{"title":"Bonding Performance of Self-etching Adhesives to Bur-cut Dentin with Active Application Mode.","authors":"Pipop Saikaew, Almas Chowdhury, Vanthana Sattabanasuk, Natchalee Srimaneekarn, Chayada Teanchai, Ricardo M Carvalho, Hidehiko Sano","doi":"10.3290/j.jad.b1645379","DOIUrl":"https://doi.org/10.3290/j.jad.b1645379","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated whether active application of self-etching adhesives would influence their microtensile bond strength (µTBS) to dentin cut with burs of different grit sizes.</p><p><strong>Materials and methods: </strong>Eighty-four human premolars were divided into 12 groups according to 1) two dentin surface preparations with either superfine- or regular-grit diamond burs; 2) three adhesives - Clearfil SE Bond 2 (SE2), Scotchbond Universal (SBU, 3M Oral Care) and G-Premio Bond (GPB, GC); and 3) two application modes of each adhesive (active or passive). Six bonded teeth per group were sectioned into sticks for µTBS testing. Statistical analyses were performed using 3-way ANOVA followed by Duncan's test (p < 0.05). Additional teeth were prepared to observe the interaction between the dentin smear layer obtained from each bur with adhesives under different application modes using transmission electron microscopy (TEM).</p><p><strong>Results: </strong>Active application significantly increased the dentin bond strength of SE2, irrespective of the kind of bur used (p < 0.05). The highest bond strength of SBU was observed when bonded to superfine-grit diamond bur-cut dentin with the active application. There was, however, no influence of the tested factors on GPB group (p > 0.05). TEM observation showed that active application promoted dentin smear layer dissolution in all adhesive groups.</p><p><strong>Conclusions: </strong>Bond strengths of self-etching adhesives to dentin are influenced by bur-cut smear layers and mainly by application mode of adhesive materials. Active application improves µTBS of self-etching adhesives by enhancing smear layer modification and resin penetration into bur-cut dentin.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 4","pages":"357-365"},"PeriodicalIF":3.3,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Surface Moisture on Bur-cut Dentin on Bonding of HEMA-free and HEMA-containing Universal Adhesives with or without Methacrylamide Monomer.","authors":"Nooruldeen Ali Saeed, Antonin Tichy, Yusuke Kuno, Keiichi Hosaka, Junji Tagami, Masatoshi Nakajima","doi":"10.3290/j.jad.b1650121","DOIUrl":"https://doi.org/10.3290/j.jad.b1650121","url":null,"abstract":"<p><strong>Purpose: </strong>The effect of surface moisture on bur-cut dentin on the microtensile bond strength (μTBS) of universal adhesives with various contents of 2-hydroxyethyl methacrylate (HEMA) and methacrylamide monomers was evaluated.</p><p><strong>Materials and methods: </strong>Flat mid-coronal dentin surfaces of human molars were exposed, and a standardized smear layer was prepared using a fine-grit diamond bur. The surfaces were either left wet or air dried for 10 s before bonding with Clearfil Universal Bond Quick (UBQ), experimental UBQ without an amide monomer (UBQexp), Scotchbond Universal (SBU), Prime&Bond Universal (PBU), or BeautiBond Universal (BBU). The specimens were built up with resin composite, sectioned into sticks and subjected to the μTBS test after 24 h or 10,000 thermal cycles. The μTBS data were analyzed using three-way ANOVA followed by pairwise comparisons with Bonferroni's correction (α = 0.05).</p><p><strong>Results: </strong>The level of dentin moisture did not significantly affect μTBS of UBQ and BBU (p > 0.05). HEMA-containing UBQ, UBQexp, and SBU exhibited higher μTBS to dry dentin, while HEMA-free PBU and BBU showed higher μTBS to wet dentin. Thermocycling significantly decreased the μTBS of UBQexp (p < 0.01) and BBU (p < 0.001) irrespective of dentin moisture level, while SBU was significantly affected only on dry dentin (p < 0.001). Thermocycling had no significant effect on UBQ and PBU containing methacrylamide monomers (p > 0.05).</p><p><strong>Conclusion: </strong>Dry surfaces enabled obtaining optimal bonding for HEMA-containing adhesives to bur-cut dentin, while wet surfaces enabled optimal bonding for HEMA-free adhesives. Methacrylamide monomers could contribute to the improvement of the initial and long-term bonding performance of universal adhesives to bur-cut dentin.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 4","pages":"327-334"},"PeriodicalIF":3.3,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39190492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: Adhesive Dentistry in the Mirror of Excellent Research.","authors":"Roland Frankenberger, Bart Van Meerbeek","doi":"10.3290/j.jad.b1492431","DOIUrl":"10.3290/j.jad.b1492431","url":null,"abstract":"","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"183"},"PeriodicalIF":2.5,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39038241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thatiana V Leite, Diogo Henrique da Silva, Gabriela de Mello Nunes Esposo, Flávio Henrique Baggio Aguiar, Adriano F Lima, Giselle M Marchi
