Endocrine Pathology最新文献_第7页

The Spectrum of Endocrine Pathology. 内分泌病理学》。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-03-18 DOI: 10.1007/s12022-023-09758-0

Sylvia L Asa, Lori A Erickson, Guido Rindi

引用次数: 0

Inflammatory and Infectious Disorders in Endocrine Pathology. 内分泌病理学中的炎症和感染性疾病。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-05-20 DOI: 10.1007/s12022-023-09771-3

Silvia Uccella, Matthias Dottermusch, Lori Erickson, Julia Warmbier, Kathleen Montone, Wolfgang Saeger

{"title":"Inflammatory and Infectious Disorders in Endocrine Pathology.","authors":"Silvia Uccella, Matthias Dottermusch, Lori Erickson, Julia Warmbier, Kathleen Montone, Wolfgang Saeger","doi":"10.1007/s12022-023-09771-3","DOIUrl":"10.1007/s12022-023-09771-3","url":null,"abstract":"A variety of inflammatory conditions may directly involve the endocrine glands, leading to endocrine dysfunction that can cause severe consequences on patients' health, if left untreated. Inflammation of the endocrine system may be caused by either infectious agents or other mechanisms, including autoimmune and other immune-mediated processes. Not infrequently, inflammatory and infectious diseases may appear as tumor-like lesions of endocrine organs and simulate neoplastic processes. These diseases may be clinically under-recognized and not infrequently the diagnosis is suggested on pathological samples. Thus, the pathologist should be aware of the basic principles of their pathogenesis, as well as of their morphological features, clinicopathological correlates, and differential diagnosis. Interestingly, several systemic inflammatory conditions show a peculiar tropism to the endocrine system as a whole. In turn, organ-specific inflammatory disorders are observed in endocrine glands. This review will focus on the morphological aspects and clinicopathological features of infectious diseases, autoimmune disorders, drug-induced inflammatory reactions, IgG4-related disease, and other inflammatory disorders involving the endocrine system. A mixed entity-based and organ-based approach will be used, with the aim to provide the practicing pathologist with a comprehensive and practical guide to the diagnosis of infectious and inflammatory disorders of the endocrine system.","PeriodicalId":55167,"journal":{"name":"Endocrine Pathology","volume":" ","pages":"406-436"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9502731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neoplasms in Struma Ovarii: A Review. 卵巢支柱肿瘤：综述。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-10-21 DOI: 10.1007/s12022-023-09789-7

Isabella Tondi Resta, Christopher M Sande, Virginia A LiVolsi

引用次数: 0

Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence. 甲状腺乳头状癌的血管肉瘤样变性：一种新的异源分化形式和异源元素患病率的系统评价。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-10-04 DOI: 10.1007/s12022-023-09787-9

Rayan Rammal, Jason K Wasserman, Aatur D Singhi, Christopher C Griffith, Raja R Seethala

{"title":"Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence.","authors":"Rayan Rammal, Jason K Wasserman, Aatur D Singhi, Christopher C Griffith, Raja R Seethala","doi":"10.1007/s12022-023-09787-9","DOIUrl":"10.1007/s12022-023-09787-9","url":null,"abstract":"Anaplastic thyroid carcinoma (ATC) demonstrates a wide variety of morphologies and is characteristically associated with a differentiated thyroid carcinoma component. Heterologous differentiation is a rare, potentially challenging phenomenon in ATC, mostly observed as osteosarcomatous or chondrosarcomatous differentiation. We now describe a novel 'glomangiosarcoma-like' differentiation, review our archival experience from two institutions (UPMC, CC), and perform a systematic review for the prevalence of heterologous elements in ATC. The patient is a 57-year-old female who presented with 4.5 cm left thyroid, and 3.4 cm neck masses. Histologically, the thyroid demonstrated a differentiated high grade papillary thyroid carcinoma, tall cell and hobnail/micropapillary subtypes transitioning into an anaplastic component with spindled to ovoid cells with hemangiopericytoma-like vasculature showing CD34 positivity, variable muscle marker expression and pericellular lace-like type IV collagen deposition. The neck mass consisted solely of the latter morphology. Targeted next-generation sequencing was performed on high grade DTC and adjacent ATC from the thyroid as well as ATC from the neck metastasis. All three components shared BRAFV600E, TERT promoter, and PIK3CA mutations confirming a clonal origin. Archival (UPMC: n = 150, CC: n = 74) and literature review showed no prior examples. Systematic review and meta-analysis of prevalence showed a baseline pooled prevalence (generalized linear mixed model) of heterologous elements of any type to be 1.6% (95% confidence interval: 1.0-2.6%) for studies where this was specifically addressed. ATC with glomangiosarcoma-like heterologous differentiation is a rarity among an already rare morphologic category with unique diagnostic pitfalls.","PeriodicalId":55167,"journal":{"name":"Endocrine Pathology","volume":" ","pages":"471-483"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstacles to Tumor Capsule Assessment in Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP). 具有乳头状核特征(NIFTP)的非侵袭性甲状腺滤泡性肿瘤肿瘤胶囊评估的障碍。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-11-18 DOI: 10.1007/s12022-023-09791-z

