IEEE Transactions on Information Technology in Biomedicine最新文献

{"title":"List of Editors and Reviewers","authors":"L. B. Carvalho","doi":"10.14209/jcis.2016.28","DOIUrl":"https://doi.org/10.14209/jcis.2016.28","url":null,"abstract":"Lists the reviewers who contributed to IEEE Transactions on Information Technology in Biomedicine.","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 1","pages":"1353-1357"},"PeriodicalIF":0.0,"publicationDate":"2017-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43593096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A resource-efficient planning for pressure ulcer prevention.","authors":"Sarah Ostadabbas,&nbsp;Rasoul Yousefi,&nbsp;Mehrdad Nourani,&nbsp;Miad Faezipour,&nbsp;Lakshman Tamil,&nbsp;Matthew Q Pompeo","doi":"10.1109/TITB.2012.2214443","DOIUrl":"https://doi.org/10.1109/TITB.2012.2214443","url":null,"abstract":"<p><p>Pressure ulcer is a critical problem for bed-ridden and wheelchair-bound patients, diabetics, and the elderly. Patients need to be regularly repositioned to prevent excessive pressure on a single area of body, which can lead to ulcers. Pressure ulcers are extremely costly to treat and may lead to several other health problems, including death. The current standard for prevention is to reposition at-risk patients every two hours. Even if it is done properly, a fixed schedule is not sufficient to prevent all ulcers. Moreover, it may result in nurses being overworked by turning some patients too frequently. In this paper, we present an algorithm for finding a nurse-effort optimal repositioning schedule that prevents pressure ulcer formation for a finite planning horizon. Our proposed algorithm uses data from a commercial pressure mat assembled on the beds surface and provides a sequence of next positions and the time of repositioning for each patient. </p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1265-73"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2214443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30859763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric decision support system for the prediction of oral cancer reoccurrence.","authors":"Konstantinos P Exarchos,&nbsp;Yorgos Goletsis,&nbsp;Dimitrios I Fotiadis","doi":"10.1109/TITB.2011.2165076","DOIUrl":"https://doi.org/10.1109/TITB.2011.2165076","url":null,"abstract":"<p><p>Oral squamous cell carcinoma (OSCC) constitutes the predominant neoplasm of the head and neck region, featuring particularly aggressive nature, associated with quite unfavorable prognosis. In this work we formulate a Decision Support System (DSS) which integrates a multitude of heterogeneous data (clinical, imaging and genomic), thus, framing all manifestations of the disease. Our primary aim is to identify the factors that dictate OSCC progression and subsequently predict potential relapses (local or metastatic) of the disease. The discrimination potential of each source of data is initially explored separately, and afterwards the individual predictions are combined to yield a consensus decision achieving complete discrimination between patients with and without a disease relapse. </p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1127-34"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2011.2165076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29948756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image analysis and length estimation of biomolecules using AFM.","authors":"Andrew Sundstrom,&nbsp;Silvio Cirrone,&nbsp;Salvatore Paxia,&nbsp;Carlin Hsueh,&nbsp;Rachel Kjolby,&nbsp;James K Gimzewski,&nbsp;Jason Reed,&nbsp;Bud Mishra","doi":"10.1109/TITB.2012.2206819","DOIUrl":"https://doi.org/10.1109/TITB.2012.2206819","url":null,"abstract":"<p><p>There are many examples of problems in pattern analysis for which it is often possible to obtain systematic characterizations, if in addition a small number of useful features or parameters of the image are known a priori or can be estimated reasonably well. Often the relevant features of a particular pattern analysis problem are easy to enumerate, as when statistical structures of the patterns are well understood from the knowledge of the domain. We study a problem from molecular image analysis, where such a domain-dependent understanding may be lacking to some degree and the features must be inferred via machine-learning techniques. In this paper, we propose a rigorous, fully-automated technique for this problem. We are motivated by an application of atomic force microscopy (AFM) image processing needed to solve a central problem in molecular biology, aimed at obtaining the complete transcription profile of a single cell, a snapshot that shows which genes are being expressed and to what degree. Reed et al (Single molecule transcription profiling with AFM, Nanotechnology, 18:4, 2007) showed the transcription profiling problem reduces to making high-precision measurements of biomolecule backbone lengths, correct to within 20-25 bp (6-7.5 nm). Here we present an image processing and length estimation pipeline using AFM that comes close to achieving these measurement tolerances. In particular, we develop a biased length estimator on trained coefficients of a simple linear regression model, biweighted by a Beaton-Tukey function, whose feature universe is constrained by James-Stein shrinkage to avoid overfitting. In terms of extensibility and addressing the model selection problem, this formulation subsumes the models we studied. </p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1200-7"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2206819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30736768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of