{"title":"Positive Synergistic Effect of Adhesives and Resin Cements Containing an Iodonium Salt on Bonding of Fiber Posts.","authors":"Thatiana V Leite, Diogo Henrique da Silva, Gabriela de Mello Nunes Esposo, Flávio Henrique Baggio Aguiar, Adriano F Lima, Giselle M Marchi","doi":"10.3290/j.jad.b1367843","DOIUrl":"https://doi.org/10.3290/j.jad.b1367843","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the push-out bond strength (PBS) of glass-fiber posts (GFP) in different root canal zones (cervical, middle, and apical), bonded with experimental simplified adhesives (ESAs) containing different initiator systems (camphorquinone [CQ] or phenylpropanodione [PPD]) with or without diphenyl iodonium hexafluorophosphate (DPI), in combination with a DPI-containing composite cement.</p><p><strong>Materials and methods: </strong>ESA blends were prepared with bisphenol glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEG-DMA), 1,3-glycerol dimethacrylate (GDMA), 2-hydroxyethyl methacrylate (HEMA), and ethanol, then divided into 12 experimental groups (n = 10) according to the initiator systems (CQ, PPD, or CQ + PPD) and the presence or absence of DPI. The roots of 120 extracted bovine incisors were prepared with #5 Largo drills and the GFP were cemented with each ESA and experimental composite cements containing 0.05 mol% of DPI. The push-out bond strength (PBS) test was performed after 24 h of storage. Failure patterns were analyzed under a stereomicroscope. Data were analyzed with split-plot two-way ANOVA and Tukey's test (α = 0.05).</p><p><strong>Results: </strong>PBS was significantly higher for DPI-containing ESAs in all regions evaluated, with the group containing 0.5 CQ + 1 PPD + 0.5 DPI exhibiting the highest PBS. There was no statistically signficant difference among groups without DPI. Most failures were classified as adhesive at the cement-dentin interface.</p><p><strong>Conclusions: </strong>The combination of an adhesive and a composite cement containing DPI salt can improve GFP bonding to root dentin, even in the apical region.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"217-222"},"PeriodicalIF":3.3,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39038244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marleen Peumans, Stefanie Vandormael, Anna Heeren, Jan De Munck, Bart Van Meerbeek
{"title":"Six-year Clinical Performance of a 2-step Self-etch Adhesive in Noncarious Cervical Lesions.","authors":"Marleen Peumans, Stefanie Vandormael, Anna Heeren, Jan De Munck, Bart Van Meerbeek","doi":"10.3290/j.jad.b1367831","DOIUrl":"https://doi.org/10.3290/j.jad.b1367831","url":null,"abstract":"<p><strong>Purpose: </strong>Mild and intermediately strong 2-step self-etch adhesives (2SEa) have been shown to bond efficiently to dentin. In general, their bonding efficiency to enamel is inferior to that of etch & rinse adhesives (E&Ra). On the other hand, their application procedure is less elaborate, and consequently leaves less room for application mistakes. The aim of this randomized controlled trial was to evaluate the clinical performance of an intermediately strong 2SEa, as compared with that of a 3-step E&Ra after 6 years of clinical functioning.</p><p><strong>Materials and methods: </strong>239 non-carious cervical lesions in 50 patients were restored with the nanohybrid composite Herculite XRV (Kerr), bonded in random order either with the 2SEa Optibond XTR ('O-XTR', Kerr) or the gold-standard control 3E&Ra Optibond FL ('O-FL', Kerr). The restorations were recalled after 1, 2 and 6 years of clinical service and examined for retention, marginal adaptation, marginal discoloration, caries occurrence, and postoperative sensitivity. Statistical analysis was performed using a logistic regression model with generalized estimating equations (2-way GEE model).</p><p><strong>Results: </strong>The patient recall rate at 6 years was 94%. The overall clinical success rate was 81.9% and 80.9% for O-XTR and O-FL, respectively. In total, 42 restorations (21 O-XTR, 21 O-FL) failed because of retention loss, severe abfraction/abrasion/erosion, severe marginal defects and/or discoloration, and/or caries. A retention rate of 92.9% and 88.9% was recorded for O-XTR and O-FL, respectively. Progressive marginal deterioration was observed over the 6-year period. Small clinically acceptable marginal defects were recorded in about 70% of the restorations (O-XTR: 69.9%; O-FL: 74.1%). Regarding marginal discoloration, 37% of the O-XTR and 30.2% of the O-FL restorations showed superficial clinically acceptable marginal discoloration. Six O-XTR and 4 O-FL restorations exhibited caries at the restoration margin. No significant difference was observed between the two groups for any of the evaluated parameters (p > 0.05).