风湿病与自身免疫疾病期刊(英文)Pub Date : 2014-02-01DOI: 10.4236/ojra.2014.41010
Narendiran Rajasekaran, Ricky Tran, Conrado Pascual, Xinmin Xie, Elizabeth D Mellins
{"title":"Reduced locomotor activity correlates with increased severity of arthritis in a mouse model of antibody-induced arthritis.","authors":"Narendiran Rajasekaran, Ricky Tran, Conrado Pascual, Xinmin Xie, Elizabeth D Mellins","doi":"10.4236/ojra.2014.41010","DOIUrl":"https://doi.org/10.4236/ojra.2014.41010","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and progressive cartilage and bone destruction that leads to a substantial loss of general functions and/or a decline in physical activities such as walking speed in humans. The K/BxN serum transfer arthritis in mice shares many immunological and pathological features with human RA. Very few studies are available in mice that investigate the changes in physical activity in relation to arthritis development. In this study we investigate the effect of arthritis on the locomotor activity of mice during K/BxN sera transfer arthritis.</p><p><strong>Methods: </strong>Arthritis was induced in Balb/c mice by injecting intraperitoneally with 200ul of K/BxN sera; Balb/c mice injected with phosphate buffered saline (PBS) served as control. Progress of arthritis was estimated by daily measurements of joint thickness. Each mouse's locomotor activity (travel distance and travel time) was assessed every day for duration of 20 minute period using the SmartCage™ platform. Data were analyzed using the SmartCage™ analysis software (CageScore™).</p><p><strong>Results: </strong>Arthritic Balb/c mice showed a reduction in distance covered and travel speed when compared to arthritis-free, control Balb/c mice. Maximum decline in locomotor activity was observed during the peak period of the disease and correlated to the increase in joint thickness in the arthritic mice.</p><p><strong>Conclusion: </strong>This report demonstrates that measuring locomotor activity of mice during progression of K/BxN sera-induced arthritis using the SmartCage™ platform offers a quantitative method to assess physical activity in mice during arthritis.</p>","PeriodicalId":64099,"journal":{"name":"风湿病与自身免疫疾病期刊(英文)","volume":"4 1","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2014-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264968/pdf/nihms623567.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32907456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
风湿病与自身免疫疾病期刊(英文)Pub Date : 2013-09-01DOI: 10.4028/www.scientific.net/AMR.778.1041
T. Tannert, J. Branco, M. Riggio
{"title":"RILEM TC \"Reinforcement of Timber Elements in Existing Structures\"","authors":"T. Tannert, J. Branco, M. Riggio","doi":"10.4028/www.scientific.net/AMR.778.1041","DOIUrl":"https://doi.org/10.4028/www.scientific.net/AMR.778.1041","url":null,"abstract":"The paper reports on the activities of the RILEM technical committee Reinforcement of Timber Elements in Existing Structures. The main objective of the committee is to coordinate the efforts to improve the reinforcement practice of timber structural elements. Recent developments related to structural reinforcements can be grouped into three categories: (i) addition of new structural systems to support the existing structure; (ii) configuration of a composite system; and (iii) incorporation of elements to increase strength and stiffness. The paper specifically deals with research carried out at the Bern University of Applied Sciences Switzerland (BFH), the University of Minho Portugal (UniMinho), and the University of Trento Italy (UNITN). Research at BFH was devoted to improve the structural performance of rounded dovetail joints by means of different reinforcement methods: i) self-tapping screws, ii) adhesive layer, and iii) a combination of self-tapping screws and adhesive layer. Research at UNITN targeted the use of dry connections for timber-to-timber composites, specifically reversible reinforcement techniques aimed at increasing the load-bearing capacity and the bending stiffness of existing timber floors. At UniMinho, double span continuous glulam slabs were strengthened with fibre-reinforced-polymers. All three examples demonstrate the improved structural performance of timber elements after reinforcing them.","PeriodicalId":64099,"journal":{"name":"风湿病与自身免疫疾病期刊(英文)","volume":"1 1","pages":"1041 - 1048"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72686551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
风湿病与自身免疫疾病期刊(英文)Pub Date : 2012-05-01DOI: 10.4236/ojra.2012.22004
Julia F Simard, Murray A Mittleman, Nancy A Shadick, Elizabeth W Karlson
