世界移植杂志(英文版)最新文献

{"title":"Knowledge and attitudes toward organ donation and transplantation among medical students in Greece: A cross-sectional survey.","authors":"Solonas Symeou, Filippos F Karageorgos, Georgios Markozannes, Vassilios Papalois, Georgios Tsoulfas","doi":"10.5500/wjt.117608","DOIUrl":"10.5500/wjt.117608","url":null,"abstract":"<p><strong>Background: </strong>Organ transplantation is the definitive treatment for end-stage organ failure, and the gap between organ demand and donation is still a major challenge to overcome. Several countries, including Greece, have reformed their transplant framework to increase organ donation, but the long waiting times and low donor rates point to limited public awareness and engagement. Medical students, as future physicians, have a critical role within transplantation systems, as their knowledge, attitudes and engagement will affect donor identification, the consent processes and how donation is communicated to the public.</p><p><strong>Aim: </strong>To assess Greek medical students' knowledge and attitudes in order to inform strategies for strengthening organ donation nationally and internationally.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted between July 2025 and September 2025 across all medical schools in Greece. A 38-item questionnaire covered baseline demographics, knowledge and attitudes toward organ donation and transplantation. Responses were summarized with descriptive statistics, and seven multivariable logistic regression models were used to identify predictors of key outcomes (significance at adjusted <i>P</i> < 0.05).</p><p><strong>Results: </strong>Among 562 respondents (mean age 21.5 years, 68.3% female), only 13.0% correctly identified all organs transplantable from deceased donors, compared with 62.0% for living donors. Misconceptions were common, and awareness of the Hellenic Transplant Organization (HTO) was limited (22.8%). While 63.4% were willing to donate posthumously, only 8.2% were registered donors. Willingness to donate during lifetime was high (95.0%) but conditional. Prior discussion with family or friends increased the likelihood of willingness for posthumous donation [odds ratio (OR) = 2.38, adjusted <i>P</i> < 0.001]. A preference for surgical specialties predicted the perception of living donor grafts as superior (OR = 2.15, adjusted <i>P</i> = 0.027), while awareness of the HTO was a strong predictor of donor card possession (OR = 6.60, adjusted <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Medical students in Greece exhibit strong intentions but limited engagement and mixed knowledge of organ donation. Strengthening transplant education, raising the visibility of national structures and fostering student-led advocacy are essential to converting willingness into action and building public trust.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"16 3","pages":"117608"},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing gender-based disparities in liver transplantation: A global analysis of surgical access and donor organ allocation.","authors":"Sofia Rozani, Alexander Papadopoulos, Giorgos Smyrnis, Francesca Albanesi, Stavros P Papadakos, Efstathia Liatsou, Venkatesh Balaraman Sundararajan, Lorenzo Petagna, Georgia Rozani, Vasileios Vougas","doi":"10.5500/wjt.124190","DOIUrl":"10.5500/wjt.124190","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sex- and gender-based inequities remain a persistent challenge in liver transplantation (LT), influencing referral pathways, waitlist outcomes, donor organ allocation, and post-transplant survival. Differences in body size, model for end-stage liver disease (MELD)-based prioritization, disease etiology, and structural healthcare factors have contributed to disparities in surgical access and organ distribution worldwide. Recent policy modifications, including MELD 3.0 implementation, aim to mitigate longstanding inequities.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To synthesize global evidence from 2000-2026 evaluating gender disparities in LT access, waitlist mortality, donor allocation practices, and surgical outcomes, and to highlight emerging strategies designed to improve equity in transplantation systems.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A narrative global analysis was conducted using recent registry analysis, multicenter cohort studies, systematic reviews, and policy evaluations published between 2000 and 2026. Key endpoints included listing probability, waitlist duration and mortality, access to deceased and living donor transplantation, allocation algorithms, donor-recipient size matching, and post-transplant outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Across studies, women consistently demonstrated reduced access to transplantation and increased waitlist mortality compared with men. Pooled analyses involving &gt; 377000 candidates reported lower transplant access for women (hazard ratio = 0.88) and increased waitlist mortality risk (hazard ratio = 1.16). Allocation systems incorporating serum creatinine and body-size metrics contributed to lower prioritization scores, with women showing higher adjusted waitlist mortality risk and increased disadvantage associated with estimated liver volume and body surface area. Disease-specific cohorts revealed longer waitlist duration and lower transplant probability among female candidates with hepatocellular carcinoma and metabolic liver disease. Policy reforms such as MELD 3.0 were associated with increased female transplant representation and reduced disparities in transplant opportunity and waitlist mortality, although improvements diminished over time, and body-size differences remained influential. Living donor LT and split-liver strategies emerged as potential mechanisms to mitigate sex-based inequities by addressing donor-recipient size mismatch and expanding organ access. Post-transplant outcomes showed complex patterns, with some data suggesting higher early mortality but improved long-term survival in women compared with men.