</p><p><strong>Conclusion: </strong>After 6 years of clinical service, Class-V restorations bonded with the 2SEa performed clinically equally well as those bonded with the 3E&Ra.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"201-215"},"PeriodicalIF":3.3,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39038243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self-etch Approach of Universal Adhesives as an Alternative to Minimize Bond Degradation on Sound Dentin vs Caries-affected Dentin over Time.","authors":"Andressa Cargnelutti Follak, Leonardo Lamberti Miotti, Tathiane Larissa Lenzi, Rachel de Oliveira Rocha, Fabio Zovico Maxnuck Soares","doi":"10.3290/j.jad.b1367889","DOIUrl":"https://doi.org/10.3290/j.jad.b1367889","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the influence of the etching strategy of universal adhesives on bond degradation to sound and artificially-induced caries-affected dentin.</p><p><strong>Materials and methods: </strong>The universal adhesives (Scotchbond Universal Adhesive; All-Bond Universal; Prime&Bond Elect) and adhesives used as controls (Adper Single Bond 2 and Clearfil SE Bond) were applied to sound and artificially-induced caries-affected bovine dentin. Microtensile bond strength was evaluated immediately (24 h) and after one year of water storage (1 year). Representative specimens were also prepared to assess nanoleakage. Bond strength data (MPa) were analyzed using three-way ANOVA and post-hoc Tukey's test (α = 0.05), considering each substrate separately.</p><p><strong>Results: </strong>Bonding degradation was observed for all universal adhesives on caries-affected dentin, irrespective of the etching strategy. On sound dentin, bonding degradation was observed when adhesives were used on the etch-and-rinse strategy.</p><p><strong>Conclusion: </strong>The universal adhesives were not capable of maintaining bond stability over time on caries-affected dentin. The self-etch strategy seems better able to maintain the durability of adhesive interfaces created on sound dentin.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"243-252"},"PeriodicalIF":3.3,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38958375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Constantinos Papadopoulos, Dimitrios Dionysopoulos, Kimon Pahinis, Elisabeth Koulaouzidou, Kosmas Tolidis
{"title":"Microtensile Bond Strength Between Resin-Matrix CAD/CAM Ceramics and Resin Cement after Various Surface Modifications and Artificial Aging.","authors":"Constantinos Papadopoulos, Dimitrios Dionysopoulos, Kimon Pahinis, Elisabeth Koulaouzidou, Kosmas Tolidis","doi":"10.3290/j.jad.b1367903","DOIUrl":"https://doi.org/10.3290/j.jad.b1367903","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of different surface modification methods on the microtensile bond strength (μTBS) of four resin-matrix CAD/CAM ceramics after artificial aging.</p><p><strong>Materials and methods: </strong>Specimens of four CAD/CAM materials (Shofu Block HC, Lava Ultimate, Brilliant Crios, and Vita Enamic) were prepared and divided into four groups. Each group received one of the following treatments: group 1 (INT): no surface modification; group 2: sandblasting with 29-μm Al2O3 particles (SB); group 3: hydrofluoric acid etching (9%) + silane (HF+Si); group 4: sandblasting with 30-μm particles of the CoJet system (CJ). The specimens of each group were luted together in pairs using resin cement (RelyX Ultimate). After one week of water storage (37°C), the sandwich specimens were sectioned into rectangular microspecimens and half of them were immediately subjected to μTBS testing, while the other half was tested after six months. Data were statistically analyzed using FFANOVA including the factors of material, treatment, and storage time, with α = 0.05.</p><p><strong>Results: </strong>After one week, the lowest μTBS was observed for INT, while the highest was found for either mechanical (SB and CJ) or chemical (HF+Si) treatments (p < 0.05). After six months, a significant decrease in μTBS was observed depending on treatment (p < 0.05), while artificial aging significantly influenced the μTBS of all experimental groups (p < 0.05). During the two storage periods, the failure type was mainly interfacial and was associated with the type of surface modification.</p><p><strong>Conclusion: </strong>After artificial aging, the μTBS appeared to depend on srface modification, while the parameter \"material\" did not influence the results. Consequently, adhesive strategies should be oriented towards surface modification techniques.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"255-265"},"PeriodicalIF":3.3,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38958376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Putsadeeporn Thammajaruk, Supanee Buranadham, Massimiliano Guazzato, Yu Wang
