Journal of Clinical and Translational Endocrinology: Case Reports最新文献

{"title":"A case report of hypogonadism and infertility in 46,XX (SRY positive) male syndrome","authors":"Benjamin Rosenstein,&nbsp;Hassan Liaqat,&nbsp;Anees Fazili","doi":"10.1016/j.jecr.2024.100181","DOIUrl":"10.1016/j.jecr.2024.100181","url":null,"abstract":"<div><div>46, XX Male Syndrome is a rare genetic condition in which an individual has a male phenotype despite having a 46, XX karyotype. This is most often due to a translocation of the SRY gene from the short arm of the Y-chromosome onto the X chromosomes during paternal meiosis. Due to the absence of the long arm of the Y-chromosome, there is a de facto deletion of AZF regions a-c, and this results in infertility. We present a case of a 35-year-old male who was diagnosed with 46,XX (SRY+) Male Syndrome upon work-up for infertility and hypogonadism.</div></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"35 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe hepatopulmonary syndrome with end-stage liver cirrhosis associated with pan-hypopituitarism in a pediatric patient","authors":"Shawn A. Haupt ,&nbsp;Jessica C. Chang ,&nbsp;Roya Zarpak ,&nbsp;Arash R. Zandieh ,&nbsp;Nada A. Yazigi ,&nbsp;Udeme D. Ekong ,&nbsp;Juan F. Guerra ,&nbsp;Thomas M. Fishbein ,&nbsp;Cal S. Matsumoto ,&nbsp;Alexander H. Kroemer ,&nbsp;Khalid M. Khan","doi":"10.1016/j.jecr.2024.100179","DOIUrl":"10.1016/j.jecr.2024.100179","url":null,"abstract":"<div><div>Cholestasis in the neonatal period requires a prompt and thorough evaluation. Panhypopituitarism is an uncommon but known cause of cholestasis. Here we present a rare and late complication of liver disease secondary to congenital hypopituitarism. Pediatric patients presenting with cholestasis and other manifestations of pituitary malfunction warrant further evaluation.</div></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"35 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of bone pain following kidney transplant: Differentiating between tertiary hyperparathyroidism and calcineurin-induced pain syndrome in post renal transplant patients","authors":"Julie Fedorko ,&nbsp;Caroline Poku","doi":"10.1016/j.jecr.2024.100178","DOIUrl":"10.1016/j.jecr.2024.100178","url":null,"abstract":"<div><div>Metabolic derangements affecting bone health are undeniably common among patients who have undergone renal transplants. Due to long-standing chronic kidney disease (CKD), secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT) are frequently observed in renal transplant patients and account for the bone disorders associated with this patient population, termed chronic kidney disease-mineral and bone disorders (CKD-MBD). As calcineurin inhibitors become increasingly commonplace in the long-term management of graft rejection, another process must be considered when working up a patient's bone pain. Calcineurin inhibitor-induced pain syndrome (CIPS) is a condition of episodic bone and articular pain that can present similarly to THPT with the presence of hypercalcemia, hyperphosphatemia and elevated alkaline phosphatase. However, CIPS can be distinguished from these other processes through its distinct imaging findings, with bone marrow and soft tissue edema on MRI and increased radiotracer uptake on bone scans. Here, we present a case of bone pain in a patient following renal transplant and the subsequent workup performed to identify the underlying process. As more and more patients undergo renal transplant and begin immunosuppression with calcineurin inhibitors, there is an increasing need for a thorough workup of bone pain and high clinical suspicion of CIPS. Furthermore, the debilitating pain associated with CIPS can be improved with reduction in immunosuppressive dosing; thus, having a high clinical suspicion for this condition can make a significant impact on patient quality of life as well as medical management of graft rejection immunosuppression.