Acta pharmaceutica Hungarica最新文献

{"title":"Evaluation of Different Pre-Processed Directly Compressible Paracetamol","authors":"Musaab Saada, Y. Özalp, Nailla Jiwa, J. T. Chunu, Emre Kara, D. Taşkent, Zeynep Atabay Taşkent","doi":"10.33892/aph.2021.91.290-292","DOIUrl":"https://doi.org/10.33892/aph.2021.91.290-292","url":null,"abstract":"density values. True density was measured using helium pycnometer","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"32 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80357898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel E3 Ligase Ligand Libraries for Degradation of Proteins Implicated in Malignant Diseases","authors":"B. Bertók, G. Dormán, Z. Várkonyi, C. Magyar","doi":"10.33892/aph.2021.91.187-188","DOIUrl":"https://doi.org/10.33892/aph.2021.91.187-188","url":null,"abstract":"","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80910603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same Product Different Regulatory Approach Around the World: Glatiramer Acetate","authors":"P. Rocco, P. Minghetti","doi":"10.33892/aph.2021.91.112-113","DOIUrl":"https://doi.org/10.33892/aph.2021.91.112-113","url":null,"abstract":"Complex drugs may be either biological, if the active ingredients are derived from a biological source, or non-biological, if obtained by chemical synthesis. In both cases, their quality depends considerably on the manufacturing process. For Non Biological Complex Drugs (NBCDs), in particular, complexity may arise either from the active substance, as in the case of glatiramer acetate (GA), or from other sources, such as the formulation, as in the case of liposomes (Figure 1) (1). GA is approved, in the US and the EU, as a diseasemodifying treatment for patients with relapsing forms of Multiple Sclerosis. It is a heterogeneous mixture of not fully characterized synthetic polypeptides, containing L-alanine, L-lysine, L-glutamic acid, L-tyrosine in the constant molar ratio 0.43:0.34:0.14:0.09, with and average molecular weight from 5 to 9 kDa and distribution range from 2.5 to 20 kDa (2). The amino acid sequences are not completely random, being the result of both the physicochemical properties of the starting materials and the fundamental reaction scheme. However, they are not completely conserved from batch to batch, even when the process is tightly controlled. Indeed along with conserved characteristics such as amino acid molar ratio other characteristics such as the specific amino acid sequences will show batch-to-batch variability (1). To address this complexity, for the marketing of GA copies, US and EU regulatory agencies have chosen a generic approach integrated with additional data. However, the implementation is different in the two jurisdictions (Figure 1).","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"69 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83677605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interfacial Properties of Biodegradable Drug Carrier Nanoparticles","authors":"Dániel Fülöp, É. Kiss, Gergő Gyula","doi":"10.33892/aph.2021.91.218-219","DOIUrl":"https://doi.org/10.33892/aph.2021.91.218-219","url":null,"abstract":"","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78723742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Iron, Silver and Gold Nanoparticles Against Opportunistic Pathogenic Yeasts and Dermatophytes","authors":"Andrea Rónavári, N. Igaz, M. K. Gopisetty, Bettina Szerencsés, Dávid Kovács, C. Vágvölgyi, Z. Kónya, M. Kiricsi, I. Pfeiffer","doi":"10.33892/aph.2021.91.310-311","DOIUrl":"https://doi.org/10.33892/aph.2021.91.310-311","url":null,"abstract":"Epidemiologic observations indicate that the number of systemic fungal infections has increased significantly during the past decades, however in human mycosis, mainly cutaneous infections predominate, generating major public health concerns and providing much of the impetus for current attempts to develop novel and efficient agents against cutaneous mycosis causing species1. Innovative, environmentally benign and economic nanotechnology-based approaches have recently emerged utilizing principally biological sources to produce nanosized structures with unique antimicrobial properties2. Due to the obvious advantages, the green synthesis of nanoparticles is a rapidly progressing area of the nanobiotechnology. In line with this, the aim of this present study was to investigate the suitability of various green materials such as Parthenocissus quinquefolia plant extract and Phaffia rhodozyma cell-free extract for the preparation of iron nanoparticles (FeNPs), silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) by biological synthesis and to determine the toxicity of nanoparticles to human keratinocyte cells as well as against various fungal species with a special emphasis on antifungal efficiency against dermatophytes.