{"title":"Shear Bond Strength of Composite Cement to Lithium-Disilicate Glass-coated Zirconia Versus Alumina Air-abraded Zirconia.","authors":"Putsadeeporn Thammajaruk, Supanee Buranadham, Massimiliano Guazzato, Yu Wang","doi":"10.3290/j.jad.b1367913","DOIUrl":"https://doi.org/10.3290/j.jad.b1367913","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the shear bond strength of composite cement to lithium-disilicate glass-ceramic coated zirconia vs to alumina air-abraded zirconia and to analyze the residual stresses on both of lithium-disilicate glass-ceramic coated zirconia vs alumina air-abraded zirconia specimens.</p><p><strong>Materials and methods: </strong>One hundred eighty zirconia disks (diameters 10 mm and 5 mm, 4.5 mm thick) were divided into two groups: lithium-disilicate glass-ceramic coating followed by hydrofluoric acid etching and Monobond N Primer (LiDi) or alumina air-abrasion (AA). For each group, two different sizes of identically pre-treated zirconia specimens were bonded with Multilink Speed Cement. A total of 90 specimens were stored in distilled water at 37°C for 24 h and then assigned to three subgroups (n = 15/test group): 1. short-term test; 2. thermocycling for 5000 cycles; 3. thermocycling for 10,000 cycles. Bond strength was tested in shear mode and results were analyzed using two-way ANOVA, followed by one-way ANOVA and Tukey's HSD (α = 0.05). Failure mode and surfaces were analyzed with optical and scanning electron microscopy. X-ray diffraction was used to analyze t-m phase transformation and residual stresses on mechanically pre-treated LiDi and AA surfaces.</p><p><strong>Results: </strong>The LiDi groups recorded higher mean bond strength than AA groups after thermocycling (p < 0.05). Thermocycling did not affect the bond strength of either LiDi or AA groups (p > 0.05). Most of specimens in AA groups exhibited mixed failure. Alumina air-abraded surfaces exhibited higher residual compressive stresses than did surfaces with a lithium-disilicate glass-ceramic coating.</p><p><strong>Conclusion: </strong>Following thermocycling, composite-zirconia bond strength of specimens with a lithium-disilicate glass-ceramic coating was greater than that of alumina air-abraded specimens.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"267-275"},"PeriodicalIF":3.3,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38958377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayara de Oliveira Souza, Raisa Santiago Sousa, Cristina Pereira Isolan, Rafael Ratto de Moraes, Giana da Silveira Lima, Diego Lomonaco, Diego Martins de Paula, Adyson Herbert Alves, Vicente de Paulo Sabóia, Victor Pinheiro Feitosa
{"title":"Intraradicular Dentin Biomodification with Natural Agents for Bonding Glass-fiber Posts.","authors":"Nayara de Oliveira Souza, Raisa Santiago Sousa, Cristina Pereira Isolan, Rafael Ratto de Moraes, Giana da Silveira Lima, Diego Lomonaco, Diego Martins de Paula, Adyson Herbert Alves, Vicente de Paulo Sabóia, Victor Pinheiro Feitosa","doi":"10.3290/j.jad.b1367855","DOIUrl":"https://doi.org/10.3290/j.jad.b1367855","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of pretreatment with different crosslinking agents on glass-fiber-post adhesive luting.</p><p><strong>Materials and methods: </strong>Single-rooted human teeth (n = 20) were randomly assigned to four groups: proanthocyanidins (PA) from grape-seed extract, cardol and cardanol (separated from cashew nut-shell liquid) and negative control (hydroethanolic solution). The solutions were applied on 37% phosphoric acid-etched dentin for 60 s. Glass-fiber posts were cemented using a three-step etch-and-rinse adhesive (Scotchbond Multi-Purpose, 3M Oral Care) and composite cement (RelyX ARC, 3M Oral Care). Slices for the push-out bond strength test were cut and tested after 24-h or 6-month storage in distilled water. The dentin underlying the adhesive layer was analyzed by micro-Raman spectroscopy to evaluate vibrational formation of collagen crosslinks. Three additional slices per group were also made and the adhesive in-situ degree of conversion (DC) was analyzed by micro-Raman spectroscopy. The results were analyzed using two-way ANOVA and Tukey's test (p < 0.05).</p><p><strong>Results: </strong>No statistically significant changes in bond strength were found over time for any of the groups, except with cardol, which increased bond strength (8.4 ± 3.9 MPa at 24 h to 15.0 ± 2.9 MPa after 6 months, p < 0.001) after aging. The formation of peaks at 1117 cm-1 and 1235 cm-1 showed the presence of collagen crosslinks for all three biomodification agents. The DC outcomes showed no statistically significant differences between groups (p = 0.514).</p><p><strong>Conclusion: </strong>Biomodification agents did not impair adhesive polymerization. Cardol demonstrated a positive influence on intraradicular dentin bonding for glass-fiber post luting.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":"23 3","pages":"223-230"},"PeriodicalIF":3.3,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39038245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}