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Soluble interleukin-2 receptor in sera of patients with Graves' disease. Graves病患者血清中可溶性白介素-2受体的变化。
Acta medica Hungarica Pub Date : 1991-01-01
C Balázs, N R Farid
{"title":"Soluble interleukin-2 receptor in sera of patients with Graves' disease.","authors":"C Balázs,&nbsp;N R Farid","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recently, in vitro production of interleukin-2 receptor induced by mitogens have been shown to be impaired in autoimmune disorders including organo-specific autoimmune diseases. The aim of this study was to investigate serum levels of soluble interleukin-2 receptor in 20 untreated patients with Graves' disease and to follow up their changes in relation to clinical picture and TSH-receptor-, anti-thyroglobulin-, anti-microsomal as well as anti-eye muscle antibodies. Soluble interleukin-2 receptor level was significantly increased in newly-diagnosed Graves' patients compared to controls (667 +/- 270 vs. 205 +/- 45 U/ml) (P less than 0.001). Among the patients sera those with active infiltrative ophthalmopathy had higher soluble interleukin-2 receptor levels than those without eye symptoms (810 +/- 313 vs. 525 +/- 180 U/ml). Soluble interleukin-2 receptor level was normalized in Methimazole-treatment-induced remission in the majority of patients except those with ophthalopathy. In five patients the soluble interleukin-2 receptor levels were studied after interruption of thyrostatic therapy; an increase was observed in three patients; thereafter hyperthyrosis relapsed in two cases. Furthermore, a correlation was found between soluble interleukin-2 receptor levels and TSH-receptor antibodies, however, the association with other immune parameters examined was not significant. In conclusion, an enhanced level of soluble interleukin-2 receptor was detected in patients with untreated Graves' disease. This finding might play a significant role in regulation of impaired cell-mediated immune mechanism and has a prognostic value for relapse of autoreactive processes.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 1-2","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12976045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parkinson's syndrome: cranial computed-tomography findings. Their dependence on sex and age. 帕金森综合征:颅计算机断层扫描结果。他们对性别和年龄的依赖。
Acta medica Hungarica Pub Date : 1991-01-01
W Grundl, R Ziegler, K P Westphal, M Hufnagl, J Szirtes, H H Kornhuber
{"title":"Parkinson's syndrome: cranial computed-tomography findings. Their dependence on sex and age.","authors":"W Grundl,&nbsp;R Ziegler,&nbsp;K P Westphal,&nbsp;M Hufnagl,&nbsp;J Szirtes,&nbsp;H H Kornhuber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cranial Computed Tomography (CCT) findings in 123 patients suffering from Parkinson's syndrome were compared with a sex- and age-matched normal control group. Signs of supratentorial atrophy--cortical and subcortical--were more significantly marked in the Parkinson group. In both groups, signs of atrophy were more prevalent in men than in women. Parkinsonian women also more frequently showed limited features, such as lacunar lesions, around the lateral ventricles. Moreover, in these patients atrophy was marked in the frontal cortex.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 3-4","pages":"127-36"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Familial myasthenia gravis: nine patients in two generations. 家族性重症肌无力:两代共9例。
Acta medica Hungarica Pub Date : 1991-01-01
A Szobor
{"title":"Familial myasthenia gravis: nine patients in two generations.","authors":"A Szobor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In two generations of a family followed up for 15 years, nine patients suffering from myasthenia gravis were observed. The family, being of special genetic importance, is unique in the literature.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 3-4","pages":"145-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal cytogenetic study of translocation carriers. 易位携带者的产前细胞遗传学研究。
Acta medica Hungarica Pub Date : 1991-01-01
A Tóth, K Rajczy, K Hajdu, Z S Intödy, J László
