Acta biologica Academiae Scientiarum Hungaricae最新文献

{"title":"Experimental studies on hypokinesis of skeletal muscle with different functions. VI.","authors":"I Sohár, O Takács, F Guba, I Sziklai, T Szilágyi","doi":"","DOIUrl":"","url":null,"abstract":"In rabbits, the right hind limb was immobilized by means of plaster cast for 1, 2, 4 or 6 weeks and the activities of some metabolic enzymes: GOT, GPT, LDH, aldolase and acid phosphatase (in part of lysosomal origin), were examined in the slow m. soleus, and in the fast m. gastrocnemius. The former muscle is known to have mainly an oxidative, while the latter mainly a glycolytic type of metabolism. The activities of enzymes highly involved in the metabolism of the muscle diminished for a certain time during atrophy, then a relative rise occurred. Acid phosphatase activity likewise decreased after an initial relative increase. Reduction of enzymatic activities is explained by the activation of proteolytic enzymes, on the basis of measurements performed in these experiments and of results published by others. The decrease of enzymatic activity was more marked in the muscle which in normal state exhibits higher activity than in the other type of muscle studied. Thus, in the gastrocnemius a high rate of degradation of glycolytic enzymes was observed, while in the soleus degradation of oxidative enzymes prevailed. This phenomenon leads to the dedifferentiation of the muscle cell during immobilization.","PeriodicalId":7056,"journal":{"name":"Acta biologica Academiae Scientiarum Hungaricae","volume":"33 4","pages":"385-90"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18183671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Golgi method in current neurobiological research. 高尔基法在当前神经生物学研究中的应用。

Acta biologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

T Tömböl

引用次数: 0

Electrical stimulation of chemical blockade of vestibular nuclei can serve as the unconditioned stimulus in the conditioned taste aversion paradigm. 前庭核化学阻断的电刺激可作为条件性味觉厌恶范式的非条件刺激。

Acta biologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

O Buresová, L V Semenov, J Bures

{"title":"Electrical stimulation of chemical blockade of vestibular nuclei can serve as the unconditioned stimulus in the conditioned taste aversion paradigm.","authors":"O Buresová, L V Semenov, J Bures","doi":"","DOIUrl":"","url":null,"abstract":"Nausea of vestibular origin can be used instead of poisoning in the conditioned taste aversion (CTA) paradigm. In an attempt to establish the forms of vestibular stimulation best suited for inducing CTA in rats, effectiveness of 2 h rotation (Exp. 1) was compared with tonal asymmetry elicited by unilateral microinjection of 5.0 microliters of 25% KCl into the vestibular complex (Exp. 2), by unilateral electrical stimulation of vestibular nuclei (100 Hz, 1 ms, 100-200 microA, 15 min--Exp. 3) or by 10 min polarization of labyrinth through electrodes inserted in the external auditory meati (Exp. 4). Nystagmus, deviation of the head and leaning towards the blocked and away from the stimulated side were typical symptoms. When the above stimuli were applied within 10 min after saccharin drinking, galvanic stimulation was ineffective, but electrical stimulation or chemical blockade of vestibular nuclei elicited marked CTA to saccharin, considerably stronger than CTA induced by rotation. It is concluded that direct interference with the activity of vestibular nuclei elicits CTA more effectively than the stimulation of the labyrinth and is, therefore, well suited for the analytical research into the mechanisms of CTA.","PeriodicalId":7056,"journal":{"name":"Acta biologica Academiae Scientiarum Hungaricae","volume":"33 2-3","pages":"139-48"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18194446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central nervous regulation of pituitary TSH response induced by thiouracil treatment or by thyroidectomy. 中枢神经调节硫脲嘧啶治疗或甲状腺切除术诱导的垂体TSH反应。

Acta biologica Academiae Scientiarum Hungaricae Pub Date : 1982-01-01

B Mess, C Rúzsás, I Rozsos

{"title":"Central nervous regulation of pituitary TSH response induced by thiouracil treatment or by thyroidectomy.","authors":"B Mess, C Rúzsás, I Rozsos","doi":"","DOIUrl":"","url":null,"abstract":"The serotoninergic neuron system of the midbrain and hypothalamus was previously shown to inhibit the basal secretion of the TRH-TSH-thyroid axis. The aim of the present study was to investigate the influence of the serotoninergic system on the TSH response of the adenohypophysis to specific loads. Serum TSH levels were determined 7 days after thyroidectomy or the beginning of thiouracil administration. Animals were simultaneously treated either by intrahypothalamic implantation of serotonin-containing needles or by intraventricular or daily subcutaneous injections of the same drug. The thiouracil-induced goitre formation and increase in serum TSH concentration were significantly diminished by serotonin treatment. Similarly, the thyroidectomy-induced rapid rise in TSH blood level was also remarkably inhibited in the serotonin-treated animals. Serotonin was proved to influence rather TRH-output than pituitary TSH secretion, since exogenous TRH, injected to serotonin-pretreated animals had the same TSH-mobilizing potency as found in the not premedicated group. It is concluded that besides the inhibition of the basal secretion of the TRH-TSH-thyroid axis by serotonin, there is an integrative role of the serotoninergic system in the mediation of the reactivity of this circuit in reply to specific influences loading pituitary-thyroid function.","PeriodicalId":7056,"journal":{"name":"Acta biologica Academiae Scientiarum Hungaricae","volume":"33 2-3","pages":"247-54"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18195388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0