European Journal of Inflammation最新文献_第8页

Point of care detection of infection/inflammation in the diabetic clinic 糖尿病临床感染/炎症的护理点检测

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221091323

Tal Levinson, Nir Tal Zehavi, S. Berliner, D. Zeltser, I. Shapira, S. Shenhar-Tsarfaty, Asaf Wasserman, I. Goldiner, O. Rogowski, M. Shtark

{"title":"Point of care detection of infection/inflammation in the diabetic clinic","authors":"Tal Levinson, Nir Tal Zehavi, S. Berliner, D. Zeltser, I. Shapira, S. Shenhar-Tsarfaty, Asaf Wasserman, I. Goldiner, O. Rogowski, M. Shtark","doi":"10.1177/1721727X221091323","DOIUrl":"https://doi.org/10.1177/1721727X221091323","url":null,"abstract":"Introduction: Patients with diabetes are prone to infections. An elevated C-reactive protein (CRP) level indicates an underlying infection/inflammation; hence, a reliable point-of-care (POC) CRP measurement, independent of glucose level, would be advantageous in rapid detection of an inflammatory process and allowing for appropriate therapy in a timely manner. Methods: A validation study of patients with type 2 diabetes mellitus diagnosed with an inflammatory condition either infectious or non-infectious underwent a capillary CRP measurement on the same blood drop used for the measurement of capillary glucose level. Results: 154 samples from patients with diabetes across a broad range of CRP levels that underwent capillary CRP measurement, demonstrating a linear profile of the dynamic range compared with the wide range CRP assay, with significant correlation of R2 = 0.9 and a slope of 0.98 (95% C.I: 0.91–1). Bland Altman analysis, presents a positive bias profile; the total difference between assays is 6.6 mg/L. The mean bias between methods is 13.34% (C.I 95% 9.8–17.5%). The total agreement between the methods is 89%, the observed Kappa index is: 0.71 with confidence interval of 0.57–0.84 indicating substantial agreement between the methods. C-reactive protein level is independent of glucose concentration. Conclusion: Point-of-care capillary CRP testing is a useful mean of early detection of infection/inflammation in patients with diabetes and enables the treating physician to rapidly assess and treat the patients underlying inflammatory process.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46333843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of azurocidin (heparin binding protein) and interleukin-1ß as prognostic indicators in COVID-19 patients 阿zurocidin（肝素结合蛋白）和白细胞介素-1ß作为新冠肺炎患者预后指标的应用

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221105129

İrem Akın Şen, Ömer Karaşahin, E. Sebin, Cem Şen

{"title":"Use of azurocidin (heparin binding protein) and interleukin-1ß as prognostic indicators in COVID-19 patients","authors":"İrem Akın Şen, Ömer Karaşahin, E. Sebin, Cem Şen","doi":"10.1177/1721727X221105129","DOIUrl":"https://doi.org/10.1177/1721727X221105129","url":null,"abstract":"Objective: Considering the published manuscripts on this subject, it is thought that IL-1B and azurocidin may be diagnostic and prognostic factors in severe COVID-19 disease. This study aimed to determine whether azurocidin and IL-1β are useful biomarkers and are associated with disease exacerbation in patients needing advanced treatment options. Material and Method: Our study was performed retrospectively. The data of a total of 291 patients followed in the hospital due to COVID-19 were collected. Among these patients, 66 randomly selected patients were included in this study. The control group consisted of 24 healthy individuals referred to the infectious disease outpatient clinic who weren’t no diagnosis of COVID-19 infection or any other infection. After the samples were taken into tubes without anticoagulant, they were kept at room temperature for 30 min. Afterwards, it was centrifuged at 1000xg for 15 min at +4° according to the instructions of the ELISA kit we used. The remaining serum was transferred to Eppendorf tubes and stored at −80° throughout this study. Results: A statistically significant strong positive correlation was determined between IL1β and azurocidin. A statistically significant weak positive correlation was found between IL1β and CRP, ferritin and neutrophil count, weak negative correlation with albumin, and moderately strong positive correlation with leukocyte count. Moreover, a statistically significant weak positive correlation was found between azurucidin and CRP, ferritin, and neutrophil counts. Conclusion: Azurocidin and IL-1β may serve as a potential therapeutic target for patients at risk of developing systemic multi-organ failure, with improved patient prognosis and prevention of death in severely ill patients. Although these results may contribute to the improvement of the follow-up and treatment of the patients and reduce mortality rates, there is a need for randomized controlled studies with a larger number of patients to be performed in the future.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49319150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory activity of ingredients from the heartwood of Vietnamese Dalbergia oliveri Gamble ex Prain 越南橄榄心材成分的抗炎活性

