Sandeep Manandhar, I. Veith, M. Parrini, Auguste Genovesio
{"title":"SAVGAN: Self-Attention Based Generation of Tumour on Chip Videos","authors":"Sandeep Manandhar, I. Veith, M. Parrini, Auguste Genovesio","doi":"10.1109/ISBI52829.2022.9761518","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761518","url":null,"abstract":"Generation of videomicroscopy sequences will become increasingly important in order to train and evaluate dynamic image analysis methods. The latter are crucial to the study of biological dynamic processes such as tumour-immune cell interactions. However, current generative models developed in the context of natural image sequences employ either a single 3D (2D+time) convolutional neural network (CNN) based generator, which fails to capture long range interactions, or two separate (spatial and temporal) generators, which are unable to faithfully reproduce the morphology of moving objects. Here, we propose a self-attention based generative model for videomicroscopy sequences that aims to take into account for the full range of interactions within a spatio-temporal volume of 32 frames. To reduce the computational burden of such a strategy, we consider the Nyström approximation of the attention matrix. This approach leads to significant improvements in reproducing the structures and the proper motion of videomicroscopy sequences as assessed by a range of existing and proposed quantitative metrics.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"30 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83381991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"TriageNet: A Multi-Agent Diagnosis Network for Imbalanced Data","authors":"Weixiang Chen, Jianjiang Feng, Jie Zhou","doi":"10.1109/ISBI52829.2022.9761420","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761420","url":null,"abstract":"Imbalanced and even long-tail distribution of different categories is a challenge for multi-class classification problem, especially for medical image diagnose whose data distribution is usually imbalanced. Toward this issue, we proposed an end-to-end multi-agent classification network called Tria-geNet, which is combined of multiple selectors and diagnostic agents. All categories are guided to different agents by selectors, and every agent is an expert in a specific group of categories. This process, which is similar to triage in hospitals, helps decrease the unbalance between categories for both selectors and agents. Experiments on an extremely imbalanced pneumonia CT dataset and a publicly available X-ray dataset Chexpert show that TriageNet is relatively robust to imbalanced data.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"8 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89104083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perfusion Imaging in Deep Prostate Cancer Detection from MP-MRI: Can We Take Advantage of it?","authors":"Audrey Duran, Gaspard Dussert, C. Lartizien","doi":"10.1109/ISBI52829.2022.9761616","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761616","url":null,"abstract":"To our knowledge, all deep computer-aided detection and diagnosis (CAD) systems for prostate cancer (PCa) detection consider bi-parametric magnetic resonance imaging (bp-MRI) only, including T2w and ADC sequences while excluding the 4D perfusion sequence,which is however part of standard clinical protocols for this diagnostic task. In this paper, we question strategies to integrate information from perfusion imaging in deep neural architectures. To do so, we evaluate several ways to encode the perfusion information in a U-Net like architecture, also considering early versus mid fusion strategies. We compare performance of multiparametric MRI (mp-MRI) models with the baseline bp-MRI model based on a private dataset of 219 mp-MRI exams. Perfusion maps derived from dynamic contrast enhanced MR exams are shown to positively impact segmentation and grading performance of PCa lesions, especially the 3D MR volume corresponding to the maximum slope of the wash-in curve as well as Tmax perfusion maps. The latter mp-MRI models indeed outperform the bp-MRI one whatever the fusion strategy, with Co-hen’s kappa score of 0.318±0.019 for the bp-MRI model and 0.378 ± 0.033 for the model including the maximum slope with a mid fusion strategy, also achieving competitive Co-hen’s kappa score compared to state of the art.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"86 1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Segmentation of Multiple Myeloma Cells Using Feature Selection Pyramid Network and Semantic Cascade Mask RCNN","authors":"Xinyun Qiu, Haijun Lei, Hai Xie, Baiying Lei","doi":"10.1109/ISBI52829.2022.9761460","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761460","url":null,"abstract":"Multiple myeloma (MM) is a blood cancer that develops when plasma cells expand abnormally in the bone marrow. The early detection of MM is beneficial for accurate treatment in time and draws increasing recognition. There are several methods to detect myeloma cells in bone marrow, such as using microscopic analysis based on the aspirate slide images. In this paper, we propose a deep learning framework called the semantic cascade Mask RCNN for the detection and segmentation of myeloma cells. The framework is also integrated with the proposed feature selection pyramid network, which is a simple and effective module to improve the segmentation performance. The mask aggregation module refines and merges the high certainty instance masks into a single segmentation map and combines the results from the extra semantic segmentation branch to generate better predictions. The extensive experiments on the SegPC-2021 Challenge dataset demonstrate that the proposed method achieves a promising performance.