有机化学国际期刊(英文)最新文献_第3页

One-Pot Synthesis of Pyrido[2,3-d]pyrimidines Catalyzed by Bismuth(III)Triflate 三酸铋催化一锅法合成吡啶[2,3-d]嘧啶

有机化学国际期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ijoc.2022.121002

Deniz Saglam, Z. Turgut

引用次数: 0

Synthesis and Characterization of 1,4-Benzodioxane-6-Carboxylic Acid Amide Analogs 1,4-苯二氧烷-6-羧酸酰胺类似物的合成与表征

有机化学国际期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ijoc.2022.123012

Nabil Idris, A. J. Anderson, O. Bakare

引用次数: 1

Peptides Radiofluorination: Main Methods and Highlights 多肽放射氟化:主要方法和重点

有机化学国际期刊(英文) Pub Date : 2022-01-01 DOI: 10.4236/ijoc.2022.124013

A. C. Bispo, Fernanda A. F. Almeida, J. B. Silva, M. Mamede

引用次数: 0

Design, Synthesis of Analgesics and Anticancer of Some New Derivatives of Benzimidazole 苯并咪唑新衍生物的设计、合成及其镇痛抗癌作用

有机化学国际期刊(英文) Pub Date : 2021-08-11 DOI: 10.4236/ijoc.2021.113011

Helmy M. Sakr, R. Ayyad, Kazem Mahmoud, A. Mansour, A. G. Ahmed

引用次数: 2

Synthesis, Molecular Structure, Anti-Plasmodial, Antimicrobial and Anti-Oxidant Screening of (E)-1-(Phthalazin-1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine and 1-[2-(1-(pyridine-3- yl)ethylidene)hydrazinyl]phthalazine (E)-1-(酞菁-1-基)-1-[(吡啶-2-基)乙基]肼嗪和1-[2-(1-(吡啶-3-基)乙基)肼基]酞菁的合成、分子结构、抗疟原虫、抗菌和抗氧化筛选

有机化学国际期刊(英文) Pub Date : 2021-08-11 DOI: 10.4236/ijoc.2021.113008

A. F. Awantu, Godfred A. Ayimele, J. J. Bankeu, E. Nantia, P. Fokou, F. Boyom, E. Nfor, B. Lenta, S. Ngouela

{"title":"Synthesis, Molecular Structure, Anti-Plasmodial, Antimicrobial and Anti-Oxidant Screening of (E)-1-(Phthalazin-1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine and 1-[2-(1-(pyridine-3- yl)ethylidene)hydrazinyl]phthalazine","authors":"A. F. Awantu, Godfred A. Ayimele, J. J. Bankeu, E. Nantia, P. Fokou, F. Boyom, E. Nfor, B. Lenta, S. Ngouela","doi":"10.4236/ijoc.2021.113008","DOIUrl":"https://doi.org/10.4236/ijoc.2021.113008","url":null,"abstract":"Two new hydralazine hydrochloride-derived Schiff bases: (E)-1-(Phthalazin- 1-yl)-1-[(Pyridin-2-yl)Ethylidene]Hydralazine (PPEH), and 1-[2-(1-(pyridine- 3-yl)ethylidene)hydrazinyl]phthalazine (PEHP), were synthesized and partially characterized by spectroscopic and crystallographic methods including IR and X-ray. The single-crystal X-ray diffraction (SCXRD) analysis of PEHP indicates that the hydralazine moiety of both ligands possesses the exocyclic C=N bond. Both, PPEH and PEHP were tested as antimicrobials and antiparasites. Just PEHP could be considered as slightly antiplasmodial and antibacterial agent. In effect, PPEH showed low antimicrobial activity against one bacterial strain with Minimum Inhibitory Concentration (MIC) value of 250 μg/ml while PEHP showed very interesting activity against 18 out of 19 bacterial strains with MIC of 31.25 - 250 μg/ml compared to the standard drug, amoxicillin. PPEH and PEHP showed higher reducing activity on ferric ions compared to Vitamin C. On the other hand, both hidrazaline synthetized derivatives showed as better reducing agents than Vitamin C on ferric ions, while again, only the PEHP showed slightly high inhibition of lipid peroxidation using Vitamin C as standard. Regarding their catalase activity, both compounds showed concentration dependent effect, but Vitamin C continued showing a higher stimulatory effect on the enzyme activity. Additionally, while PPEH showed less than 80% inhibition in the preliminary antiplasmodial assay and so was not considered for the dose-response studies, PEHP displayed an inhibition percentage of 83.60% and 50% Inhibitory Concentration (IC50) value of 44.13 μg/mL compared to the standard drug, artemisinin and was classified as slightly active.","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47159336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Development of Novel Benzimidazole Derivates as Potent and Selective Akt Kinase Inhibitors Using In-silico Approaches 新型苯并咪唑衍生物作为强效和选择性Akt激酶抑制剂的计算机研究进展

