Acta medica Iugoslavica最新文献

{"title":"[Parameters significant for the prognosis of chronic myeloid leukemia in the chronic phase].","authors":"J Maras,&nbsp;I Ribicić,&nbsp;M Maras-Simunić,&nbsp;L Skare","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 46 patients with chronic myeloid leukaemia and their clinical and laboratory findings as parameters which might have an influence on survival were investigated. There was 28 (61%) males and 18 (39%) females. The mean age was 52 years. The patients were treated by busulfan with daily doses of 6 to 10 mg during one to two months, following the treatment by the lower doses of busulfan. A complete remission was achieved in 40 (87%) patients, in 4 (9%) there was a partial remission, and in 2 (4%) no remission at all. The median duration of chronic phase was 36 months, and the median survival for all patients was 43 months. The females survived longer than the males, but there was no significant difference in the survival time (median 46:38 months). The patient's age did not appear to influence prognosis. No differences in survival was noted between the patients with the haemoglobin level higher or lower than 110 g/L (chi 2 = 1.64). The size of the spleen was not a factor of statistical significance for the patients analysed. In patients with leukocytosis higher than 100 x 10(9)/L and those with more than 6% basophils in the bone-marrow smears, the survival was worse than in patients with the finding below this value (chi 2 = 3.55; 3.87). In the group of patients with platelet count higher than 350 x 10(9)/L, the survival was significantly worse than in patients with the finding below this value (chi 2 = 4.67; p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 4","pages":"389-97"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13247298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle molecular weight substances and uremic polyneuropathy.","authors":"L Dukanović,&nbsp;J Petrović,&nbsp;J Potić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of 25 uremic patients on regular hemodialysis was examined during 12 months after six-hour dialyses twice a week were changed to five-hour dialyses thrice a week. Twelve of the patients suffered from polyneuropathy, while 13 did not show signs of this uremic complication. The effect was studied of the increase of the amount of dialyses on the severity of polyneuropathy, checked by neurological and electromyographic methods, as well as on the serum levels of uremic middle molecular weight substances (MMS). Sera of the patients were subjected to gel filtration on Sephadex G-15 columns. This analysis resolved MMS into five distinct fractions in the range of middle molecular weight. Sera of the patients with polyneuropathy contained more of MMS in the 2nd and 4th fractions than those without signs of polyneuropathy. During 12 months of treatment with three hemodialyses a week, a significant improvement of polyneuropathy, together with a pronounced decrease of the serum levels of the 2nd and 4th MMS fractions were evidenced. A statistically significant negative linear relationship of polyneuropathy signs and the serum levels of MMS in these two fractions was registered.</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 2","pages":"117-28"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13315509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations of ultrasonic anatomy of the hepatic veins within the human liver.","authors":"I Lamanna,&nbsp;A Bilić,&nbsp;N Ljubicić,&nbsp;B Bakula","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study was to investigate various physiological variations of the hepatic veins within the liver of the 60 healthy subjects. All participants required physical examinations, different laboratory tests and upper abdominal ultrasonogram--all completely normal. Demonstration of the hepatic veins have been performed on sector real-time systems. The results clearly demonstrated that the physiological variations of the hepatic veins are very common. Ultrasonography obviously represents a diagnostic method of choice in the evaluation of anatomy of the hepatic venous system.</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 2","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13344445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma aldosterone and cortisol levels in experimental acute renal failure.","authors":"M A Ivić,&nbsp;S Strahinjić,&nbsp;V Stefanović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Deranged adrenal cortical function was previously described in different stress situations. The aim of this work was to study the plasma cortisol and aldosterone levels in acute renal failure induced by the uranyl nitrate injection or bilateral ureteral ligation. In both groups of uremic dogs on the first day of uremia there was a significant elevation of the plasma cortisol level, being more pronounced and lasting longer after bilateral ureteral ligation. In sham operated controls a modest elevation was recorded. The plasma aldosterone level rose significantly from the first day in both groups of uremic animals. A further progressive elevation continued the following days and a highly elevated aldosterone levels remained until the end of the experiments. A minor but significant elevation of plasma aldosterone was also found in sham operated controls. This study has established increased plasma cortisol and aldosterone levels attributable to the operative stress and failing kidney function in acute uremia.