European Journal of Inflammation最新文献_第2页

F4/80+CD206+ M2-like macrophages contribute to bone erosion in collagen-induced arthritis by differentiating into osteoclasts F4/80+CD206+ m2样巨噬细胞通过分化为破骨细胞参与胶原诱导关节炎的骨侵蚀

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-08-08 DOI: 10.1177/1721727x231194595

HeHe Sun, Hongmin Wang, Chenhui Gao, Li Tai, Yueyao Yang, Hongliang Dong, Xiaoming Gao

{"title":"F4/80+CD206+ M2-like macrophages contribute to bone erosion in collagen-induced arthritis by differentiating into osteoclasts","authors":"HeHe Sun, Hongmin Wang, Chenhui Gao, Li Tai, Yueyao Yang, Hongliang Dong, Xiaoming Gao","doi":"10.1177/1721727x231194595","DOIUrl":"https://doi.org/10.1177/1721727x231194595","url":null,"abstract":"Rheumatoid arthritis is an autoimmune disease characterized by synovial inflammation-driven cartilage and bone destruction, a process mainly mediated by osteoclasts. In recent years M2-like macrophages have been found to play an important role in the pathological process of RA by mediating pro-inflammatory effects, but their roles in the bone destruction of autoimmune arthritis have not been reported. In this study we identified that an abundant cell population of CD45+CD11b+Gr-1-F4/80+CD206+ cells, which were normally classified as M2-like macrophages, was present in synovium of collagen-induced arthritis (CIA) mice, and these cells had the potential to differentiate into osteoclasts. These M2-like macrophages sorted from CIA synovium highly expressed RANK and could be activated by RANKL and M-CSF to acquire osteoclast markers and bone resorption function both in vitro and in vivo. Furthermore, in vitro differentiated M2 macrophages from both CIA mouse bone marrow and RA patient peripheral blood mononuclear cells were also able to differentiate into osteoclasts, confirming the general osteoclastogenesis capability of M2 subtype macrophages. All these results suggest that synovial F4/80+CD206+ M2-like macrophages in RA may be novel osteoclast precursors and contribute significantly to bone erosive changes seen in RA. Our studies provided new directions and targets for the diagnosis and treatment of rheumatoid arthritis.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47107093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of scutellarin on acute myocardial ischemia/reperfusion injury in isolated rat heart 黄芩苷对离体大鼠急性心肌缺血再灌注损伤的影响

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-08-07 DOI: 10.1177/1721727x231192289

Daoxu Qu, Peiwen Feng, Xinjie Zhang, Mingjie Zhou

引用次数: 0

Evaluation of vascular density and structural changes in inflammatory bowel diseases 炎症性肠病的血管密度和结构变化评估

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-07-14 DOI: 10.1177/1721727x231190246

S. Bilgin, Ahmet Yekta Tüzün

{"title":"Evaluation of vascular density and structural changes in inflammatory bowel diseases","authors":"S. Bilgin, Ahmet Yekta Tüzün","doi":"10.1177/1721727x231190246","DOIUrl":"https://doi.org/10.1177/1721727x231190246","url":null,"abstract":"The two most common types of inflammatory bowel disease (IBD) are ulcerative colitis (UC) and Crohn’s disease (CD). Although these diseases mainly affect the intestinal system, they can also affect other systems, especially the vascular system. The objective of this study is to evaluate ocular microvascular and structural changes in IBD. A total of 42 patients with IBD (22 UC and 20 CD) followed in the gastroenterology clinic and 42 healthy controls matched for gender and age were enrolled in the study. All participants underwent optical coherence tomography angiography. Macular vessel density, central retinal, and choroidal thicknesses were measured. No significant differences were observed between IBD patients and control subjects as regards superficial vascular plexus density, deep vascular plexus density, and choriocapillaris vascular density, retinal and choroidal thickness in the macular area ( p > .05). Although not statistically significant, vascular density generally increased. On the other hand, retinal and choroidal thickness were decreased. It could be said that there is a reactive increase in retinal vascular density and a decrease in retinal and choroidal thickness as a result of atherosclerotic changes in IBD.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47938828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between IL-25, IL-33 and atopic dermatitis: A systematic review and meta-analysis IL-25、IL-33与特应性皮炎的相关性：系统综述和荟萃分析