{"title":"Prenatal cytogenetic study of translocation carriers.","authors":"A Tóth,&nbsp;K Rajczy,&nbsp;K Hajdu,&nbsp;Z S Intödy,&nbsp;J László","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 37 prenatal diagnoses were analysed: 10 observations in which one of the parents carried a Robertsonian translocation and 27 observations in which one a reciprocal translocation was carried by one of the parents. The segregations of the inherited chromosome structural rearrangements were analysed in relation to the methods of ascertainment of the anomaly in the family, and the types of rearrangement. The mode of ascertainment proved to be a very useful indicator of the risk: those cases ascertained through abnormal livebirths had a 44% risk in our series, but there was no unbalanced fetus in the group ascertained through recurrent abortions.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 3-4","pages":"151-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum elastase-type enzymes and their correlation to blood lipids in male patients with atherosclerosis. 男性动脉粥样硬化患者血清弹性酶型酶及其与血脂的关系。
Acta medica Hungarica Pub Date : 1991-01-01
A Landi, M Bihari-Varga, L Keller
{"title":"Serum elastase-type enzymes and their correlation to blood lipids in male patients with atherosclerosis.","authors":"A Landi,&nbsp;M Bihari-Varga,&nbsp;L Keller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum elastase-type activity, elastase inhibitory capacity and their relation to lipids were examined in 140 male patients with ischaemic vascular disease (coronary, cerebral, peripheral) and in 60 control subjects. Serum elastase-type activity was found to be significantly lower, inhibitory capacity significantly higher, in the groups of patients than in the controls. HDL- and HDL2 cholesterol as well as apo A concentration showed significant negative correlation with elastase inhibitory capacity both in atherosclerotic and in control subjects.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 3-4","pages":"203-10"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contribution to the understanding of degenerative pathology and a proposal of a global therapeutic solution. 对理解退行性病理的贡献和全球治疗解决方案的建议。
Acta medica Hungarica Pub Date : 1991-01-01
J P Willem
{"title":"Contribution to the understanding of degenerative pathology and a proposal of a global therapeutic solution.","authors":"J P Willem","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 1-2","pages":"112-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12976946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostaglandin E2 in renal transplant recipients. 肾移植受者前列腺素E2的变化。
Acta medica Hungarica Pub Date : 1991-01-01
M M el-Sharabasy, M N el-Naggar
{"title":"Prostaglandin E2 in renal transplant recipients.","authors":"M M el-Sharabasy,&nbsp;M N el-Naggar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prostaglandin E2 (PGE2), sodium, potassium and creatinine were determined in the blood and urine of 50 renal transplant recipients treated for at least one year post transplantation with cyclosporine A or azathioprine as immunosuppressive agent. Fourteen healthy subjects were used as a control group. The urinary PGE2 excretion was significantly decreased in the renal transplant recipients on azathioprine therapy while it was unchanged in the patients treated with cyclosporine A. At the same time, a significant decrease in urinary excretion of sodium and potassium was found. On the other hand, a high elevation of blood PGE2 concentration was observed while no significant changes were seen in sodium and potassium in the blood of these renal transplant recipients. It is suggested that an association exists between urinary PGE2 reduction and immunosuppressive treatments in renal transplant recipients and that PGE2 may regulate intrarenal haemodynamics and influence renal tubular electrolyte excretion. Finally, urinary PGE2 can be used as an indicator of successful renal transplantation.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 3-4","pages":"225-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12984116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colloidal bismuth subcitrate evokes adaptive cytoprotection in rat gastric mucosa. 胶体亚柠檬酸铋对大鼠胃粘膜的适应性细胞保护作用。
Acta medica Hungarica Pub Date : 1991-01-01
G A Balint