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Gender disparities in LT arise from multifactorial interactions among biological differences, allocation algorithms, surgical considerations, and systemic healthcare inequities. Although policy innovation such as MELD 3.0 have improved equity, persistent gaps in surgical access and donor allocation remain globally. Futur","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"16 3","pages":"124190"},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and attitudes towards organ donation among Egyptian physicians: A single-centre study from a tertiary academic hospital.","authors":"Maha Mohsen Hussein, Iman Fawzy Montasser, Manar Mohamed Ellaban, Mohamed Mohamed Bahaa El-Din, Mahmoud El-Meteini","doi":"10.5500/wjt.120199","DOIUrl":"10.5500/wjt.120199","url":null,"abstract":"<p><strong>Background: </strong>In Egypt, living donor liver transplantation is currently the only option for patients with end-stage liver disease. Although efforts to establish a national deceased organ transplantation programme are currently ongoing, implementation of the organ transplantation law faces challenges in terms of executive regulations and cultural barriers. Continuous medical education is must for promoting organ donation successfully.</p><p><strong>Aim: </strong>To evaluate awareness of and attitudes towards organ donation programmes among Egyptian physicians.</p><p><strong>Methods: </strong>This online cross-sectional survey was conducted at Ain Shams University Hospitals for more than 1 month (August 2024). A questionnaire covering demographics, knowledge, and attitudes towards organ donation was distributed through an online platform.</p><p><strong>Results: </strong>A total of 391 physicians participated (42.9% MD holders, 35.9% master's degree holders, and 21.2% residents). Most participants (79.6%) represented medical specialties. Satisfactory general knowledge of organ transplantation was reported by only 20% of the participants, whereas 50% were aware of the Egyptian organ transplantation law. With respect to attitudes, 42% accepted being a living donor, and 38% would donate to a relative. With respect to deceased donations, 40% agreed to be donors, whereas 28% remained undecided.</p><p><strong>Conclusion: </strong>Despite limited specific knowledge of organ donation and transplantation laws, Egyptian physicians demonstrate a generally positive attitude towards becoming organ donors. Continuous medical education is essential to promote organ donation successfully.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"16 3","pages":"120199"},"PeriodicalIF":0.0,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normothermic regional perfusion mobile teams in controlled donation after circulatory death pathway: Evidence and peculiarities.","authors":"Chiara Lazzeri, Manuela Bonizzoli, Giuseppe Feltrin, Adriano Peris","doi":"10.5500/wjt.v14.i4.97860","DOIUrl":"10.5500/wjt.v14.i4.97860","url":null,"abstract":"<p><p>To facilitate the implementation of controlled donation after circulatory death (cDCD) programs even in hospitals not equipped with a local Extracorporeal Membrane Oxygenation (ECMO) team (Spokes), some countries and Italian Regions have launched a local cDCD network with a ECMO mobile team who move from Hub hospitals to Spokes for normothermic regional perfusion (NRP) implantation in the setting of a cDCD pathway. While ECMO teams have been clearly defined by the Extracorporeal Life Support Organization, regarding composition, responsibilities and training programs, no clear, widely accepted indications are to date available for NRP teams. Although existing NRP mobile networks were developed due to the urgent need to increase the number of cDCDs, there is now the necessity for transplantation medicine to identify the peculiarities and responsibility of a NRP team for all those centers launching a cDCD pathway. Thus, in the present manuscript we summarized the characteristics of an ECMO mobile team, highlighting similarities and differences with the NRP mobile team. We also assessed existing evidence on NRP teams with the goal of identifying the characteristic and essential features of an NRP mobile team for a cDCD program, especially for those centers who are starting the program. Differences were identified between the mobile ECMO team and NRP mobile team. The common essential feature for both mobile teams is high skills and experience to reduce complications and, in the case of cDCD, to reduce the total warm ischemic time. Dedicated training programs should be developed for the launch of <i>de novo</i> NRP teams.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"97860"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical use of donor-derived cell-free DNA in kidney transplantation.","authors":"Vishal Jaikaransingh, Bhaktidevi Makadia, Hafiz S Khan, Irtiza Hasan","doi":"10.5500/wjt.v14.i4.97219","DOIUrl":"10.5500/wjt.v14.i4.97219","url":null,"abstract":"<p><p>Traditional monitoring of kidney transplant recipients for allograft dysfunction caused by rejection involves serial checks of serum creatinine with biopsy of the renal allograft if dysfunction is suspected. This approach is labor-intensive, invasive and costly. In addition, because this approach relies on a rise in serum creatinine above historical baselines, injury to the allograft can be extensive before this rise occurs. In an effort to address this, donor-derived cell-free DNA (dd-cf DNA) is being used with increasing frequency in the clinical setting as a means of diagnosing a rejection of the renal allograft early in the course. This can potentially allow for early intervention to minimize not only injury, but the intensity of antirejection therapy needed and the avoidance of side effects. Here, we will review the available methodology for the determination and quantification of dd-cf DNA, the data supporting its use in clinical practice and the limitations of this technology.