Frigid Zone Medicine最新文献

The impact of low ambient temperature on cardiovascular health 低环境温度对心血管健康的影响

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0021

Guoqing Zhang, Cuiqing Liu, Qinghua Sun

引用次数: 0

The effects of cold stimulation and exercise on human health 冷刺激和运动对人体健康的影响

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0022

Jie Tian, Jiangli Li, Yunbo Zhang, Fengjuan Yang

{"title":"The effects of cold stimulation and exercise on human health","authors":"Jie Tian, Jiangli Li, Yunbo Zhang, Fengjuan Yang","doi":"10.2478/fzm-2023-0022","DOIUrl":"https://doi.org/10.2478/fzm-2023-0022","url":null,"abstract":"Abstract Cold stimulation and exercise are two independent stimulus variables, each yielding unique impacts on human health. However, in many cases, individuals often encounter both factors simultaneously, particularly in colder regions where outdoor physical activity is prevalent. Despite numerous studies exploring the effects of cold exposure and exercise independently, only a limited number of comprehensive reviews have evaluated their combined influence on health. This review aims to bridge this gap by meticulously examining the potential benefits and detriments of both cold stimulation and exercise on human health. Specifically, the review focuses on their impacts on cardiovascular, respiratory, and immune function, as well as the favorable effects of moderate exercise on the human body. While evidence suggests that cold exposure can enhance health outcomes in certain disease contexts, it also poses risks, particularly for vulnerable populations. Furthermore, while moderate exercise is generally beneficial, engaging in physical activity in cold weather conditions can increase the risk of hypothermia, frostbite, and other cold-related injuries. Consequently, there is an urgent need to develop safe and effective guidelines for exercising in cold weather, particularly for individuals living in colder regions. This review emphasizes the necessity for further research on the combined effects of cold stimulation and exercise, with the goal of informing public health policies and guidelines for physical activity in cold weather conditions.","PeriodicalId":62563,"journal":{"name":"Frigid Zone Medicine","volume":"34 1","pages":"176 - 185"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90822549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The intricate relationship between cold exposure and gut microbiota 寒冷暴露与肠道微生物群之间的复杂关系

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0018

Guanqun Li, Le Li

引用次数: 0

Comparisons of different statistical models for analyzing the effects of meteorological factors on COVID-19 气象因素对COVID-19影响的不同统计模型比较

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0020

Yulu Zheng, Zheng Guo, Zhiyuan Wu, Jun Wen, Haifeng Hou

{"title":"Comparisons of different statistical models for analyzing the effects of meteorological factors on COVID-19","authors":"Yulu Zheng, Zheng Guo, Zhiyuan Wu, Jun Wen, Haifeng Hou","doi":"10.2478/fzm-2023-0020","DOIUrl":"https://doi.org/10.2478/fzm-2023-0020","url":null,"abstract":"Abstract Objective This general non-systematic review aimed to gather information on reported statistical models examing the effects of meteorological factors on coronavirus disease 2019 (COVID-19) and compare these models. Methods PubMed, Web of Science, and Google Scholar were searched for studies on “meteorological factors and COVID-19” published between January 1, 2020, and October 1, 2022. Results The most commonly used approaches for analyzing the association between meteorological factors and COVID-19 were the linear regression model (LRM), generalized linear model (GLM), generalized additive model (GAM), and distributed lag non-linear model (DLNM). In addition to these classical models commonly applied in environmental epidemiology, machine learning techniques are increasingly being used to select risk factors for the outcome of interest and establishing robust prediction models. Conclusion Selecting an appropriate model is essential before conducting research. To ensure the reliability of analysis results, it is important to consider including non-meteorological factors (e.g., government policies on physical distancing, vaccination, and hygiene practices) along with meteorological factors in the model.","PeriodicalId":62563,"journal":{"name":"Frigid Zone Medicine","volume":"49 1","pages":"161 - 166"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82607783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers 基于网络药理学的方法探索维生素A治疗糖尿病足溃疡的生物靶点和机制

