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Journal of Medical Colleges of PLA最新文献

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锌指蛋白300（ZNF300）参与非小细胞肺癌获得性多药耐药和恶性进展的作用及机制研究 锌指蛋白300（ZNF300）参与非小细胞肺癌获得性多药耐药和恶性进展的作用及机制研究
Journal of Medical Colleges of PLA Pub Date : 2020-01-01 DOI: 10.27001/d.cnki.gtjyu.2020.000279
余世龙
{"title":"锌指蛋白300（ZNF300）参与非小细胞肺癌获得性多药耐药和恶性进展的作用及机制研究","authors":"余世龙","doi":"10.27001/d.cnki.gtjyu.2020.000279","DOIUrl":"https://doi.org/10.27001/d.cnki.gtjyu.2020.000279","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142059685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
巴戟天丸抗老年性骨质疏松作用及其制剂工艺研究 巴戟天丸抗老年性骨质疏松作用及其制剂工艺研究
Journal of Medical Colleges of PLA Pub Date : 2020-01-01 DOI: 10.26998/d.cnki.gjuyu.2020.000347
徐武牧
{"title":"巴戟天丸抗老年性骨质疏松作用及其制剂工艺研究","authors":"徐武牧","doi":"10.26998/d.cnki.gjuyu.2020.000347","DOIUrl":"https://doi.org/10.26998/d.cnki.gjuyu.2020.000347","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142062529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
X射线激发光遗传学的可行性研究 X射线激发光遗传学的可行性研究
Journal of Medical Colleges of PLA Pub Date : 2020-01-01 DOI: 10.27002/d.cnki.gsjyu.2020.000214
兰斌
{"title":"X射线激发光遗传学的可行性研究","authors":"兰斌","doi":"10.27002/d.cnki.gsjyu.2020.000214","DOIUrl":"https://doi.org/10.27002/d.cnki.gsjyu.2020.000214","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142060585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-297c-5p参与川芎嗪调控小鼠脑微血管内皮细胞紧密连接机制研究 miR-297c-5p参与川芎嗪调控小鼠脑微血管内皮细胞紧密连接机制研究
Journal of Medical Colleges of PLA Pub Date : 2020-01-01 DOI: 10.27002/d.cnki.gsjyu.2020.000173
关韶宇
{"title":"miR-297c-5p参与川芎嗪调控小鼠脑微血管内皮细胞紧密连接机制研究","authors":"关韶宇","doi":"10.27002/d.cnki.gsjyu.2020.000173","DOIUrl":"https://doi.org/10.27002/d.cnki.gsjyu.2020.000173","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142060863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway. 通过抑制氧化应激和 TGF-β1/Smad 通路，长期中等强度运动可减轻 2 型糖尿病大鼠的心肌纤维化。
Journal of Medical Colleges of PLA Pub Date : 2019-11-01 Epub Date: 2019-08-07 DOI: 10.1007/s12576-019-00696-3
Shi-Qiang Wang, Dan Li, Yang Yuan
{"title":"Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway.","authors":"Shi-Qiang Wang, Dan Li, Yang Yuan","doi":"10.1007/s12576-019-00696-3","DOIUrl":"10.1007/s12576-019-00696-3","url":null,"abstract":"<p><p>Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously reported, in which oxidative stress and the TGF-β1/Smad signaling pathway may play key roles. There is little direct experimental evidence that exercise alleviates myocardial fibrosis in type 2 diabetes mellitus (T2DM). Here we established a type 2 diabetic model by using streptozotocin and a high-fat diet. Rats were divided into groups of normal control (NC), T2DM and T2DM plus exercise (T2DME). The T2DME group received further treadmill training at moderate intensity for 8 weeks. Histological and biochemical methods were used to detect the benefits of exercise to T2DM. Results showed that the weight of rats in the T2DM group dropped dramatically, along with significant increases