Chinese Geographical Science最新文献_第10页

Antibody Profiling in Naïve and Semi-immune Individuals Experimentally Challenged with Plasmodium vivax Sporozoites. 用间日疟原虫孢子虫实验挑战天真和半免疫个体的抗体谱分析

IF 3.8 2区地球科学

Chinese Geographical Science Pub Date : 2016-03-25 eCollection Date: 2016-03-01 DOI: 10.1371/journal.pntd.0004563

Myriam Arévalo-Herrera, Mary Lopez-Perez, Emmanuel Dotsey, Aarti Jain, Kelly Rubiano, Philip L Felgner, D Huw Davies, Sócrates Herrera

{"title":"Antibody Profiling in Naïve and Semi-immune Individuals Experimentally Challenged with Plasmodium vivax Sporozoites.","authors":"Myriam Arévalo-Herrera, Mary Lopez-Perez, Emmanuel Dotsey, Aarti Jain, Kelly Rubiano, Philip L Felgner, D Huw Davies, Sócrates Herrera","doi":"10.1371/journal.pntd.0004563","DOIUrl":"10.1371/journal.pntd.0004563","url":null,"abstract":"Background: Acquisition of malaria immunity in low transmission areas usually occurs after relatively few exposures to the parasite. A recent Plasmodium vivax experimental challenge trial in malaria naïve and semi-immune volunteers from Colombia showed that all naïve individuals developed malaria symptoms, whereas semi-immune subjects were asymptomatic or displayed attenuated symptoms. Sera from these individuals were analyzed by protein microarray to identify antibodies associated with clinical protection.Methodology/principal findings: Serum samples from naïve (n = 7) and semi-immune (n = 9) volunteers exposed to P. vivax sporozoite-infected mosquito bites were probed against a custom protein microarray displaying 515 P. vivax antigens. The array revealed higher serological responses in semi-immune individuals before the challenge, although malaria naïve individuals also had pre-existing antibodies, which were higher in Colombians than US adults (control group). In both experimental groups the response to the P. vivax challenge peaked at day 45 and returned to near baseline at day 145. Additional analysis indicated that semi-immune volunteers without fever displayed a lower response to the challenge, but recognized new antigens afterwards.Conclusion: Clinical protection against experimental challenge in volunteers with previous P. vivax exposure was associated with elevated pre-existing antibodies, an attenuated serological response to the challenge and reactivity to new antigens.","PeriodicalId":55258,"journal":{"name":"Chinese Geographical Science","volume":"32 1","pages":"e0004563"},"PeriodicalIF":3.8,"publicationDate":"2016-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66820055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis. 输尿管远端结石患儿使用α-1肾上腺素能阻滞剂：系统回顾和荟萃分析。

2区地球科学

Chinese Geographical Science Pub Date : 2015-11-01 DOI: 10.1590/S1677-5538.IBJU.2015.0048

F P Glina, P M V Castro, G G R Monteiro, G C Del Guerra, Sidney Glina, M Mazzurana, W M Bernardo

{"title":"The use of alpha-1 adrenergic blockers in children with distal ureterolithiasis: a systematic review and meta-analysis.","authors":"F P Glina, P M V Castro, G G R Monteiro, G C Del Guerra, Sidney Glina, M Mazzurana, W M Bernardo","doi":"10.1590/S1677-5538.IBJU.2015.0048","DOIUrl":"10.1590/S1677-5538.IBJU.2015.0048","url":null,"abstract":"Introduction: Urinary lithiasis is the main urologic cause of emergency treatment in adult patient. In the past years, the incidence in children population has increased. However, literature about the use of alpha-1 adrenergic blockers in pediatric population with distal ureterolithiasis is still scarce. The drug acts by decreasing ureter contractions, especially in the distal portion, facilitating calculus expulsion.Objective: This review has the objective to evaluate the use of alpha-1 adrenergic blockers as medical expulsive treatment in children with distal ureterolithiasis.Evidence acquisition: An electronic literature search was performed using the MEDLINE, COCHRANE, and LILACS databases. We further searched manually the references of the primary studies. Searches were concluded on October 4th, 2014. Articles were selected, independently and in pairs, by the respective titles and summaries. Any divergence was resolved by consensus.Evidence synthesis: Alpha-1 adrenergic antagonists increased the probability of calculus expulsion by 27% (NNT=4). Calculi smaller than 5mm, increased by 33% (NNT=3). Larger than 5mm, increased by 34% (NNT=3).Conclusion: Alpha-1 adrenergic blocker use is related with a greater incidence of expulsion of ureteral calculi, smaller or greater than 5mm, and fewer episodes of pain when compared to ibuprofen. However it is necessary larger samples to enhance the power analysis of the expulsion of ureteral calculi larger than 5mm and the episodes of pain.Patient summary: This review analyzed the outcome of alpha adrenergic antagonist in children with ureteral calculi. We conclude that it is the best medicine for use, since it helps the expulsion of the stone.","PeriodicalId":55258,"journal":{"name":"Chinese Geographical Science","volume":"29 1","pages":"1049-57"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83347977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of extreme temperature event and its response to regional warming in Northwest China in past 45 years 近45 a西北地区极端气温事件特征及其对区域变暖的响应

IF 3.4 2区地球科学

Chinese Geographical Science Pub Date : 2008-03-01 DOI: 10.1109/ICBBE.2008.307

Jinhu Yang, C. Ren, Zhihong Jiang

{"title":"Characteristics of extreme temperature event and its response to regional warming in Northwest China in past 45 years","authors":"Jinhu Yang, C. Ren, Zhihong Jiang","doi":"10.1109/ICBBE.2008.307","DOIUrl":"https://doi.org/10.1109/ICBBE.2008.307","url":null,"abstract":"Using the daily maximum and minimum temperature dataset from 128 stations from 1960 to 2004 in Northwest China, daily extreme high temperature (EHT) and extreme low temperature (ELT) thresholds were determined by centesimal method for different stations at first, then yearly EHT and ELT events were counted up in different stations, and the characteristics of their spatio-temporal distribution were diagnosed at last. The study drew following conclusions: 1) The consistent anomaly distribution characteristic was the most important mode of the EHT and ELT events in Northwest China. 2) The spatial distribution of the EHT and ELT events can be divided into five sub-regions, namely, the north of Qinghai and west of Gansu, the north of Xinjiang, the south of Xinjiang, the east of Northwest China and the south of Qinghai. 3) The EHT events showed remarkable increasing trend in all of five sub-regions, but only in the north of Qinghai and west of Gansu area, sudden change phenomenon occurred; the ELT events showed decreasing trend in all of five sub-regions, and sudden change phenomenon occurred in Northwest China except for south of Qinghai. 4) In all of five sub-regions the EHT events showed remarkable 12–14yr period oscillation, and the ELT event showed significant 13–15yr and 7–8yr period oscillation. 5) The EHT and ELT events displayed remarkable positive and negative responses to regional warming of Northwest China respectively.","PeriodicalId":55258,"journal":{"name":"Chinese Geographical Science","volume":"38 1","pages":"70-76"},"PeriodicalIF":3.4,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89014018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Study on the migrant labour force of China in recent years--a case study of Nanhai City, Guangdong Province. 近年来中国流动劳动力研究——以广东省南海为例

IF 3.4 2区地球科学

Chinese Geographical Science Pub Date : 1997-01-01 DOI: 10.1007/s11769-997-0068-z

X Yan

引用次数: 1