{"title":"Age determination by measurement of pulp volume of canine teeth in patients with cleft lip and palate: a retrospective study.","authors":"Elif Akbas Akca, Rabia Duman Tepe, Ilknur Ozcan, Hulya Cakir Karabas","doi":"10.1007/s11282-025-00802-9","DOIUrl":"https://doi.org/10.1007/s11282-025-00802-9","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluates the potential of pulp volume/total tooth-volume measurements of canine teeth in relation to chronologic age in patients with cleft lip and palate (CLP). The significance of this study lies in its exploration of the usability of these measurements for age determination in CLP patients, providing a novel perspective to the existing literature.</p><p><strong>Methods: </strong>Cone beam computed tomography images of 33 patients (16 females, 17 males) with unilateral CLP aged 14-45 years and 33 age- and sex-matched healthy individuals (16 females, 17 males) were retrospectively evaluated. Using ITK-SNAP software, pulp and whole tooth volumes of canine teeth on the non-defect side of CLP patients and the corresponding side of healthy individuals were measured. Their relationship with chronologic age was evaluated, and comparisons were made between the CLP and control groups.</p><p><strong>Results: </strong>No statistically significant difference was observed between the whole tooth volume, pulp volume, and pulp volume/total tooth-volume ratios of the control and CLP groups. A paired t test comparing chronologic age and calculated mean age of both groups found no significant difference.</p><p><strong>Conclusions: </strong>The results show that the pulp and total tooth-volume ratios of canine teeth in the non-defect areas of individuals with unilateral CLP correlate with chronologic age and can be used reliably for age determination. This indicates that individuals with CLP can be evaluated similarly to healthy individuals, allowing accurate age estimation based on dental measurements.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Performance comparison in workflow efficiency between a remotely installed 3D workstation and an on-premises image processing workstation for dental cone-beam CT image reconstruction.","authors":"Ryoichi Tanaka, Hiroki Mouri, Noriaki Takahashi, Mitsuru Izumisawa, Masayuki Hoshino, Riku Sakamoto, Takaki Kanamori, Ami Shimamura, Ryota Sakai, Emi Kanno, Motoi Sawano","doi":"10.1007/s11282-025-00806-5","DOIUrl":"https://doi.org/10.1007/s11282-025-00806-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to compare the image processing times of dental cone beam CT (CBCT) images using a remote medical image processing workstation (RW) versus on-premises image processing (OP) and assess its impact on workflow efficiency.</p><p><strong>Methods: </strong>Data from 100 CBCT cases were randomly selected and processed using the OP3D VISION 17-19DX (EH Japan Co., Ltd.). In the OP environment, OnDemand 3D Dental (Cybermed Inc.) was used on a local terminal, while the RW setup involved a remote workstation-ZIO STATION (Ziosoft Inc.) connected via a 2 Gbps network. Seven experienced dentists processed the same data in both environments, and various processing times, including data transfer, re-slicing, 3D reconstruction, and PACS transfer, were compared.</p><p><strong>Results: </strong>The RW environment showed significantly shorter data transfer and re-slicing times than the OP environment. However, 3D image reconstruction times were similar between the two setups. Overall, processing time was significantly reduced in the RW environment. Variability in processing times among operators was observed, with most achieving reductions in the RW environment.</p><p><strong>Conclusions: </strong>Remote processing of dental CBCT images using a dedicated image processing device offers equivalent or improved performance compared to on-premises processing. This approach can enhance workflow efficiency by reducing processing times and freeing up local resources, although further research is needed to optimize remote display protocols and multi-client access.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral RadiologyPub Date : 2025-01-21DOI: 10.1007/s11282-025-00805-6
Débora Costa Ruiz, Rocharles Cavalcante Fontenele, Hugo Gaêta-Araujo, Amanda Farias-Gomes, Matheus L Oliveira, Deborah Queiroz Freitas, Francisco Haiter-Neto
