Gold Bulletin最新文献

{"title":"Microbial-mediated synthesis of gold nanoparticles—current insights and future vistas","authors":"Muhammad Nadeem,&nbsp;Laiba Pervez,&nbsp;Ameer Muhammad Khan,&nbsp;Rachel A. Burton,&nbsp;Sana Ullah,&nbsp;Akhtar Nadhman,&nbsp;Jonathan Celli","doi":"10.1007/s13404-023-00335-1","DOIUrl":"10.1007/s13404-023-00335-1","url":null,"abstract":"<div><p>Nanotechnology is an emerging field with a multitude of applications in medicine, agriculture, and engineering. To date, several methods are used for the synthesis of metallic nanoparticles including chemical, physical, and green methods. The later method is preferred for the synthesis of NPs due to its safe nature, efficiency, and minimal toxicity. Recently, gold nanoparticles (AuNPs) have been attracting attention due to their excellent biocompatibility and diverse medical applications. A diverse group of microorganisms or their metabolites (bacteria, fungi, and yeast) have been utilized to synthesize AuNPs from their respective bulk salts. This review focuses on the resources exploited for biosynthesis of AuNPs, the current understanding about their synthesis, and the emerging trends, along with their mechanistic antimicrobial and anticancer applications. This review also highlights the current challenges and future potential applications of AuNPs.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 2","pages":"69 - 81"},"PeriodicalIF":2.2,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excited-state gold catalyzed activation of inert C–Cl bonds","authors":"Xiaopeng Wu,&nbsp;Yibin Sun,&nbsp;Chen Mingqi,&nbsp;Yeli Fan","doi":"10.1007/s13404-023-00332-4","DOIUrl":"10.1007/s13404-023-00332-4","url":null,"abstract":"<div><p>Chloroalkanes have richer structures and cheaper costs than iodide/brominated compounds, while rarely used as electrophilic reagents for constructing C(sp³)–C(sp³) bonds due to their low reduction potential and strong bond dissociation energy. Recently, a new catalytic strategy involving dinuclear gold complexes has overcome this limitation. The photoinduced gold-catalyzed mode initiated the C(sp³)–Cl electrophilic activation, lead to the divergent conversion of chloroalkanes as chloroalkyl, alkyl cation and carbene equivalent precursor of carbon chain propagation, and involved a novel mechanism of inner-sphere SET process between dinuclear gold complex catalyst and chloroalkane.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"107 - 110"},"PeriodicalIF":2.2,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00332-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation of Au(III) from hydrochloric acid solutions containing Pd(II), Cu(II) and Ni(II) by solvent extraction with a mixture of Cyanex 272 and TBP","authors":"Thi Nhan Hau Nguyen,&nbsp;Si Joeng Song,&nbsp;Man Seung Lee","doi":"10.1007/s13404-023-00333-3","DOIUrl":"10.1007/s13404-023-00333-3","url":null,"abstract":"<div><p>Etching solutions of spent printed circuit boards contain a small amount of valuable metals like Au(III) and Pd(II). In order to meet the increasing demand for gold and palladium, it is necessary to recover these metals from the etching solutions. In this work, solvent extraction experiments were done to separate Au(III) from the synthetic hydrochloric acid solutions containing Pd(II), Cu(II), and Ni(II). Single Cyanex 272 and TBP and their mixture were employed to investigate the selective extraction of Au(III) from other metal ions in the HCl concentration range from 1 to 9 M. Single Cyanex 272 and the mixture of Cyanex 272 and TBP successfully separated Au(III) from the solution, while a small amount of Pd(II), Cu(II) and Ni(II) were co-extracted with Au(III) by TBP. The mixture of Cyanex 272 and TBP showed synergism for the extraction of Au(III). The dependence of Au(III) extraction on the mole fraction of TBP in the mixture was pronounced when HCl concentration was 1 and 3 M. The Au(III) loaded into the mixture was completely stripped by low concentration of thiourea and sodium thiosulfate. Pure gold metal was recovered from the thiourea stripping solution by chemical reduction with ascorbic acid. Complete reduction of Au(III) was possible at 80 °C for 30 min when the molar ratio of ascorbic acid to Au(III) was 20.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 2","pages":"59 - 68"},"PeriodicalIF":2.2,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00333-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold nanoparticle-based drug nanocarriers as a targeted drug delivery system platform for cancer therapeutics: a systematic review","authors":"A’liyatur Rosyidah,&nbsp;Supavadee Kerdtoob,&nbsp;Wecka Imam Yudhistyra,&nbsp;Asef Wildan Munfadlila","doi":"10.1007/s13404-023-00331-5","DOIUrl":"10.1007/s13404-023-00331-5","url":null,"abstract":"<div><p>Cancer was the world’s second major cause of death. Several treatments were available, including chemotherapy, radiotherapy, immunotherapy, and surgery. However, they are restricted due to their risk to normal cells, their ability to destroy the immune system, and conferring increased risk of secondary cancer