Acta medica Iranica最新文献_第3页

The Sera miRNA Pattern in Patients Inflammatory Bowel Disease 炎症性肠病患者的血清 miRNA 模式

Acta medica Iranica Pub Date : 2024-06-08 DOI: 10.18502/acta.v61i10.15659

Mohammad Hossein Ghorbani, Vahid Chaleshi, Nazanin Amiri, Maryam Nasserinejad, Shaghayegh Baradaran Ghavami, S. Shahrokh, M. Vosough, H. A. Aghdaei, M. Zali

{"title":"The Sera miRNA Pattern in Patients Inflammatory Bowel Disease","authors":"Mohammad Hossein Ghorbani, Vahid Chaleshi, Nazanin Amiri, Maryam Nasserinejad, Shaghayegh Baradaran Ghavami, S. Shahrokh, M. Vosough, H. A. Aghdaei, M. Zali","doi":"10.18502/acta.v61i10.15659","DOIUrl":"https://doi.org/10.18502/acta.v61i10.15659","url":null,"abstract":"Inflammatory bowel disease comprising Crohn's disease and ulcerative colitis presents with periods of flares and remission. Many reports have identified different dysregulated miRNAs in patients with IBD. Finding new biomarkers in IBD patients can help to launch a novel non-invasive approach for diagnosis and prognosis for patients with UC and CD. This study aimed to evaluate the plasma expression pattern of the miRNAs panel in IBD patients compared to healthy individuals. 73 plasma samples were included; 58 patients with IBD (33 individuals in flare and 25 in remission phase) and 15 healthy controls were enrolled in the study. The miRNA expression was measured by qRT-PCR using miScript SYBR Green PCR Kit (QIAGEN). Our results showed the expression level of miR-16-5P was significantly increased in the active phase compared to the inactive phase (P=0.0138) and in CD patients compared to UC patients (P=0.0216). There was a significant difference in the expression of miR-29a in Crohn's patients compared to healthy subjects (P=0.04). Measuring the expression of mir-106a; a significant increase was observed compared to healthy individuals (P=0.03) and patients with CD (P=0.0143) in proportion of UC patients’ group. The miR-126 expression significantly increased in patients with active disease compared to patients in the inactive phase (P=0.0413) and healthy controls (P=0.0492). This study showed evidence for differential expression levels of plasma panel of miR-16, miR-29a, miR-106a, and miR-126 in IBD patients compare to healthy individuals. We illustrate that miRNAs in plasma correlate with disease activity and can be used as a practical and non-invasive biomarker for early diagnosis and monitoring of the treatment protocol.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Effectiveness of Combined Intra-Articular Injection of Ozone and High Molecular Weight Hyaluronic Acid in Patients With Knee Osteoarthritis 评估膝骨关节炎患者关节内联合注射臭氧和高分子量透明质酸的效果

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15289

Shervin Shahinpour, Mohsen Amirsabotki, Nader Ali Nazemian Yazdi

{"title":"Evaluation of Effectiveness of Combined Intra-Articular Injection of Ozone and High Molecular Weight Hyaluronic Acid in Patients With Knee Osteoarthritis","authors":"Shervin Shahinpour, Mohsen Amirsabotki, Nader Ali Nazemian Yazdi","doi":"10.18502/acta.v61i9.15289","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15289","url":null,"abstract":"Osteoarthritis is one of the major causes of disability and a source of social cost in the elderly. Its prevalence is increasing due to ageing and increasing obese population. The knee is one of the most common joints to be affected by osteoarthritis and it can lead to serious effects on one’s mobility, quality of life and livelihood. One of non-surgical treatments is intra-articular injection. Injection of both ozone and hyaluronic acid into knee joint are common methods for treatment of knee osteoarthritis. The aim of this study was to evaluate reduction of pain and improvement of function in patients who received combination of intra-articular injection of high molecular weight hyaluronic acid and ozone. In this retrospective case series study data of patients with knee osteoarthritis who underwent intra-articular injection of high molecular weight hyaluronic acid with ozone were evaluated. Participants had fulfilled Western Ontario and McMaster Universities Arthritis Index (WOMAC) short form questionnaire before, three days, one month and six months after the intra-articular injection. Pain reduction and function improvement factors were assessed according to the WOMAC short form questionnaire. A total of 65 patients were evaluated in this study. There was significant decrease in the total score of WOMAC SF (stiffness and function) in all three follow-ups (P<0.001). Also, patients who had more severe pain before the injection benefited more from the intra-articular injection. Our study showed that the effectiveness of intra-articular injection of high molecular weight hyaluronic acid with ozone does not depend on the age, sex and BMI of patients. Injection of high molecular weight hyaluronic acid and ozone into the joint cause to significant improvement in patient’s knee pain and function. It is recommended that the combination of high molecular weight hyaluronic acid and ozone be considered as an effective treatment in the process of these patients.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Effects of Lidocaine in Different Fields of Medicine 评估利多卡因在不同医学领域的作用