{"title":"TNF-<i>α</i> Antagonist and Infection in Rheumatoid Arthritis.","authors":"Julia F Simard, Murray A Mittleman, Nancy A Shadick, Elizabeth W Karlson","doi":"10.4236/ojra.2012.22004","DOIUrl":"10.4236/ojra.2012.22004","url":null,"abstract":"<p><strong>Background: </strong>Anti-TNF treatment may increase infection risk, although this has been difficult to study because the timing of anti-TNF treatment is driven by disease activity, which may influence infection susceptibility leading to confounding that varies over time. We evaluated the association between anti-TNF initiation in rheumatoid arthritis (RA) patients on disease modifying anti-rheumatic drugs (DMARD) and infection using multiple approaches adjusting for time-varying confounding.</p><p><strong>Methods: </strong>383 anti-TNF-naïve RA patients on ≥1 non-biologic-DMARD at enrollment from the Brigham and Women's Rheumatoid Arthritis Sequential Study (BRASS) were followed up to two years. Pooled logistic regressions estimated the association between anti-TNF and infection by including time-varying covariates in the adjusted models and inverse probability treatment weighting (IPTW).</p><p><strong>Results: </strong>Adjustment for time-varying disease activity and other suspected confounders yielded non-statistically significant positive associations between anti-TNF start and infection regardless of analytic approach (RR<sub>mvar_adj</sub> = 2.1, 95% CI: 0.8 - 5.8).</p><p><strong>Conclusions: </strong>Incorporating changing clinical status, and treatment indications and consequences, yielded consistently (though not significantly) elevated relative risks of infection associated with anti-TNF initiation. Due to limited statistical power, we cannot draw firm conclusions. However, we have illustrated multiple approaches adjusting for potential time-varying confounding in longitudinal studies and hope to replicate the approaches in larger studies.</p>","PeriodicalId":64099,"journal":{"name":"风湿病与自身免疫疾病期刊(英文)","volume":"2 2","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089359/pdf/nihms490244.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32499964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
风湿病与自身免疫疾病期刊(英文)Pub Date : 2012-05-01DOI: 10.4236/ojra.2012.22003
Deana D Hoganson, Jun Chen, Richard L Ehman, Jayant A Talwalkar, Clement J Michet, Meng Yin, Cynthia S Crowson, Eric L Matteson
{"title":"Magnetic Resonance Elastography for Liver Fibrosis in Methotrexate Treatment.","authors":"Deana D Hoganson, Jun Chen, Richard L Ehman, Jayant A Talwalkar, Clement J Michet, Meng Yin, Cynthia S Crowson, Eric L Matteson","doi":"10.4236/ojra.2012.22003","DOIUrl":"https://doi.org/10.4236/ojra.2012.22003","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatic magnetic resonance elastography (MRE) allows for noninvasive assessment of liver fibrosis. The purpose of this study was to evaluate the usefulness of MRE in detecting and quantifying liver fibrosis in patients with rheumatoid arthritis (RA) who have received methotrexate (MTX).</p><p><strong>Methods: </strong>The association between mean liver stiffness value as determined by MRE and variables of interest was determined. The decision for a liver biopsy in participants with an abnormal liver stiffness was made based on clinical judgment.</p><p><strong>Results: </strong>Sixty-five RA patients were enrolled. Mean liver stiffness value by MRE was abnormal in 7 patients, suggestive of hepatic injury. As a result of findings from the MRE, biopsies were performed in 5 patients and all correlated with elevated liver stiffness values. Elevated mean liver stiffness values were associated with body mass index (BMI) (OR= 1.18 per 1 kg/m<sup>2</sup>; 95% CI: 1.03, 1.36; p=0.017). Neither the total MTX dose nor the duration of MTX treatment was associated with mean liver stiffness value (p=0.51 and P=0.20, respectively).</p><p><strong>Conclusions: </strong>MRE provides a reliable, non-invasive assessment of liver fibrosis in patients with RA receiving MTX. Patients with RA receiving MTX who have an elevated BMI may be at increased risk for chronic hepatic injury, regardless of MTX cumulative dose or duration of treatment.</p>","PeriodicalId":64099,"journal":{"name":"风湿病与自身免疫疾病期刊(英文)","volume":"2 2","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2012-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4236/ojra.2012.22003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34167314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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