initial equivalency for protein structure alignment based on encoded local structures.","authors":"Kenneth Hung,&nbsp;Jui-Chih Wang,&nbsp;Cheng-Wei Chen,&nbsp;Cheng-Long Chuang,&nbsp;Kun-Nan Tsai,&nbsp;Chung-Ming Chen","doi":"10.1109/TITB.2012.2204892","DOIUrl":"https://doi.org/10.1109/TITB.2012.2204892","url":null,"abstract":"<p><p>Most alignment algorithms find an initial equivalent residue pair followed by an iterative optimization process to explore better near-optimal alignments in the surrounding solution space of the initial alignment. It plays a decisive role in determining the alignment quality since a poor initial alignment may make the final alignment trapped in an undesirable local optimum even with an iterative optimization. We proposed a vector-based alignment algorithm with a new initial alignment approach accounting for local structure features called MIRAGE-align. The new idea is to enhance the quality of the initial alignment based on encoded local structural alphabets to identify the protein structure pair whose sequence identity falls in or below twilight zone. The statistical analysis of alignment quality based on Match Index (MI) and computation time demonstrated that MIRAGE-align algorithm outperformed four previously published algorithms, i.e., the residue-based algorithm (CE), the vector-based algorithm (SSM), TM-align, and Fr-TM-align. MIRAGE-align yields a better estimate of initial solution to enhance the quality of initial alignment and enable the employment of a non-iterative optimization process to achieve a better alignment. </p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1185-92"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2204892","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30706060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Examination of the Motor Unit Number Index (MUNIX) in muscles paralyzed by spinal cord injury.","authors":"Xiaoyan Li,&nbsp;Faezeh Jahanmiri-Nezhad,&nbsp;William Zev Rymer,&nbsp;Ping Zhou","doi":"10.1109/TITB.2012.2193410","DOIUrl":"https://doi.org/10.1109/TITB.2012.2193410","url":null,"abstract":"<p><p>The objective of this study was to assess whether there is evidence of motor unit loss in muscles paralyzed by spinal cord injury (SCI), using a measurement called motor unit number index (MUNIX). The MUNIX technique was applied in SCI (n=12) and neurologically intact (n=12) subjects. The maximum M waves and voluntary surface electromyography (EMG) signals at different muscle contraction levels were recorded from the first dorsal interosseous (FDI) muscle in each subject. The MUNIX values were estimated using a mathematical model describing the relation between the surface EMG signal and the ideal motor unit number count derived from the M wave and surface EMG measurements. We recorded a significant decrease in both maximum M wave amplitude and in estimated MUNIX values in paralyzed FDI muscles, as compared with neurologically intact muscles. Across all subjects, the maximum M wave amplitude was 8.3 ± 4.4 mV for the paralyzed muscles and 14.4 ± 2.0 mV for the neurologically intact muscles (p<0.0001). These measurements, when combined with voluntary EMG recordings, resulted in a mean MUNIX value of 112 ± 71 for the paralyzed muscles, much lower than the mean MUNIX value of 228 ± 49 for the neurologically intact muscles (p<0.00001). A motor unit size index was also calculated, using the maximum M wave recording and the MUNIX values. We found that paralyzed muscles showed a mean motor unit size index value of 80.7 ± 17.7 ìV, significantly higher than the mean value of 64.9 ± 10.1 ìV obtained from neurologically intact muscles (p<0.001). The MUNIX method used in this study offers several practical benefits compared with the traditional motor unit number estimation technique because it is noninvasive, induces minimal discomfort due to electrical nerve stimulation, and can be performed quickly. The findings from this study help understand the complicated determinants of SCI induced muscle weakness and provide further evidence of motoneuron degeneration after a spinal injury. </p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1143-9"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2193410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30564988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross layer design for optimised region of interest of ultrasound video data over mobile WiMAX.","authors":"Carl J Debono,&nbsp;Brian W Micallef,&nbsp;Nada Y Philip,&nbsp;Ali Alinejad,&nbsp;Robert S H Istepanian,&nbsp;Nazar N Amso","doi":"10.1109/TITB.2012.2201164","DOIUrl":"https://doi.org/10.1109/TITB.2012.2201164","url":null,"abstract":"<p><p>The application of advanced error concealment techniques applied as a post-process to conceal lost video information in error-prone channels, such as the wireless channel, demand additional processing at the receiver. This increases the delivery delay and needs more computational power. However, in general, only a small region within medical video is of interest to the physician and thus if only this area is considered, the number of computations can be curtailed. In this paper we present a technique whereby the Region of Interest (ROI) specified by the physician is used to delimit the area where the more complex concealment techniques are applied. A cross layer design approach in mobile WiMAX wireless communication environment is adopted in this paper to provide an optimized Quality of Experience (QoE) in the region that matters most to the mobile physician while relaxing the requirements in the background, ensuring real-time delivery. Results show that a diagnostically acceptable Peak Signal-to-Noise-Ratio (PSNR) of about 36 dB can still be achieved within reasonable decoding time.