Asian Nursing Research最新文献

{"title":"The relationship between PEEP variability and 28-day mortality in patients with ARDS: a retrospective study from MIMIC-IV database.","authors":"Shaona Liao, Nie Anliu, Shuzeng Zhang, Zhi-Sheng Zhang, Rui Chu Zhang, Xiangfen Su, Jianfeng Li","doi":"10.1016/j.anr.2026.07.002","DOIUrl":"https://doi.org/10.1016/j.anr.2026.07.002","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the relationship between PEEP variability and 28-day mortality in patients with Acute Respiratory Distress Syndrome (ARDS).</p><p><strong>Methods: </strong>A retrospective analysis was performed utilizing data from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Patients with ARDS were categorized into survival and death groups based on 28-day mortality. Differences between these groups were assessed using chi-square tests, t-tests, and the Mann-Whitney U test. Binary logistic regression analysis was performed to identify factors influencing 28-day mortality in ARDS patients. The restricted cubic spline (RCS) was used to examine the dose-response relationship between PEEP variability and 28-day mortality, with subgroup analyses by ARDS severity and interaction tests for PEEP variability and ARDS severity.</p><p><strong>Results: </strong>Among 555 included patients, 348 were in the survival group and 207 in the death group. Binary logistic regression indicated PEEP variability was independently associated with 28-day mortality in ARDS patients. RCS analysis revealed a significant nonlinear correlation (χ² = 8.71, df = 1, p = .003). Low PEEP variability predicted higher 28-day mortality, with the risk curve plateauing at 28.9%. Subgroup analyses revealed a significant nonlinear association in the mild ARDS subgroup (χ²=10.11, df=1, p=.002), with a comparable 28.9% threshold. The moderate-to-severe subgroup showed no significance (χ²=0.03, df=1, p=.854) but consistent trends and an identical inflection point. Interaction analysis confirmed no significant interaction between PEEP variability and ARDS severity (p_{for interaction}=.197).</p><p><strong>Conclusions: </strong>Lower PEEP variability was significantly associated with a higher 28-day mortality risk in ARDS patients, with a threshold at 28.9%. These findings highlight the potential prognostic value of PEEP variability, which may serve as a cost-effective indicator to facilitate individualized PEEP titration in mechanically ventilated ARDS patients. Further prospective studies are warranted to validate these findings.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148586098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a sequential simulation and online learning intervention on psychiatric mental health nurses' motivational interviewing knowledge, confidence, and skill performance for medication adherence: a cluster-randomized controlled trial.","authors":"Wen-Ling Hsieh, I-Hsien Li, Tsui-Mei Hung, Chin-Kuai Chiu, Wen-I Liu","doi":"10.1016/j.anr.2026.07.001","DOIUrl":"https://doi.org/10.1016/j.anr.2026.07.001","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness of a sequential dual-track learning intervention that combined a simulation-based motivational interviewing (MI) workshop with online practice learning in enhancing psychiatric mental health nurses' (PMHNs') knowledge, confidence, and performance in MI for medication adherence.</p><p><strong>Methods: </strong>A parallel cluster-randomized controlled trial was conducted in four psychiatric hospitals. Participants were allocated to experimental or control groups. The intervention consisted of an 8-hour simulation-based MI workshop followed by a four-month online practice learning phase. Outcomes-MI knowledge, confidence, and skill performance-were assessed at baseline (T0), immediately after the workshop (T1), and after online practice learning (T2). Changes over time were analyzed using repeated-measures analysis of variance.</p><p><strong>Results: </strong>In total, 107 PMHNs completed all three assessments (experimental = 52; control = 55). The sequential dual-track learning intervention produced significant group-by-time effects for knowledge (F (2, 210) = 4.96, p = .011), confidence (F (2, 210) = 4.63, p = .011), and skill performance (F (2, 210) = 41.20, p < .001). The experimental group showed substantially greater gains than the control group at T1, and these gains were observed at T2, with no significant T2-T1 differences despite a small decline in mean skill scores.