航天医学与医学工程Pub Date : 2006-10-02DOI: 10.2514/6.IAC-06-A2.P.06
P. Kostov, A. P. Ivanova, S. Sapunova, I. Ilieva, Assoc. Prof. S. Tz. Doncheva, A. Tzvetkova
{"title":"Ground Based Verification Tests and Equipment for Selection of Root-Zone Media for Higher Plant Cultivation in Space","authors":"P. Kostov, A. P. Ivanova, S. Sapunova, I. Ilieva, Assoc. Prof. S. Tz. Doncheva, A. Tzvetkova","doi":"10.2514/6.IAC-06-A2.P.06","DOIUrl":"https://doi.org/10.2514/6.IAC-06-A2.P.06","url":null,"abstract":"","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2006-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69063760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effects of simulated weightlessness on ALP, ACP, collagen I, and biomechanics of hind-limb bones in rats].","authors":"Xin-sheng Cao, Xing-yu Wu, Yan-hong Wu, Lian-jia Yang, Li-fan Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate effects of 3 weeks simulated weightlessness on biomechanical parameters, alkaline phosphatase (ALP), acid phosphatase (ACP) and collagen I of hind-limb bones in tail-suspended rats.</p><p><strong>Method: </strong>Fourteen male SD rats were divided equally into control group (CON) and experimental group; tail-suspended (TS) was used to simulate weightlessness. After 3 weeks tail-suspension, biomechanical parameters of femur were measured; ALP, ACP and collagen I of tibia were observed.</p><p><strong>Result: </strong>Elastic load, maximum load, and bending rigidity coefficient decreased significantly (P<0.01), while the maximum deformation and bending toughness coefficient increased markedly (P<0.01 or P<0.05). Morphological results showed that ALP declines significantly in TS group, ACP and type I collagen increased significantly in TS group.</p><p><strong>Conclusion: </strong>After tail-suspension for 3 weeks, growth of rat's weight bearing bones are suppressed, biomechanical capability declines, and collagen I metabolism becomes disordered.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"255-8"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25634933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong-zhi Shi, Yong-zhi Li, Xian-yun Shen, Quan-chun Fan, Gui-e Bai
{"title":"[Regulative effects of Chinese herb-compound on blood rheology and circulatory system of rabbits under simulated weightlessness].","authors":"Hong-zhi Shi, Yong-zhi Li, Xian-yun Shen, Quan-chun Fan, Gui-e Bai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To investigate effects of Chinese herb-compound on blood rheology and circulatory system of rabbits under simulated weightlessness in order to provide bases for protecting against the influence of simulated weightlessness on cardiovascular function.</p><p><strong>Method: </strong>Rabbits were exposed to head-down tilt (HDT -20 degrees) for 9 d to simulate weightlessness. The effect of Chinese herb-compound on indices related to blood rheology, blood-fat and orthostatic tolerance in these rabbits were examined.</p><p><strong>Result: </strong>After head-down tilt, hematocrit value and red blood cells deformability decreased significantly; cholesterol and low density lipoprotein increased markedly; plasma fibrinogen content and triglyceride showed increasing trend. Administration of the Chinese herb-compound didn't improve the blood rheology indices, but showed a trend to decrease triglyceride and to inhibit the increase of cholesterol. In the head-up tilt (HUT) plus lower body negative pressure (LBNP) experiment, orthostatic tolerance time of the rabbits in the control group decreased, and myocardial ischemic changes in ECG, such as dropped ST segment, inverse T wave, and arrhythmia were observed. While in the Chinese herb-compound group, the heart rate of the rabbits kept smooth, ischemic changes in ECG were not clear, and orthostatic tolerance time increased.</p><p><strong>Conclusion: </strong>The Chinese herb-compound shows an effect of preventing orthostatic tolerance from decreasing, and improves blood-fat metabolism. It regulates different human systems on the whole, and increases ability of adaptation to ill environment.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"251-4"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25634934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Zhu, Zhong-yuan Shi, Xiao-mei Wu, Zhi-jun Zhang, Shu-yi Jin