</div></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"35 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143171339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of “hyperandrogenism” confounded by dermatology biotin prescriptions","authors":"Sumal S. Sundar,&nbsp;Srushti Shankar,&nbsp;Madhumati S. Vaishnav,&nbsp;Leena Lekkala,&nbsp;Chandraprabha Siddalingappa,&nbsp;Kavitha Muniraj,&nbsp;Thummala Kamala,&nbsp;Reshma B. Vijay,&nbsp;Vasanthi Nath,&nbsp;Mandyam D. Chitra,&nbsp;Pushpa Ravikumar,&nbsp;Siddartha Dinesha,&nbsp;Tejeswini Deepak,&nbsp;Sathyanarayana Srikanta","doi":"10.1016/j.jecr.2024.100177","DOIUrl":"10.1016/j.jecr.2024.100177","url":null,"abstract":"<div><div>Immunoassay interferences, including those from exogenous substances like biotin, can lead to misinterpretation of laboratory results and clinical decision-making challenges. A 28-year-old unmarried female presented to dermatologist with 4-year history of acne, hirsutism, and hair loss. Hormonal assays using chemiluminescence immunoassays (CLIA) and enzyme-linked immunosorbent assays (ELISA) revealed alarmingly high testosterone levels, suggesting neoplastic androgen excess and severe insulin resistance. This prompted referral to endocrinology for further evaluation. Patient's menarche occurred at age 11, with regular menstrual cycles. Family history indicated diabetes and hirsutism, but not infertility. Physical examination revealed body mass index (BMI) of 21.8 kg/m² and Ferriman-Gallwey score of 11. Despite severe biochemical hyperandrogenism, her clinical presentation was mild. Differential diagnoses included polycystic ovary syndrome (PCOS) and late-onset congenital adrenal hyperplasia (CAH). Repeat hormonal testing, performed at multiple laboratories using liquid chromatography-mass spectrometry (LCMS), CLIA, and ELISA, showed normal testosterone, free testosterone, and insulin levels, suggesting that the initial results were falsely elevated. Review of her dermatology prescriptions revealed that she had taken a single 10 mg tablet of biotin 33 hours before first blood draw, leading to diagnosis of biotin interference in immunoassays. After the two-week biotin washout period, her subsequent endocrinology work-up had indicated “normalized” hormonal levels. Pelvic and abdominal ultrasound imaging revealed normal ovaries and adrenal areas. Thus, biotin associated testosterone (and insulin) immunoassay interference can confound clinical diagnosis and management. Any observed discordance between clinical symptoms, signs and hormonal levels should raise possibility of immunoassay interferences, reemphasizing need for heightened physician awareness.</div></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"34 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Incidental” lipoadenoma of the parathyroid gland: A case report of a rare entity","authors":"Francesca Signorini ,&nbsp;Marco Puccini ,&nbsp;Gabriele Materazzi ,&nbsp;Clara Ugolini","doi":"10.1016/j.jecr.2024.100176","DOIUrl":"10.1016/j.jecr.2024.100176","url":null,"abstract":"<div><p>Parathyroid lipoadenoma is an uncommon type of parathyroid adenoma and a rare cause of primary hyperparathyroidism (PHPT). The rarity of this entity, the difficult detection on imaging and the resemblance with normal parathyroid tissue microscopically makes its diagnosis difficult. We reported the case of an asymptomatic 48-year-old male treated for amiodarone-induced thyrotoxicosis and incidental sporadic PHPT, that supplements and supports the rare literature data concerning the knowledge, diagnosis, and treatment of parathyroid lipoadenoma.</p></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"33 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214624524000157/pdfft?md5=250ad7cc6d0f2bc5d5d8b0b4c552d9d2&pid=1-s2.0-S2214624524000157-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary carcinoma arising in a thyroglossal duct cyst: A case report","authors":"Desalegn Fekadu ,&nbsp;Bereket Girum ,&nbsp;Gemechis Asefa ,&nbsp;Abdi Alemayehu ,&nbsp;Michael Tekelhaimanot","doi":"10.1016/j.jecr.2024.100175","DOIUrl":"https://doi.org/10.1016/j.jecr.2024.100175","url":null,"abstract":"<div><p>Thyroglossal duct cysts are one of the most common causes of anterior neck swelling. Thyroglossal duct carcinoma arising from these cysts is quite rare; it occurs in less than 1 % of all the thyroglossal duct cysts. Imaging plays a crucial role in evaluating these lesions and suggesting further pathologic workup in suspicious cases. We report a case of a 30-year-old woman with a diagnosis of papillary carcinoma within the thyroglossal duct cyst.