有机化学国际期刊(英文) Pub Date : 2021-08-11 DOI: 10.4236/ijoc.2021.113009

Rasha Ghanem Kattoub, Faten Sliman, Mohammad Kousara

引用次数: 0

Pharmacophore Based Virtual Screening for Identification of Novel CDK2 Inhibitors 基于药效团的新型CDK2抑制剂的虚拟筛选

有机化学国际期刊(英文) Pub Date : 2021-06-30 DOI: 10.4236/ijoc.2021.112007

A. Issa, Faten Sliman, J. Harbali

引用次数: 0

Novel Tandem Three Consecutive Reactions: Aza-Wittig, Imine Condensation and Electrophilic Aromatic Substitution Strategy to Indolizine Synthesis 新的串联三连续反应：氮杂-维蒂希、亚胺缩合和亲电芳香取代策略合成吲唑嗪

有机化学国际期刊(英文) Pub Date : 2021-06-30 DOI: 10.4236/ijoc.2021.112006

Julio C. González-Rodríguez, Carlos González-Romero, E. Cuevas-Yáñez, J. Vega, C. Jankowski, D. Corona-Becerril

引用次数: 0

Multi-technique characterization and conservation of an ancient Egyptian fabric from King Khufu first solar ship 胡夫国王第一艘太阳能船古埃及织物的多技术表征和保护

有机化学国际期刊(英文) Pub Date : 2021-02-18 DOI: 10.21203/rs.3.rs-202536/v1

E. Nabil, Tawfik A Khattab, S. Kamel

{"title":"Multi-technique characterization and conservation of an ancient Egyptian fabric from King Khufu first solar ship","authors":"E. Nabil, Tawfik A Khattab, S. Kamel","doi":"10.21203/rs.3.rs-202536/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-202536/v1","url":null,"abstract":"\u0000 Textiles are among the most fragile artefacts in the world. They have been difficult to preserve even in the best circumstances. Herein, we studied an artefact fabric of a special nature in terms of usage. Despite the multiple applications of textiles, the piece understudy is one of the unique pieces that the ancient Egyptian used as fenders for King Khufu first solar boat which is the second-largest discovery in Egypt history. The boat was discovered inside a limestone pit. It was disassembled and arranged in several layers. Four pillows of wrapped fabric were found in the first layer, which were used as boat fenders. This use is in itself a great discovery of the role played by textiles in the manufacture of ancient boats. Thus, we conducted tests and analytical studies of those fenders using a scanning electron microscopy (SEM) and an optical microscope to identify the type and nature of fibers, spinning method and aspects of damage. Both energy-dispersive X-ray (EDX) analysis and infrared analysis (FT-IR) were employed to explore the elemental content of the sample and to study the functional groups of the fabric. These analytical processes were useful in carrying out the restoration and preservation work necessary for the artefact under study.","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42116315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Alternative and Potential Uses for the Sulfur Byproducts Produced from Oil and Gas Fields 油气田产硫副产物的替代和潜在用途

有机化学国际期刊(英文) Pub Date : 2021-01-28 DOI: 10.4236/IJOC.2021.111002

Saba Khan, S. Amani, M. Amani

{"title":"Alternative and Potential Uses for the Sulfur Byproducts Produced from Oil and Gas Fields","authors":"Saba Khan, S. Amani, M. Amani","doi":"10.4236/IJOC.2021.111002","DOIUrl":"https://doi.org/10.4236/IJOC.2021.111002","url":null,"abstract":"Along with oil and gas operations, huge amounts of sulfur byproducts are produced. For example, in the State of Qatar which has the third largest proven reserves of natural gas, an incredible amount of sulfur is produced as byproduct from its natural gas processing facilities. The amount of produced sulfur surpasses by far the amount that can be utilized currently in the country. Hydrogen sulfide (H2S) existing in natural gas extracted from Qatar’s North Field is converted to elemental sulfur using the conventional Claus process. Managing byproduct sulfur from natural gas processing is a key aspect of economic development and environmental protection in many countries with oil and gas facilities. Therefore, new markets must be found to utilize sulfur to avoid disposal crises. Sulfur byproduct from natural gas can be utilized for various applications. This paper discusses alternative potential uses for sulfur in addition to the current practices of sulfur utilization. Some of these alternative applications of sulfur byproducts include the potential usage for medicinal uses, road construction, batteries, hydrogen production, structural additives, solar energy, waste treatment, arsenite removal, and production of maize.","PeriodicalId":64796,"journal":{"name":"有机化学国际期刊(英文)","volume":"11 1","pages":"14-23"},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47866164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1