in blood glucose, myocardial fibrosis and oxidative stress, associated with upregulated expression of factors of myocardial fibrosis, except Smad7. Exercise largely reversed T2DM-induced alterations in factors of myocardial fibrosis, including suppressing expression of MMP-2, CTGF, TGF-β1, p-Smad2 and p-Smad3, and increased expression of TIMP-1 and Smad7. Therefore, exercise might be considered an alternative therapeutic remedy for diabetic cardiomyopathy.</p>","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"23 1","pages":"861-873"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78348006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
大鼠骨髓间充质干细胞来源外泌体对退变髓核细胞的影响 大鼠骨髓间充质干细胞来源外泌体对退变髓核细胞的影响
Journal of Medical Colleges of PLA Pub Date : 2019-01-01 DOI: 10.27001/d.cnki.gtjyu.2019.000364
蒋长青
{"title":"大鼠骨髓间充质干细胞来源外泌体对退变髓核细胞的影响","authors":"蒋长青","doi":"10.27001/d.cnki.gtjyu.2019.000364","DOIUrl":"https://doi.org/10.27001/d.cnki.gtjyu.2019.000364","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142052773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
基于β-NaREF4:Ln3+纳米粒-光敏剂耦合系统构建及其在X射线激发光动力学治疗中的应用 基于β-NaREF4:Ln3+纳米粒-光敏剂耦合系统构建及其在X射线激发光动力学治疗中的应用
Journal of Medical Colleges of PLA Pub Date : 2019-01-01 DOI: 10.27002/d.cnki.gsjyu.2019.000093
张晓峰
{"title":"基于β-NaREF4:Ln3+纳米粒-光敏剂耦合系统构建及其在X射线激发光动力学治疗中的应用","authors":"张晓峰","doi":"10.27002/d.cnki.gsjyu.2019.000093","DOIUrl":"https://doi.org/10.27002/d.cnki.gsjyu.2019.000093","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142051961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
过氧化氢响应性自发光纳米粒的构建及其在肿瘤成像和光动力治疗中的应用研究 过氧化氢响应性自发光纳米粒的构建及其在肿瘤成像和光动力治疗中的应用研究
Journal of Medical Colleges of PLA Pub Date : 2019-01-01 DOI: 10.27001/d.cnki.gtjyu.2019.000383
安会杰
{"title":"过氧化氢响应性自发光纳米粒的构建及其在肿瘤成像和光动力治疗中的应用研究","authors":"安会杰","doi":"10.27001/d.cnki.gtjyu.2019.000383","DOIUrl":"https://doi.org/10.27001/d.cnki.gtjyu.2019.000383","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142052721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
金线莲内生真菌促进宿主生长代谢及增强抗病性作用研究 金线莲内生真菌促进宿主生长代谢及增强抗病性作用研究
Journal of Medical Colleges of PLA Pub Date : 2019-01-01 DOI: 10.26998/d.cnki.gjuyu.2019.000004
叶冰竹
{"title":"金线莲内生真菌促进宿主生长代谢及增强抗病性作用研究","authors":"叶冰竹","doi":"10.26998/d.cnki.gjuyu.2019.000004","DOIUrl":"https://doi.org/10.26998/d.cnki.gjuyu.2019.000004","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142053676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
线粒体转位蛋白TSPO在高糖诱导的血管再狭窄中的作用及其机制研究 线粒体转位蛋白TSPO在高糖诱导的血管再狭窄中的作用及其机制研究
Journal of Medical Colleges of PLA Pub Date : 2019-01-01 DOI: 10.27001/d.cnki.gtjyu.2019.000264
巩正藩
{"title":"线粒体转位蛋白TSPO在高糖诱导的血管再狭窄中的作用及其机制研究","authors":"巩正藩","doi":"10.27001/d.cnki.gtjyu.2019.000264","DOIUrl":"https://doi.org/10.27001/d.cnki.gtjyu.2019.000264","url":null,"abstract":"","PeriodicalId":61608,"journal":{"name":"Journal of Medical Colleges of PLA","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142052747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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