development. Nanotechnology was extensively researched and used in cancer treatment because nanoparticles could play an essential role in drug delivery. Furthermore, nanoparticle drug delivery systems have been shown to help overcome cancer-related drug resistance. Gold nanoparticles have unique physical, chemical, and biological properties, making them suitable candidates for non-toxic drug carriers. Because of their nanorange size, surface modifications of gold nanoparticles could improve their stability, minimize nanoparticle aggregation, and enhance attachment to anti-cancer agents and target cells, further increasing their ability to penetrate cell membranes and reduce toxicity. This review aims to discuss the current research in targeting drug delivery for anti-cancer agents using gold nanoparticles. By conducting a literature search through the PubMed and Scopus database up to April 2022 using the term gold nanoparticles, targeted drug delivery, chemotherapy, gene therapy, and cancer, this review summarized report on the implementation of gold nanoparticles for targeted drug-delivery systems for cancer therapeutics. The targeting ligands included folic acid, aptamers, hyaluronic acid, glutathione, peptides, and antibodies. According to the findings of studies, implementing gold nanoparticles as nanocarriers significantly improves drug delivery of anti-cancer agents to cancer cells without affecting other untargeted cells. Enhanced cell uptake, increase in drug toxicity, inhibition of tumor growth, and selective drug target are also reported to be the advantages of gold nanoparticle-based targeted drug delivery carriers.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"121 - 134"},"PeriodicalIF":2.2,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00331-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41228895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy","authors":"Qing Hong,&nbsp;Xinchun Jin,&nbsp;Chenheng Zhou,&nbsp;Jiahui Shao","doi":"10.1007/s13404-023-00330-6","DOIUrl":"10.1007/s13404-023-00330-6","url":null,"abstract":"","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"157 - 157"},"PeriodicalIF":2.2,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold nanoparticles with amyloid-β reduce neurocell cytotoxicity for the treatment and care of Alzheimer’s disease therapy","authors":"Qing Hong,&nbsp;Xinchun Jin,&nbsp;Chenheng Zhou,&nbsp;Jiahui Shao","doi":"10.1007/s13404-023-00327-1","DOIUrl":"10.1007/s13404-023-00327-1","url":null,"abstract":"<div><p>Protein oligomerization contributes to Alzheimer’s disease development (AD). A nanoparticle that can speed up the oligomerization of proteins is generally considered harmful. Gold nanoparticles (AuNPs) have been reported to be making headway in biological platforms, but they may also have the capacity to stimulate protein oligomerization. Our goal herein was to investigate the neurotoxicity and oligomerization of amyloid-β-1-42 (Aβ_1-42) in the presence of AuNPs. The precipitation approach was used to create AuNPs, which were then analyzed using transmission electron microscopy (TEM), ThT, Congo red, and CD spectroscopy. The results demonstrated that the 50-nm-sized fabricated AuNPs guided acceleration in Aβ_1-42. In addition, cytotoxicity studies on PC 12 cells showed that Aβ_1-42 with AuNPs were less toxic than untreated oligomers Aβ_1-42 in terms of inducing cell death, oxidative apoptosis, stress, and membrane leakage. In conclusion, our investigation sheds light on how AuNPs stimulate the development of cytotoxic oligomers by binding to proteins in Alzheimer’s disease.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"135 - 144"},"PeriodicalIF":2.2,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00327-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41228956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical sensing based on Au particle@SiO2@CQDs nanocomposites","authors":"Huiqin Li,&nbsp;Lihua Wu,&nbsp;Hui Lei,&nbsp;Cui Deng,&nbsp;Fan Huang,&nbsp;Lijun Ren,&nbsp;Hongge Zhang,&nbsp;Weiwei Zhao,&nbsp;Qian Zhao","doi":"10.1007/s13404-023-00329-z","DOIUrl":"10.1007/s13404-023-00329-z","url":null,"abstract":"<div><p>In this study, carbon quantum dots (CQDs) were first synthesized using a hydrothermal method, and then, Au@SiO₂ core-shell nanomaterials were synthesized using layer-by-layer assembly. CQDs were adsorbed on the surface of Au@SiO₂ nanoparticles through self-assembly to form Au@SiO₂/CQDs nanocomposite materials. Transmission electron microscopy and X-ray diffraction were used to characterize the size, shape, element composition, and structure of nanocomposites; ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy were used to analyze the optical properties of nanocomposites. The results show that Au@SiO₂/CQD nanomaterials have a core-shell structure with good morphology and exhibit excellent luminescence characteristics. The electrochemical performance of nanocomposites was characterized using electrochemical means, and a hydrogen peroxide sensor was constructed for the sensitive detection of hydrogen peroxide, thus realizing the rapid and sensitive detection of hydrogen peroxide at levels as low as 0.2 mM. The electrode GCE modified with Au@SiO₂/CQDs exhibits good selectivity and stability in the detection of hydrogen peroxide.