Allergy & Clinical Immunology International最新文献_第4页

Genetic mechanisms of aspirin hypersensitivity 阿司匹林过敏的遗传机制

Allergy & Clinical Immunology International Pub Date : 2006-07-01 DOI: 10.1027/0838-1925.18.4.150

Hae‐Sim Park, G. Hur, Seung-Hyun Kim, Y. Ye, Sang-Ha Kim

引用次数: 2

Dendritic cells in allergic disease - innocent bystanders or prime suspects? 过敏性疾病中的树突状细胞——无辜的旁观者还是主要嫌疑人?

Allergy & Clinical Immunology International Pub Date : 2006-03-01 DOI: 10.1027/0838-1925.18.2.71

S. Yerkovich, A. Rate, J. Upham

{"title":"Dendritic cells in allergic disease - innocent bystanders or prime suspects?","authors":"S. Yerkovich, A. Rate, J. Upham","doi":"10.1027/0838-1925.18.2.71","DOIUrl":"https://doi.org/10.1027/0838-1925.18.2.71","url":null,"abstract":"Background: Dendritic cells (DC) are potent antigen-presenting cells that have a critical role in regulating immune responses. It is now widely recognized that DC play an important role in allergic diseases in both the initial sensitization phase and in the maintenance of allergic airway inflammation. Methods/Data base: A review of the literature. Results/Conclusion: DC form a close network within the respiratory mucosa, and are rapidly recruited from the circulation in response to allergen challenge. Studies from animal models have indicated that these DC capture allergens from the airway and subsequently prime a T-helper cell type 2 (Th2)-mediated immune response, with the development of airway inflammation. Increased DC numbers are also present in humans with allergic disease and evidence is increasing to suggest that there are functional differences between DC of allergic and normal individuals. While several mechanisms have been proposed to explain how DC are involved in the dysregulated immune response to seemingly harmless allergens in individuals with allergic disease, the exact pathways involved remain to be elucidated. However, it can be seen that DC are one of the central mediators in allergic disease and it will be important to increase our understanding of their role in the allergic setting to provide future therapies.","PeriodicalId":55539,"journal":{"name":"Allergy & Clinical Immunology International","volume":"91 1","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85408912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mouse models of asthma: what physiological evidence are they based on? 小鼠哮喘模型:基于什么生理证据?

Allergy & Clinical Immunology International Pub Date : 2006-03-01 DOI: 10.1027/0838-1925.18.2.76

G. Zosky, P. Sly, D. Turner

{"title":"Mouse models of asthma: what physiological evidence are they based on?","authors":"G. Zosky, P. Sly, D. Turner","doi":"10.1027/0838-1925.18.2.76","DOIUrl":"https://doi.org/10.1027/0838-1925.18.2.76","url":null,"abstract":"Background: Asthma is a chronic inflammatory disease of the lungs that is characterized by airway hyperresponsiveness (AHR) to bronchoconstricting stimuli. The physiological response of the asthmatic lung to inhaled allergen is often characterized by two distinct phases: An early-phase response (EPR) within the first hour following exposure which subsides, and a late-phase response (LPR) that is more prolonged and may occur several hours later. Ideally, a mouse model of asthma should be able to mimic all phases of the lung dysfunction associated with asthma. Methods/Data base: A review of the literature. Results/Conclusions: To date, a majority of the studies using mouse models of asthma have focussed on AHR as a physiological outcome measure. The few studies that have examined the EPR and LPR have been limited by the use of inappropriate and inaccurate measures of lung mechanics. On the basis of current evidence, it would appear that LPR is not correlated with presence of AHR in mice. Future studies should be aimed at determining the presence of a physiological late-phase response in mouse models of asthma and whether or not it is correlated with AHR as seen in human asthmatics.","PeriodicalId":55539,"journal":{"name":"Allergy & Clinical Immunology International","volume":"13 1","pages":"76-79"},"PeriodicalIF":0.0,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81316946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Five great allergists 五大过敏症专家

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.1.22

M. Kaliner, H. Claman, K. Ishizaka, S. Johansson, P. Norman, D. Talmage

引用次数: 0

Minthostachys verticillata (Griseb.) Epling

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.6.234

Laura Noelia Cariddi, M. González-Pereyra, M. Gambero, A. M. Maldonado, M. Demo, M. Isola, L. Franzoni, L. Sabini

引用次数: 2

Allergy Goes Global: Ragweed Comes to Central Europe 过敏走向全球:豚草来到中欧

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.5.178

J. Ring

引用次数: 0

Welcome to Philadelphia 欢迎来到费城

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.5.177

M. Blaiss

引用次数: 0

Asthma Mortality Worldwide 全球哮喘死亡率

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.5.214

H. Neffen

引用次数: 0

In the Palm of Your Hand 在你的掌心

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.3.134

C. Hogrefe

引用次数: 14

Bronchopulmonary Dysplasia in Premature Infants 早产儿支气管肺发育不良

Allergy & Clinical Immunology International Pub Date : 2006-01-01 DOI: 10.1027/0838-1925.18.5.192

M. Frieri, Eliezer Seguerra, Viviana Sirven

引用次数: 4