</p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1007-14"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2201164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30657978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A serious game for learning ultrasound-guided needle placement skills.","authors":"Wing-Yin Chan,&nbsp;Jing Qin,&nbsp;Yim-Pan Chui,&nbsp;Pheng-Ann Heng","doi":"10.1109/TITB.2012.2204406","DOIUrl":"https://doi.org/10.1109/TITB.2012.2204406","url":null,"abstract":"<p><p>Ultrasound-guided needle placement is a key step in a lot of radiological intervention procedures such as biopsy, local anesthesia and fluid drainage. To help training future intervention radiologists, we develop a serious game to teach the skills involved. We introduce novel techniques for realistic simulation and integrate game elements for active and effective learning. This game is designed in the context of needle placement training based on the some essential characteristics of serious games. Training scenarios are interactively generated via a block-based construction scheme. A novel example-based texture synthesis technique is proposed to simulate corresponding ultrasound images. Game levels are defined based on the difficulties of the generated scenarios. Interactive recommendation of desirable insertion paths is provided during the training as an adaptation mechanism. We also develop a fast physics-based approach to reproduce the shadowing effect of needles in ultrasound images. Game elements such as time-attack tasks, hints and performance evaluation tools are also integrated in our system. Extensive experiments are performed to validate its feasibility for training. </p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1032-42"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2204406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30700786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of thermal and non-thermal effects of UHF RFID exposure on biological drugs.","authors":"Giovanni Calcagnini,&nbsp;Federica Censi,&nbsp;Michele Maffia,&nbsp;Luca Mainetti,&nbsp;Eugenio Mattei,&nbsp;Luigi Patrono,&nbsp;Emanuela Urso","doi":"10.1109/TITB.2012.2204895","DOIUrl":"https://doi.org/10.1109/TITB.2012.2204895","url":null,"abstract":"<p><p>The Radio Frequency Identification (RFID) technology promises to improve several processes in the healthcare scenario, especially those related to traceability of people and things. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies in the healthcare field. Among these, the evaluation of potential thermal and non-thermal effects due to the exposure of biopharmaceutical products to electromagnetic fields is very challenging, but still slightly investigated. This paper aims to setup a controlled RF exposure environment, in order to reproduce a worst-case exposure of pharmaceutical products to the electromagnetic fields generated by the UHF RFID devices placed along the supply chain. Radiated powers several times higher than recommended by current normative limits were applied (10 W and 20 W). The electric field strength at the exposed sample location, used in tests, was as high as 100 V/m. Non-thermal effects were evaluated by chromatography techniques and in vitro assays. The results obtained for a particular case study, the ActrapidTM human insulin preparation, showed temperature increases lower than 0.5 °C and no significant changes in the structure and performance of the considered drug.</p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1051-57"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2204895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30706062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data interoperability and multimedia content management in e-Health systems.","authors":"Mehedi Masud,&nbsp;M Shamim Hossain,&nbsp;Atif Alamri","doi":"10.1109/TITB.2012.2202244","DOIUrl":"https://doi.org/10.1109/TITB.2012.2202244","url":null,"abstract":"<p><p>E-Health systems provide a collaborative platform for sharing patients medical data typically stored in distributed autonomous healthcare data sources. Each autonomous source stores its medical and multimedia data without following any global structure. This causes heterogeneity in the underlying sources with respect to the data and storage structure. Therefore, a data interoperability mechanism is required for sharing the data among the heterogeneous sources. A proper metadata structure is also necessary to represent multimedia content in the sources to enable efficient query processing. Considering these needs, we present an interoperability solution for sharing data among heterogeneous data sources. We also propose a metadata management framework for medical multimedia con-tent including X-ray, ECG, MRI, and ultrasound images. The framework identifies features, generates and represents metadata, and produces identifiers for the medical multimedia content to facilitate efficient query processing. The framework has been tested with various user queries and the accuracy of the query results evaluated by means of precision, recall, and user feedback methods. The results confirm the effectiveness of the proposed approach.</p>","PeriodicalId":55008,"journal":{"name":"IEEE Transactions on Information Technology in Biomedicine","volume":"16 6","pages":"1015-23"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/TITB.2012.2202244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30675745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}