{"title":"Influence of a handheld X-ray unit in the diagnosis of proximal caries lesions using different digital systems.","authors":"Débora Costa Ruiz, Rocharles Cavalcante Fontenele, Hugo Gaêta-Araujo, Amanda Farias-Gomes, Matheus L Oliveira, Deborah Queiroz Freitas, Francisco Haiter-Neto","doi":"10.1007/s11282-025-00805-6","DOIUrl":"https://doi.org/10.1007/s11282-025-00805-6","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the influence of a handheld X-ray unit in the diagnosis of proximal caries lesions using different digital systems by comparing with a wall-mounted unit.</p><p><strong>Methods: </strong>Radiographs of 40 human teeth were acquired using the Eagle X-ray handheld unit (Alliage, São Paulo, Brazil) set at 2.5 mA, 60 kVp and an exposure time of 0.45 s. Then, new radiographs of the teeth were acquired using the Focus X-ray wall-mounted unit (Instrumentarium, Tuusula, Finland) set at 7 mA, 60 kVp, and exposure time of 0.16 s. Three digital systems were used: a photostimulable phosphor plate receptor (Express system) and two complementary metal oxide semiconductor sensors (Digora Toto and SnapShot systems). Five oral and maxillofacial radiologists individually assessed the radiographs. Area under the receiver-operating characteristic curve (AUC), sensitivity, and specificity were calculated from the responses of the examiners and compared using Analysis of Variance at a significance level of 5%. The weighted Kappa index evaluated the intra- and inter-examiner agreements for caries lesions diagnosis.</p><p><strong>Results: </strong>The handheld X-ray unit did not influence on the diagnostic metrics for the three digital systems used when compared with the wall-mounted unit (p > 0.05). The SnapShot showed higher AUC value than Digora Toto (p < 0.05). The mean values of intra- and inter-examiner agreements were 0.654 (substantial) and 0.365 (fair), respectively.</p><p><strong>Conclusions: </strong>The diagnostic accuracy for detecting proximal caries lesions is not influenced by the use of a handheld X-ray unit, regardless of the digital system used.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral RadiologyPub Date : 2025-01-20DOI: 10.1007/s11282-025-00803-8
Mailon Cury Carneiro, Lukas Mendes de Abreu, Laura Vidoto Paludetto, Paulo Sérgio da Silva Santos, Izabel Regina Fischer Rubira-Bullen, Cássia Maria Fischer Rubira
{"title":"Radiomorphometric indices for measuring mandibular bone quality in oncologic patients.","authors":"Mailon Cury Carneiro, Lukas Mendes de Abreu, Laura Vidoto Paludetto, Paulo Sérgio da Silva Santos, Izabel Regina Fischer Rubira-Bullen, Cássia Maria Fischer Rubira","doi":"10.1007/s11282-025-00803-8","DOIUrl":"https://doi.org/10.1007/s11282-025-00803-8","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study compared the thickness and degree of resorption of the mandibular cortex in patients with head and neck cancer (AG), patients with cancer at sites other than the head and neck (BG), and patients with no cancer (CG) to describe and compare the changes in the mandible after antineoplastic therapy and their possible clinical implications.</p><p><strong>Materials and methods: </strong>A total of 287 panoramic radiographs were examined. The following radiomorphometric indices were analyzed: mental index (MI), panoramic mandibular index (PMI), and mandibular cortical index (MCI). Analysis of variance (ANOVA) and the Kruskal‒Wallis test, with p < 0.05 considered significant, were performed.</p><p><strong>Results: </strong>Males predominated in the AG (83%), while females predominated in the BG and CG (78.6 and 62%, respectively). In the AG, tongue carcinoma (22.1%) was prevalent, while in the BG, breast carcinoma was predominant (53.8%). All parameters measured in the AG and BG patients were significantly lower than those in the CG patients: MI (p < 0.001), right PMIc/a (p < 0.001), left PMIc/a (p < 0.001), right PMIc/b (p = 0.004), left PMIc/b (p < 0.001), and MCI (p < 0.001).</p><p><strong>Conclusions: </strong>Radiomorphometric indices MI, PMI, and MCI were significantly lower in panoramic radiographs of patients with head and neck cancer and patients with cancer in other regions of the body than in those of nononcological patients.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of the correlation between the volume of tongue, oral cavity, tongue/oral cavity volume ratio and the upper airway in unilateral cleft subjects: A CBCT study.","authors":"Fatemeh Akbarizadeh, Navid Fathi, Shahram Hamedani","doi":"10.1007/s11282-024-00800-3","DOIUrl":"10.1007/s11282-024-00800-3","url":null,"abstract":"<p><strong>Objectives: </strong>The current study was conducted to assess the volume of the tongue, oral cavity, and tongue/oral cavity and their correlation with the volume of the upper airway in cleft subjects compared with the control group.</p><p><strong>Methods: </strong>The study population included 60 CBCT images from dental school. The sample comprised 30 unilateral cleft patients and 30 sex and age-matched healthy subjects. The CBCT images were imported to the Mimics software in DICOM format. Then, the segmentation process was done in order to create distinct masks for the upper airway, oral cavity, and tongue. The software calculated the volume of the created masks.