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15292

S. Samadi, Ebrahim Espahbodi, Zahid Hussain Khan, Melika Arab Bafrani

引用次数: 0

Comparison of Hemodynamic Effects of Dose Response vs. Conventional Dosing of Propofol for Anesthesia Induction Under Bispectral Index Monitoring: A Clinical Trial 在双谱指数监测下比较剂量反应与常规剂量的异丙酚对麻醉诱导的血流动力学影响：临床试验

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15287

Zahra Khazaeipour, Niloufar Khoshnam-Rad, Khalil Pestei, S. Samadi

{"title":"Comparison of Hemodynamic Effects of Dose Response vs. Conventional Dosing of Propofol for Anesthesia Induction Under Bispectral Index Monitoring: A Clinical Trial","authors":"Zahra Khazaeipour, Niloufar Khoshnam-Rad, Khalil Pestei, S. Samadi","doi":"10.18502/acta.v61i9.15287","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15287","url":null,"abstract":"Propofol is an advantageous agent for anesthesia induction. It can cause dose-related hemodynamic adverse effects. The bispectral index (BIS) is a brain function monitor utilized to assess the depth of anesthesia. This study aimed to compare the adverse hemodynamic effects of BIS-guided response dosing with conventional weight-based dosing of Propofol. In this clinical trial, patients were anesthetized with propofol in two different orthopedic operating rooms. In one operating room, patients received propofol with dose-response method (group A), and the other received weight-based dosing (group B). For both groups, BIS was used as an index of anesthesia depth. Hemodynamic parameters were recorded at baseline, during induction, and at different time points. A total of 73 patients were included in the final analysis. The mean dose of propofol for induction was higher in the control group than in the response-guided group (1.94±1.65 vs. 1.09±0.32, respectively, P=0.006). There were no reported significant adverse hemodynamic effects in patients of the two groups. Response-guided propofol dosing can be used to decrease propofol dose during anesthesia induction. Further studies are needed to investigate the clinical benefit of this dosing strategy.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"43 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Epidural Analgesia on Cesarean Section Rates and Neonatal Outcomes: A Retrospective Cohort Study 硬膜外镇痛对剖腹产率和新生儿结局的影响：回顾性队列研究

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15284

Asghar Hajipour, Alireza Montaseri, M. Rahimi, Amirhossein Orandi, Laila Rahmah, S. Samadi

{"title":"The Impact of Epidural Analgesia on Cesarean Section Rates and Neonatal Outcomes: A Retrospective Cohort Study","authors":"Asghar Hajipour, Alireza Montaseri, M. Rahimi, Amirhossein Orandi, Laila Rahmah, S. Samadi","doi":"10.18502/acta.v61i9.15284","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15284","url":null,"abstract":"This retrospective cohort study aimed to assess the frequency of emergency cesarean sections with epidural analgesia and its implications on Apgar scores and Neonatal Intensive Care Unit (NICU) admissions among patients at Tehran University of Medical Sciences Hospitals from 2017 to 2018. Data from 7170 patients were extracted from the hospital information system (HIS) through a consensus method. Descriptive statistics, cross-tabulation, and logistic regression analyses were conducted using Stata v17 software. Out of 9387 patients, 62.7% underwent cesarean sections, and 37.1% had normal vaginal deliveries. Epidural analgesia was administered to 127 patients, with 98.4% achieving successful normal vaginal delivery. Nulliparous women constituted 64.29% of those receiving epidural analgesia. Apgar scores at five and ten minutes were comparable between epidural and non-epidural groups. Emergency cesarean rates with epidural analgesia were low (1.6%). Findings align with previous research indicating no significant impact of epidural analgesia on Apgar scores. Nulliparous women predominated in the epidural group, consistent with pain pattern disparities. The study supports recent research showing epidural analgesia does not increase emergency cesarean rates, even in high-risk pregnancies. This study suggests that epidural analgesia does not significantly impact Apgar scores, NICU admissions, or emergency cesarean rates. While the comprehensive dataset enhances reliability, retrospective design limitations are acknowledged. Prospective studies exploring factors contributing to neonatal mortality and overall labor duration are recommended for more robust evidence.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"14 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a Novel Blended Virtual Reality and Clinical Learning Environment on the Learning Transfer of Anesthesiology Residents 新型混合虚拟现实和临床学习环境对麻醉学住院医生学习迁移的影响

