The Journal of Physical Chemistry 最新文献

{"title":"Culturally adapted CBT for postnatal depression","authors":"","doi":"10.1038/d41591-024-00077-3","DOIUrl":"https://doi.org/10.1038/d41591-024-00077-3","url":null,"abstract":"In British South Asian women, a culturally adapted and community-informed cognitive behavioral therapy intervention led to higher early recovery rates than the usual treatment.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"87 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the limits of life extension","authors":"","doi":"10.1038/d41591-024-00076-4","DOIUrl":"https://doi.org/10.1038/d41591-024-00076-4","url":null,"abstract":"The twentieth century saw unprecedented rises in life expectancy in high-income countries, but data suggest that this trend will not continue in the current century without radical interventions to slow biological aging.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"16 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping metastatic breast cancer complexity through single-cell and spatial profiling","authors":"","doi":"10.1038/s41591-024-03308-9","DOIUrl":"10.1038/s41591-024-03308-9","url":null,"abstract":"Techniques for single-cell and spatial expression profiling hold great promise for defining the complexity of metastatic microenvironments, but different methods give different representations. We profile 67 biopsies of metastatic breast cancer using up to 6 different methods, provide a systematic comparison and reveal spatial aspects of breast cancer biology across diverse clinicopathological features.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"30 11","pages":"3067-3068"},"PeriodicalIF":58.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features","authors":"Johanna Klughammer, Daniel L. Abravanel, Åsa Segerstolpe, Timothy R. Blosser, Yury Goltsev, Yi Cui, Daniel R. Goodwin, Anubhav Sinha, Orr Ashenberg, Michal Slyper, Sébastien Vigneau, Judit Jané‐Valbuena, Shahar Alon, Chiara Caraccio, Judy Chen, Ofir Cohen, Nicole Cullen, Laura K. DelloStritto, Danielle Dionne, Janet Files, Allison Frangieh, Karla Helvie, Melissa E. Hughes, Stephanie Inga, Abhay Kanodia, Ana Lako, Colin MacKichan, Simon Mages, Noa Moriel, Evan Murray, Sara Napolitano, Kyleen Nguyen, Mor Nitzan, Rebecca Ortiz, Miraj Patel, Kathleen L. Pfaff, Caroline B. M. Porter, Asaf Rotem, Sarah Strauss, Robert Strasser, Aaron R. Thorner, Madison Turner, Isaac Wakiro, Julia Waldman, Jingyi Wu, Jorge Gómez Tejeda Zañudo, Diane Zhang, Nancy U. Lin, Sara M. Tolaney, Eric P. Winer, Edward S. Boyden, Fei Chen, Garry P. Nolan, Scott J. Rodig, Xiaowei Zhuang, Orit Rozenblatt-Rosen, Bruce E. Johnson, Aviv Regev, Nikhil Wagle","doi":"10.1038/s41591-024-03215-z","DOIUrl":"10.1038/s41591-024-03215-z","url":null,"abstract":"Although metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and biospecimen limitations. In this study, we assembled a multi-modal spatial and cellular map of 67 tumor biopsies from 60 patients with metastatic breast cancer across diverse clinicopathological features and nine anatomic sites with detailed clinical annotations. We combined single-cell or single-nucleus RNA sequencing for all biopsies with a panel of four spatial expression assays (Slide-seq, MERFISH, ExSeq and CODEX) and H&E staining of consecutive serial sections from up to 15 of these biopsies. We leveraged the coupled measurements to provide reference points for the utility and integration of different experimental techniques and used them to assess variability in cell type composition and expression as well as emerging spatial expression characteristics across clinicopathological and methodological diversity. Finally, we assessed spatial expression and co-localization features of macrophage populations, characterized three distinct spatial phenotypes of epithelial-to-mesenchymal transition and identified expression programs associated with local T cell infiltration versus exclusion, showcasing the potential of clinically relevant discovery in such maps. Single-nucleus and single-cell RNA sequencing plus spatial profiling with four methods of core biopsies from 60 patients with metastatic breast cancer reveal patient-specific gene expression programs of breast cancer metastases that are maintained across time, site of metastasis and spatial profiling method, with spatial phenotypes correlating with microenvironmental features.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"30 11","pages":"3236-3249"},"PeriodicalIF":58.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41591-024-03215-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142541947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations to promote equity, diversity and inclusion in decentralized clinical trials","authors":"Olalekan Lee Aiyegbusi, Samantha Cruz Rivera, Paul Kamudoni, Nicola Anderson, Philip Collis, Alastair K. Denniston, Rosie Harding, Sarah E. Hughes, Kamlesh Khunti, Dipak Kotecha, Harlan Krumholz, Xiaoxuan Liu, Christel McMullan, Barbara Molony-Oates, Joao Monteiro, Puja Myles, Khadija Rerhou Rantell, Katherine Soltys, Ravinder Verdi, Roger Wilson, Melanie J. Calvert","doi":"10.1038/s41591-024-03323-w","DOIUrl":"10.1038/s41591-024-03323-w","url":null,"abstract":"Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. Rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer and store electronic data. While some studies have demonstrated the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges that may create or worsen existing health inequalities and limit the generalizability of trial results. Here we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity and inclusion. Digitally enabled and decentralized clinical trials could enable large-scale recruitment of diverse participants—but careful consideration of the barriers faced by underserved groups will be crucial to their success.