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221132273

N. Nhan, P. Nguyen, Dam Thi Bich Hanh, D. My, N. D. Nguyen, Truong Ba Phong, Nguyen Thi Mai Huong, M. Tran, N. Tram, D. To

{"title":"Anti-inflammatory activity of ingredients from the heartwood of Vietnamese Dalbergia oliveri Gamble ex Prain","authors":"N. Nhan, P. Nguyen, Dam Thi Bich Hanh, D. My, N. D. Nguyen, Truong Ba Phong, Nguyen Thi Mai Huong, M. Tran, N. Tram, D. To","doi":"10.1177/1721727X221132273","DOIUrl":"https://doi.org/10.1177/1721727X221132273","url":null,"abstract":"Objectives: To investigate the phytochemical constituents of Vietnamese Dalbergia oliveri and their inhibition of NO production. Methods: The ethyl acetate soluble fraction was subjected to column chromatography using silica gel and Sephadex LH-20 to isolate compounds. The chemical structures of isolated compounds were identified by nuclear magnetic resonance data and comparison with previously reported literature. The anti-inflammation effects of the isolated compounds on the lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells were measured using the Griess reaction. Results: Nine secondary metabolites (1−9) were isolated successfully from the heartwood of D. oliveri. The chemical structures of these compounds were identified as daidzein (1), formononetin (2), 3,7-dihydroxy-4′-methoxyflavone (3), liquiritigenin (4), 3′-methoxydaidzein (5), dalbergin (6), butin (7), sativanone (8), and isoliquiritigenin (9). This is the first time that compounds 1, 3, 5−8 have been isolated from D. oliveri. In the NO production inhibition, compounds 7 and 9 exhibited the most potent inhibitory activity, with IC50 values of 7.6 and 11.2 μM, respectively, followed by 3−6, with IC50 values from 19.6 to 28.7 μM. Conclusion: The results suggested that D. oliveri and its natural products might exert anti-inflammatory effects due to their NO-inhibiting actions.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44101641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Efficacy of bortezomib in reduction of systemic lupus erythematosus disease activity index score: A meta-analysis 硼替佐米降低系统性红斑狼疮活动指数评分的疗效：一项荟萃分析

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221105152

Huan-Ran He, Man Luo, J. Xiong

{"title":"Efficacy of bortezomib in reduction of systemic lupus erythematosus disease activity index score: A meta-analysis","authors":"Huan-Ran He, Man Luo, J. Xiong","doi":"10.1177/1721727X221105152","DOIUrl":"https://doi.org/10.1177/1721727X221105152","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by the production of auto-antibodies against nuclear and cytoplasmic antigens, which can affect multiple organs. To date, no meta-analysis has reported the efficacy of bortezomib in SLE. We performed a meta-analysis to investigate the efficacy of bortezomib in patients with SLE. Methods: We searched the PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese BioMedical databases for articles published before 18 August 2021 to identify all studies relevant to SLE. The following were our inclusion criteria: (1) written in all languages, (2) bortezomib administration in patients with SLE and, (3) a clear description of SLE Disease Activity Index (SLEDAI) scores. Following were the exclusion criteria: (1) duplicate publications (the most recent article was included for analysis)and, (2) animal experiments, case reports, meeting reports, and reviews. The pooled data were analysed using a fixed- or random-effects model, depending on heterogeneity (determined using the I2 index). Results: Three articles that described 29 patients were included in this study. The forest plot showed a positive association between bortezomib therapy and SLE based on analysis of SLEDAI scores, with an odds ratio of 11.30 (95% confidence interval 7.03–15.56, p < .00001). Conclusion: Bortezomib treatment can reduce the SLEDAI scores in patients with SLE, which suggests the usefulness of this therapeutic approach for SLE.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44665520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of pentoxifylline on T-cell viability under inflammatory conditions 己酮可可碱对炎症条件下T细胞活力的保护作用

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221120753

Sungjin Park, Sung-Hyuk Choi, Young-Duck Cho, Jung-Youn Kim, Hanjin Cho, Kyung-Hwan Kim, Won Kim

