{"title":"Role of MSX1 in the development of non-syndromic clefts in the sub-Himalayan region of India","authors":"Madhubari Vathulya , Neetu Singh , Manisha Naithani , Sanjay Dvivedi , Mohit Jadli , Nilotpal Chowdhary , Konstanze Scheller , Peter Kessler","doi":"10.1016/j.bjoms.2025.04.003","DOIUrl":"10.1016/j.bjoms.2025.04.003","url":null,"abstract":"<div><div>Non-syndromic cleft lip and palate (NSCL/P) is a prevalent congenital anomaly influenced by genetic and environmental factors. The role of the MSX1 gene in NSCL/P has been explored in various populations, with conflicting results. This study investigates the association between MSX1 single nucleotide polymorphisms (SNPs) rs11726039 and rs3821949 and NSCL/P in a sub-Himalayan population of India. A total of 395 subjects, including 216 patients and 179 controls, were genotyped using TaqMan assays. The study also considered environmental factors, such as maternal smoking and folic acid intake. Statistical analysis, including odds ratios (OR), Fisher’s exact test, and Hardy-Weinberg equilibrium, was used to assess the association between the SNPs (single nuclear polymorphisms) and NSCL/P. While rs11726039 showed no significant association in either patient or parental samples, rs3821949 indicated a protective effect in fathers (OR = 0.44, p = 0.001) but not in patients. The findings highlight population-specific variations in the genetic aetiology of NSCL/P and the need for larger studies to confirm the role of MSX1 SNPs in the sub-Himalayan region. Despite being located in the same country, differences in genetic associations were noted between the sub-Himalayan and South Indian populations, underscoring the complexity of genetic interactions in NSCL/P.</div></div>","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Pages 441-446"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical, histopathological, and epidemiological characterisation of accessory parotid gland tumours in relation to parotid and submandibular gland tumours: observations based on 2653 cases of the Polish Salivary Network Database","authors":"Małgorzata Wierzbicka , Patrycja Gazinska , Heng-Chang Chen , Pawel Burduk , Ewelina Bartkowiak , Wioleta Pietruszewska , Dominik Stodulski , Agata Leduchowska , Jarosław Markowski , Aleksandra Piernicka-Dybich , Małgorzata Wierzchowska , Joanna Czech , Katarzyna Amernik , Alicja Chańko , Daniel Majszyk , Antonii Bruzgielewicz , Bogusław Mikaszewski","doi":"10.1016/j.bjoms.2024.09.014","DOIUrl":"10.1016/j.bjoms.2024.09.014","url":null,"abstract":"<div><div>Salivary gland tumours comprise one of the most complex and rare groups of heterogeneous lesions encountered in oral pathology. Large clinical and population-based epidemiological studies are inherently limited. This multicentre prospective study was conducted between 2017 and 2021 using the Polish Salivary Network Database (PSND). A dataset of 2653 cases of salivary gland tumours was analysed, focusing on the submandibular gland (n = 173), accessory parotid gland (n = 100), and parotid gland (n = 2375). Epidemiological and pathological factors were considered to identify the risk of malignancy and differences between tumours of the submandibular, parotid, and accessory parotid glands. A significant difference was observed in the median age of patients with tumours of the submandibular (50.5 years) and accessory parotid glands (51.5 years) compared with that of patients with parotid gland tumours (60.0 years) (p < 0.001). Factors such as tobacco usage (p < 0.001) and place of residence (p = 0.015) were associated with these differences. Sex was not a differentiating factor in the risk of malignancy. In females, 106/173 patients had tumours in the submandibular gland, 61/100 had tumours in the accessory parotid, and 1282/2375 had tumours in the parotid. In males, 67/173 had tumours in the submandibular gland, 39/100 had tumours in the accessory parotid, and 1093/2375 had tumours in the parotid. Significant differences were found in submandibular and parotid tumour locations between village and city inhabitants (p = 0.016). The nature of tumours located in the parotid, comprising the superficial and deep lobes, was distinct in relation to accessory parotid tumours. Accessory parotid tumours exhibited more similarities to those originating in the submandibular region. These findings have the potential to impact future clinical approaches. However, additional validation studies are needed.</div></div>","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Pages 447-454"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaymit Patel (Consultant Restorative Dentistry) , Julia Csikar (Associate Professor Dental Public Health) , Anke Korfage (Dentist- Maxillofacial Prosthodontist) , Max Witjes (Professor Dental Public Health) , Gail Douglas (Professor Dental Public Health) , Anastasios Kanatas (Professor Oral and Maxillofacial Surgery)
{"title":"Do the existing quality-of-life tools appropriately measure oral health-related quality of life in head and neck cancer? A scoping review","authors":"Jaymit Patel (Consultant Restorative Dentistry) , Julia Csikar (Associate Professor Dental Public Health) , Anke Korfage (Dentist- Maxillofacial Prosthodontist) , Max Witjes (Professor Dental Public Health) , Gail Douglas (Professor Dental Public Health) , Anastasios Kanatas (Professor Oral and Maxillofacial Surgery)","doi":"10.1016/j.bjoms.2025.05.004","DOIUrl":"10.1016/j.bjoms.2025.05.004","url":null,"abstract":"<div><div>Head and neck cancers and their respective treatments have a profound impact on quality of life. Many oropharyngeal and oral cancers are likely to have implications for oral health-related quality of life (OHRQoL), but research investigating tools to measure this are lacking. We conducted a scoping review to ascertain the