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"69 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88531208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Extending the Capability of Linear Array Ultrasound Probe to Concave Array Using Low-Cost Acoustic Lens for High Frame Rate Focused Imaging","authors":"Pisharody Harikrishnan Gopalakrishnan, Mahesh Raveendranatha Panicker","doi":"10.1109/ISBI52829.2022.9761480","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761480","url":null,"abstract":"In the current scenario medical practitioners use different types of transducer probes for imaging organs at different depths and with varying field of view. Normally linear arrays are used for near-field imaging while convex probes are used for far-field imaging. In both the cases, focusing is achieved through electronics delays, which will reduce the frame rate to maximum of 50 fps. In this work, an approach towards a low-cost setup using gel based acoustic lens for converting a linear array transducer probe with plane wave transmission to a concave array to induce focused ultrasound (US) B-Mode imaging is attempted. Results from Simulation, in vitro experiments with pin phantoms and in vivo experiments with human carotid showed promising results. The experimental results yielded an improvement in the lateral and axial resolution of 36.67 % and 28.57 % respectively which were pre-validated using simulation results yielding similar outcomes of 47.50 % lateral and 33.33 % axial resolution.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"89 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85715041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suvadip Mukherjee, V. Meas-Yedid, M. Bokobza, T. Lagache, A. Corthay, J. Olivo-Marin
{"title":"Spatial Analysis For Histopathology: A Statistical Approach","authors":"Suvadip Mukherjee, V. Meas-Yedid, M. Bokobza, T. Lagache, A. Corthay, J. Olivo-Marin","doi":"10.1109/ISBI52829.2022.9761498","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761498","url":null,"abstract":"A pattern analysis approach is proposed to model spatial interaction between the immune cells and the islets of cancer cells within the tumor microenvironment. Embedded in a statistical null hypothesis paradigm, the proposed solution provides a novel mechanism to extract quantitative, system-level snap-shot of the tumor microenvironment during immunotherapy. Experimental results on synthetic and real histopathological data suggest the potential of our technique in mining robust information from the spatial distribution of immune cells at different time-points during cancer treatment. This statistical framework could be potentially adopted in future large-scale experimental studies to objectively monitor disease progression and the patient’s response to immune therapy.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"49 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86436756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zheling Meng, Yangyang Zhu, Xiao Fan, Jie Tian, F. Nie, Kun Wang
{"title":"CEUSegNet: A Cross-Modality Lesion Segmentation Network for Contrast-Enhanced Ultrasound","authors":"Zheling Meng, Yangyang Zhu, Xiao Fan, Jie Tian, F. Nie, Kun Wang","doi":"10.1109/ISBI52829.2022.9761594","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761594","url":null,"abstract":"Contrast-enhanced ultrasound (CEUS) is an effective imaging tool to analyze spatial-temporal characteristics of lesions and diagnose or predict diseases. However, delineating lesions frame by frame is a time-consuming work, which brings challenges to analyzing CEUS videos with deep learning technology. In this paper, we proposed a novel U-net-like network with dual top-down branches and residual connections, named CEUSegNet. CEUSegNet takes US and CEUS part of a dual-amplitude CEUS image as inputs. Cross-modality Segmentation Attention (CSA) and Cross-modality Feature Fusion (CFF) are designed to fuse US and CEUS features on multiple scales. Through our method, lesion position can be determined exactly under the guidance of US and then the region of interest can be delineated in CEUS image. Results show CEUSegNet can achieve a comparable performance with clinicians on metastasis cervical lymph nodes and breast lesion dataset.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"170 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86567342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thanh M. Huynh, C. Nguyen, Khoa N. A. Nguyen, Trung Bui, S. Q. Truong