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"145 - 155"},"PeriodicalIF":2.2,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of nanofibrous vinyl brushes of clay minerals as an active support for gold nanoparticles for catalytic reduction","authors":"Talha Baig,&nbsp;Shaista Taimur,&nbsp;Afza Shahid","doi":"10.1007/s13404-023-00328-0","DOIUrl":"10.1007/s13404-023-00328-0","url":null,"abstract":"<div><p>This study encompasses the synthesis of gold nanoparticles (GNPs) captured on nanofibrous vinyl brushes (NVBs) using sepiolite nanoclay as a matrix. The diameter of GNPs was found to be 2–8 nm investigated by a particle-size analyzer. Due to the high surface reactivity, GNPs are more susceptible to agglomeration which reduces their efficacy as catalyst. A suitable support could be employed to arrest the discrete gold particles on its surface. The distinct textural morphology of sepiolite allows it to be a promising choice as support. Silanol groups on the surface of sepiolite nanofibers were consumed to graft vinyl brushes using hydrolyzed vinyl triethoxy silane. This grafting was characterized by FT-IR spectroscopy. Morphological studies of developed nanocomposites (AuNVBs) were conducted by TEM and FESEM revealing evidently the incorporation of well-distributed GNPs. XRD diffractograms have validated the connectivity of GNPs on NVBs surface. GNPs immobilized on the surface of NVBs are commendable candidates as catalyst to enhance the reaction rate for the conversion of 4- nitrophenol to 4- aminophenol.</p><h3>Graphical abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 2","pages":"97 - 105"},"PeriodicalIF":2.2,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41181106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Pseudomonas aeruginosa and Acinetobacter baumannii genomic DNA using gold nanoprobes","authors":"Marjan Bagherinajafabad,&nbsp;Hassan Bardania,&nbsp;Elham Moazamian,&nbsp;Seyed Sajjad Khoramrooz","doi":"10.1007/s13404-023-00326-2","DOIUrl":"10.1007/s13404-023-00326-2","url":null,"abstract":"<div><p>Conventional techniques for microbial detection are time-consuming, expensive, and unsuitable. The use of nanoparticles is a valuable technique for the detection of bacterial as well as viral DNA. Gold nanoparticles (gold NPs) have been used as a promising detector for rapid and low-cost identification of microbes with high sensitivity. In this study, gold nanoparticles-probes were used to identify <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> genomic DNA. Thiol-functionalized probes were attached to gold NPs. Hybridization of the probe with the amplified product of Oprl and glta genes resulted in accumulation of gold nanoparticles in a cross-linked manner, caused a color change of the reaction mixture, which indicated the presence of <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> in the sample. To study the sensitivity, the polymerase chain reaction product with different bacteria was used, and results were compared. The gold nanoparticle-based colorimetric assay can be used as a direct and rapid method with high sensitivity for specific identification of these pathogens in clinical and food samples.</p></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 3","pages":"111 - 120"},"PeriodicalIF":2.2,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13404-023-00326-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41229332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Control of protein density on nanoparticles for SERS-based immunoassays","authors":"Francis Nsiah,&nbsp;Mark T. McDermott","doi":"10.1007/s13404-023-00325-3","DOIUrl":"10.1007/s13404-023-00325-3","url":null,"abstract":"<div><h2>Abstract\u0000</h2><div><p>The paper presented herein provides a novel Raman mapping procedure developed to pattern-modified gold nanoparticles on planar gold substrates. This work began with the development of a simple approach to the fabrication and reading of protein microarrays based on the use of microfluidic channels in PDMS and SERS detection. The assay consisted of anti-bovine IgG which was tethered to the nanoparticle via a bifunctional coupling agent and surface-bound bovine IgG. The Raman spectral intensity of the symmetric nitro stretch of the DSNB-modified nanoparticle was used as a diagnostic tool for biomolecular interactions. The work described herein seeks to probe the binding event and also addresses the possible causes of the higher signals observed in such binding events. It is also a contribution to an ongoing investigation into the effect of Raman reporter labels on the observed signals in immunoassays which use SERS as the readout technique.</p></div></div>","PeriodicalId":581,"journal":{"name":"Gold Bulletin","volume":"56 1","pages":"31 - 42"},"PeriodicalIF":2.2,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5146630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}