世界胃肠药理与治疗学杂志:英文版(电子版)最新文献

{"title":"Downstaging of advanced hepatocellular carcinoma followed by liver transplantation using immune checkpoint inhibitors: Where do we stand?","authors":"Hirak Pahari, Javid A Peer, Shikhar Tripathi, Suresh K Singhvi, Ushast Dhir","doi":"10.4292/wjgpt.v15.i5.97570","DOIUrl":"https://doi.org/10.4292/wjgpt.v15.i5.97570","url":null,"abstract":"<p><p>Liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) and chronic liver disease (CLD) is limited by factors such as tumor size, number, portal venous or hepatic venous invasion and extrahepatic disease. Although previously established criteria, such as Milan or UCSF, have been relaxed globally to accommodate more potential recipients with comparable 5-year outcomes, there is still a subset of the population that has advanced HCC with or without portal vein tumor thrombosis without detectable extrahepatic spread who do not qualify or are unable to be downstaged by conventional methods and do not qualify for liver transplantation. Immune checkpoint inhibitors (ICI) such as atezolizumab, pembrolizumab, or nivolumab have given hope to this group of patients. We completed a comprehensive literature review using PubMed, Google Scholar, reference citation analysis, and CrossRef. The search utilized keywords such as 'liver transplant', 'HCC', 'hepatocellular carcinoma', 'immune checkpoint inhibitors', 'ICI', 'atezolizumab', and 'nivolumab'. Several case reports have documented successful downstaging of HCC using the atezolizumab/bevacizumab combination prior to LT, with acceptable early outcomes comparable to other criteria. Adverse effects of ICI have also been reported during the perioperative period. In such cases, a 1.5-month interval between ICI therapy and LT has been suggested. Overall, the results of downstaging using combination immunotherapy were encouraging and promising. Early reports suggested a potential ray of hope for patients with CLD and advanced HCC, especially those with multifocal HCC or branch portal venous tumor thrombosis. However, prospective studies and further experience will reveal the optimal dosage, duration, and timing prior to LT and evaluate both short- and long-term outcomes in terms of rejection, infection, recurrence rates, and survival.</p>","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"15 5","pages":"97570"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hindi translation and validation of the English version of the gastrointestinal symptom rating scale questionnaire: An observational study.","authors":"Neha Jindal, Anuraag Jena, Krishan Kumar, Bijaya K Padhi, Rajni Sharma, Vaneet Jearth, Usha Dutta, Vishal Sharma","doi":"10.4292/wjgpt.v15.i5.97261","DOIUrl":"https://doi.org/10.4292/wjgpt.v15.i5.97261","url":null,"abstract":"<p><strong>Background: </strong>The gastrointestinal symptom rating scale (GSRS) is a questionnaire in English language which is designed to assess the clinical symptoms in patients with irritable bowel syndrome (IBS) and peptic ulcer disease. This validated scale has questions on around 15 items and has been validated in patients with dyspepsia and IBS.</p><p><strong>Aim: </strong>To translate and validate the English version of the GSRS questionnaire to the Hindi version.</p><p><strong>Methods: </strong>The purpose of the present work was to create a Hindi version of this questionnaire for use in the Indian population. The process involved various steps as per the World Health Organization methodology including initial forward translation, backward translation, and assessment by an expert committee. Initial pilot testing was followed by testing in healthy and diseased individuals.</p><p><strong>Results: </strong>The Hindi translation was pilot tested in 20 individuals and further validated in healthy controls (<i>n</i> = 30, 15 females) and diseased individuals (<i>n</i> = 72, 27 females). The diseased group included patients with functional dyspepsia and IBS. Cronbach's alpha for internal consistency on the final translated GSRS questionnaire was 0.715 which is considered adequate. Twelve questions significantly differentiated the diseased population from the healthy population (<i>P</i> value < 0.05) in the translated Hindi version of the GSRS.</p><p><strong>Conclusion: </strong>The translated Hindi GSRS can be used to evaluate gastrointestinal function in clinical trials and community surveys in Hindi speaking populations.