available tools for measuring OHRQoL in head and neck cancer patients. The primary objective was to compile a summary of the existing tools and determine their completeness, validity, and reliability. The literature search yielded 1239 articles. Thirty-one studies were included in the review and multiple tools were identified. None of the tools assessed all potential OHRQoL impacts, and none had undergone comprehensive testing using a range of assessments. Most of the tools did not adhere to published guidance, with only the European Organisation for Research and Treatment of Cancer (EORTC) citing methodological guidance in their survey tool development protocols. All tools achieved recommended readability scores in English. Due to methodological flaws in the evidence base, it was not possible to definitively establish the completeness of any available tool. There was discordance between tools regarding the relevant OHRQoL impacts. Several tools failed to assess accepted domains of OHRQoL, calling into question their concordance with the construct of OHRQoL. In addition, there was a lack of adherence to published standards regarding both the construction and testing methods for quality-of-life instruments. Studies reporting on OHRQoL in head and neck cancer may, therefore, not comprehensively assess the actual impacts of the disease and its treatment.</div></div>","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Pages 415-422"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Training groups / Instructions to Authors","authors":"","doi":"10.1016/S0266-4356(25)00159-7","DOIUrl":"10.1016/S0266-4356(25)00159-7","url":null,"abstract":"","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Page IBC"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tom Bray , Charlie Rose , Lyndon Meehan , Liam Addy , Petros Mylonas
{"title":"What are the oral health implications of using snus? A systematic review","authors":"Tom Bray , Charlie Rose , Lyndon Meehan , Liam Addy , Petros Mylonas","doi":"10.1016/j.bjoms.2025.03.015","DOIUrl":"10.1016/j.bjoms.2025.03.015","url":null,"abstract":"<div><div>Many consider the consumption of smokeless tobacco (SLT) a risk to oral health. Snus is being increasingly used, and the aim of this systematic review was to determine the oral health effects of this. Medline, Web of Science, and Scopus were searched using oral health related terms and the term snus. Studies concerning SLT products other than snus were excluded. The literature search identified 47 studies suitable for inclusion. Five out of six epidemiological studies did not report an elevated risk of oral cancer in users of snus. However, three observational studies presented cases of oral cancer at the site of snus placement. Snus was consistently associated with the development of oral mucosal lesions, or snuff dipper’s lesions (SDLs). Studies indicate that quitting the habit leads to rapid SDL regression, and that taking up the habit leads to its rapid initiation. Evidence in this review suggests that snus may not increase the risk of oral cancer. Further research is required to supplement the current evidence in this area, and to investigate the range of snus products now available.</div></div>","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Pages 423-428"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Virtual special issue: current thinking in orthognathic surgery","authors":"Geoff Chiu","doi":"10.1016/j.bjoms.2025.04.004","DOIUrl":"10.1016/j.bjoms.2025.04.004","url":null,"abstract":"","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Pages 413-414"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fixation technique in total temporomandibular joint replacement for edentulous patients: a technical note","authors":"Sinan Yasin Ertem , Daniel E. Perez","doi":"10.1016/j.bjoms.2025.05.003","DOIUrl":"10.1016/j.bjoms.2025.05.003","url":null,"abstract":"","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":"63 6","pages":"Pages 469-470"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative study of the aesthetic outcomes of two techniques for bilateral cleft lip repair.","authors":"Z Al Asaadi, N Narayan, A Sawyer, M C Swan","doi":"10.1016/j.bjoms.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.bjoms.2025.06.006","url":null,"abstract":"<p><p>Facial aesthetics are an important factor in quality of life following cleft lip surgery with the appearance of the nasolabial region a key outcome measure for patients and their families. Analysing the aesthetic outcome is difficult as it encompasses personal evaluation and judgment. The aim of this study was to determine whether subjective assessment can differentiate aesthetic outcomes between two surgeons who use differing surgical techniques for primary bilateral cleft lip repair. Five-year postoperative frontal photographs of bilateral cleft lip and palate patients (cropped as per the Asher-McDade aesthetic index) were analysed by 35 blinded surgical and lay reviewers using a five-point Likert scale (1 = excellent, 5 = very poor). The repairs were carried out by two different surgeons. The assessments were repeated at a later date to assess intra-rater reliability. A total of 38 consecutive cases of bilateral cleft lip repairs carried out by two surgeons were assessed. Seventeen cases were carried out by Surgeon A and 21 by Surgeon B. The mean Likert score for surgical/lay assessors for Surgeon A was 2.67/2.69 and for Surgeon B 2.90/2.83. Inter-rater reliability was excellent and intra-rater reliability was found to be slight. Subjective assessment using clinical photography is a useful tool in assessing aesthetic outcomes in bilateral cleft lip repair.</p>","PeriodicalId":55318,"journal":{"name":"British Journal of Oral & Maxillofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}