</p><p><strong>Results: </strong>The volume of tongue, oral and upper airway were significantly lower in cleft patients than in the control group (P value < 0.05 taken as statistically significant). There was a weak but statistically significant correlation between the U.A.W.V and T.V in both cleft and non-cleft subjects. Additionally, there was a statistically significant correlation between the O.C.V and the U.A.W.V in cleft subjects.</p><p><strong>Conclusions: </strong>Except than the proportion of tongue/oral cavity volume, other volumetric measurements were significantly lower in cleft subjects than control group. This reveals that clefts are not necessarily more susceptible to obstructive sleep apnea. Also, the positive correlation between the volume of the tongue and oral cavity with the upper airway confirms that early expansion of the maxillary region in clefts helps significantly in increasing their upper airway volume.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges in detecting various peri-implant bone defects on modified intraoral oblique radiographic projections: evaluation of an artificial mandibular model.","authors":"Takayuki Oshima, Rieko Asaumi, Shin Ogura, Taisuke Kawai","doi":"10.1007/s11282-024-00798-8","DOIUrl":"https://doi.org/10.1007/s11282-024-00798-8","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to evaluate the effectiveness of oblique radiographic projection using the intraoral paralleling technique in detecting various peri-implant bone defects.</p><p><strong>Methods: </strong>Artificial mandibular models with appropriate radiopacity were created. An alveolar bone model without bone defects and models with 12 types of peri-implant bone defects (buccal, circumferential, and mixed types with different widths and depths) were created. A total of 273 images were obtained with orthoradial projections and 10-, 20-, and 30-degree oblique projections using a modified receptor holder. Two observers independently evaluated the images to detect bone defects. The grayscale values (GVs) of the peri-implant region and the adjacent area were measured and compared. The relationship between the GV and the observers' results was examined. The area under the curve (AUC) and inter-observer agreement were calculated.</p><p><strong>Results: </strong>Circumferential and mixed bone defects were detected on the orthoradial projections, while buccal defects were not detected. However, the detection of buccal defects was markedly improved using the oblique projections. In particular, the highest detection rates were obtained using the 20-degree oblique projection. There were no significant correlations between the GV and the bone defect detection rate. The AUCs for the two observers were 0.712 and 0.669. The inter-observer agreement was 0.502.</p><p><strong>Conclusions: </strong>Compared with orthoradial projections, the use of oblique projection images greatly improved the ability of observers to detect peri-implant bone defects on the buccal side. The results provide new evidence for the selection of radiographic images in the follow-up of implant treatment.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral RadiologyPub Date : 2025-01-14DOI: 10.1007/s11282-025-00804-7
Ceyda Gürhan, Hasan Yiğit, Selim Yılmaz, Cihat Çetinkaya
{"title":"A novel deep learning-based pipeline architecture for pulp stone detection on panoramic radiographs.","authors":"Ceyda Gürhan, Hasan Yiğit, Selim Yılmaz, Cihat Çetinkaya","doi":"10.1007/s11282-025-00804-7","DOIUrl":"https://doi.org/10.1007/s11282-025-00804-7","url":null,"abstract":"<p><strong>Objectives: </strong>Pulp stones are ectopic calcifications located in pulp tissue. The aim of this study is to introduce a novel method for detecting pulp stones on panoramic radiography images using a deep learning-based two-stage pipeline architecture.</p><p><strong>Materials and methods: </strong>The first stage involved tooth localization with the YOLOv8 model, followed by pulp stone classification using ResNeXt. 375 panoramic images were included in this study, and a comprehensive set of evaluation metrics, including precision, recall, false-negative rate, false-positive rate, accuracy, and F1 score was employed to rigorously assess the performance of the proposed architecture.</p><p><strong>Results: </strong>Despite the limited annotated training data, the proposed method achieved impressive results: an accuracy of 95.4%, precision of 97.1%, recall of 96.1%, false-negative rate of 3.9%, false-positive rate of 6.1%, and a F1 score of 96.6%, outperforming existing approaches in pulp stone detection.</p><p><strong>Conclusions: </strong>Unlike current studies, this approach adopted a more realistic scenario by utilizing a small dataset with few annotated samples, acknowledging the time-consuming and error-prone nature of expert labeling. The proposed system is particularly beneficial for dental students and newly graduated dentists who lack sufficient clinical experience, as it aids in the automatic detection of pulpal calcifications. To the best of our knowledge, this is the first study in the literature that propose a pipeline architecture to address the PS detection tasks on panoramic images.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral RadiologyPub Date : 2025-01-08DOI: 10.1007/s11282-024-00801-2