{"title":"CapNeXt: Unifying Capsule And Resnext For Medical Image Segmentation","authors":"Thanh M. Huynh, C. Nguyen, Khoa N. A. Nguyen, Trung Bui, S. Q. Truong","doi":"10.1109/ISBI52829.2022.9761649","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761649","url":null,"abstract":"Capsule Network is a contemporary approach to image analysis that emphasizes part-whole relationships. However, its applications to segmentation tasks are limited due to training difficulties such as initialization and convergence. In this study, we propose a novel Capsule Network, called CapNeXt, that unifies Capsule and ResNeXt architectures for medical image segmentation. CapNeXt advances the existing capsule-based segmentation model by integrating optimization techniques from Convolutional Neural Networks (CNN) to make training much easier than other contemporary Capsule-based segmentation methods. Experimental results on two public datasets show that CapNeXt outperforms the CNNs and other Capsule architectures in 2D and 3D segmentation tasks by 1% of the Dice score. The code will be released on GitHub after being accepted.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"24 11-12","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72561444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Timaná, Hector Chahuara, Lokesh Basavarajappa, A. Basarab, K. Hoyt, R. Lavarello
{"title":"Simultaneous Imaging of Ultrasonic Backscatter and Attenuation Coefficients for Liver Steatosis Detection in a Murine Animal Model","authors":"José Timaná, Hector Chahuara, Lokesh Basavarajappa, A. Basarab, K. Hoyt, R. Lavarello","doi":"10.1109/ISBI52829.2022.9761657","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761657","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. While early diagnosis is the most effective course of action, NAFLD diagnosis procedures are still limited since they are invasive and have a heavy component of subjectivity. In this paper, we present an approach based on Quantitative ultrasound (QUS) and Support Vector Machines (SVM) to detect liver steatosis based on the estimation of backscatter (BSC) and attenuation coefficients (AC) in a murine animal model. We tested our proposed method with data acquired from a population of 21 rats that were randomly divided into two groups subjected to two different diets. The results yielded by the estimation method at 15 MHz show a clear difference in the estimated QUS modalities in healthy liver, where BSC and AC mean and standard deviation values were found to be 0.22 ± 0.28 cm−1• sr−1 and 0.54 ± 0.03 dB MHz−1• cm−1, respectively, with respect to fatty liver, where BSC• and AC mean values were found to be 0.74 ± 0.80 cm−1 • sr−1 and 0.64 ± 0.06 dB • MHz−1• cm−1, respectively. Furthermore, the SVM achieved an accuracy of 97.6% when discriminating between healthy and steatotic liver, thus constituting a promising alternative for non-invasive NAFLD diagnosis.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"137 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79575753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafsanjany Kushol, Abbas Masoumzadeh, Dong Huo, S. Kalra, Yee-Hong Yang
{"title":"Addformer: Alzheimer’s Disease Detection from Structural Mri Using Fusion Transformer","authors":"Rafsanjany Kushol, Abbas Masoumzadeh, Dong Huo, S. Kalra, Yee-Hong Yang","doi":"10.1109/ISBI52829.2022.9761421","DOIUrl":"https://doi.org/10.1109/ISBI52829.2022.9761421","url":null,"abstract":"Alzheimer’s disease is the most prevalent neurodegenerative disorder characterized by degeneration of the brain. It is classified as a brain disease causing dementia that presents with memory loss and cognitive impairment. Experts primarily use brain imaging and other tests to rule out the disease. To automatically detect Alzheimer’s patients from healthy controls, this study adopts the vision transformer architecture, which can effectively capture the global or long-range relationship of image features. To further enhance the network’s performance, frequency and image domain features are fused together since MRI data is acquired in the frequency domain before being transformed to images. We train the model with selected coronal 2D slices to leverage the transfer learning property of pre-training the network using ImageNet. Finally, the majority voting of the coronal slices of an individual subject is used to generate the final classification score. Our proposed method has been evaluated on the publicly available benchmark dataset ADNI. The experimental results demonstrate the advantage of our proposed approach in terms of classification accuracy compared with that of the state-of-the-art methods. Our code is available at https://github.com/rkushol/ADDFormer.","PeriodicalId":6827,"journal":{"name":"2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI)","volume":"27 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74762713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}