新发传染病电子杂志最新文献

The Impacts of Anti-Inflammatory Agents on COVID-19 Cytokine Storm 抗炎药对COVID-19细胞因子风暴的影响

新发传染病电子杂志 Pub Date : 2021-09-30 DOI: 10.3390/ecms2021-10910

I. Chukwuma, V. Apeh, F. Nworah, Chidi Augustine Madueke, V. Nwanelo

{"title":"The Impacts of Anti-Inflammatory Agents on COVID-19 Cytokine Storm","authors":"I. Chukwuma, V. Apeh, F. Nworah, Chidi Augustine Madueke, V. Nwanelo","doi":"10.3390/ecms2021-10910","DOIUrl":"https://doi.org/10.3390/ecms2021-10910","url":null,"abstract":": The re-emergence of severe acute respiratory syndrome coronavirus 2 A(SARS-CoV-2) in Wuhan, China, has placed an unprecedented economic and health burden globally. The SARS-CoV-2 high mortality rate has brought great challenges to researchers, clinicians, and health workers in their bid to discover appropriate therapeutic interventions. The search for the ultimate remedy was initially centered on the use of antiviral agents targeting receptors and proteins involved in the pathophysiology of SARS-CoV-2. However, the upsurge of interest in repurposing anti-inﬂammatory agents was born out of the reported risks posed by a cytokine storm on COVID-19-induced fatality. A cytokine storm, as a result of the unregulated production of pro-inﬂammatory cytokines and other chemical mediators, triggers coagulopathy, viral sepsis, pneumonitis shock, and acute respiratory syndrome, which may lead directly to respiratory and organ failure and ultimately the death of the patient. The overwhelming evidence has shown that the early prediction of cytokine storm using serum chemistry and hematological markers and the use of appropriate anti-inﬂammatory agents will avert COVID-19 complications. These include the use of repurposed interferon (IFN) therapy and inhibitors of interleukin-1 (IL-1 β ), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α ), and Janus kinase (JAKs) to nip the cytokine storm in the bud. This review critically used information retrieved from PubMed, China National Knowledge Infrastructure, Embase, Medline, and Google Scholar to elaborate on the mechanism and complications of COVID-19 cytokine storm, therapeutic interventions, and the way forward to discovering effective biocompatible drug targets.","PeriodicalId":57778,"journal":{"name":"新发传染病电子杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83632155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological Value of Nephrotoxic Effects of Doxorubicin and PLGA-Doxorubicin 阿霉素和plga -阿霉素肾毒性作用的形态学价值

新发传染病电子杂志 Pub Date : 2021-08-31 DOI: 10.3390/ecms2021-10834

I. Tsvetkov, N. Zolotova, A. Kosyreva, D. Dzhalilova, L. Mikhailova, V. Kudelkina, A. Shelkov, O. Makarova, V. Chernikov, V. Razzhivina

引用次数: 0

F- and OH-Containing Isopulegol-Derived Octahydro-2H-Chromenes as Agents against Influenza A Virus 含F和oh的异戊二酚衍生的八氢- 2h -铬烯抗甲型流感病毒的作用