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"97219"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging-based prediction of hepatocellular carcinoma recurrence after microwave ablation as bridge therapy: A glimpse into the future.","authors":"Cristian Lindner, Rodrigo San Martín, Andrés Concha, David Clemo, Jorge Valenzuela","doi":"10.5500/wjt.v14.i4.98653","DOIUrl":"10.5500/wjt.v14.i4.98653","url":null,"abstract":"<p><p>Liver transplantation (LT) remains the treatment of choice for early-stage hepatocellular carcinoma (HCC) and offers the best long-term oncological outcomes. However, the increasing waiting list for LT has led to a significant dropout rate as patients experience tumor progression beyond the Milan criteria. Currently, locoregional therapies, such as microwave ablation (MWA), have emerged as promising bridge treatments for patients awaiting LT. These therapies have shown promising results in preventing tumor progression, thus reducing the dropout rate of LT candidates. Despite the efficacy of MWA in treating HCC, tumoral recurrence after ablation remains a major challenge and significantly impacts the prognosis of HCC patients. Therefore, accurately diagnosing tumoral recurrence post-ablation is crucial. Recent studies have developed novel imaging features based on magnetic resonance imaging of HCC, which could provide essential information for predicting early tumoral recurrence after MWA. These advancements could address this unresolved challenge, improving the clinical outcomes of patients on the LT waiting list. This article explored the current landscape of MWA as a bridge therapy for HCC within the Milan criteria, highlighting the emerging role of novel imaging-based features aimed at improving the prediction of tumor recurrence after MWA.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"98653"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supervised <i>vs</i> home-based exercise program in kidney transplant recipients: A pilot pragmatic non-randomized study.","authors":"Anna Crepaldi, Giovanni Piva, Nicola Lamberti, Michele Felisatti, Luca Pomidori, Yuri Battaglia, Fabio Manfredini, Alda Storari, Pablo Jesús López-Soto","doi":"10.5500/wjt.v14.i4.96244","DOIUrl":"10.5500/wjt.v14.i4.96244","url":null,"abstract":"<p><strong>Background: </strong>Although the benefits of exercise for kidney transplant recipients (KTRs) have been widely demonstrated, these patients experience several barriers in undertaking a structured exercise program in hospital and non-hospital facilities.</p><p><strong>Aim: </strong>To compare the effects of a supervised moderate-intensity gym-based intervention with a home-based low-intensity walking program on exercise capacity in KTRs.</p><p><strong>Methods: </strong>KTRs were asked to choose between two six-month programs. The first group performed a low-intensity interval walking intervention at home-based exercise intervention (HBex). The second group performed a supervised training program at an adapted physical activity gym (Sgym), including aerobic and resistance training. The outcomes, collected at baseline and at the end of the programs, included the 6-minute walking test, the peak oxygen consumption (VO2peak) during a treadmill test, the 5-time sit-to-stand test, and blood pressure.</p><p><strong>Results: </strong>Seventeen patients agreed to participate and self-selected into the HBex (<i>n</i> = 9) and Sgym (<i>n</i> = 8) groups. Two patients in the Sgym group dropped out because of familial problems. At baseline, patients in the HBex group were significantly older and had lower walking distance, VO2peak, and lower limb strength. Primary outcome changes were significantly greater in the HBex group than in the Sgym group (52 ± 23 m <i>vs</i> 8 ± 34; <i>P</i> = 0.005). No other significant differences between groups were observed. Both groups improved most of the outcomes in the within-group comparisons, with significant variations in VO2 peak.</p><p><strong>Conclusion: </strong>Six-month moderate-intensity supervised or low-intensity home-based training programs effectively improved exercise capacity in KTRs. Gym-based programs combine aerobic and resistance training; however, in-home walking may be proposed for frail KTRs.