</p></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"33 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214624524000145/pdfft?md5=d88b12a7763bfab63c3612299daecf6a&pid=1-s2.0-S2214624524000145-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor shrinkage in a tamoxifen-treated non-functioning pituitary neuroendocrine tumor with positive estrogen receptor-beta (ERβ): A case report and review of the literature","authors":"Haydar Ali Tajuddin Amalina ,&nbsp;Sukor Norlela ,&nbsp;Azizan Elena Aisha ,&nbsp;Kamaruddin Nor Azmi ,&nbsp;Omar Ahmad Marzuki ,&nbsp;Geok Chin Tan ,&nbsp;Mustangin Muaatamarulain ,&nbsp;Mohamed Mukari Shahizon Azura ,&nbsp;Alias Azmi ,&nbsp;Abd Latif Kartikasalwah ,&nbsp;Poh Sen Tay ,&nbsp;Idris Nurdillah ,&nbsp;Kasim Fauziah ,&nbsp;Wan Ismail Wan Ruza Iswati","doi":"10.1016/j.jecr.2024.100174","DOIUrl":"https://doi.org/10.1016/j.jecr.2024.100174","url":null,"abstract":"<div><p>Administration of selective estrogen receptor modulators (SERMs) and anti-estrogens has been shown to reduce the size of pituitary tumors. However, previous studies were performed on animal pituitary tumors or tissue cultures. We administered oral tamoxifen to a postoperative patient with a nonfunctioning pituitary neuroendocrine tumor (NF-PitNET) to investigate its potential effect on tumor volume. This case report presents the case of a 47-year-old female patient with a null cell adenoma who had undergone surgical resection as primary treatment and was left with a residual tumor that grew significantly. She was treated with tamoxifen 20–40 mg daily for one year. She was followed up to assess tamoxifen adherence, tolerability, and adverse events. The resected pituitary tumor was stained with estrogen receptor alpha (ERα) and beta (ERβ), proliferation markers (ki-67 and p53), and H&amp;E staining for mitotic count. MRI of the pituitary gland was performed before starting treatment, after 6 months, and after 1 year of tamoxifen therapy. Her resected tumor showed high-intensity ERβ staining in the absence of ERα expression. She was able to tolerate oral tamoxifen therapy without side effects. Tamoxifen therapy resulted in a remarkable reduction in residual tumor volume of up to 87 % in this patient. Tamoxifen has a potential therapeutic effect in treating patients with residual NF-PitNET tumors that have regrown after primary resection. This finding may provide an alternative treatment modality for recurrent NF-PitNET. ERβ expression may predict response to tamoxifen in this subset of patients.</p></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"33 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214624524000133/pdfft?md5=0dd5cfc42d89716da2efac64721a33a1&pid=1-s2.0-S2214624524000133-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sixth-nerve palsy in a patient with uncontrolled type 1 diabetes","authors":"Sohi Mistry ,&nbsp;Omar Zmeili","doi":"10.1016/j.jecr.2024.100170","DOIUrl":"https://doi.org/10.1016/j.jecr.2024.100170","url":null,"abstract":"<div><h3>Background/objective</h3><p>Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications in patients with diabetes. Specifically, sixth nerve palsy is the most common.</p></div><div><h3>Case report</h3><p>A 51-year-old female with a past medical history of type 1 diabetes on insulin and hypertension presented with complaints of worsening headache and diplopia. Physical exam was remarkable for recurrent sixth-nerve palsy. Patient was hemodynamically stable. Labs showed blood glucose of 367 mg/dL (70–100 mg/dL), an anion gap of 2 mmol/L (3–13 mmol/L), creatinine of 0.61 mg/dl (0.66–1.25 mg/dL), sodium of 129 mmol/L (135–145 mmol/L), and potassium of 4.4 mmol/L (3.5–5.1 mmol/L). Her hemoglobin A1C was 13.0 % Her complete blood count shows a white blood cell count of 6000/μL (3600-10,700/μL) and a hemoglobin of 14 g/dL (13.0–18.0 g/dL). Magnetic resonance venography of the head was negative for cerebral venous sinus thrombosis and magnetic resonance imaging of the brain was negative for acute abnormalities. Blood glucose readings improved during hospitalization after optimizing her insulin regimen. She was recommended to follow-up with outpatient endocrinology to discuss use of an insulin pump to better control her diabetes.</p></div><div><h3>Discussion</h3><p>Sixth-nerve palsy is a frequent but lesser-known neuro-ophthalmologic complication of poorly controlled diabetic patients.</p></div><div><h3>Conclusion</h3><p>Studies have shown a higher incidence of diabetes in patients with sixth-nerve palsy, warranting a more focused medical evaluation along with close observation and tighter control of blood glucose levels and hemoglobin A1C.