</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 3","pages":"177-84"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13543942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Correlation of risk factors and disorders of neurophysiologic development in children at risk].","authors":"M Stojcević-Polovina","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 1","pages":"55-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13487118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Echocardiographic analysis of changes in the heart in patients with systemic lupus erythematosus].","authors":"A Smalcelj,&nbsp;Z Durakovic,&nbsp;I Cukusić,&nbsp;I Bogdan,&nbsp;V Grgić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty-six patients, 49 females and 7 males, with the confirmed diagnosis of systemic lupus erythematosus were examined by M-mode, 2--D and Doppler echocardiography. Pericardial effusion was found in 15 patients (27%), while pericardial thickening was suspected in 6 additional patients (37.5% altogether). Two patients had the signs of a pericardial tamponade, but both of them were uraemic. Libman-Sacks endocarditis was suspected in 4 patients (7.5%) because of verrucous changes in the aortic or mitral valve and regurgitant jet. Slight to moderate left ventricular hypocontractility was present in 3 patients (5%), while 3 additional patients had borderline values of the left ventricular contractility parameters. Left ventricular hypertrophy, usually mild, was found in 21 patients (37.5%). Echocardiographic signs of pulmonary hypertension were present in 2 patients (3.6%). It has been concluded that pericardial affection is frequent during the course of systemic lupus erystematosus, while a diffuse myocardial involvement is rare, except the consequences of arterial hypertension and accelerated coronary atherosclerosis. Libman-Sacks endocarditis still represents a diagnostic problem. For a more precise definition of cardiac involvement in systemic lupus erythematosus, a comparative analysis of the disease activity and immunosuppressive therapy is needed.</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 5","pages":"513-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13232618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Recurrences of viral hepatitis A].","authors":"O Jelić,&nbsp;J Fornet-Sapcevski,&nbsp;L Kovacevíc,&nbsp;N Pandak,&nbsp;D Jelić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the study was to examine the frequency, severity, persistence and etiology of relapses occurring during the hepatitis A viral infection. Therefore, a prospective study of 910 patients suffering from hepatitis A (HA) was carried out. The clinical examination and determination of glutamyl pyruvic transaminase (GPT) in the serum every 7-14 days till recovery (usually during 6--8 months) were performed. HAV infection was confirmed by detecting anti-HAV IgM in the blood of all the examined by radioimmunoassay. In 876 (93.3%) patients HA had typical clinical features and a monophasic course. All cases made a rapid clinical recovery and liver function tests improved strikingly between 1 and 4 months after the onset of illness. However, in 34 (3.7%) of 910 patients, after an asymptomatic interval of 4--8 weeks, relapsing hepatitis occurred. Mild clinical symptoms: fatigue, myalgia, nausea, epigastric discomfort accompanied by the elevated levels of GPT in the serum were noticed in 11 patients, while 3 of them redeveloped jaundice. In 23 remaining patients relapses of hepatitis were asymptomatic, except for the reappearance of icterus in six cases. The only way to establish the exacerbation of the disease was through the pathological findings of GPT in the serum, which increased 10--60 times above the upper limit of the normal value. While 25 patients had one relapse, in 9 there were two or more relapses, so that hepatitis had a biphasic or polyphasic course. The second relapse was registered 3--6 weeks after the first one disappeared. Through biochemical tests the average values of the GPT were established: 1566 U/L in the acute stage, 107 U/L during the early stage of convalescence and 1016 U/L during the first relapse of hepatitis. After the first relapse and during remission, in 9 patients the average values of GPT in the serum were 84 U/L, while during the second relapse 518 U/L. Clinical signs of relapsing hepatitis disappeared approximately in 4 days, but liver function tests decreased slowly and persisted elevated between 5 and 12 months. A possibility of establishing the etiology of relapsing hepatitis, which has yet remained unknown, is discussed. Anti-HAV IgM were present in all 34 patients during the initial and relapsing phase of hepatitis and in 26 cases in the latter phase of convalescence between 9 and 11 months after the beginning of the disease. Serological tests excluded infection with hepatitis B, cytomegalovirus and Epstein-Barr virus. With a great probability other infections and toxic agents damaging the liver could have been excluded.