</p>","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"15 5","pages":"97261"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11401017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary complications associated with weight loss, cholelithiasis and choledocholithiasis.","authors":"Marcelo A Ribeiro, Gabriela K Tebar, Helena B Niero, Leticia S Pacheco","doi":"10.4292/wjgpt.v15.i4.95647","DOIUrl":"10.4292/wjgpt.v15.i4.95647","url":null,"abstract":"<p><p>Biliary complications like cholelithiasis and choledocholithiasis are more common in bariatric surgery patients due to obesity and rapid weight loss. Patients with a body mass index > 40 face an eightfold risk of developing cholelithiasis. Post-bariatric surgery, especially after laparoscopic Roux-en-Y gastric bypass (LRYGB), 30% of patients develop biliary disease due to rapid weight loss. The aim of this review is to analyze the main biliary complications that occur after bariatric surgery and its management. A review of the literature was conducted mainly from 2010 up to 2023 with regard to biliary complications associated with bariatric patients in SciELO, PubMed, and MEDLINE. Patients undergoing LRYGB have a higher incidence (14.5%) of symptomatic calculi post-surgery compared to those undergoing laparoscopic sleeve gastrectomy at 4.1%. Key biliary complications within 6 to 12 months post-surgery include: Cholelithiasis: 36%; Biliary colic/dyskinesia: 3.86%; Acute cholecystitis: 0.98%-18.1%; Chronic cholecystitis: 70.2%; Choledocholithiasis: 0.2%-5.7% and Pancreatitis: 0.46%-9.4%. Surgeons need to be aware of these complications and consider surgical treatments based on patient symptoms to enhance their quality of life.</p>","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"15 4","pages":"95647"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and tolerability of chitin-glucan combined with simethicone (GASTRAP^® DIRECT) in irritable bowel syndrome: A prospective, open-label, multicenter study.","authors":"Nathalie Talbodec, Pauline Le Roy, Peggy Fournier, Benoit Lesage, Elodie Lepoutre, François Castex, Jean Michel Godchaux, Lionel Vandeville, Benjamin Bismuth, Xavier Lesage, Pauline Bayart, Michael Genin, Christel Rousseaux, Veronique Maquet, Salvatore Modica, Pierre Desreumaux, Caroline Valibouze","doi":"10.4292/wjgpt.v15.i3.90757","DOIUrl":"10.4292/wjgpt.v15.i3.90757","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS), defined according to the Rome IV diagnostic criteria, is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain related to altered bowel habits. First-line recommended treatments are limited to combining drugs targeting predominant symptoms, particularly pain (antispasmodics), constipation (laxatives), and diarrhea (loperamide), yielding only a limited therapeutic gain. GASTRAP^® DIRECT is a class IIa medical formulation composed of a combination of chitin-glucan and simethicone indicated for the symptomatic treatment of gas-related gastrointestinal disorders by combining different mechanisms of action.</p><p><strong>Aim: </strong>To evaluate the efficacy, tolerability, and safety of 4-week GASTRAP^® DIRECT treatment in patients with IBS.</p><p><strong>Methods: </strong>In this prospective, multicenter, open-label trial, 120 patients with IBS received three sticks of GASTRAP^® DIRECT (1.5 g/d of chitin-glucan and 0.75 mg/d of simethicone) per day for 4 weeks. The primary endpoint was the responder rate, defined as the number of patients whose abdominal pain score decreased by ≥ 30% from baseline to week (W) 4. The analysis was performed using the per-protocol set. Cardinal symptoms, impact of global symptoms on daily life, change in stool consistency, and improvement in defecatory disorders were evaluated.</p><p><strong>Results: </strong>Overall, 100 patients were evaluated. At W4, 67% (95%CI: 57-75) showed improvement in abdominal pain (score: 5.8 ± 2.4 <i>vs</i> 2.9 ± 2.0, <i>P</i> < 0.0001). Similar improvements were observed for bloating [8.0 ± 1.7 <i>vs</i> 4.7 ± 2.9, <i>P</i> < 0.0001; 60% (95%CI: 50-70) responders], abdominal distension [7.2 ± 2.1 <i>vs</i> 4.4 ± 3.1, <i>P</i> < 0.0001; 53% (95%CI: 43-63) responders], and impact of global symptoms on daily life [7.1 ± 2.0 <i>vs</i> 4.6 ± 2.9, <i>P</i> < 0.0001; 54% (95%CI: 44-64) responders]. Stool consistency improved in most patients (90% and 57% for patients with liquid and hard stools, respectively). Overall, 42% of patients with defecatory disorders reported very much/considerable improvements by W2. No severe adverse event occurred, and tolerability was rated \"good\" or \"very good\" by 93% of patients.