世界免疫学杂志(英文版)最新文献

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Role of myeloid-derived suppressor cells in autoimmune disease. 骨髓源性抑制细胞在自身免疫性疾病中的作用

世界免疫学杂志(英文版) Pub Date : 2014-03-27 DOI: 10.5411/wji.v4.i1.26

Kristen R Crook, Peng Liu

{"title":"Role of myeloid-derived suppressor cells in autoimmune disease.","authors":"Kristen R Crook, Peng Liu","doi":"10.5411/wji.v4.i1.26","DOIUrl":"https://doi.org/10.5411/wji.v4.i1.26","url":null,"abstract":"Myeloid-derived suppressor cells (MDSCs) represent an important class of immunoregulatory cells that can be activated to suppress T cell functions. These MDSCs can inhibit T cell functions through cell surface interactions and the release of soluble mediators. MDSCs accumulate in the inflamed tissues and lymphoid organs of patients with autoimmune diseases. Much of our knowledge of MDSC function has come from studies involving cancer models, however many recent studies have helped to characterize MDSC involvement in autoimmune diseases. MDSCs are a heterogeneous group of immature myeloid cells with a number of different functions for the suppression of T cell responses. However, we have yet to fully understand their contributions to the development and regulation of autoimmune diseases. A number of studies have described beneficial functions of MDSCs during autoimmune diseases, and thus there appears to be a potential role for MDSCs in the treatment of these diseases. Nevertheless, many questions remain as to the activation, differentiation, and inhibitory functions of MDSCs. This review aims to summarize our current knowledge of MDSC subsets and suppressive functions in tissue-specific autoimmune disorders. We also describe the potential of MDSC-based cell therapy for the treatment of autoimmune diseases and note some of hurdles facing the implementation of this therapy.","PeriodicalId":71060,"journal":{"name":"世界免疫学杂志(英文版)","volume":"4 1","pages":"26-33"},"PeriodicalIF":0.0,"publicationDate":"2014-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302755/pdf/nihms654159.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33003429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 67

Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects. 光动力疗法后的免疫反应可增强抗癌和抗菌效果。

世界免疫学杂志(英文版) Pub Date : 2014-03-27 DOI: 10.5411/wji.v4.i1.1

Eleonora Reginato, Peter Wolf, Michael R Hamblin

{"title":"Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects.","authors":"Eleonora Reginato, Peter Wolf, Michael R Hamblin","doi":"10.5411/wji.v4.i1.1","DOIUrl":"10.5411/wji.v4.i1.1","url":null,"abstract":"Photodynamic therapy (PDT) is a clinically approved procedure for treatment of cancer and infections. PDT involves systemic or topical administration of a photosensitizer (PS), followed by irradiation of the diseased area with light of a wavelength corresponding to an absorbance band of the PS. In the presence of oxygen, a photochemical reaction is initiated, leading to the generation of reactive oxygen species and cell death. Besides causing direct cytotoxic effects on illuminated tumor cells, PDT is known to cause damage to the tumor vasculature and induce the release of pro-inflammatory molecules. Pre-clinical and clinical studies have demonstrated that PDT is capable of affecting both the innate and adaptive arms of the immune system. Immune stimulatory properties of PDT may increase its beneficial effects giving the therapy wider potential to become more extensively used in clinical practice. Be sides stimulating tumor-specific cytotoxic T-cells capable to destroy distant untreated tumor cells, PDT leads to development of anti-tumor memory immunity that can potentially prevent the recurrence of cancer. The immunological effects of PDT make the therapy more effective also when used for treatment of bacterial infections, due to an augmented infiltration of neutrophils into the infected regions that seems to potentiate the outcome of the treatment.","PeriodicalId":71060,"journal":{"name":"世界免疫学杂志(英文版)","volume":"4 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2014-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214901/pdf/nihms-580818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32788260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0