{"title":"Colloidal bismuth subcitrate evokes adaptive cytoprotection in rat gastric mucosa.","authors":"G A Balint","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The 6-keto-prostaglandin-F1 alpha content (as the stable break-down product of prostacyclin) of rat antral and fundic gastric, as well as of duodenal mucosa, significantly increases after 1, 5 and 10 mg/kg orally administered colloidal bismuth subcitrate treatment. The results indicate that (i) colloidal bismuth subcitrate-induced stimulation of endogenous prostacyclin content (\"adaptive cytoprotection\") of rat gastroduodenal mucosa may contribute to its therapeutic effect; (ii) the effect of colloidal bismuth subcitrate is not due exclusively to the bismuth content of the molecule, but seems to be connected with the structure of colloidal bismuth subcitrate itself; (iii) the effect seems to be dose-dependent, showing a dose-response relationship.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 3-4","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12985631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
99-m technetium (Dupont Cardiolite) investigations in postinfarction patients with Holter-checked silent ischaemia. 99-m锝(Dupont Cardiolite)在梗死后伴有霍尔特检查的无症状缺血患者中的研究。
Acta medica Hungarica Pub Date : 1991-01-01
M Horváth, E Böszörményi, M Kármán, I Berényi, J Molnár, A Pszota, M Szalai, L Németh
{"title":"99-m technetium (Dupont Cardiolite) investigations in postinfarction patients with Holter-checked silent ischaemia.","authors":"M Horváth,&nbsp;E Böszörményi,&nbsp;M Kármán,&nbsp;I Berényi,&nbsp;J Molnár,&nbsp;A Pszota,&nbsp;M Szalai,&nbsp;L Németh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sixteen middle-aged, normotensive, slightly overweight male patients with previous myocardial infarction were studied during Holter-checked silent myocardial ischaemia. As reference, stress and late 201-T1 scintigraphy served for comparison with Cardiolite-MIBI silent ischaemic perfusion scan, both carried out in planar mode. The circumferential profiles differed in 9 cases, on region of interest basis the segment number difference was 10, but the late distribution segment number was near to both ischaemic numbers. The quantitative scores were distinctive (ratio 133-128/103) indicating the silent ischaemia appeared in the peri-infarct area. The silent ischaemic MIBI and stress 201-T1 ischaemic score difference was reduced by means of repeated SPECT investigation. With gated radionuclide ventriculography there was -4.3% difference between the left ventricular ejection fractions, measured with first pass MIBI technique during silent ischaemia and afterwards in basal state. The impairment of the left ventricular function was reflected on the stroke pattern of our Holter-based radiocyclogram, as well. Taking the 43.7-48.0 = -4.3% \"ischaemic shift\" into consideration it was a close correlation (r = 0.90) between the two kinds of ejection fraction determination. The major rhythm failures (occurring during the 24 h Holter monitoring) decreased to a higher degree the left ventricular ejection fraction than silent ischaemia or silent ischaemia and minor rhythm failure together (38-42-50%).</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 1-2","pages":"61-72"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12976049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exogenous superoxide dismutase uptake by the myocardium and kidney in an ischaemic reperfusion model in dogs. 狗缺血再灌注模型中心肌和肾脏摄取外源性超氧化物歧化酶的研究。
Acta medica Hungarica Pub Date : 1991-01-01
L Kónya, A Fülöp, I Bártfai, G Szénási
{"title":"Exogenous superoxide dismutase uptake by the myocardium and kidney in an ischaemic reperfusion model in dogs.","authors":"L Kónya,&nbsp;A Fülöp,&nbsp;I Bártfai,&nbsp;G Szénási","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The renal and cardiac tissues of dogs were examined with autoradiographic method in ischaemic reperfusion trials with the aim of studying the access of exogenous superoxide dismutase (SOD) enzyme to the cells. Penetration of SOD into the cells was demonstrated. The enzyme showed special affinity to the mitochondira and myofilaments in the myocardium and it was seen both in the glomeruli and the tubules in the kidney. In both organs the uptake of the enzyme was most abundant in the ischaemic regions than in tissues with intact circulation.</p>","PeriodicalId":7090,"journal":{"name":"Acta medica Hungarica","volume":"48 1-2","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12975236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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