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-06-29 DOI: 10.1177/1721727x231183670

B. Zhou, Xueping Yue, S. Liang, S. Shang, L. Xiang, K. Zhou, Linfeng Li

{"title":"Association between IL-25, IL-33 and atopic dermatitis: A systematic review and meta-analysis","authors":"B. Zhou, Xueping Yue, S. Liang, S. Shang, L. Xiang, K. Zhou, Linfeng Li","doi":"10.1177/1721727x231183670","DOIUrl":"https://doi.org/10.1177/1721727x231183670","url":null,"abstract":"Objective: To evaluate the association between IL-25, IL-33 and AD more generally. Methods: Databases, including PubMed, Web of Science, EMBASE, Scopus, CNKI and Sinomed were searched. Based on the criteria, publications were collected. The evaluation of study quality was through Newcastle-Ottawa Scale (NOS). Fixed or random effect model was selected according to the between-study heterogeneity to evaluate the association. The analysis procedure and the construction plots were using Review Manager 5.3 software. Results: Six studies were included. A total of 282 subjects were included from four studies to analyze the association between IL-25 and AD. The level of IL-25 was significantly elevated in AD patients, comparing with the control subjects (SMD = 0.89, 95% CI: 0.64, 1.14, p < 0.05). For IL-33, a total of 247 subjects were included from two studies, and the level of IL-33 was also significantly elevated in AD patients comparing to the control subjects (SMD = 0.49, 95% CI: 0.19, 0.80, p < 0.05). Conclusions: The serum levels of IL-25, IL-33 are elevated in AD patients of this study. The IL-25 and IL-33 are significantly associated with the risk of AD. Further studies with larger samples, in multiple countries and focused on different age groups are need.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45119832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytic acid regulates proliferation of colorectal cancer cells by downregulating NF-kB and β-catenin signalling 植酸通过下调NF-kB和β-catenin信号传导调节结直肠癌细胞的增殖

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-06-29 DOI: 10.1177/1721727x231182622

Jianyu Feng, Yandong Liu, Chunnan Zhang, Menglin Ji, Cuiyun Li

{"title":"Phytic acid regulates proliferation of colorectal cancer cells by downregulating NF-kB and β-catenin signalling","authors":"Jianyu Feng, Yandong Liu, Chunnan Zhang, Menglin Ji, Cuiyun Li","doi":"10.1177/1721727x231182622","DOIUrl":"https://doi.org/10.1177/1721727x231182622","url":null,"abstract":"Phytic acid (PYT) also known as inositol hexakisphosphate or inositol polyphosphate has shown a broad range of biological effects including anti-inflammatory, antioxidant, and anticancer effects in several preclinical studies. This study aimed to investigate the effects of PYT in vitro on HCT116 and HT-29 cell lines and to analyse the intricate mechanism of NF-κB-β-catenin signalling pathways. Both cell lines were treated with PYT, and analysed for cell viability, apoptosis, progression of cell cycle, and DNA fragmentation. Gene and protein expression analysis was performed to assess the molecular mechanism. PYT suppressed the proliferation of colorectal cancer cell lines in a dose- and time-dependent manner with an estimated IC50 value of 2.96 and 3.35 mm, respectively. PYT caused cell cycle arrest at the G2/M phase in both CRC cell lines and induced mitochondrial intrinsic apoptosis via activation of caspase-9 and caspase-3 cascade. PYT suppressed the expression of pro-inflammatory markers especially COX-2 and iNOS, and IL-lβ, IL-6, and IL-10. Analysing the mechanism behind the effects of PYT showed that it suppressed the levels of NF-κB and β-catenin and inhibited the levels of cyclin Dl and c-Myc (its downstream targets) and COX-2. The results collectively indicate the potent anti-inflammatory and anti-proliferative effects of PYT in CRC cell lines that were mediated by downregulating the β-catenin and NF-κB signalling pathways. Results advocate that natural supplementation of PYT can be an effective preventive approach in controlling cancer of colorectal region.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42272411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-33 promotes the epithelial-mesenchymal transition of renal tubular epithelial cells via the NF-κB/Twist1 signalling pathway 白细胞介素-33通过NF-κB/Twist1信号通路促进肾小管上皮细胞向间质转化