</p><p><strong>Conclusion: </strong>The sequential dual-track learning intervention, integrating a simulation-based MI workshop with online practice learning, effectively improved PMHNs' MI knowledge, confidence, and skill performance for medication adherence and provides a flexible, scalable model for evidence-based continuing education in psychiatric nursing.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT06004492 (August 16, 2023).</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of an online maternal-fetal interaction promotion program using a photo diary.","authors":"Sangyoun Jang, Kyung-Sook Bang","doi":"10.1016/j.anr.2026.06.004","DOIUrl":"https://doi.org/10.1016/j.anr.2026.06.004","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a program to promote maternal-fetal interactions during pregnancy and to evaluate its effectiveness.</p><p><strong>Methods: </strong>This study used a quasi-experimental, non-equivalent control group pretest-posttest design. The participants were 34 pregnant women at 16-28 weeks of gestation. The program was developed according to the five stages of the analysis, design, development, implementation, and evaluation (ADDIE) instructional design model, based on Barnard's child health assessment interaction model. The maternal-fetal interaction promotion program consisted of five sessions of real-time, online photo-diary-based interventions. Data were analyzed using descriptive statistics, the Mann-Whitney U test, the chi-square test, and Fisher's exact test.</p><p><strong>Results: </strong>The results showed significant differences in maternal-fetal interaction beliefs (z = 2.66, p = .007), maternal-fetal interaction (z = 2.63, p = .008), and happiness (z = 2.47, p = .012) between the experimental and control groups.</p><p><strong>Conclusions: </strong>This study confirmed that a maternal-fetal interaction promotion program using a photo diary via interactive real-time videos can help pregnant women improve their maternal-fetal interaction beliefs, interactions, and happiness. This program contributes to the expansion of community nursing practices by providing online interventions for pregnant women.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elder abuse and its associated factors in community settings in South Korea.","authors":"Hyeyeon Yeon, Jina Choo","doi":"10.1016/j.anr.2026.06.003","DOIUrl":"https://doi.org/10.1016/j.anr.2026.06.003","url":null,"abstract":"<p><strong>Purpose: </strong>Elder abuse is an underdetected yet consequential public health issue in rapidly aging societies. This study estimated its population-level prevalence and examined associated factors among community-dwelling older adults in South Korea.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using data from the 2023 National Survey of Older Koreans (N = 10,078). Population-representative estimates were derived using complex-sample procedures incorporating stratification, clustering, and sampling weights. Elder abuse was defined as any self-reported physical, sexual, or emotional abuse in the past year. Complex-sample multivariable logistic regression was used to estimate adjusted odds ratios (aORs).</p><p><strong>Results: </strong>The weighted prevalence of past-year elder abuse was 4.8%, with emotional abuse predominating. Dependence in basic activities of daily living was significantly associated with higher odds of abuse, while independence in instrumental activities of daily living was also associated with increased odds (aOR = 2.39), indicating heterogeneity in vulnerability pathways. Participation in volunteer group activities was significantly associated with lower odds (aOR = 0.43). Higher levels of informal social contact were significantly associated with increased odds of sexual abuse (aOR = 6.49).</p><p><strong>Conclusions: </strong>Elder abuse reflects complex, multi-domain vulnerabilities shaped by functional status and social exposure. These findings underscore the need for targeted screening and strengthened community-based surveillance, and provide a foundation for advancing the role of community health nurses in identifying hidden at-risk populations and leading coordinated, community-based elder abuse prevention efforts.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decent work in nursing: A concept analysis.","authors":"Mohamed Ali Zoromba, Heba Emad El-Gazar","doi":"10.1016/j.anr.2026.06.001","DOIUrl":"https://doi.org/10.1016/j.anr.2026.06.001","url":null,"abstract":"<p><strong>Purpose: </strong>To clarify the concept of decent work in nursing, establish an operational definition, and propose a research agenda for future studies.</p><p><strong>Methods: </strong>Walker and Avant's concept analysis was used. Scopus, Web of Science, PubMed, CINAHL, and APA PsycINFO databases were searched using the keywords \"decent work,\" \"decent,\" \"nurses,\" and \"nursing\" for studies published in English between 1999 and 2024.