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"30 11","pages":"3075-3084"},"PeriodicalIF":58.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41591-024-03323-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory reforms will boost African vaccine production and access","authors":"Niteen Wairagkar, Alex Juma Ismail, Dalia M. N. Abouhussein, Moji Christianah Adeyeye, Delese Mimi Darko, Adam Mitangu Fimbo, Richard T. Rukwata, Boitumelo (Tumi) Semete-Makokotlela, Michele Sidibe, Nicaise Ndembi","doi":"10.1038/s41591-024-03314-x","DOIUrl":"https://doi.org/10.1038/s41591-024-03314-x","url":null,"abstract":"Growing momentum to transform the African regulatory landscape should enable 60% of the vaccines needed in Africa to be locally produced by 2040.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"126 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unprecedented spread and genetic evolution of the Oropouche virus","authors":"Marcia C. Castro, Antônio Silva Lima Neto","doi":"10.1038/s41591-024-03336-5","DOIUrl":"https://doi.org/10.1038/s41591-024-03336-5","url":null,"abstract":"The current Oropouche fever outbreak has been traced to a novel reassortant virus that emerged about a decade ago, which highlights the importance of One Health surveillance in preventing, predicting, detecting and responding to emerging threats.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"49 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital AVATAR therapy for distressing voices in psychosis: the phase 2/3 AVATAR2 trial","authors":"Philippa A. Garety, Clementine J. Edwards, Hassan Jafari, Richard Emsley, Mark Huckvale, Mar Rus-Calafell, Miriam Fornells-Ambrojo, Andrew Gumley, Gillian Haddock, Sandra Bucci, Hamish J. McLeod, Jeffrey McDonnell, Moya Clancy, Michael Fitzsimmons, Hannah Ball, Alice Montague, Nikos Xanidis, Amy Hardy, Thomas K. J. Craig, Thomas Ward","doi":"10.1038/s41591-024-03252-8","DOIUrl":"https://doi.org/10.1038/s41591-024-03252-8","url":null,"abstract":"<p>Distressing voices are a core symptom of psychosis, for which existing treatments are currently suboptimal; as such, new effective treatments for distressing voices are needed. AVATAR therapy involves voice-hearers engaging in a series of facilitated dialogues with a digital embodiment of the distressing voice. This randomized phase 2/3 trial assesses the efficacy of two forms of AVATAR therapy, AVATAR-Brief (AV-BRF) and AVATAR-Extended (AV-EXT), both combined with treatment as usual (TAU) compared to TAU alone, and conducted an intention-to-treat analysis. We recruited 345 participants with psychosis; data were available for 300 participants (86.9%) at 16 weeks and 298 (86.4%) at 28 weeks. The primary outcome was voice-related distress at both time points, while voice severity and voice frequency were key secondary outcomes. Voice-related distress improved, compared with TAU, in both forms at 16 weeks but not at 28 weeks. Distress at 16 weeks was as follows: AV-BRF, effect −1.05 points, 96.5% confidence interval (CI) = −2.110 to 0, <i>P</i> = 0.035, Cohen’s <i>d</i> = 0.38 (CI = 0 to 0.767); AV-EXT −1.60 points, 96.5% CI = −3.133 to −0.058, <i>P</i> = 0.029, Cohen’s <i>d</i> = 0.58 (CI = 0.021 to 1.139). Distress at 28 weeks was: AV-BRF, −0.62 points, 96.5% CI = −1.912 to 0.679, <i>P</i> = 0.316, Cohen’s <i>d</i> = 0.22 (CI = −0.247 to 0.695); AV-EXT −1.06 points, 96.5% CI = −2.700 to 0.586, <i>P</i> = 0.175, Cohen’s <i>d</i> = 0.38 (CI = −0.213 to 0.981). Voice severity improved in both forms, compared with TAU, at 16 weeks but not at 28 weeks whereas frequency was reduced in AV-EXT but not in AV-BRF at both time points. There were no related serious adverse events. These findings provide partial support for our primary hypotheses. AV-EXT met our threshold for a clinically significant change, suggesting that future work should be primarily guided by this protocol. ISRCTN registration: ISRCTN55682735.</p>","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"47 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using AVATAR therapy to conquer auditory hallucinations","authors":"Merete Nordentoft","doi":"10.1038/s41591-024-03312-z","DOIUrl":"https://doi.org/10.1038/s41591-024-03312-z","url":null,"abstract":"AVATAR therapy, in which patient and therapist interact with a digital embodiment of patients’ auditory hallucinations, effectively reduces distress and symptom frequency, which could be a game-changer for patients.","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"61 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes","authors":"Muthiah Vaduganathan, Gerasimos Filippatos, Brian L. Claggett, Akshay S. Desai, Pardeep S. Jhund, Alasdair Henderson, Meike Brinker, Peter Kolkhof, Patrick Schloemer, James Lay-Flurrie, Prabhakar Viswanathan, Carolyn S. P. Lam, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Peter Rossing, Luis M. Ruilope, Stefan D. Anker, Bertram Pitt, Rajiv Agarwal, John J. V. McMurray, Scott D. Solomon","doi":"10.1038/s41591-024-03372-1","DOIUrl":"https://doi.org/10.1038/s41591-024-03372-1","url":null,"abstract":"<p>Correction to: <i>Nature Medicine</i> https://doi.org/10.1038/s41591-024-03264-4, published online 1 September 2024.</p>","PeriodicalId":58,"journal":{"name":"The Journal of Physical Chemistry ","volume":"63 1","pages":""},"PeriodicalIF":82.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}