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15285

S. Mousavi, Morteza Karami, S. Mireskandari, S. Samadi

{"title":"Effects of a Novel Blended Virtual Reality and Clinical Learning Environment on the Learning Transfer of Anesthesiology Residents","authors":"S. Mousavi, Morteza Karami, S. Mireskandari, S. Samadi","doi":"10.18502/acta.v61i9.15285","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15285","url":null,"abstract":"The use of educational technology is considered a necessity due to the increasing changes in medical education. This study aimed to design a novel blended virtual reality and clinical learning environment (CLE) and to investigate its effectiveness in the learning transfer of anesthesiology residents during spinal anesthesia procedures. In this experimental study, 25 residents (academic year 2020/2021) were randomly divided into blended (n=11) and clinical (n=14) groups. Spinal anesthesia training for the blended group was performed in the virtual training laboratory (week 1) and the operating room (from week 2 to week 4), while for the CLE group, it was only performed in the operating room. Training, based on task-centered learning, was provided for both groups, and then, a 360-degree assessment of learning transfer was conducted by professors, patients, co-workers, and self-assessments using a standard questionnaire. Data were analyzed using non-parametric tests. There was a significant difference in the learning transfer of residents between the blended and CLE groups (U=39, P=0.03<0.05). There was also a significant difference in the subcategories of learning transfer according to the professors and co-workers; however, there was no significant difference according to the patients and self-assessments. The blended VR/CLE learning environment was more effective than CLE in improving residents’ learning transfer. Besides, an increase in scores indicated an improvement in professional competence.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"83 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anesthesia in Ancient Persia Down to the 21st Century 古波斯直至 21 世纪的麻醉技术

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15278

Z. Hussain Khan, S. Samadi

引用次数: 0

Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine 支气管镜检查中患者满意度和镇静效果的比较分析：芬太尼/氯苯那敏与氯胺酮/氯苯那敏比较

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15281

M. Khajavi, Leila Sadat Hosseini, M. Pazoki, Seyed Hamidreza Sharifnia, R. S. Moharari, Pejman Pourfakhr, Parisa Kianpour, Abbas Ostadalipour, A. Najafi, F. Etezadi

{"title":"Comparative Analysis of Patient Satisfaction and Sedation Outcomes in Bronchoscopy: Fentanyl/Chlorpheniramine vs. Ketamine/Chlorpheniramine","authors":"M. Khajavi, Leila Sadat Hosseini, M. Pazoki, Seyed Hamidreza Sharifnia, R. S. Moharari, Pejman Pourfakhr, Parisa Kianpour, Abbas Ostadalipour, A. Najafi, F. Etezadi","doi":"10.18502/acta.v61i9.15281","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15281","url":null,"abstract":"This randomized clinical trial aimed to assess and compare patient satisfaction and sedation outcomes in bronchoscopy procedures using two distinct sedation protocols: fentanyl/chlorpheniramine (FC) and ketamine/chlorpheniramine (KC). Ninety patients undergoing simple bronchoscopy and bronchoalveolar lavage were randomly assigned to receive either FC (1 µg/kg fentanyl and 10 mg chlorpheniramine) or KC (0.5 mg/kg ketamine and 10 mg chlorpheniramine). Lidocaine was also administered during bronchoscopy. Primary outcomes included patient satisfaction scores, while secondary outcomes encompassed sedation levels, bronchoscopist satisfaction, cough rates, lidocaine usage, and physiological parameters. Patients in the FC group exhibited significantly higher satisfaction levels compared to the KC group (P=0.002). Bronchoscopist satisfaction was also superior in the FC group (P=0.001). Although cough rates did not differ significantly, severe persistent coughs were more prevalent in the KC group. Physiological parameters such as oxygen saturation were comparable, but the KC group demonstrated higher increases in systolic blood pressure and heart rate. The use of fentanyl/chlorpheniramine resulted in higher patient and bronchoscopist satisfaction during simple bronchoscopy and bronchoalveolar lavage compared to ketamine/chlorpheniramine. This study suggests that the combination of fentanyl and chlorpheniramine may be a preferable sedation choice for bronchoscopy procedures.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"38 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Video Laryngoscopy Versus Direct Laryngoscopy in Novices: A Randomized Clinical Trial 视频喉镜与直接喉镜在新手中的应用：随机临床试验