</p><p><strong>Results: </strong>Nineteen articles were included for analysis. Six defining attributes of decent work in nursing were identified and structured into two hierarchical levels: higher-order foundational attributes (social protection, human rights protection, and appreciation of the nursing profession), and functional attributes (social dialogue, compensation satisfaction, and career development). Antecedents were categorized into organizational-related and personal-related factors. The consequences of decent work were classified into four categories: nurse-related, healthcare organizational-related, moral-related, and attachment-related outcomes. This concept analysis establishes an operational definition of decent work in nursing as an integrated framework of professional justice and human dignity that incorporates higher-order foundational and functional attributes.</p><p><strong>Conclusions: </strong>Future research should focus on exploring decent work across diverse nursing roles and contexts, employing varied research methodologies, and developing specialized tools to effectively assess decent work in nursing.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFORMATICS AND HEALTHCARE TECHNOLOGY COMPETENCY AMONG NURSES IN A LOW-RESOURCED COUNTRY: A MIXED-METHODS RESEARCH.","authors":"Hyejin Jeon, Hyunsook Shin, Turnisa Yusupova, Medina Muratbekova, Madina Zhamankulova, Begimai Karypova","doi":"10.1016/j.anr.2026.05.003","DOIUrl":"https://doi.org/10.1016/j.anr.2026.05.003","url":null,"abstract":"<p><strong>Purpose: </strong>The integration of information and communication technology in healthcare potentially improve access to healthcare services, support clinical decision-making, and enhance healthcare processes, leading to positive patient outcomes, especially in low-resource settings. The aim of this study was to identify the perceptions and characteristics of nurses regarding informatics and healthcare technology competency in the Kyrgyz Republic.</p><p><strong>Methods: </strong>An exploratory sequential mixed-methods design was used. A total of 346 nurses and nursing managers participated in this study (focus group interviews, n = 54; survey, n = 292); nine focus group interviews and a survey were conducted to collect data on nurses' perceptions of informatics and healthcare technology competency and related issues.</p><p><strong>Results: </strong>Five qualitative themes were identified: working with digital systems in comprehensive and multifaceted ways in daily practice, accessing health databases, optimizing nursing workflow and data use, redefining professional roles in a digital shift, and adapting to new systems and changing practices. Quantitatively, across 38 items assessing informatics and healthcare technology competency, perceived importance exceeded self-reported performance (overall means 1.25 vs 1.06; p < .001). In the importance-performance analysis, nurses in the Kyrgyz Republic placed informatics knowledge in the high-importance/high-performance quadrant (1.30 vs 1.14), basic computer skills in high-importance/low-performance (1.34 vs 1.09), and informatics skills in low-importance/low-performance (1.17 vs 1.04).</p><p><strong>Conclusion: </strong>The findings indicate that nurses in the Kyrgyz Republic recognized the importance of informatics and healthcare technology competency and showed understanding aligned with the changing healthcare environment. Within low-resource settings, nurses adapted their practice by reconfiguring workflows to maintain efficiency and continuity of care; however, performance across competency domains lagged behind perceived importance. Strengthening this competency through gradual, comprehensive training and context-sensitive infrastructure development-tailored to each country and practice setting-may support the transition from basic technology use to applied informatics and ultimately contribute to improved population health outcomes in low-resource regions.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet Needs of Patients with Parkinson's Disease and Their Caregivers During the Discharge Transition: A Qualitative Descriptive Study.","authors":"Kai Zhao, Dongxiang Zheng, Yan Li, Lu Sun, Guanrong Guo, Linjiao Li, Xuelun Guo, Danlei Wang","doi":"10.1016/j.anr.2026.05.002","DOIUrl":"https://doi.org/10.1016/j.anr.2026.05.002","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the care needs of patients with Parkinson's disease and their caregivers during the hospital-to-home transition, framed by Transition Theory, to provide an empirical basis for developing a comprehensive transitional care program.