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0023

X. Wan, Qiuhai Qin, Ruitang Xie, Xin Li, M. Su

{"title":"Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers","authors":"X. Wan, Qiuhai Qin, Ruitang Xie, Xin Li, M. Su","doi":"10.2478/fzm-2023-0023","DOIUrl":"https://doi.org/10.2478/fzm-2023-0023","url":null,"abstract":"Abstract Background In some developing countries, people have little knowledge about the causes of diabetic foot ulcers. Therefore, public health education for patients on these conditions is a prerequisite for effective pharmacological treatment. Diabetic foot ulcers are a complex symptom of diabetes and are hard to cure due to the lack of efficacious medicine and alternative treatment approaches. Vitamin A (VA) is known to have potent biological functions, including skin repair and immunoregulation. However, the potential pharmacological effects and molecular mechanisms of VA on foot ulcers are still to be discovered. Methods By using bioinformatic/computational analyses, including network pharmacology, gene ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis, we aimed to identify and reveal the pharmacological targets, molecular mechanisms, biological functions, and signaling pathways of VA in the treatment of diabetic foot ulcers. Results A total of 66 intersection genes were identified as candidate targets of VA, which are related to diabetic foot ulcers. Therein, 18 core genes/targets, namely JUN, MAPK1, THRB, MAPK14, MTNR1B, CXCR3, ESR1, AR, HDAC1, IL-10, CNR1, DRD2, EGFR, ADRA2A, CCND1, RXRB, RARA, and RXRA, were further identified. Furthermore, the biological processes, cell components, and molecular functions which may underlie the effects of VA against diabetic foot ulcers were characterized. Conclusion Based on our findings, we concluded that the pharmacological effects of VA on diabetic foot ulcers primarily involve the promotion of cellular regeneration and proliferation and the inhibition of inflammatory response. The core genes/targets may potentially serve as promising biomarkers for the diagnosis of diabetic foot ulcers.","PeriodicalId":62563,"journal":{"name":"Frigid Zone Medicine","volume":"22 1","pages":"186 - 192"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88334604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderate cold exposure contributes to the extension of lifespan by alleviating the aggregation of disease-related proteins 适度的低温暴露有助于通过减轻疾病相关蛋白的聚集来延长寿命

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0017

Tingting Li, Yue Yuan

引用次数: 0

Clinical characteristics, management, and prevention of coronavirus disease 2019 2019冠状病毒病的临床特征、管理和预防

Frigid Zone Medicine Pub Date : 2023-08-01 DOI: 10.2478/fzm-2023-0019

Weijie Guan, Jianxing He

引用次数: 0

Advances in the application of cryotherapy to the treatment of breast cancer 冷冻疗法在乳腺癌治疗中的应用进展

Frigid Zone Medicine Pub Date : 2023-05-01 DOI: 10.2478/fzm-2023-0016

Tian-Qi Ma, Yue-ren Fan, Yihang Zhao, Bin Liu

引用次数: 0

Silicon dioxide nanoparticles inhibit the effects of cold exposure on metabolism and inflammatory responses in brown adipocytes 二氧化硅纳米颗粒抑制冷暴露对棕色脂肪细胞代谢和炎症反应的影响

Frigid Zone Medicine Pub Date : 2023-05-01 DOI: 10.2478/fzm-2023-0013

Yongqiang Zhang, Li Zhang, Shuai Wu, Guanyu Zhang, Xiaodie Wei, Xi Li, Danfeng Yang