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15283

Reza Effatdoost, Babak Eslami, O. Nabavian, Maziar Maghsoudloo, Khalil Pestei, S. Samadi, Mohammad Dehghan-Tazerjani

{"title":"Video Laryngoscopy Versus Direct Laryngoscopy in Novices: A Randomized Clinical Trial","authors":"Reza Effatdoost, Babak Eslami, O. Nabavian, Maziar Maghsoudloo, Khalil Pestei, S. Samadi, Mohammad Dehghan-Tazerjani","doi":"10.18502/acta.v61i9.15283","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15283","url":null,"abstract":"Intubating the trachea is a challenging task, especially for novice intubators. Successful intubation, in the shortest possible time, prevents hypoxia and hemodynamic disturbances. During the last few decades, video laryngoscopy has proven to be a helpful tool for intubating patients successfully, especially in difficult cases. However, novices must be proficient with a video laryngoscopy. It is not entirely clear which method, direct laryngoscopy or video laryngoscopy, is more successful for tracheal intubation in individuals who have recently started their airway management training. In this study, we aim to investigate this issue. 150 patients were randomly assigned to either direct laryngoscopy or video laryngoscopy by first-year anesthesia assistants. Intubation time, intubation success rate, Cormack-Lehane score, and instances of using the Optimal external laryngeal manipulation (OELM) maneuver, were recorded. The rate of successful intubation was higher in the direct laryngoscopy group, and the time taken was less. The direct laryngoscopy provided a better view of the glottis than the video laryngoscopy, although this difference was not statistically significant. Direct laryngoscopy resulted in a higher frequency of OELM. Based on our study, the success rate and speed of intubation in novices were higher with direct laryngoscopy compared to video laryngoscopy.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"15 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Recent Advances in Smart Homes for Improving Sleep Hygiene, and Sleep Quality 智能家居在改善睡眠卫生和睡眠质量方面的最新进展综述

Acta medica Iranica Pub Date : 2024-04-05 DOI: 10.18502/acta.v61i9.15279

S. Samadi, Sepehr Samadi, Behnam Samadi, Mehrshad Samadi, Mehrdad Samadi, Mojtaba Shahbazi

{"title":"A Review of Recent Advances in Smart Homes for Improving Sleep Hygiene, and Sleep Quality","authors":"S. Samadi, Sepehr Samadi, Behnam Samadi, Mehrshad Samadi, Mehrdad Samadi, Mojtaba Shahbazi","doi":"10.18502/acta.v61i9.15279","DOIUrl":"https://doi.org/10.18502/acta.v61i9.15279","url":null,"abstract":"With the rising attention towards improving the quality of life and mental health, sleep hygiene and sleep quality have recently been the main topics of numerous studies. Quality of sleep not only affects our physical status but also plays a pivotal role in our psychological and emotional states. Sleep deprivation can increase the risk of cardiovascular and metabolic diseases along with the risk of impaired concentration and consequent road injury and accidents. As technology has become a main figure in our daily lives, technological advances have paid a great interest in improving the quality of sleep by enhancing the detection of sleep-related disorders and sleep abnormalities, particularly in the setting of smart homes and the Internet of Things (IoT). Smartphone applications, portable wearable gadgets, and devices along with more sophisticated and precise algorithms are now endeavoring to help us improve our quality of sleep and subsequently our quality of life. Hence, this review aims to illustrate a vivid picture of recent advancements in smart homes and their related technologies for improving sleep quality.","PeriodicalId":6946,"journal":{"name":"Acta medica Iranica","volume":"19 8S7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0