Archiv Fur Entwicklungsmechanik Der Organismen最新文献

Assessing Longwall Gateroad Ground Response and Support Alternatives. 评估长壁加特鲁德地面响应和支持替代方案。

IF 1.9

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2021-05-13 DOI: 10.1007/s42461-021-00430-x

Gabriel S Esterhuizen, Ted Klemetti, Morgan M Sears, Peter Zhang, Mark van Dyke, Heather Dougherty, I Berk Tulu

{"title":"Assessing Longwall Gateroad Ground Response and Support Alternatives.","authors":"Gabriel S Esterhuizen, Ted Klemetti, Morgan M Sears, Peter Zhang, Mark van Dyke, Heather Dougherty, I Berk Tulu","doi":"10.1007/s42461-021-00430-x","DOIUrl":"10.1007/s42461-021-00430-x","url":null,"abstract":"Ground falls in longwall gateroad entries remain a concern in modern longwall operations. The gateroads are subject to changing horizontal and vertical ground stress induced by longwall extraction. These stress changes can result in failure of the strata around an entry leading to large deformations of the entry roof, floor, and ribs. The gateroad support systems are required to control the failed strata while maintaining safe access to the longwall face and unimpeded ventilation. This paper presents research that was conducted to better understand the stability issues in gateroad excavations and to develop procedures for evaluating support and layout alternatives for longwall gateroads. Using the results of a field-monitoring program and numerical model analysis of case histories, a conceptual model of gateroad support needs was developed. The conceptual model formed the basis for developing a set of equations that can be used to estimate likely roof sag and support loading for given roof geology and longwall-induced loading conditions. The developed equations were used to compare predicted gateroad stability to field study results, showing satisfactory agreement. The calculation procedures are used to demonstrate their application in assessing support alternatives at a case study mine. It is concluded that the developed analysis procedures provide realistic assessments of likely ground stability and can be used to evaluate alternative gateroad support systems at operating longwall mines.","PeriodicalId":55488,"journal":{"name":"Archiv Fur Entwicklungsmechanik Der Organismen","volume":"41 1","pages":"1739-1759"},"PeriodicalIF":1.9,"publicationDate":"2021-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11119955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73315642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differentiation without cleavage in the egg of the annelid chaetopterus pergamentaceus 无卵裂环节动物卵的分化

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2018-02-21 DOI: 10.1007/BF02188500

F. R. Lillie

引用次数: 23

Plaque imaging to refine indications for emerging lipid-lowering drugs. 通过斑块成像来完善新兴降脂药物的适应症。

IF 7.1

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2017-01-01 Epub Date: 2016-11-04 DOI: 10.1093/ehjcvp/pvw034

Mohammad Alkhalil, Joshua T Chai, Robin P Choudhury

{"title":"Plaque imaging to refine indications for emerging lipid-lowering drugs.","authors":"Mohammad Alkhalil, Joshua T Chai, Robin P Choudhury","doi":"10.1093/ehjcvp/pvw034","DOIUrl":"10.1093/ehjcvp/pvw034","url":null,"abstract":"Statins have been effective in reducing adverse cardiovascular events. Their benefits have been proportional to the level of plasma LDL-cholesterol reduction and seem to extend to patients with 'normal' levels of cholesterol at outset. Statins are also inexpensive and have a favourable side-effect profile. As a result, they are used widely (almost indiscriminately) in patients with atherosclerotic vascular disease, and in those at risk of disease. Next generation lipid-modifying drugs seem unlikely to offer the same simplicity of application. The recent trials of new classes of lipid modifying drugs underline the need for a risk stratification tool which is not based on patients' category of diagnosis (for example, post-myocardial infarction) but based on the characterization of disease in that individual patient. Mechanistic staging, a process that matches the target of the drug action with an identifiable disease characteristic, may offer an opportunity to achieve more precise intervention. The upshots of this targeted approach will be greater efficacy, requiring smaller clinical trials to demonstrate effectiveness; a reduced number needed to treat to yield benefits and more cost-effective prescribing. This will be important, as purchasers require ever more rigorous demonstration of both efficacy and cost-effectiveness. In this context, we will discuss available pharmacological strategies of lipid reduction in anti-atherosclerotic treatment and how plaque imaging techniques may provide an ideal method in stratifying patients for new lipid-modifying drugs.","PeriodicalId":55488,"journal":{"name":"Archiv Fur Entwicklungsmechanik Der Organismen","volume":"26 1","pages":"58-67"},"PeriodicalIF":7.1,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73191430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease. 通过全脑核磁共振成像可预测阿尔茨海默氏症患者的雷氏听觉言语学习测试得分。