</p><p><strong>Conclusion: </strong>GASTRAP^® DIRECT is safe and well tolerated, alleviating IBS symptoms rapidly in 2 weeks. This open-label study suggests that the combination of chitin-glucan and simethicone could be beneficial in patients with IBS.</p>","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"15 3","pages":"90757"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and outcomes of peptic ulcer bleed in a Pakistani population: A single-center observational study.","authors":"Nazish Butt, Muhammad Tayyab Usmani, Nimrah Mehak, Saba Mughal, Fakhar Ali Qazi-Arisar, Ghulam Mohiuddin, Gulzar Khan","doi":"10.4292/wjgpt.v15.i3.92305","DOIUrl":"10.4292/wjgpt.v15.i3.92305","url":null,"abstract":"<p><strong>Background: </strong>Peptic ulcer disease (PUD) remains a significant healthcare burden, contributing to morbidity and mortality worldwide. Despite advancements in therapies, its prevalence persists, particularly in regions with widespread nonsteroidal anti-inflammatory drugs (NSAIDs) use and <i>Helicobacter pylori</i> infection.</p><p><strong>Aim: </strong>To comprehensively analyse the risk factors and outcomes of PUD-related upper gastrointestinal (GI) bleeding in Pakistani population.</p><p><strong>Methods: </strong>This retrospective cohort study included 142 patients with peptic ulcer bleeding who underwent upper GI endoscopy from January to December 2022. Data on demographics, symptoms, length of stay, mortality, re-bleed, and Forrest classification was collected.</p><p><strong>Results: </strong>The mean age of patients was 53 years, and the majority was men (68.3%). Hematemesis (82.4%) and epigastric pain (75.4%) were the most common presenting symptoms. Most patients (73.2%) were discharged within five days. The mortality rates at one week and one month were 10.6% and 14.8%, respectively. Re-bleed within 24 h and seven days occurred in 14.1% and 18.3% of patients, respectively. Most ulcers were Forrest class (FC) III (72.5%). Antiplatelet use was associated with higher mortality at 7 and 30 d, while alternative medications were linked to higher 24-hour re-bleed rates. NSAID use was associated with more FC III ulcers. Re-bleed at 24 h and 7 d was strongly associated with one-week or one-month mortality.</p><p><strong>Conclusion: </strong>Antiplatelet use and rebleeding increase the risk of early mortality in PUD-related upper GI bleeding, while alternative medicines are associated with early rebleeding.</p>","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"15 3","pages":"92305"},"PeriodicalIF":0.0,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fuzhuan brick tea affects obesity process by modulating gut microbiota","authors":"Zhi-Peng Li, Dong-Hui Xu, Lian-Ping He, Xin-Juan Wang","doi":"10.4292/wjgpt.v13.i3.30","DOIUrl":"https://doi.org/10.4292/wjgpt.v13.i3.30","url":null,"abstract":"The effect of Fuzhuan brick tea (FBT) on metabolism in obese mice is mediated by regulation of N-methyltransferase by aryl hydrocarbon receptor. The expression of the phosphatidylethanolamine N-methyltransferase gene is regulated by many transcription factors, and those specific to this effect need further investigation. Experimental animal studies have been designed to observe the effects of a single drug or the sequential effects of drugs. A washout period should be included if different drugs (e.g., antibiotics and FBT) are given to avoid or reduce additive effects or synergy. Currently, most experimental studies performed in mice used only male animals. However, experience has revealed that the results of using only male mice are very likely to have sex differences.","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"13 1","pages":"30 - 32"},"PeriodicalIF":0.