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"96244"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing growth in pediatric renal transplant recipients: An update.","authors":"Manoji Gamage, Randula Ranawaka","doi":"10.5500/wjt.v14.i4.95967","DOIUrl":"10.5500/wjt.v14.i4.95967","url":null,"abstract":"<p><p>Growth retardation is a significant complication observed in pediatric renal transplant recipients, originating from a multifactorial etiology. Factors contributing to growth impairment encompass pre-transplant conditions such as primary kidney disease, malnutrition, quality of care, growth deficits at the time of transplantation, dialysis adequacy, and the use of recombinant human growth hormone. Additionally, elements related to the renal transplant itself, such as living donors, corticosteroid usage, and graft functioning, further compound the challenge. Although renal transplantation is the preferred renal replacement therapy, its impact on achieving final height and normal growth in children remains uncertain. The consequences of growth delay extend beyond the physiological realm, negatively influencing the quality of life and social conditions of pediatric renal transplant recipients, and ultimately affecting their educational and employment outcomes. Despite advancements in graft survival rates, growth retardation remains a formidable clinical concern among children undergoing renal transplantation. Major risk factors for delayed final adult height include young age at transplantation, pre-existing short stature, and the use of specific immunosuppressive drugs, particularly steroids. Effective management of growth retardation necessitates early intervention, commencing even before transplantation. Strategies involving the administration of recombinant growth hormone both pre- and post-transplant, along with protocols aimed at minimizing steroid usage, are important for achieving catch-up growth. This review provides a comprehensive outline of the multifaceted nature of growth retardation in pediatric renal transplant recipients, emphasizing the importance of early and targeted interventions to mitigate its impact on the long-term well-being of these children from birth to adolescence.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"95967"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New frontiers in retinal transplantation.","authors":"Francesco Saverio Sorrentino, Patrick Di Terlizzi, Francesco De Rosa, Carlo Salati, Leopoldo Spadea, Caterina Gagliano, Mutali Musa, Marco Zeppieri","doi":"10.5500/wjt.v14.i4.97690","DOIUrl":"10.5500/wjt.v14.i4.97690","url":null,"abstract":"<p><p>New frontiers about retinal cell transplantation for retinal degenerative diseases start from the idea that acting on stem cells can help regenerate retinal layers and establish new synapses among retinal cells. Deficiency or alterations of synaptic input and neurotrophic factors result in trans-neuronal degeneration of the inner retinal cells. Thus, the disruption of photoreceptors takes place. However, even in advanced forms of retinal degeneration, a good percentage of the ganglion cells and the inner nuclear layer neurons remain intact. This phenomenon provides evidence for obtaining retinal circuitry through the transplantation of photoreceptors into the subretinal region. The eye is regarded as an optimal organ for cell transplantation because of its immunological privilege and the relatively small number of cells collaborating to carry out visual activities. The eyeball's immunological privilege, characterized by the suppression of delayed-type hypersensitivity responses in ocular tissues, is responsible for the low rate of graft rejection in transplant patients. The main discoveries highlight the capacity of embryonic stem cells (ESCs) and induced pluripotent stem cells to regenerate damaged retinal regions. Recent progress has shown significant enhancements in transplant procedures and results. The research also explores the ethical ramifications linked to the utilization of stem cells, emphasizing the ongoing issue surrounding ESCs. The analysis centers on recent breakthroughs, including the fabrication of three-dimensional retinal organoids and the innovation of scaffolding for cell transportation. Moreover, researchers are currently assessing the possibility of CRISPR and other advanced gene editing technologies to enhance the outcomes of retinal transplantation. The widespread use of universally recognized safe surgical and imaging methods enables retinal transplantation and monitoring of transplanted cell growth toward the correct location. Currently, most therapy approaches are in the first phases of development and necessitate further research, including both pre-clinical and clinical trials, to attain favorable visual results for individuals suffering from retinal degenerative illnesses.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"97690"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac evaluation of renal transplant candidates with heart failure.","authors":"Amer Ashaab Belal, Alfonso Hernandez Santos, Amir Kazory","doi":"10.5500/wjt.v14.i4.96017","DOIUrl":"10.5500/wjt.v14.i4.96017","url":null,"abstract":"<p><p>Patients with advanced kidney disease are at elevated risk of developing heart failure and appropriate risk stratification is important to permit them to receive kidney transplantation. The American Heart Association and American College of Cardiology joint statement provides guidance on risk stratification for the major cause of heart failure for these patients in its recommendations for coronary heart disease. Herein we provide an overview of the available literature on risk stratification for nonischemic heart failure and functional heart disease states such as pulmonary hypertension. Many of these options for optimizing these patients before transplant include optimizing their volume status, often with more aggressive ultrafiltration. Kidney transplantation remains the treatment of choice for patients with advanced kidney disease and cardiac disease, the correction of the azotemic substances with kidney transplantation has been associated with improved survival than remaining on dialysis long-term. The findings in the studies reviewed here are expected to help clinicians refine current strategies for evaluating potential kidney transplant recipients.</p>","PeriodicalId":68893,"journal":{"name":"世界移植杂志(英文版)","volume":"14 4","pages":"96017"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}