{"name":"Acta geneticae medicae et gemellologiae","volume":"46 2","pages":"105-21"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s0001566000000660","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20416144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Abstraction skillfulness in monozygotic and dizygotic twin pairs. 同卵双胞胎和异卵双胞胎的抽象技巧。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000751

S Nicole, C Del Miglio

引用次数: 7

Ultrasound examination in twin pregnancy and late fetal death. 双胎妊娠和晚期死胎的超声检查。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s000156600000043x

H Rydhstroem, B Walles

{"title":"Ultrasound examination in twin pregnancy and late fetal death.","authors":"H Rydhstroem, B Walles","doi":"10.1017/s000156600000043x","DOIUrl":"https://doi.org/10.1017/s000156600000043x","url":null,"abstract":"Objective: To test the hypothesis that the (case) twin later to succumb in utero has biparietal diameter measurements (by ultrasound) different from those (control) twins surviving the perinatal period.Material and methods: Information from the Medical Birth Registry, National Board of Health and Welfare, Stockholm, was used to identify all births in a defined population in southern Sweden with about 20,000 deliveries each year. In 3,019 twin pregnancies between 1973 and 1989, one or both twins were stillborn in 47 cases (gestational duration > or = 28 weeks, birthweight > or = 500 g). For each case pregnancy, two control pregnancies were selected, the matching criteria being: same delivery unit, same parity (0, I, II, III+), similar year of delivery (+/- 1 year) and maternal age (+/- 5 years). Data on ultrasound examinations were extracted from the original medical records. Screening in early second trimester started at one of the units as early as 1973 and at the latest of 12 units in 1982.Results: There was no obvious difference between cases and controls in intra-pair discordant biparietal diameter (BPD) measured in early second trimester. Nor was there any evident difference in the rate of deviant BPD between cases and controls. In all, 8% of dead male and 24% of dead female fetuses were by definition small-for-gestational age (< -2 standard deviations).Conclusions: No significant difference was seen between cases and controls regarding deviating biparietal diameters. Abdominal diameter may be a better predictor of subsequent fetal death (not analysed in this study), though only about 15% of all dead twins were deemed small-for-gestational age.","PeriodicalId":7118,"journal":{"name":"Acta geneticae medicae et gemellologiae","volume":"46 4","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s000156600000043x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20770676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends of twinning rates in ten countries, 1972-1996. 1972-1996年10个国家的双胞胎率趋势。

Acta geneticae medicae et gemellologiae Pub Date : 1997-01-01 DOI: 10.1017/s0001566000000441

Y Imaizumi

{"title":"Trends of twinning rates in ten countries, 1972-1996.","authors":"Y Imaizumi","doi":"10.1017/s0001566000000441","DOIUrl":"https://doi.org/10.1017/s0001566000000441","url":null,"abstract":"Trends of twinning rates were analyzed using vital statistics in Austria, Finland, Norway, Sweden, Canada, Australia, Hong Kong, Israel, Japan, and Singapore during the period from 1972 to 1996. The twinning rates increased significantly year by year in each country. During these periods, the twinning rate increased by twenty percent in Austria and Canada, and by sixty percent in Norway and Sweden. The twinning rate was 1.6 times higher in Sweden than in Hong Kong in 1972 and by eighty percent in Israel in 1995. Twinning rates were higher in European countries, Canada, and Australia than in Asia. The variations of the twinning rates among countries were not only due to biological factors, but also to assisted reproductive techniques. In Australia, the overall twinning rate was 1.3 times higher in the nuptial births (14.1 per 1000 births) than in the ex-nuptial births (10.7) during the period 1994-1996. As for maternal age, twinning rates in Sweden increased year by year for maternal age groups except the youngest and the oldest age groups. In Sweden, the rising twinning rate has been attributed to the higher proportion of mothers (for the 25-39 year old age groups) treated with ovulation-inducing hormones and attributed to in-vitro fertilization.","PeriodicalId":7118,"journal":{"name":"Acta geneticae medicae et gemellologiae","volume":"46 4","pages":"209-18"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/s0001566000000441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20770677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55