</p></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"32 ","pages":"Article 100170"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214624524000091/pdfft?md5=6a45b3e0a3c99c9dc5b3993f582a420b&pid=1-s2.0-S2214624524000091-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141090769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudohypoaldosteronism: A challenging diagnosis with management pitfalls - Case series","authors":"Amir Babiker ,&nbsp;Haya Aldabas ,&nbsp;Shahad Alanazi ,&nbsp;Bashayer Alahmadi ,&nbsp;Waleed Tamimi ,&nbsp;Mohsen Al Atawi ,&nbsp;Fahad Aljuraibah ,&nbsp;Angham Almutair","doi":"10.1016/j.jecr.2024.100172","DOIUrl":"10.1016/j.jecr.2024.100172","url":null,"abstract":"<div><h3>Background</h3><p>Pseudohypoaldosteronism (PHA) is a rare, but life threatening condition, that usually presents with impressive hyperkalemia. It can be initially missed as congenital adrenal hyperplasia (CAH). We present a series of patients to increase the awareness of treating physicians about misdiagnosis and pitfalls in management.</p></div><div><h3>Case report</h3><p>We admitted 4 cases of PHA in our institution between 2017–2021. All of them had a delay in the initial diagnosis due to similarity of presentation to CAH that is more encountered in clinical practice. They presented with variable symptoms of vomiting, poor feeding, weight loss, dehydration, and fever. In addition, they all had profound hyperkalemia reaching 10–11 meqL and significant hyponatremia reaching 129 meqL. Case one and four both showed initial normal levels of serum aldosterone that were found to be high after dilution of the samples. During follow-up periods of 31 months to 4 years, all of these patients required regular adjustment of kayexalate, sodium chloride and sodium bicarbonate doses according to weight changes to keep a normal serum sodium level and a potassium level below 5.5 meqL.</p></div><div><h3>Discussion</h3><p>Our patients' series demonstrates challenges that may face physicians during PHA management. PHA mimics CAH in clinical and biochemical presentation. Also, there are technical issues regarding the accuracy of serum aldosterone measurement. Moreover, the use of a potassium chelating agent requires careful and close follow up for optimization of doses to avoid life threatening hyperkalemia. This requires frequent follow-up to ensure monitoring, dose adjustment and early detection of electrolytes’ imbalance.</p></div><div><h3>Conclusion</h3><p>PHA, as in our patients, can be associated with a delay in both the diagnosis and early start of management. Our series also demonstrates that an optimal adjustment of treatment doses is critical for rapidly growing young children.</p></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"32 ","pages":"Article 100172"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221462452400011X/pdfft?md5=1b906fc4b2515aa0897668c5a9a686d0&pid=1-s2.0-S221462452400011X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141049592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal diabetes mellitus May Offer the Missing Link to monogenic diabetes in family members: A case report","authors":"Emir Tas,&nbsp;Esraa Al-Hosain,&nbsp;Swetha Movva,&nbsp;Tyler Colangelo,&nbsp;Nursen Gurtunca","doi":"10.1016/j.jecr.2024.100171","DOIUrl":"https://doi.org/10.1016/j.jecr.2024.100171","url":null,"abstract":"<div><p>Neonatal diabetes mellitus (NDM) is a rare type of monogenic diabetes. It is predominantly described as insulin-requiring hyperglycemia before the age of 6 months. Diagnosis of NDM can be difficult due to its varying clinical presentation. Prompt genetic testing is paramount to determine the appropriate management. In this report, we demonstrate a case where genetic testing has led to an accurate diagnosis of NDM in a 7-month-old infant who was successfully switched from subcutaneous insulin to oral anti-diabetics. Identification of the infant's genetic diagnosis led to the correction of the father's misdiagnosis of type 1 diabetes mellitus to monogenic diabetes. Reclassification of the father's diabetes allowed the replacement of his long-lasting insulin therapy with oral anti-diabetics and the improvement of glycemic control. This report highlights the value of genetic testing in NDM diagnosis beyond the first six months of life and how NDM diagnosis in an index case could help with the correct diagnosis, classification, and treatment of other family members with diabetes even after several years of insulin treatment.</p></div>","PeriodicalId":56186,"journal":{"name":"Journal of Clinical and Translational Endocrinology: Case Reports","volume":"32 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214624524000108/pdfft?md5=4d856017e5f90eac1417fb57534a7f4b&pid=1-s2.0-S2214624524000108-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141068818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}