</p><p><strong>Method: </strong>s: A descriptive qualitative study was conducted between July and August 2025. We performed semi-structured interviews with 12 patient-caregiver dyads selected via purposive sampling. Data were analyzed using thematic analysis. Meleis's Transition Theory served as a theoretical lens to guide the refinement, organization, and interpretation of the themes.</p><p><strong>Results: </strong>Four core themes of unmet needs were identified: (1) the need for practical knowledge and skills for disease self-management; (2) continuity of care to bridge the hospital-community gap; (3) psychological support for both patients and caregivers to cope with role changes; and (4) access to social and financial resources. These themes collectively reveal a significant gap between existing discharge support and the actual needs of families.</p><p><strong>Conclusions: </strong>The transition from hospital to home for patients with Parkinson disease is a complex process that is further complicated by limited self-management capacity and fragmented healthcare services. To achieve a successful transition, care must extend beyond standard discharge instructions to an integrated \"hospital-community-family\" model. Such an integrated model is essential for reducing hospital readmissions, alleviating caregiver burden, and ultimately improving the long-term quality of life of individuals with Parkinson disease.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tri-Lens Bibliometric Analysis of Nursing Leadership: Governance, Succession, and Global Equity.","authors":"Alex S Borromeo, Angieliza Villanueva, Jimmy Torres, Brando M Rayray, Aldrin Darilag, Walton Wider","doi":"10.1016/j.anr.2026.05.001","DOIUrl":"https://doi.org/10.1016/j.anr.2026.05.001","url":null,"abstract":"<p><strong>Purpose: </strong>This study mapped the global intellectual and thematic structure of nursing leadership research by integrating three often separate domains: governance, succession, and equity. It examined how these domains are connected in the literature across nursing education and practice.</p><p><strong>Methods: </strong>We conducted a bibliometric analysis of Web of Science Core Collection records (1970-2025) using a tri-lens search strategy, yielding 315 peer-reviewed articles. We reported publication and citation trends (including total citations and H-index), then performed co-citation and co-word network analyses in VOSviewer (association-strength normalization). Thematic mapping was conducted in Biblioshiny (bibliometrix, R) using Louvain clustering and Callon centrality-density to classify themes as motor, basic, niche, or emerging/declining.</p><p><strong>Results: </strong>The dataset accrued 4,402 citations (H-index = 31), with publication growth accelerating after 2015. Co-citation analysis identified four intellectual pillars: (1) leadership capacity building, (2) equity-focused leadership, (3) transition and workforce development, and (4) policy-driven leadership preparation. Co-word analysis also produced four thematic clusters: academic leadership, simulation-based preparation, equity/racism in leadership, and staff development across education-practice-research contexts. Across both maps, governance-, succession-, and equity-related topics were adjacent but largely concentrated in separate cluster communities, with limited cross-cluster connectors.</p><p><strong>Conclusion: </strong>Nursing leadership research is expanding but remains structurally fragmented across governance, succession, and equity domains. The key contribution of this study is the tri-lens evidence that these domains are conceptually related yet weakly integrated in empirical knowledge structures. Findings support the need to align governance design, leadership pipeline development, and equity mechanisms in nursing education and leadership planning.</p>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prediction Model for Prolonged Length of Stay After Cholecystectomy in Patients with Chronic Acalculous Cholecystitis and Nursing Recommendations","authors":"Ke Xu ,&nbsp;Xiaoxia Fang ,&nbsp;Yuhou Shen ,&nbsp;Huimin Wang ,&nbsp;Bingru Yang","doi":"10.1016/j.anr.2025.12.008","DOIUrl":"10.1016/j.anr.2025.12.008","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to inform a basis for nursing intervention through investigating the clinical risk factors for prolonged length of stay (PLOS) in patients with chronic acalculous cholecystitis (CAC) after cholecystectomy and constructing a predictive model.