{"title":"Silicon dioxide nanoparticles inhibit the effects of cold exposure on metabolism and inflammatory responses in brown adipocytes","authors":"Yongqiang Zhang, Li Zhang, Shuai Wu, Guanyu Zhang, Xiaodie Wei, Xi Li, Danfeng Yang","doi":"10.2478/fzm-2023-0013","DOIUrl":"https://doi.org/10.2478/fzm-2023-0013","url":null,"abstract":"Abstract Objective Nanoparticles (NPs) in haze are potentially hazardous to health, which is more severe in the winter. Brown adipose tissue (BAT) plays important roles in obesity, insulin resistance, and diabetes. Though the toxicology of NPs has been intensively studied, few studies have been reported on the antagonistic effects between Silicon dioxide(SiO2) NPs and cold exposure in brown adipocytes. Materials and methods We evaluated changes by quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) on metabolism genes, plasticity genes and the inflammatory responses genes in brown adipocytes in vitro. Results The expression of adipogenic genes PRDM16, Dio2, PGC-1α and UCP1 was upregulated upon cold exposure (P < 0.05), but downregulated by SiO2 NPs (P < 0.05). The results demonstrated that there was antagonistic effect between SiO2 NPs and cold exposure on the plasticity genes and metabolism genes in brown adipocytes, where the main effects of SiO2 NPs or cold exposure on the plasticity genes and metabolism genes were significant (P < 0.05). Moreover, the levels of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α were upregulated by SiO2 NPs or cold exposure (P < 0.05). The factorial analysis indicated that there was also antagonistic effect between SiO2 NPs and cold exposure on the toxic effects in brown adipocytes, in which the main effects of cold exposure and/or SiO2 NPs on the toxic effects were significant (P < 0.05). Conclusion SiO2 NPs inhibit the effect of cold exposure on metabolic genes and inflammatory responses genes in brown adipocytes.","PeriodicalId":62563,"journal":{"name":"Frigid Zone Medicine","volume":"10 1","pages":"97 - 104"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89512053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold exposure alters proteomic profiles of the hypothalamus and pituitary in female rats 低温暴露改变了雌性大鼠下丘脑和垂体的蛋白质组学特征

Frigid Zone Medicine Pub Date : 2023-05-01 DOI: 10.2478/fzm-2023-0015

Xiangyu Bian, Xi Li, Tong Xu, Li Zhang, Yongqiang Zhang, Shuai Wu, Renren Yang, Weiyun Dong, Chang-jiang Guo, Danfeng Yang, Weina Gao

{"title":"Cold exposure alters proteomic profiles of the hypothalamus and pituitary in female rats","authors":"Xiangyu Bian, Xi Li, Tong Xu, Li Zhang, Yongqiang Zhang, Shuai Wu, Renren Yang, Weiyun Dong, Chang-jiang Guo, Danfeng Yang, Weina Gao","doi":"10.2478/fzm-2023-0015","DOIUrl":"https://doi.org/10.2478/fzm-2023-0015","url":null,"abstract":"Abstract Objective Studies have shown that both short-term and long-term cold exposures disturb the biological process. The aim of the present study is to investigate the effects of intermittent cold exposure on proteomic profiles in the hypothalamus and pituitary of female Sprague-Dawley (SD) rats. Materials and methods The rats were exposed to -10°C in a cabin for 4 h per day, and the treatment lasted for 14 days. The comparative label-free LC-MS/MS analysis was performed to investigate the changes of proteomic profiles in the hypothalamus and pituitary. ELISA analysis was used to validate the expression of differential proteins. Results 22 differential proteins in the hypothalamus and 75 differential proteins in the pituitary were identified by the label-free proteomic analysis. Gene ontology annotation and enrichment analysis indicated that cold exposure disrupted protein phosphorylation, filopodium assembly, intracellular protein transport, peripheral nervous system neuron axonogenesis, spinal cord development, Golgi organization, positive regulation of pseudopodium assembly, and cell-cell adhesion. Three proteins (Cdc42, Ptprs, and Setd7) were down-regulated in the cold exposure group. Conclusion The results indicate that intermittent cold exposure alters the proteomic profiles of hypothalamus and pituitary in female rats.","PeriodicalId":62563,"journal":{"name":"Frigid Zone Medicine","volume":"112 1","pages":"114 - 125"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87699527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0