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-06-29 DOI: 10.1177/1721727x231186877

Ziyu Zhang, Wenqiang Gu, Zepeng Li, Xiao Chen, Weixing Xu, Xianwei Li

{"title":"Interleukin-33 promotes the epithelial-mesenchymal transition of renal tubular epithelial cells via the NF-κB/Twist1 signalling pathway","authors":"Ziyu Zhang, Wenqiang Gu, Zepeng Li, Xiao Chen, Weixing Xu, Xianwei Li","doi":"10.1177/1721727x231186877","DOIUrl":"https://doi.org/10.1177/1721727x231186877","url":null,"abstract":"Objectives: Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells (RTECs) is a pathogenic factor for renal interstitial fibrosis (RIF). Interleukin-33 (IL-33) is related to the occurrence and development of RIF, but the underlying mechanism remains unclear. Here, we investigated whether IL-33 mediates the EMT of RTECs by activating the NF-κB/Twist1 signalling pathway. Methods: In vivo, the RIF animal model induced by unilateral ureteral obstruction (UUO) was established. The effects of exogenous IL-33 and anti-IL-33 antibodies were evaluated. In vitro, the EMT of RTECs was induced by IL-33. The inhibition of the nuclear factor kappa-B (NF-κB) by the pyrrolidine dithiocarbamate (PDTC) and the knockdown of the suppression of tumorigenicity 2 (ST2) by small interference RNA were used to observe whether IL-33 mediates the EMT of RTECs through the NF-κB/Twist1 signaling pathway. Results: In vivo, exogenous IL-33 significantly aggravated UUO-induced pathological damage and collagen deposition, down-regulated E-cadherin expression, and up-regulated α-smooth muscle actin and Vimentin expressions. Moreover, exogenous IL-33 increased the levels of phospho-IκB-α (p-IκB-α) and phospho-NF-κB p65 (p-NF-κB p65), NF-κB p65 nuclear translocation, and Twist1 nuclear expression. However, these effects were reversed by the anti-IL-33 antibody. In vitro , the increases in the levels of p-IκB-α, p-NF-κB p65, NF-κB p65 nuclear translocation, and Twist1 nuclear expression induced by IL-33 were inhibited by the knockdown of PDTC or ST2. IL-33-mediated EMT of RTECs was also significantly reversed. However, NF-κB inhibitor PDTC had no significant effect on ST2 expression. Conclusions: The IL-33/ST2 axis may up-regulate the expression of Twist1 through the NF-κB signalling pathway, thereby inducing the EMT of RTECs and leading to RIF.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44109633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of the role of myeloid-derived growth factor on acute lung injury in vitro and In vivo 髓源性生长因子在体外和体内急性肺损伤中的作用研究

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-06-27 DOI: 10.1177/1721727x231185390