{"title":"[Prevention of Rhodiola-astragalus membranaceus compounds against simulated plateau hypoxia brain injury in rat].","authors":"Li Zhu, Zhong-yuan Shi, Xiao-mei Wu, Zhi-jun Zhang, Shu-yi Jin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To observe the protective effects of Rhodiola-astragalus membranaceus mixture against brain damage during hypoxia under simulated plateau environment and the mechanisms maybe involved in.</p><p><strong>Method: </strong>Adult SD rats were randomly divided into 3 groups, which were normoxic control, simulated plateau hypoxia, and Rhodiola-astragalus membranaceus mixture pretreatment group. Rats in the latter two groups were exposed to simulated 8000 m altitude in a hypobaric chamber for 7 h. Water content, Na+, K(+)-ATPase activity and SOD activity in cerebral tissue, malondialdehyde (MDA) and lactic acid content in cerebral homogenate and serum were measured.</p><p><strong>Result: </strong>As compared with control group, cerebral water content was significantly higher in hypoxia group, while it was obviously lower in pretreatment group. MDA contents of hypoxia group both in cerebral homogenate and serum were higher than that of control group, while the pretreatment group they were both decreased obviously. Lactic acid content of hypoxia group in cerebral and in serum increased markedly and decreased drastically in pretreatment group compared to that of hypoxic group.</p><p><strong>Conclusion: </strong>Rhodiola-astragalus membranaceus mixture has preventive effects on hypoxic damage induced by simulated plateau environment. This prevention may be related to the antagonistic effect on membrane lipid peroxidation and the inhibition on the accumulation of lactic acid in brain tissue and serum.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"303-5"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25635298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Quantitative ultrasonic naked gene delivery and the effect control].","authors":"Wei Wang, Wen-heng Sun, Zheng-zhong Bian, Qin-wu Zhou, Ya-lin Miao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study ultrasonic naked gene delivery and its effect control, and to investigate the new methods, which are easy-to-use, reliable and non-cytotoxic for application in gene therapy so as to build an optimal parameter set.</p><p><strong>Method: </strong>Suspensions of different kinds of cells were exposed to calibrated ultrasound field (35.1 kHz) with different parameters for gene delivery. Morphology, membrane permeability, naked gene expression efficiency, threshold of cell damage and cell viability were examined by laser scanning confocal microscopy, fluorescent microscopy, flow cytometry and spectrophotometer.</p><p><strong>Result: </strong>The plasmid of green fluorescent protein (GFP) was delivered into S180 cells under optimal parameters without cell damage. The transfection rate was about 35.83% +/- 2.53% (n=6) in viable cells. The GFP expression intensity in ultrasound exposure group had a higher fluorescent peak than AVV-GFP group and control group (P<0.001).</p><p><strong>Conclusion: </strong>Ultrasound can effectively deliver naked gene into cells using optimal parameters without cell damage. The gene uptake depends on energy accumulation at 90% of cell viability, and the tendency of apoptosis is found in S180 tumor cells.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"271-5"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25635415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A new type of active noise cancellation earmuffs].","authors":"Wen-bin Yu, Zhe Wu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To develop a new type of feedback active noise cancellation earmuff (ANCE) for aviator's helmet.</p><p><strong>Method: </strong>A mathematical model of such a structure was established based on frequency response function and automatic control theory. The method and role for designing ANCE controllers were summarized and the optimum design method was used for designing the controllers.</p><p><strong>Result: </strong>The acoustic components and simulation circuit were well matched. One of the prototype can attenuate the noise more than 15 dB in the frequency range of 50-2000 Hz (19 dB at the highest).</p><p><strong>Conclusion: </strong>The noise cancellation value of this earmuff has achieved international level and it can be mass-produced.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"306-7"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25635414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effects of 100 Hz vibration on ultrastructure of soleus muscle in tail-suspended rats].","authors":"Wei Yang, Xiao-li Fan, Xin-ai Song","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study the effects of 100 Hz vibration on ultrastructure of intrafusal and extrafusal fibers in soleus muscle of tail-suspended rats.</p><p><strong>Method: </strong>Weightlessness was simulated by tail suspension of female rats. The ultrastructure of intrafusal and extrafusal fibers of soleus muscle were examined after exposure to 100 Hz vibration.</p><p><strong>Result: </strong>The ultrastructure of intrafusal and extrafusal fibers of soleus muscles showed obvious retrograde changes after 7 d tail suspension, whereas these changes were not obvious after 7 d tail suspension plus 100 Hz vibration.