</div></div><div><h3>Methods</h3><div>The prediction model for the PLOS in patients with CAC after cholecystectomy was developed using a retrospective research design. Data were extracted from Medical Information Mart for Intensive Care IV. Logistic regression was used to explore the influencing factors of PLOS using the interpolated data. A variety of statistical methods, such as receiver operating characteristic (ROC) analysis, decision curve analysis, 5-fold cross-validation method, and SHapley Additive exPlanations, were conducted to assess, validate, and interpret the prediction model.</div></div><div><h3>Results</h3><div>The study included 204 patients with CAC who underwent cholecystectomy. The average age was 60.23 ± 14.30 years, with 65.2% experiencing a PLOS. Multivariable logistic regression analysis showed that age (odds ratio [OR] = 1.04, 95% confidence interval [CI]: 1.01-1.08), calcium (OR = 0.48, 95% CI: 0.24-0.93), ciprofloxacin (OR = 3.08, 95% CI: 1.14-9.91), fentanyl (OR = 4.08, 95% CI: 1.36-14.53), and mild liver disease (MLD) (OR = 0.30, 95% CI: 0.11-0.76) may be the influencing factors for PLOS. The prediction model based on the five variables demonstrated moderate discrimination capacity according to ROC and decision curve analysis. The ROC results based on the 5-fold cross-validation method revealed that the average area under the curve was 0.75 (95%CI: 0.67-0.83) in the training set, 0.71 (95%CI: 0.54-0.88) in the validation set, and 0.72 (95%CI: 0.53-0.90) in the test set. SHapley Additive exPlanations analysis identified age as the most influential factor, followed by calcium, fentanyl, ciprofloxacin, and MLD.</div></div><div><h3>Conclusion</h3><div>The prediction model, based on age, calcium, fentanyl, ciprofloxacin, and MLD, demonstrated moderate discrimination capacity in predictive PLOS in patients with CAC after cholecystectomy. These findings may support the identification of at-risk patients and inform early nursing interventions.</div></div>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":"20 2","pages":"Pages 189-196"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Chemotherapy-Related Cognitive Impairment and Biomarkers in Older Patients With Cancer: A Systematic Review","authors":"Ji Yea Lee PhD, RN ,&nbsp;Soomin Hong PhD, OCN, RN","doi":"10.1016/j.anr.2025.12.007","DOIUrl":"10.1016/j.anr.2025.12.007","url":null,"abstract":"<div><h3>Purpose</h3><div>Chemotherapy-related cognitive impairment (CRCI) is a prevalent and distressing issue among older adults with cancer, affecting quality of life and treatment adherence. While its mechanisms remain unclear, biomarkers have emerged as promising tools for understanding CRCI. This systematic review aimed to explore the relationships between cognitive impairment following chemotherapy and biomarkers in older patients with cancer.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted through December 2024 across PubMed, CINAHL, Embase, PsycINFO, and the Cochrane Library. An additional hand search was performed through July 2025. The focus was on patients over 60 years of age with CRCI and associated biomarkers. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, and the methodological quality of included studies was assessed using the Joanna Briggs Institute checklist to ensure rigor and reliability.</div></div><div><h3>Results</h3><div>Six of the initial 6324 articles met the inclusion criteria, and seven additional studies were identified through manual searching. In total, 13 studies identified several biomarkers associated with CRCI in older patients with cancer. These included serum hemoglobin, brain-derived neurotrophic factor, percent cerebral oxyhemoglobin, functional network connectivity, and individual alpha peak frequency.</div></div><div><h3>Conclusions</h3><div>This review highlights several biomarkers potentially associated with CRCI in older patients with cancer, though consistent and definitive biomarkers remain elusive. Further research is needed to clarify the biological mechanisms underlying CRCI and inform the development of interventions aimed at preventing cognitive decline in this vulnerable population. The identification of validated biomarkers will be critical for advancing personalized nursing and improving clinical outcomes in older adults with cancer.</div><div>The research protocol was registered in advance on the International Prospective Register of Systematic Reviews under CRD42022353113.</div></div>","PeriodicalId":55450,"journal":{"name":"Asian Nursing Research","volume":"20 2","pages":"Pages 197-208"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}