Wenhui Gong, S. Jiang, Jianbo Wang, Qian Gong, Chengxin Zhang, Shenglin Ge

{"title":"A study of the role of myeloid-derived growth factor on acute lung injury in vitro and In vivo","authors":"Wenhui Gong, S. Jiang, Jianbo Wang, Qian Gong, Chengxin Zhang, Shenglin Ge","doi":"10.1177/1721727x231185390","DOIUrl":"https://doi.org/10.1177/1721727x231185390","url":null,"abstract":"Objectives: Bone marrow-derived mesenchymal stem cells (BMSCs) are considered to have potential clinical application value in the treatment of acute lung injury (ALI). Myeloid-derived growth factor (MYDGF) can promote the proliferation of stem cell. We hypothesized that MYDGF may play a role in reducing lung injury in vitro and in vivo through bone marrow mesenchymal stem cells. Methods: An in vitro model of lipopolysaccharide (LPS)(MLE-12) was established, which was divided into five groups: A: MLE-12; B: MLE-12+LPS; C: MLE-12+LPS + BMSCs; D: MLE-12+LPS + MYDGF; and E: MLE-12+LPS + BMSCs + MYDGF. A Cell Counting Kit-8 was used to detect the OD value. And an ALI model was constructed by inducing mice with a lipopolysaccharide. Forty male Balb/c mice were randomly divided into five groups: A control group; B: model group; C: LPS + BMSCs; D: LPS + MYDGF; E: LPS +BMSCs +MYDGF. Specimens were collected after 24 h. Hematoxylin-eosin (HE)-staining was performed on the tissue sections. The protein concentration in the alveolar lavage fluid was measure by bicinchoninic acid (BCA). The NF-κB, p-Akt, Bax, and Bcl-2 protein expression was detected through Western blotting, and Enzyme linked immunosorbent assay (ELISA) was used to measure the expression of serum interleukin-6, interleukin-10, and TNF-α. Results: Compared with the model group, BMSCs and MYDGF can alleviate the ALI induced by lipopolysaccharide in vitro and vivo ( p < .05). Conclusion: We found that the combined treatment effect of MYDGF and BMSCs was better than using MYDGF or BMSCs alone. We speculate that a pretreatment with MYDGF after ALI in mice may improve the survival and growth of transplanted MSCs, thereby improving the curative effect of cell transplantation.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44405022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of dexmedetomidine on Tourniquet induced lung injury in patients undergoing total knee arthroplasty: A randomized trial 右美托咪定对全膝关节置换术患者止血带所致肺损伤的保护作用:一项随机试验

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-05-25 DOI: 10.1177/1721727x231179671

Wenjie Cheng, Jizheng Zhang, Zhe Wu, Xiaohua Sun, Wanlu Ren

{"title":"Protective effect of dexmedetomidine on Tourniquet induced lung injury in patients undergoing total knee arthroplasty: A randomized trial","authors":"Wenjie Cheng, Jizheng Zhang, Zhe Wu, Xiaohua Sun, Wanlu Ren","doi":"10.1177/1721727x231179671","DOIUrl":"https://doi.org/10.1177/1721727x231179671","url":null,"abstract":"To investigate whether dexmedetomidine (Dex) can reduce the severity of tourniquet-induced lung injury. 36 patients undergoing total knee arthroplasty with a tourniquet were randomly assigned to the control (ischemia/reperfusion [I/R]) group and Dex group. Patients in the Dex group received a loading dose of Dex (0.8 μg/kg over 10 min intravenously) followed by continuous infusion of Dex (0.5 μg/kg/h intravenously) until the end of the surgery. The I/R group received an equal amount of 0.9% saline instead of Dex. The serum concentrations of tumor necrosis factor-α (TNF-α), Clara cell protein (CC-16), soluble receptor for advanced glycation end products (sRAGE), and brain-derived neurotrophic factor (BDNF) were measured and arterial blood gas analysis was performed before anesthesia and 30 min, 6 h, and 24 h after tourniquet release. In the I/R group, compared with baseline, the TNF-α, CC-16, and sRAGE concentrations were higher ( p < 0.05) and the BDNF concentration was lower ( p < 0.05) at most time points. In the Dex group, the TNF-α, CC-16, and sRAGE concentrations were lower than those in the I/R group ( p < 0.05), whereas the concentration of BDNF was higher ( p < 0.05). In the arterial blood gas analysis, the Dex group showed a significantly higher partial pressure of oxygen and arterial/alveolar oxygen tension ratio ( p < 0.05) and a significantly lower alveolar/arterial oxygen tension difference than the I/R group ( p < 0.05). Dex administration partly inhibits the release of proinflammatory cytokines, affording protection against tourniquet-induced lung injury.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44651563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of high-sensitivity C-reactive protein reference intervals for apparently healthy children in Addis Ababa, Ethiopia 埃塞俄比亚亚的斯亚贝巴表面健康儿童超敏C反应蛋白参考区间的测定

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-05-23 DOI: 10.1177/1721727x231177137

O. Mohammed, Melkitu Kassaw, Endalkachew Befekadu, L. G/Egzeabher, A. Mekonen, D. Bikila, F. Challa, A. Belay, Mistire Wolde, Kassu Desta, A. Tsegaye