{"title":"Protective effects of pentoxifylline on T-cell viability under inflammatory conditions","authors":"Sungjin Park, Sung-Hyuk Choi, Young-Duck Cho, Jung-Youn Kim, Hanjin Cho, Kyung-Hwan Kim, Won Kim","doi":"10.1177/1721727X221120753","DOIUrl":"https://doi.org/10.1177/1721727X221120753","url":null,"abstract":"Introduction: Pentoxifylline (PTX) reduces the levels of pro-inflammatory cytokines; however, its effects on immune system is not well understood. The aim of this study was to investigate the effect of PTX on T cells under inflammatory conditions in co-culture with THP-1-derived macrophages. Methods: Toll-like receptor 4 (TLR4) and macrophage migration inhibitory factor (MIF) levels were measured after addition of PTX to lipopolysaccharide (LPS)-stimulated differentiated THP-1 cells. T cell viability and MIF levels were measured after PTX was added to prostaglandin E2 (PGE2)-stimulated Jurkat T-cell leukemia line. Co-culture was conducted to determine the effect of LPS-stimulated differentiated THP-1 cells that are affected by PTX on Jurkat cells. To prevent the direct effects of LPS and PTX on Jurkat cells, LPS and PTX were washed from THP-1 cells before co-culture. T cell viability and interleukin-2 (IL-2) levels were determined in Jurkat cells. Results: Increase in the MIF concentration and TLR4 expression level in differentiated THP-1 cells stimulated with LPS were reversed after PTX addition. However, PTX did not improve T cell viability in PGE2–stimulated Jurkat cells. Co-culturing Jurkat cell and LPS-stimulated differentiated THP-1 cells resulted in a decreased viability of T cells. The addition of PTX restored T cell viability to normal control levels and IL-2 expression level in Jurkat cells. Conclusion: LPS-stimulated THP-1-derived macrophages reduced the T cell viability under inflammation. However, PTX restored T cells viability and IL-2 back to normal levels. Therefore, the immunomodulatory action of PTX may be mediated by macrophage-T cell interactions.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42310506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of CORIN in patients with heart failure: A systematic review and meta-analysis 心衰患者CORIN的评价:系统回顾和荟萃分析

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221130650

Nianxin Jiang, B. Jiang, Xuan Zhang, W. Yong, S. Zhuang

{"title":"Evaluation of CORIN in patients with heart failure: A systematic review and meta-analysis","authors":"Nianxin Jiang, B. Jiang, Xuan Zhang, W. Yong, S. Zhuang","doi":"10.1177/1721727X221130650","DOIUrl":"https://doi.org/10.1177/1721727X221130650","url":null,"abstract":"Objectives: We aim to evaluate the association between CORIN and heart failure. Methods: This study used PubMed, EMBASE, Cochrane database, and China National Knowledge Database (CNKI) to search for CORIN-related full-text articles with heart failure patients. We drew forest plots, performed sensitivity and bias analyses based on the included data. Next, we used Review Manager 5.2 software to assess the heterogeneity among selected articles. Results: Our meta-analysis results showed there was significant relationship between CORIN and heart failure (HF). There was significant difference of CORIN between heart failure group and control group (MD = −293.88, 95% confidence interval [-380.26, −207.49], p < .00001; heterogeneity p < .0001, I2= 97%) and there was significant difference in CORIN between ischemic group and non-ischemic group (MD = 88.79, 95% confidence interval [70.46107.12], heterogeneity p < .000, p = 0.94, l2= 0%). In subgroup analysis, there were significant differences in three different HF levels. Limited publication bias was observed, and this study was robust. Conclusion: In short, the results showed that CORIN was closely related with heart failure and might be helpful in the diagnosis of heart failure.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43588246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats Sprague-Dawley大鼠膝关节内重复注射七氟醚的临床和组织学安全性评估

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/20587392211072639

Ainara Achaerandio-de Nova, M. D. Berenguer-Romero, Syonghyun Nam Cham, Mónica Gómez-Juárez Sango, Sergio Losa-Palacios, Á. Escudero-Jiménez, M. Gerónimo-Pardo