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45446653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis disorder and splinter hemorrhages: A case report","authors":"Ankith Bhasi, Itish Patnaik, P. Panda, Ashutosh Kumar Singh","doi":"10.4292/wjgpt.v13.i2.23","DOIUrl":"https://doi.org/10.4292/wjgpt.v13.i2.23","url":null,"abstract":"BACKGROUND Eosinophilia and related organ damage are extensively studied hot topics among rare disorders. Any addition to the cohort of available case reports of the same will be adding knowledge for better management of this less known entity. CASE SUMMARY In this article, we describe a 27-year-old Indo-Aryan man who presented with abdominal pain, abdominal distension, and loose stools for variable days. He had splinter hemorrhages in the majority of fingernails. He was diagnosed with predominant eosinophilic gastrointestinal involvement with bowel obstruction and ascites, and was managed with intravenous immunoglobulin. He was subsequently treated with oral low dose steroid therapy and responded completely. CONCLUSION Our experience is evidence that prompt management of this hypereosinophilic lethal gastrointestinal (all three layers) infiltrative disease provides a cure and avoids complications. Splinter nail hemorrhages may be seen in the same disease.","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"13 1","pages":"23 - 29"},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48040204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity.","authors":"Silvia Bona, Sabrina Alves Fernandes, Andrea C Janz Moreira, Graziella Rodrigues, Elizângela G Schemitt, Fabio Cangeri Di Naso, Cláudio A Marroni, Norma P Marroni","doi":"10.4292/wjgpt.v13.i2.11","DOIUrl":"10.4292/wjgpt.v13.i2.11","url":null,"abstract":"<p><strong>Background: </strong>Melatonin (MLT) is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations, due to its action against free radicals.</p><p><strong>Aim: </strong>To evaluate the effect of MLT on carbon tetrachloride (CCl₄) induced liver injury in rats in terms of oxidative stress, reticular stress, and cell damage.</p><p><strong>Methods: </strong>Twenty male Wistar rats (230-250 g) were divided into four groups: Control rats, rats treated with MLT alone, rats treated with CCl₄ alone, and rats treated with CCl₄ plus MLT. CCl₄ was administered as follows: Ten doses every 5 d, ten every 4 d, and seven every 3 d. MLT was administered intraperitoneally at a dose of 20 mg/kg from the 10^th wk to the end of the experiment (16^th wk).</p><p><strong>Results: </strong>MLT was able to reduce the release of liver enzymes in the bloodstream and to decrease oxidative stress in CCl₄ treated rats by decreasing the level of thiobarbituric acid reactive substances and increasing superoxide dismutase activity, with a lower reduction in serum zinc levels, guaranteeing a reduction in liver damage; additionally, it increased the expression of nuclear factor (erythroid-derived 2)-like 2 and decreased the expression of Kelch-like ECH-associated protein 1. MLT also decreased the expression of the proteins associated with endoplasmic reticulum stress, <i>i.e.,</i> glucose-regulated protein 78 and activating transcription factor 6, as well as of heat shock factor 1 and heat shock protein 70.</p><p><strong>Conclusion: </strong>MLT has a hepatoprotective effect in an experimental model of CCl₄-induced liver injury, since it reduces oxidative stress, restores zinc levels, and modulates endoplasmic reticulum stress.</p>","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"13 1","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45324182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for recurrence after bowel resection for Crohn’s disease","authors":"Zexian Chen, Yong-le Chen, Xiao-ming Huang, Xu-tao Lin, Xiao-wen He, P. Lan","doi":"10.4292/wjgpt.v10.i4.67","DOIUrl":"https://doi.org/10.4292/wjgpt.v10.i4.67","url":null,"abstract":"BACKGROUND Complications of Crohn’s disease such as intestinal obstruction, fistula or perforation often need surgical treatment. Nearly 70%-80% patients with Crohn’s disease would receive surgical treatment during the lifetime. However, surgical treatment is incurable for Crohn’s disease. The challenge of recurrence postoperatively troubles both doctors and patients. Over 50% patients would suffer recurrence postoperatively. Some certain risk factors are associated with recurrence of Crohn’s disease. AIM To evaluate the risk factors for endoscopic recurrence and clinical recurrence after bowel resection in Crohn’s disease. METHODS Patients diagnosed Crohn’s disease and received intestinal resection between April 2007 and December 2013 were included in this study. Data on the general demographic information, preoperative clinical characteristics, surgical information, postoperative clinical characteristics were