IF 4.2

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2016-12-18 eCollection Date: 2017-01-01 DOI: 10.1016/j.nicl.2016.12.011

Elaheh Moradi, Ilona Hallikainen, Tuomo Hänninen, Jussi Tohka

{"title":"Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease.","authors":"Elaheh Moradi, Ilona Hallikainen, Tuomo Hänninen, Jussi Tohka","doi":"10.1016/j.nicl.2016.12.011","DOIUrl":"10.1016/j.nicl.2016.12.011","url":null,"abstract":"Rey's Auditory Verbal Learning Test (RAVLT) is a powerful neuropsychological tool for testing episodic memory, which is widely used for the cognitive assessment in dementia and pre-dementia conditions. Several studies have shown that an impairment in RAVLT scores reflect well the underlying pathology caused by Alzheimer's disease (AD), thus making RAVLT an effective early marker to detect AD in persons with memory complaints. We investigated the association between RAVLT scores (RAVLT Immediate and RAVLT Percent Forgetting) and the structural brain atrophy caused by AD. The aim was to comprehensively study to what extent the RAVLT scores are predictable based on structural magnetic resonance imaging (MRI) data using machine learning approaches as well as to find the most important brain regions for the estimation of RAVLT scores. For this, we built a predictive model to estimate RAVLT scores from gray matter density via elastic net penalized linear regression model. The proposed approach provided highly significant cross-validated correlation between the estimated and observed RAVLT Immediate (R = 0.50) and RAVLT Percent Forgetting (R = 0.43) in a dataset consisting of 806 AD, mild cognitive impairment (MCI) or healthy subjects. In addition, the selected machine learning method provided more accurate estimates of RAVLT scores than the relevance vector regression used earlier for the estimation of RAVLT based on MRI data. The top predictors were medial temporal lobe structures and amygdala for the estimation of RAVLT Immediate and angular gyrus, hippocampus and amygdala for the estimation of RAVLT Percent Forgetting. Further, the conversion of MCI subjects to AD in 3-years could be predicted based on either observed or estimated RAVLT scores with an accuracy comparable to MRI-based biomarkers.","PeriodicalId":55488,"journal":{"name":"Archiv Fur Entwicklungsmechanik Der Organismen","volume":"5 1","pages":"415-427"},"PeriodicalIF":4.2,"publicationDate":"2016-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73176659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further studies on the action of Salt-Solutions and of other agents on the Eggs of Arbacia 盐溶液及其他药剂对紫金蟹卵作用的进一步研究

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2015-08-26 DOI: 10.1007/BF02156645

T. Morgan

引用次数: 9

Further experiments on the regeneration of the tail of fishes 鱼尾再生的进一步实验

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2015-08-13 DOI: 10.1007/BF02188503

T. Morgan

引用次数: 23

Observations and experiments on regeneration in Planarians 涡虫再生的观察与实验

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2015-08-13 DOI: 10.1007/BF02162271

H. Randolph

引用次数: 56

Variation and regulation of abnormalities in Hydra 九头蛇畸形的变异与调控

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2012-05-11 DOI: 10.1007/BF02318644

H. H. Parke

引用次数: 11

Activities of polar bodies of Cerebratulus 小脑属植物极体的活动

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2012-04-16 DOI: 10.1007/BF02152957

E. A. Andrews

引用次数: 1

Regeneration in Bipalium Bipalium的再生

Archiv Fur Entwicklungsmechanik Der Organismen Pub Date : 2012-03-05 DOI: 10.1007/BF02156194

T. Morgan

引用次数: 10