Chemical Immunology最新文献

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Inflammatory cell activation by eosinophil granule proteins. 嗜酸性粒细胞颗粒蛋白激活炎症细胞。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058783
L L Thomas, S M Page
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引用次数: 11
The bronchial epithelial origins of asthma. 哮喘的支气管上皮起源。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058817
S T Holgate
{"title":"The bronchial epithelial origins of asthma.","authors":"S T Holgate","doi":"10.1159/000058817","DOIUrl":"https://doi.org/10.1159/000058817","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"62-71"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
The role of adhesion in eosinophil function. 粘附在嗜酸性细胞功能中的作用。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058820
A J Wardlaw
{"title":"The role of adhesion in eosinophil function.","authors":"A J Wardlaw","doi":"10.1159/000058820","DOIUrl":"https://doi.org/10.1159/000058820","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"93-111"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058820","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
T cells and fibrosis. T细胞和纤维化。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058824
B G Marshall, R J Shaw
{"title":"T cells and fibrosis.","authors":"B G Marshall, R J Shaw","doi":"10.1159/000058824","DOIUrl":"https://doi.org/10.1159/000058824","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"148-58"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058824","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Enzymic and signal transduction properties of CD38/NADase and PC-1/phosphodiesterase. CD38/NADase和PC-1/磷酸二酯酶的酶学和信号转导特性。
Chemical Immunology Pub Date : 2000-01-01
T Katada, K Kontani, T Wada, N Hosoda, S Hoshino, H Nishina
{"title":"Enzymic and signal transduction properties of CD38/NADase and PC-1/phosphodiesterase.","authors":"T Katada, K Kontani, T Wada, N Hosoda, S Hoshino, H Nishina","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"75 ","pages":"60-78"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21695839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system. cd38 -环adp核糖信号系统的生理和病理意义。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058766
H Okamoto, S Takasawa, K Nata, I Kato, A Tohgo, N Noguchi
{"title":"Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system.","authors":"H Okamoto, S Takasawa, K Nata, I Kato, A Tohgo, N Noguchi","doi":"10.1159/000058766","DOIUrl":"https://doi.org/10.1159/000058766","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"75 ","pages":"121-45"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21695842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Scientific overview of 20 years' work in the Department of Allergy and Clinical Immunology under the guidance of Professor A.B. Kay. 在A.B. Kay教授的指导下,过敏和临床免疫学部门20年工作的科学概述。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058812
D S Robinson
{"title":"Scientific overview of 20 years' work in the Department of Allergy and Clinical Immunology under the guidance of Professor A.B. Kay.","authors":"D S Robinson","doi":"10.1159/000058812","DOIUrl":"https://doi.org/10.1159/000058812","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Regulation of Th2 cytokine gene transcription. Th2细胞因子基因转录的调控。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058813
P Lavender, D Cousins, T Lee
{"title":"Regulation of Th2 cytokine gene transcription.","authors":"P Lavender,&nbsp;D Cousins,&nbsp;T Lee","doi":"10.1159/000058813","DOIUrl":"https://doi.org/10.1159/000058813","url":null,"abstract":"<p><p>Because of the different functions of IL-4, IL-13 and IL-5, it would perhaps be surprising if common transcriptional mechanisms occur. However, because of the physical proximity of their genes within the human 5q locus, chromatin remodelling during T-cell differentiation may make transcription of all the genes permissible. If co-ordinate regulation were to take place, it might be argued that similar factors might be involved in expression of all of the cytokines. Emerging data on c-Maf and GATA3 regulation of IL-4 and IL-5 respectively argues that diverse proteins may be required for transcriptional activation. Alternatively, these factors may be responsible for regulating transcriptional competence, allowing fine control over generation of particular cytokines depending upon recognition of physiological cues. If competent for transcription, common factors, such as members of the NFAT and/or AP-1 families, may operate to regulate cytokine levels. To support this, we have recently identified a conserved palindrome located within the promoters of the different Th2-type cytokines, which acts as an enhancer of transcription. Central to the capacity to express Th2 cytokines is likely to be the ability to remodel chromatin at the locus. It remains to be determined whether a single factor, or combination of factors acts to regulate this event. It is also unclear what the boundaries of remodelling within the locus are, i.e. whether IL-4 and IL-13 may be within open chromatin and IL-5 in a closed environment, and whether there is a hierarchy which determines whether particular cytokines are preferentially expressed irrespective of competence.</p>","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"16-29"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Novel immunosuppressants in asthma. 哮喘中的新型免疫抑制剂。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058822
O M Kon
{"title":"Novel immunosuppressants in asthma.","authors":"O M Kon","doi":"10.1159/000058822","DOIUrl":"https://doi.org/10.1159/000058822","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"124-34"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058822","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
C-C chemokine expression in atopic and nonatopic asthma. C-C趋化因子在特应性和非特应性哮喘中的表达。
Chemical Immunology Pub Date : 2000-01-01 DOI: 10.1159/000058826
S Ying
{"title":"C-C chemokine expression in atopic and nonatopic asthma.","authors":"S Ying","doi":"10.1159/000058826","DOIUrl":"https://doi.org/10.1159/000058826","url":null,"abstract":"","PeriodicalId":55266,"journal":{"name":"Chemical Immunology","volume":"78 ","pages":"178-88"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000058826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22472128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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