collected. Continuous data are expressed as median (inter quartile range), and categorical data as frequencies and percentages. Kaplan-Meier method was applied to estimate the impact of the clinical variables above on the cumulative rate of postoperative endoscopic recurrence and clinical recurrence, then log-rank test was applied to test the homogeneity of those clinical variables. Multivariate Cox proportional hazard regression analysis was performed to identify the risk factors of postoperative endoscopic recurrence and clinical recurrence. RESULTS A total of 64 patients were included in this study. The median follow-up time for the patients was 17 (9.25-25.75) mo. In this period, 41 patients (64.1%) had endoscopic recurrence or clinical recurrence. Endoscopic recurrence occurred in 34 (59.6%) patients while clinical recurrence occurred in 28 (43.8%) patients, with the interval between the operation and recurrence of 13.0 (8.0-24.5) months and 17.0 (8.0-27.8) mo, respectively. In univariate analysis, diagnosis at younger age (P < 0.001), disease behavior of penetrating (P = 0.044) and preoperative use of anti-tumor necrosis factor (TNF) (P = 0.020) were significantly correlated with endoscopic recurrence, while complication with perianal lesions (P = 0.032) and preoperative use of immunomodulatory (P = 0.031) were significantly correlated with clinical recurrence. As to multivariate analysis, diagnostic age (P = 0.004), disease behavior (P = 0.041) and preoperative use of anti-TNF (P = 0.010) were independent prognostic factors for endoscopic recurrence, while complication with perianal lesions (P = 0.023) was an independent prognostic factor for clinical recurrence. CONCLUSION Diagnostic age, disease behavior, preoperative use of anti-TNF and complication with perianal lesions were independent risk factors for postoperative recurrence in Crohn’s disease.","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"10 1","pages":"67 - 74"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48463839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel device for monitoring respiratory rate during endoscopy-A thermodynamic sensor","authors":"Vaibhav Wadhwa, Adalberto Gonzalez, Kristen Selema, R. Feldman, R. Lopez, J. Vargo","doi":"10.4292/wjgpt.v10.i3.57","DOIUrl":"https://doi.org/10.4292/wjgpt.v10.i3.57","url":null,"abstract":"BACKGROUND Monitoring ventilation accurately is an indispensable aspect of patient care in procedural settings. The current gold standard method of monitoring ventilation is by measuring exhaled carbon dioxide concentration, known as capnography. A new device utilizing thermodynamic measurement, the Linshom Respiratory Monitoring Device (LRMD), has been designed to measure respiratory rate (RR) by using the temperature of exhaled breath. We hypothesized that the temperature sensor is at least equivalent in accuracy to capnography in monitoring ventilation. AIM To determine if the temperature sensor is equivalent to capnography in monitoring procedural ventilation. METHODS In this prospective study, participants were individually fitted with a face mask monitored by both LRMD and capnography. The following data were collected: gender, age, body mass index, type of procedure, and doses of medication. For each patient, we report the mean RR for each device as well as the mean difference. All analyses were performed using SAS, and a P < 0.05 was considered statistically significant. RESULTS Twelve consecutive patients undergoing endoscopic procedures at our institution were enrolled. Four patients were excluded due to incomplete data, inadequate data, patient cooperation, and capnography failure. Overall, we found that LRMD RR highly correlated to capnography RR (P < 0.001); the average capnography RR increases by 0.66 breaths for every one additional breath measured by the LRMD. In addition, apnea rates were 7.4% for the capnography and 6.4% for the LRMD (95% confidence interval: 0.92-1.10). CONCLUSION The LRMD correlated with the gold standard capnography with respect to respiratory rate detection and apnea events. The LRMD could be used as an alternative to capnography for measuring respiration in endoscopy.","PeriodicalId":60311,"journal":{"name":"世界胃肠药理与治疗学杂志:英文版(电子版)","volume":"10 1","pages":"57 - 66"},"PeriodicalIF":0.0,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48282908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}