Ivan J Stojanov, Ozgur Mete, Sylvia L Asa

引用次数: 0

The Unique Importance of Differentiation and Function in Endocrine Neoplasia. 分化和功能在内分泌肿瘤中的独特重要性。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-04-12 DOI: 10.1007/s12022-023-09762-4

Sylvia L Asa, Silvia Uccella, Arthur Tischler

引用次数: 0

The Driver Role of Pathologists in Endocrine Oncology: What Clinicians Seek in Pathology Reports. 病理学家在内分泌肿瘤学中的驱动作用：临床医生在病理报告中的需求。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-05-11 DOI: 10.1007/s12022-023-09768-y

Shereen Ezzat, Wouter W de Herder, Marco Volante, Ashley Grossman

{"title":"The Driver Role of Pathologists in Endocrine Oncology: What Clinicians Seek in Pathology Reports.","authors":"Shereen Ezzat, Wouter W de Herder, Marco Volante, Ashley Grossman","doi":"10.1007/s12022-023-09768-y","DOIUrl":"10.1007/s12022-023-09768-y","url":null,"abstract":"Endocrine neoplasia represents an increasingly broad spectrum of disorders. Endocrine neoplasms range from incidental findings to potentially lethal malignancies. In this paper, we cover the impact of pathology in the interpretation of the clinic-pathological, genetic, and radiographic features underpinning these neoplasms. We highlight the critical role of multidisciplinary interactions in structuring a rational diagnostic and efficient therapeutic plan and emphasize the role of histopathological input in decision-making. In this context, standardized pathology reporting and second opinion endocrine pathology review represent relevant tools to improve the overall diagnostic workup of patients affected by endocrine tumors in every specific scenario. In fact, although a relevant proportion of cases may be correctly identified based on clinical presentation and biochemical/imaging investigations, a subset of cases presents with atypical findings that may lead to an inappropriate diagnosis and treatment plan based on a wrong pathological diagnosis if all pieces of the puzzle are not correctly considered. Pathologists have a responsibility to actively guide clinicians before and during surgical procedures to prevent unnecessary interventions. In all areas of endocrine pathology, pathologists must understand the complexity of tissue preservation and assay sensitivities and specificities to ensure the optimal quality and interpretation of diagnostic material. Finally, pathologists are central actors in tumor tissue biobanking, which is an expanding field in oncology that should be promoted while adhering to strict ethical and methodological standards.","PeriodicalId":55167,"journal":{"name":"Endocrine Pathology","volume":" ","pages":"437-454"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9443572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine Pathology Society Hubert Wolfe Award for 2023: Call for Nominations. 2023年内分泌病理学会休伯特·沃尔夫奖:提名征集。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 DOI: 10.1007/s12022-023-09792-y

引用次数: 0

Insights Obtained from the Nontumorous Glandular Tissue in Patients with Endocrine Tumors. 从内分泌肿瘤患者的非瘤性腺体组织中获得的启示