新发传染病电子杂志 Pub Date : 2021-08-31 DOI: 10.3390/ecms2021-10836

I. Ilyina, O. S. Patrusheva, V. Zarubaev, K. Volcho, N. Salakhutdinov

{"title":"F- and OH-Containing Isopulegol-Derived Octahydro-2H-Chromenes as Agents against Influenza A Virus","authors":"I. Ilyina, O. S. Patrusheva, V. Zarubaev, K. Volcho, N. Salakhutdinov","doi":"10.3390/ecms2021-10836","DOIUrl":"https://doi.org/10.3390/ecms2021-10836","url":null,"abstract":": Monoterpenes, which have a unique diverse structure and are inexpensive, available and often enantiomerically pure, are an attractive renewable raw material for the development of phys-iologically active agents. One of the important methods to the utilization of monoterpenes is their interaction with carbonyl compounds resulting in heterocyclic compounds. Often these products exhibit analgesic, antiviral or neuroprotective properties. Earlier, we discovered anti-influenza A (H1N1) virus activity of several compounds with a hydro-2H-chromene scaffold, which were synthesized by the Prins reaction using p-menthane alcohols and carbonyl compounds; montmorillo-nite K10 or nanosized halloysite catalyst were used as the reaction catalysts [1]. Chromenols pro-duced from an (–)-isopulegol and aliphatic ketones (acetone and cyclopentanone) demonstrated high activity in combination with low toxicity against the influenza virus [1]. The introduction of the fluorine atom into the molecule is an important strategy in the development of new biologically active compounds, which enables changing lipophilicity and electrostatic interactions and increas-ing the metabolic stability of compounds and, so affects their physiological activity. Here we synthesized fluoro- and hydroxy-containing octahydro-2 H -chromenes by the Prins reaction starting from an (–)-isopulegol and a wide range of aromatic aldehydes in the presence of the BF 3 ∙Et 2 O/H 2 O system acting as both an acid catalyst and a fluorine source. Activity of the synthesized compounds against the influenza A/Puerto Rico/8/34 (H1N1) virus was studied. The highest activity was demonstrated by fluoro- and hydroxy-containing 2,4,6-trimethoxybenzaldehyde derivatives. These compounds were supposed to be capable of binding to viral hemagglutinin, which is an agreement with data on the effect of compounds on the viral fusogenic activity as well as with molecular dock-ing studies.","PeriodicalId":57778,"journal":{"name":"新发传染病电子杂志","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79769373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Benzothiazole Moiety and Its Derivatives as Antiviral Agents 苯并噻唑片段及其衍生物作为抗病毒药物

新发传染病电子杂志 Pub Date : 2021-08-31 DOI: 10.3390/ecms2021-10839

Khyati Bhagdev, S. Sarkar

引用次数: 4

LAG-3 Role in Infection LAG-3在感染中的作用

新发传染病电子杂志 Pub Date : 2021-08-31 DOI: 10.3390/ecms2021-10835

L. Chocarro, E. Blanco, H. Arasanz, A. Bocanegra, L. Fernández-Rubio, M. Echaide, M. Garnica, P. Ramos, G. Kochan, D. Escors

{"title":"LAG-3 Role in Infection","authors":"L. Chocarro, E. Blanco, H. Arasanz, A. Bocanegra, L. Fernández-Rubio, M. Echaide, M. Garnica, P. Ramos, G. Kochan, D. Escors","doi":"10.3390/ecms2021-10835","DOIUrl":"https://doi.org/10.3390/ecms2021-10835","url":null,"abstract":": Lymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple biological activities over T cell activation and effector functions. LAG-3 plays a regulatory role in immunity and emerged some time ago as an inhibitory immune checkpoint molecule. A systematic research was performed using the PubMed and ClinicalTrial.gov databases. Articles published up to 2021 meeting the inclusion criteria were investigated. LAG-3 expression has been linked to in-creased pathology in certain infections, such as the ones caused by Salmonella, Plasmodium para-sites, Mycobacterium tuberculosis, human immunodeficiency virus (HIV), non-pathogenic simian immunodeficiency virus (SIV), in hepatitis B virus (HBV), human papillomavirus (HPV), chronic hepatitis C virus (HCV), lymphocytic choriomeningitis virus (LCMV) and herpes simplex virus 1 (HSV-1). Here, we will discuss the impaired control of cell-mediated immunity associated with high accumulation of LAG-3 after infection, in most cases associated with a high bacterial/viral load, a reduced survival rate or persisting metabolic and inflammation disorders. Interestingly, the in vitro blockade of PD-1/LAG-3 interactions enhanced cytokine production in response to some of these infections.","PeriodicalId":57778,"journal":{"name":"新发传染病电子杂志","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82286135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronaviridae: Infectious Bronchitis Virus 冠状病毒科:传染性支气管炎病毒

新发传染病电子杂志 Pub Date : 2016-10-13 DOI: 10.1007/978-3-319-47426-7_5

A. S. Abdel-Moneim

引用次数: 11

Equine Coronavirus Infection 马冠状病毒感染

新发传染病电子杂志 Pub Date : 2016-10-13 DOI: 10.1007/978-3-319-47426-7_4

N. Pusterla, R. Vin, C. Leutenegger, L. Mittel, T. Divers

引用次数: 4

Emerging Infectious Diseases in Camelids 骆驼类新发传染病

新发传染病电子杂志 Pub Date : 2016-10-13 DOI: 10.1007/978-3-319-47426-7_20

A. Khalafalla