Nida Geçkil, Katibe Tuğçe Temur
{"title":"A retrospective comparative fractal and radiomorphometric analysis of the effect of bisphosphonate use pattern and duration on the mandible.","authors":"Nida Geçkil, Katibe Tuğçe Temur","doi":"10.1007/s11282-024-00801-2","DOIUrl":"https://doi.org/10.1007/s11282-024-00801-2","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study was to investigate the effect of two different bisphosphonate types on bone using dental panoramic radiographs (DPRs) and to compare these findings with a healthy cohort.</p><p><strong>Study design: </strong>Panoramic dental radiographs of bisphosphonate users (30) and healthy individuals (30) were retrospectively evaluated for the study. Regarding FA, standardized 50 × 50 pixel regions of interest (ROI) were identified for each patient. Moreover, the assessment encompassed Mandibular Cortical Width (MCW), Panoramic Mandibular Index (PMI), and Mandibular Cortical Index (MCI). A significance level of p < 0.05 was deemed to be statistically significant.</p><p><strong>Results: </strong>The case group showed significantly higher MCW and PMI measurements than the control group (p < 0.001). Right and left MCI measurements differed depending on the type of drug used (p = 0.008 and p = 0.019, respectively). No discernible correlation was found between the time elapsed since the last dose and any measurement values (p > 0.05).</p><p><strong>Conclusion: </strong>This study showed that bisphosphonate type and duration of drug use have a significant effect on changes in cortical bone structure. The persistence of these effects, unaffected by the time since the previous dose, suggests that bisphosphonates have a long-lasting effect on bone.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral RadiologyPub Date : 2025-01-01DOI: 10.1007/s11282-024-00783-1
Do Hoang Viet, Le Hoang Son, Do Ngoc Tuyen, Tran Manh Tuan, Nguyen Phu Thang, Vo Truong Nhu Ngoc
{"title":"Correction: Comparing the accuracy of two machine learning models in detection and classification of periapical lesions using periapical radiographs.","authors":"Do Hoang Viet, Le Hoang Son, Do Ngoc Tuyen, Tran Manh Tuan, Nguyen Phu Thang, Vo Truong Nhu Ngoc","doi":"10.1007/s11282-024-00783-1","DOIUrl":"10.1007/s11282-024-00783-1","url":null,"abstract":"","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":"151"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral RadiologyPub Date : 2025-01-01Epub Date: 2024-11-11DOI: 10.1007/s11282-024-00784-0
Nesrin Dundar, Elif Aslan, Onur Mutlu
{"title":"Fractal dimension, lacunarity, and bone area fraction analysis of peri-implant trabecular bone after prosthodontic loading.","authors":"Nesrin Dundar, Elif Aslan, Onur Mutlu","doi":"10.1007/s11282-024-00784-0","DOIUrl":"10.1007/s11282-024-00784-0","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the structural alterations in peri-implant bone occurring 5 years after prosthodontic loading in panoramic radiography (PR).</p><p><strong>Methods: </strong>PR images of 44 mandibular and 33 maxillary implants along with 42 healthy control teeth taken before and 5 years after prosthodontic loading were included. Two regions-of-interest (ROI) were selected from mesial and distal surrounding bone of each implant and tooth. Then, the selected ROIs were divided to obtain three sub-ROIs (coronal, middle, and apical) on each side. A total of eight ROIs and sub-ROIs from each implant and control tooth were used for the calculations of fractal dimension (FD), lacunarity, and bone area fraction (BA/TA). The paired-sample t test was used to compare measurements before and 5 years after loading (p = 0.05).</p><p><strong>Results: </strong>Overall evaluation of 77 implants showed that FD decreased at the middle and apical peri-implant bone levels 5 years after loading (p < 0.05). In mandibular implants, BA/TA decreased after loading (p < 0.05). While FD decreased at the coronal level (p = 0.022), lacunarity increased at the middle level of mandibular implants (p < 0.05). In maxillary implants, FD decreased at the middle and BA/TA decreased at the coronal level (p < 0.05). On the other hand, BA/TA increased at the apical level of maxillary implants (p = 0.016) after loading. None of the parameters revealed any difference in the control group (p > 0.05).</p><p><strong>Conclusions: </strong>FD and BA/TA can be used to analyze structural changes in peri-implant bone after prosthodontic loading. Additionally, FD, lacunarity and BA/TA may provide useful information about changes occurring at different levels of peri-implant bone.</p>","PeriodicalId":56103,"journal":{"name":"Oral Radiology","volume":" ","pages":"120-130"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}