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1007/s12022-023-09759-z

Arthur S Tischler, Virginia A LiVolsi, Sylvia L Asa

{"title":"Insights Obtained from the Nontumorous Glandular Tissue in Patients with Endocrine Tumors.","authors":"Arthur S Tischler, Virginia A LiVolsi, Sylvia L Asa","doi":"10.1007/s12022-023-09759-z","DOIUrl":"10.1007/s12022-023-09759-z","url":null,"abstract":"The pathology of neoplasia tends to focus on the tumor that requires characterization, grading, and staging. However, nontumorous tissue surrounding the lesion can also provide information, particularly about pathogenetic mechanisms. In endocrine tissues, this takes the form of precursor lesions that characterize several genetic predisposition syndromes. In addition, because of the unique functional aspects of endocrine neoplasia, the nontumorous tissue provides evidence of hormone excess, with hyperplasia and/or atrophy and other involutional changes allowing the pathologist to confirm both hormone function by the tumor and the effects of medical therapies. In this article, we review the various clinically relevant features that should be assessed and reported to enhance clinical management of patients with endocrine neoplasms. For example, in thyroid there may be inflammatory thyroiditis or goiter of various etiologies; there may be C-cell hyperplasia either as a preneoplastic lesion in patients with genetic predisposition to medullary thyroid carcinoma or as a reactive phenomenon. Drug-induced changes can be seen in thyroid and adrenal cortex. In neuroendocrine tissues, the nontumorous tissues may show precursor lesions such as endocrine cell hyperplasia/dysplasia; there may be related or unrelated hyperplastic or neoplastic lesions. Some tissues, such as pituitary corticotrophs and adrenal cortex, develop changes that reflect feedback suppression by hormone excess that can serve as biomarkers of tumor functionality and provide enhanced clinicopathologic correlates.","PeriodicalId":55167,"journal":{"name":"Endocrine Pathology","volume":" ","pages":"393-405"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9566744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors. 用于甲状腺肿瘤可靠分子诊断的NIFTP特异性mRNA标记物的鉴定。

IF 4.4 2区医学

Endocrine Pathology Pub Date : 2023-09-01 Epub Date: 2023-09-02 DOI: 10.1007/s12022-023-09781-1

So-Yeon Lee, Jong-Lyul Park, Kwangsoon Kim, Ja Seong Bae, Jae-Yoon Kim, Seon-Young Kim, Chan Kwon Jung

{"title":"Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors.","authors":"So-Yeon Lee, Jong-Lyul Park, Kwangsoon Kim, Ja Seong Bae, Jae-Yoon Kim, Seon-Young Kim, Chan Kwon Jung","doi":"10.1007/s12022-023-09781-1","DOIUrl":"10.1007/s12022-023-09781-1","url":null,"abstract":"Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a low-risk thyroid tumor with a favorable prognosis. Nonetheless, differentiating NIFTP from other thyroid tumors remains challenging, necessitating reliable diagnostic markers. This study is aimed at discovering NIFTP-specific mRNA markers through RNA sequencing analysis of thyroid tumor tissues. We performed mRNA expression profiling for 74 fresh frozen thyroid tissue samples, including NIFTP and benign and malignant follicular-cell-derived tumors. NIFTP/malignant tumors showed 255 downregulated genes and 737 upregulated genes compared to benign tumors. Venn diagram analysis revealed 19 significantly upregulated and 7 downregulated mRNAs in NIFTP. Akaike information criterion analysis allowed us to select OCLN, ZNF423, LYG1, and AQP5 mRNA markers. We subsequently developed a predictive model based on logistic regression analysis using these four mRNAs, which we validated in independent samples (n = 90) using a qRT-PCR assay. This model demonstrated high accuracy in predicting NIFTP in discovery dataset (AUC (area under the receiver operating characteristic) = 0.960) and the validation dataset (AUC = 0.757). Our results suggest that OCLN, ZNF423, LYG1, and AQP5 mRNA markers might serve as reliable molecular markers for identifying NIFTP among other thyroid tumors, ultimately aiding in accurate diagnosis and management of NIFTP patients.","PeriodicalId":55167,"journal":{"name":"Endocrine Pathology","volume":" ","pages":"311-322"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10142946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0