{"title":"Determination of high-sensitivity C-reactive protein reference intervals for apparently healthy children in Addis Ababa, Ethiopia","authors":"O. Mohammed, Melkitu Kassaw, Endalkachew Befekadu, L. G/Egzeabher, A. Mekonen, D. Bikila, F. Challa, A. Belay, Mistire Wolde, Kassu Desta, A. Tsegaye","doi":"10.1177/1721727x231177137","DOIUrl":"https://doi.org/10.1177/1721727x231177137","url":null,"abstract":"Objective: Since then, the reference intervals of serum hsCRP in apparently healthy Ethiopian children are unknown. Therefore, this study aimed to determine the reference intervals of serum hsCRP for apparently healthy children. Methods: In this cross-sectional study, a total of 492 apparently healthy children aged 5–17 years were recruited from residents of Addis Ababa. Well-trained professionals took anthropometric measurements. The biochemical analysis was performed with the automatic biochemical analyzer Cobas Integra 400 Plus from Roche. The 2.5th and 97.5th percentile limits were calculated using a non-parametric method as per the Clinical Laboratory Standard Institute (CLSI) guide. A box plot was used to show the distribution of hsCRP by age and gender. Furthermore, bivariate and multivariable logistic regression analyses were carried out to evaluate factors associated with elevated hsCRP levels. Percentiles were displayed by age subgroup and sex. p-values <0.05 were considered statistically significant. Results: The study included 245 boys and 247 girls. For the age group of 5–11 years, the combined 2.5th and 97.5th percentiles, which can be used as a reference interval for children in Addis Ababa, were 0.15–6.78 mg/L, while for the older age group (12–17 years), the determined percentile was 0.14–4.40 mg/L. Likewise, the current study shows that never or occasionally eating vegetables and/or fruits (AOR = 2.28, 95% CI, 0.84–4.97), and being obese (AOR = 3.63, 95% CI, 1.14–11.53) were independent risk factors for elevated serum hsCRP concentrations. Conclusion: This study is the first to determine the reference intervals of hsCRP concentrations among apparently healthy Ethiopian children. Notable differences were observed in the established percentiles of hsCRP in comparison with published literature.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42020561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pemphigus and thyroid disease: A systematic review and meta-analysis 天疱疮和甲状腺疾病:一项系统综述和荟萃分析

IF 0.7 4区医学

European Journal of Inflammation Pub Date : 2023-05-21 DOI: 10.1177/1721727x231177815

Linxi Zeng, Xin Huang, Yue-ping Yao, G. Zhang

{"title":"Pemphigus and thyroid disease: A systematic review and meta-analysis","authors":"Linxi Zeng, Xin Huang, Yue-ping Yao, G. Zhang","doi":"10.1177/1721727x231177815","DOIUrl":"https://doi.org/10.1177/1721727x231177815","url":null,"abstract":"No consensus exists regarding the association between pemphigus and thyroid disease. To explore the relationship between the two conditions by synthesizing the existing data. We performed this review based on PubMed, Embase and Web of Science (from inception to 2022) and used the Newcastle-Ottawa scale for assessing the quality of studies. The outcome was represented by pooled odds ratios (ORs) with 95% confidence intervals (CI). And the publication bias and sensitivity analyses were developed. Our analyze finally included six studies containing 17,567 pemphigus patients. Overall, we revealed that pemphigus is significantly associated with hypothyroidism (OR 1.70, 95% CI 1.54–1.87), while not with thyroid cancer (OR 0.93, 95% CI 0.41–2.11) and autoimmune thyroid disease (AITD) (OR 1.64, 95% CI 0.91–2.95). In subgroup analyses, pemphigus was also not associated with Graves’ disease (OR 0.97, 95% CI 0.63–1.49) and Hashimoto’s thyroiditis (OR 1.32, 95% CI 0.88–1.97). Our results reveal a significant association between pemphigus and hypothyroidism. Considering other relevant studies, we also speculate that the prevalence of AITD is higher in pemphigus patients than in the general population.","PeriodicalId":55162,"journal":{"name":"European Journal of Inflammation","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45667045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0