</p><p><strong>Conclusion: </strong>High frequency vibration can counteract the effect of simulated weightlessness on ultrastructure of intrafusal and extrafusal fibers in soleus muscles of rats.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"259-61"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25634935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effect of oxygen-increased respirator on SaO2 and heart rate under plateau environment].","authors":"Er-ping Luo, Guang-hao Shen, Xiao-ming Wu, Li-hua Lu, Qiao-ling Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To study effects of oxygen-increased respirator on blood oxygen saturation (SaO2) and heart rate under altitude hypoxic environment.</p><p><strong>Method: </strong>Nine subjects were carried to the plateau of 3700 m by air for the first time, and then four trials were carried out two hours later. First, SaO2 and heart rate were examined during rest without oxygen-increased respirators, and then the examination was repeated by using the respirators. Second, the examinations were repeated during loaded exercise test without respirators. After rest for one hour, test of using the respirators during motion was carried out finally.</p><p><strong>Result: </strong>During rest, after using respirators, the level of SaO2 increased significantly while heart rate decreased notably (P<0.05) than those without respirators. During loaded-bicycle exercise, after using respirators, the level of SaO2 increased significantly (P<0.05) than that without respirators, while heart rate didn't show significant difference (P>0.05). But, the recoveries of heart rate after three minutes and fives minutes were better than those without respirators (P<0.05).</p><p><strong>Conclusion: </strong>Oxygen-increased respirator can improve the capacity of workload under altitude hypoxic environment. It can promote the acclimation to high altitude.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"297-9"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25635417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Design of software for fluorescence microscopy system to measure cytosolic free calcium in living cell].","authors":"Jing Sun, Shu-yan Song, An-lian Qu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To design software based on the double-wavelength fluorescence microscopy to measure cytosolic free calcium ([Ca2+]i) in living cell.</p><p><strong>Method: </strong>Through analyzing the work principles of monochromator, the function relation between output wavelength and voltage was obtained. Based on the analysis results as the arithmetic of the software, the application was developed in the integration development environment of VC ++ 6.0, by using the framework of Microsoft Foundation Class Library (MFC) and multithread technology.</p><p><strong>Result: </strong>The authors has realized the software and constructed a fluorescence microscopy system using the software, PC, monochromator, fluorescence microscope, MPT and data acquisition to measure the [Ca2+]i in single living beta cell.</p><p><strong>Conclusion: </strong>Using this software, the [Ca2+]i in living cell can be detected. It has been proved to be an effective tool for the research in cellular biophysics.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"300-2"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25635418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Citation analysis of Space Medicine & Medical Engineering].","authors":"Hua Yang, Qiu-lan Zheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the academic research level and the popularity of Space Medicine & Medical Engineering (SMME).</p><p><strong>Method: </strong>With the Chinese Medical Citation Index (CMCI), the amount and distribution of the originals of SMME, which were cited by the journal included in CMCI, were analyzed according to method of citation analysis.</p><p><strong>Result: </strong>The average of original papers cited by other researchers was 2.25, and this was more than other medical journals. The authors of these cited papers were from 13 Provinces in China, Beijing and Shannxi Province were in the front of this research area. There were 109 citing journals, and self-citing rate was 43.97%.</p><p><strong>Conclusion: </strong>A series of high quality papers has been published by the SMME, and its own edition characteristics keep its research level steady. Not only has the journal become an important information source of space medical engineering but also a core journal in medicine research as well.</p>","PeriodicalId":63677,"journal":{"name":"航天医学与医学工程","volume":"18 4","pages":"308-12"},"PeriodicalIF":0.0,"publicationDate":"2005-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25635301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}