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82683520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Complex Morphological Characterization of Core-Shell Fibrous Mats for Chronic Wound Healing","authors":"Adrienn Kazsoki, A. Farkas, Diána Balogh‐Weiser, E. Mancuso, P. Sharma, D. Lamprou, R. Zelkó","doi":"10.33892/aph.2021.91.247-248","DOIUrl":"https://doi.org/10.33892/aph.2021.91.247-248","url":null,"abstract":"In the recent past, one of the major challenges of the pharmaceutical industry was to overcome the poor aqueous solubility and permeability of new drug candidates, leading to their low bioavailability [1]. To solve these problems, novel structures were developed involving the polymer-based nanofibrous drug delivery systems [2,3]. The unique properties of the nanofibers as the high porosity with interconnected pore network and the increased surface area of the fibrous sheets, together with the active pharmaceutical ingredients can be embedded into the polymeric matrix carrier in an amorphous state, could lead to an increased dissolution and thus the bioavailability of drugs with a lower solubility [4,5]. Due to their structure, the formulation of nanofibrous materials loaded with different drugs have been widely used as drug delivery systems, scaffolds for tissue engineering and wound bandage. Electrospinning is a well controllable, simple and cost-effective technique for preparing matrices with nanometer-sized fibers with similar features and morphologies to the extracellular matrix (ECM) [6]. The ECM is the non-cellular component presents within all tissues and organs and plays a vital role in the wound healing process [7]. Therefore from those materials which can mimic their structure are believed to stimulate cell proliferation and could help the wound healing [6]. The diverse field of application of the nanofibrous materials required adequate functionalityrelated characteristics. One of the emerging improvements is the development of a bi-component core-shell fiber structure [8], which can offer several benefits for these samples: the core polymer/ composite can provide the required mechanical, physicochemical properties, and can control the release of the incorporated drug(s). The shell materials could preserve the unstable active pharmaceutical ingredients embedded into the core from the unfavorable environmental effect, which can increase the hydrophilicity and the biocompatibility of the fibrous samples. Besides that, one of the significant advantages of this core-shell nanostructures lies in the potential to tailor release properties of the incorporated drug and combine features of different polymers to achieve the required functionality-related characteristic and mechanical properties also [5].","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84413145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Drug Delivery Systems: From Nano- and Microparticles to Smart Pills","authors":"I. Antal","doi":"10.33892/aph.2021.91.128-129","DOIUrl":"https://doi.org/10.33892/aph.2021.91.128-129","url":null,"abstract":"microcapsules are compo-nents of multiparticulate drug carriers structural patient-centered Depending on the mode of be into solid (capsules, tablets, semi-solid (gels, creams, pastes) or liquid (solutions, suspen-sions, or parenteral) dosage forms","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88831325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Throughput Screening for Bioactive Natural Compounds from Plant Extracts by HPTLC Hyphenations","authors":"Á. Móricz, D. Krüzselyi, Maryam Jamshidi-Aidji, P. Ott, G. Morlock","doi":"10.33892/aph.2021.91.276-277","DOIUrl":"https://doi.org/10.33892/aph.2021.91.276-277","url":null,"abstract":"In the last decade, effect-directed analysis (EDA) gave new impetus for the discovery of new potential drug compounds from natural sources. Highperformance thin-layer chromatography (HPTLC) was established as a high-throughput and reliable separation technique that is frequently utilized for screening of highly complex samples, such as crude plant extracts. HPTLC combined with biological and biochemical assays and high-resolution mass spectrometry (HRMS) followed by bioassay-guided isolation and NMR was demonstrated as a straightforward strategy for bioanalysis of natural products [1,2]. Diabetes and Alzheimer’s disease (AD) represent two of the global health issues. Type 2 diabetic patients, the majority of the people with diabetes, suffer from the hyperglycemia. The salivary and pancreatic α-amylases and αand β-glucosidases are involved in the degradation and digestion of polyand oligosaccharides to glucose, hence, glucosidase and amylase inhibitors are of therapeutic interest in type 2 diabetes as well as overweight and obesity [3,4]. AD is associated with the loss of cholinergic neurons in the brain and decrease in the neurotransmitter acetylcholine. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are crucially involved in the hydrolysis of the acetylcholine into choline. Hence, AChE-selective and dual AChE/BChE inhibitors represented the first generation of medicines for the decrease of the AD progression rate [5]. The fight against infectious diseases, a major global public hazard, is also a challenge due to the increase in the emergence of the (multi)drug-resistant microorganisms [6]. In this study (HP)TLC combined with direct αand β-glucosidase, α-amylase and antimicrobial assays will be demonstrated for the comparison of the bio-profiles (the enzyme inhibitory and antibacterial potentials) of invasive goldenrod species.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77562632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future of the Hungarian Drug Market : Role of the Hungarian Regulatory Authority","authors":"M. Szentiványi","doi":"10.33892/aph.2021.91.131-132","DOIUrl":"https://doi.org/10.33892/aph.2021.91.131-132","url":null,"abstract":"The National Institute of Pharmacy and Nutrition (NIPN) has a long tradition as the safeguard of patient safety and as an institution that is committed to ensure that Hungarian patients have access to good quality, safe and efficacious medicines. During the last few years responsibilities of the Institute has been broaden and now we are also a key player in the regulation of special food and medical devices. During the past two decades a transition can be seen in the role of medicines agencies. While in the past the role of regulators was mainly acting as a gatekeeper, nowadays we also need to act as enablers. And while ensuring regulatory compliance of new medicines is still a key activity, our role cannot be narrowed down to the review of documents and other authorization tasks. This is due to the enormous development in the field of biotechnology, precision medicine, the revolution in synthetic biology, just to name a few. On one hand regulators need to be prepared for these new scientific challenges, on the other hand we have to be ready to give the necessary regulatory support to those developers that are coming from various fields and have limited knowledge and experience in regulatory issues.","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78573439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionone: The Molecule that Shaped the History of Western Civilization","authors":"G. Petroianu","doi":"10.33892/aph.2021.91.158-159","DOIUrl":"https://doi.org/10.33892/aph.2021.91.158-159","url":null,"abstract":"Cleopatra VII (69–30 BC) was the last Ptolemaic ruler of Hellenistic Egypt (the Dynasty was started upon the death of Alexander the Great by Ptolemy the Savior, one of his generals or body guards, and ended with the death of Cleopatra and the Roman conquest in 30 BC). The Queen is probably best known for her love affairs with Julius Caesar (10044 BC) and then Marcus Antonius (83-30 BC). Rightly or wrongly she became the epitome of shrewd seduction, leading brave Roman commanders on a path to debauchery and destruction. Among the customs of the time was the heavy use of perfumes. The sails of the ship on which Cleopatra received Marcus Antonius, we are told by Enobarbus in Shakespeare’s eponymous play, were soaked in fragrances: Purple the sails and so perfumed that the winds were lovesick. Cleopatra’s willingness to please went beyond the external use of perfumes; attributed to her is the ingestion of small amounts of turpentine [the resin of the terebinth tree (Pistacia terebinthus)] or of the derived oil (Oleum terebinthinae) with the purpose of conferring to her urine a more pleasing scent reminding of violets (Figure 1). In his textbook of pediatrics John Apley (19081980) states I have sniffed a smell like violets in the urine of a child who drank turpentine, as Cleopatra of Egypt did for that effect (1,2).","PeriodicalId":6941,"journal":{"name":"Acta pharmaceutica Hungarica","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83760275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}