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 5","pages":"565-76"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13233949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of large wildlife in the maintenance of natural foci of tick-borne meningoencephalitis in northern Croatia].","authors":"B Borcić,&nbsp;B Raos,&nbsp;D Kranzelić,&nbsp;J Abu Eldan,&nbsp;V Filipović","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Between 1986-1988 sera from 245 game animals--37 roe deers, 102 red deers, 81 wild boars and 25 hares--shot in 8 different localities of Nort Croatia, a well-known nosoareal of tick-borne encephalitis, were tested for TBE virus heminhibiting antibodies. The following percentages of positive animals were found: 24, 39, 39 and 0% respectively. Most of the animals examined, 180 of them, were shot in lowland woods of the commune of Nasice and its surroundings. There the percentage of positive animals was somewhat higher: 36, 41, 42 and 0 respectively. As these animals regularly participate in the feeding cycle of the ubiquitous wood tick Ixodes ricinus, the main vector of the tick-borne meningoencephalitis virus, it is infered that they (the hare being excluded in this study), apart from myomorphous mammals, play an important role in the transmission chain of the tick-borne meningoencephalitis virus in the respective natural foci of this zoonosis.</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 4","pages":"399-406"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13247299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conventional B-mode and transvaginal color Doppler in ultrasound assessment of ectopic pregnancy.","authors":"A Kurjak,&nbsp;I Zalud,&nbsp;G Volpe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study was arranged in two parts. In the first part, 43 of the clinically suspected ectopic pregnancies were sent for a transvaginal color Doppler examination. Both cystic and complex adnexal masses were carefully scanned for their Doppler flow characteristics. The Pourcelot index (RI) was calculated and the RI 0.40 was used as a cut-off point to differentiate the trophoblastic (RI less than 0.40) and the normal blood flow (RI greater than 0.40). The diagnosis was confirmed by the beta hCG serum test. Three false-negative and one false-positive findings were obtained. The transvaginal color and pulsed Doppler study of the flow within ectopic pregnancy has a high degree of sensitivity (87.5%), specificity (94.7%) and accuracy (90.7%). Pelvic sonograms of another 110 patients with proven ectopic pregnancy were reviewed retrospectively. The ectopic gestational sac with the alive embryo was documented in 11.8% cases and without the embryo in 30.4% cases. A mixed, solid or cystic adnexal mass was detected in 57.8% patients. Intrauterine findings showed a pseudogestational sac in 13.6% cases, a cluster configuration in 18.6% cases and a linear configuration in 67.8% cases. Criteria for the ultrasound diagnosis of ectopic pregnancy influencing its specificity, sensitivity and accuracy are discussed.</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 2","pages":"91-103"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13344447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Quantification of mitral regurgitation using Doppler echocardiography].","authors":"I Bogdan,&nbsp;Z Duraković,&nbsp;V Brida,&nbsp;A Smalcelj","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Examining 18 patients without regurgitation (control group) and 20 patients with mitral regurgitation the method of Doppler echokardiography, the pulsating and continual wave, was applied. Both groups consisted of patients with heart diseases in whom a heart catheterization was indicated for the evaluation of the actual state. Thus, the competence of the mitral orifice was also evaluated. The aim of the investigation was to quantify or more accurately estimate the degree of mitral regurgitation. The accuracy of the Doppler method was tested by means of the measured cardiac stroke volumes of the right heart side in both groups with the probability higher than 80% but lower than 90% (0.80 less than p 0.23 less than 0.90), and by testing the cardiac stroke volumes of the right heart and the diastolic volumes of the left heart (control group: mitral and pulmonal orifice) with the probability higher than 70% and lower than 80% with the error of 6% of the measured volume. The regurgitation mitral fraction (RF) was presented as the difference between the total forwards volume (TFV) in the mitral orifice and the net forwards volume (NFV) in the pulmonal orifice and calculated in cm3, and as the regurgitation fraction index (RFI) in percentages (RFI = 1--NFV/TFV). It was also expressed as the regurgitation volume index (RVI) whose values were divided into degrees, according to the literature data. Numerical values of the regurgitation fraction and the regurgitation fraction index were classified in the mitral insufficiency degrees from 1 to 4. A fast regurgitation screening was possible due to the regurgitation fraction index, which is lower than the 45% of the diastolic volume in the cases of mild mitral insufficiency, while the values over 45% denote severe mitral insufficiency. The obtained values of the regurgitation fraction and index divided into degrees showed a close correlation with the angioventriculographic degrees obtained by heart catheterization. Cardiac output measured by the Doppler and Fick methods in the group with regurgitation showed a high correlation coefficient (r = 0.85) (0.60 less than p 0.47 less than 0.70).</p>","PeriodicalId":7058,"journal":{"name":"Acta medica Iugoslavica","volume":"44 2","pages":"147-61"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13502802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}