{"title":"Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats","authors":"Ainara Achaerandio-de Nova, M. D. Berenguer-Romero, Syonghyun Nam Cham, Mónica Gómez-Juárez Sango, Sergio Losa-Palacios, Á. Escudero-Jiménez, M. Gerónimo-Pardo","doi":"10.1177/20587392211072639","DOIUrl":"https://doi.org/10.1177/20587392211072639","url":null,"abstract":"Objectives We investigated the effects of repeated intra-articular injections of liquid sevoflurane to articular structures, as this inhalational anesthetic is being repurposed as an antimicrobial agent, which would make sevoflurane a novel alternative for the treatment of septic arthritis. Methods The left knees of nine Sprague-Dawley rats were injected with 150 μL of liquid sevoflurane for five consecutive days, whereas the right knees were injected with the same volume of saline to serve as controls. Animals were examined daily for clinical signs of local and systemic toxic effects attributable to sevoflurane. Rats were euthanized in groups of three at days 7, 14, and 35 after the first injection, and left and right knees were sent for histological assessment. Results Local signs on knees consisted of transient bilateral scabs, and an unexpected subcutaneous emphysema affecting only left knees, which was attributed to sevoflurane. No rat presented with limp, and animal welfare was good during the study period. Two out of the three left knees from rats sacrificed at day 7 showed mild histological changes, specifically a mild infiltration of lymphocytes. All other seven left knees as well as all nine right knees were completely normal at histological examination. Conclusion We concluded that repeated intra-articular injections of sevoflurane seemed safe for articular structures in noninfected knees. Further studies focused on the safety of intra-articular sevoflurane in infected knees, as well as on its effectiveness for the treatment of septic arthritis are warranted.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41993678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of D-dimer to fibrinogen ratio for patients with acute myocardial infarction D-二聚体与纤维蛋白原比值对急性心肌梗死患者的预后价值

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221132381

Litao Zhang, Jia-Suo Jiang, Jie Li, Min Wang, Jun Zhou

{"title":"Prognostic value of D-dimer to fibrinogen ratio for patients with acute myocardial infarction","authors":"Litao Zhang, Jia-Suo Jiang, Jie Li, Min Wang, Jun Zhou","doi":"10.1177/1721727X221132381","DOIUrl":"https://doi.org/10.1177/1721727X221132381","url":null,"abstract":"Objective Myocardial infarction is a severe disease with high in-hospital mortality without aggressive clinical treatment. The study aims to evaluate prognostic worth of D-dimer-to-fibrinogen (FIB) ratio (DFR) for patients with acute myocardial infarction (AMI). Methods 133 patients (65 (37, 93) years old) from our hospital (China) with AMI were enlisted from January 2017 to December 2019. Patients were assigned into the survivor and nonsurvivor group based on in-hospital outcomes. Receiver operating characteristics (ROC) and multivariate analysis were fulfilled to analyze the prognostic value of DFR. Results The degree of DFR in the nonsurvivor group was significantly higher than that in the survivor group (p < 0.05). Logistic regression analysis presented that DFR (hazard ratio (HR), 2.207; 95% confidence interval (CI), 1.050–4.640; p = 0.037) was independently related with in-hospital death. ROC demonstrated that the area under the curve (AUC) of DFR was = 0.808 (0.725–0.892) (sensitivity, 85.3%; specificity, 69.7%). Conclusion DFR might be a new independent predictor of in-hospital death for AMI patients. Further studies are needed to validate this preliminary finding.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48926778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical significance of serum GPX2 levels in patients with osteoarthritis was suppressed and reduced inflammation of osteoarthritis through STAT3 function STAT3功能对骨关节炎患者血清GPX2水平的抑制和减轻炎症的临床意义

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/20587392211070411

Jinli Du, Jieying Zhang

{"title":"Clinical significance of serum GPX2 levels in patients with osteoarthritis was suppressed and reduced inflammation of osteoarthritis through STAT3 function","authors":"Jinli Du, Jieying Zhang","doi":"10.1177/20587392211070411","DOIUrl":"https://doi.org/10.1177/20587392211070411","url":null,"abstract":"The main alterations of osteoarthritis are degenerative lesions of articular cartilage and secondary hyperostosis. Despite the unclear pathogenic mechanism, experimental studies have confirmed that the incidence of osteoarthritis is closely associated with inflammation-related substances. In this study, we explored the significance of serum GPX2 levels in patients with osteoarthritis and the mechanism of GPX2 in the anti-inflammation effects in osteoarthritis. As a result, serum GPX2 level was down-regulated and there was a negative correlation between GPX2 levels and IL-1β levels in patients with osteoarthritis. Over-expression of GPX2 decreased the inflammatory levels and down-regulation of GPX2 increased inflammatory levels in vitro. In contrast, GPX2 combined and regulated STAT3 protein expression. Over-expression of GPX2 promoted ubiquitination-STAT3 protein expression to decrease p-STAT3 protein expression in vitro. The inhibition of STAT3 attenuated the anti-inflammation effects of GPX2 in osteoarthritis. Thus, we proposed that GPX2 was down-regulated in patients with osteoarthritis and GPX2 played vital roles in osteoarthritis for clinical diagnosis or therapy.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46093669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small-sized shiny sclerotic plaques: Think early morphea 小尺寸有光泽的硬化斑块:考虑早期睡眠

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2022-01-01 DOI: 10.1177/1721727X221105130

Hiroki Hashimoto, T. Nakahara

引用次数: 0