International Medical Journal最新文献

{"title":"MULTIPLE ENDOCRINE NEOPLASIA IN PRACTICE OF PRIMARY CARE AND FAMILY PHYISICIANS","authors":"V. Pozhar, O. Doroshenko, M. Shevchuk","doi":"10.37436/2308-5274-2020-1-2","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-2","url":null,"abstract":"Multiple endocrine neoplasia is characterized with a predisposition to tumors involving two or more endocrine glands. The four main forms of the disease are inherited as an autosomal dominant syndrome or may occur sporadically. In addition to these four forms, six other syndromes are associated with the presence of multiple endocrine and other neoplasms of the organs: hyperparathyroidism − jaw tumors, Carney complex, von Hippel−Lindau disease, neurofibromatosis type 1, Cowden syndrome and McCune − Albright syndrome. The diagnosis of multiple endocrine neoplasia syndrome can be established in humans by one of the three available criteria: clinical features, family history, genetic analysis. Mutation analysis during these syndromes is useful in clinical practice to confirm the clinical diagnosis; identifying family members who tolerate the mutation and need to be screened, and identifying family members who do not tolerate the mutation. Syndrome of multiple endocrine neoplasia (Wermer syndrome) is characterized by the presence of a triad of tumors, including tumors of the parathyroid glands, pheochromocytoma and tumors of the parathyroid gland. It occurs less frequently in combination with Hirschsprung's disease, caused by the absence of vegetative ganglion cells in the intestine terminal parts, that leads to colonic enlargement, severe constipation and obstruction. This syndrome may be associated with cutaneous lichen amyloidosis, the clinical manifestations of which are pruritus and lichenoid lesions, usually located in the upper back. A clinical case of MEN2 syndrome in a 52−year−old patient is presented. It is noted that for such patients, in addition to timely syndromic rather than component diagnosis of this endocrine multipathology, the spread of neoplastic process in medullary thyroid cancer to its capsule and surrounding tissues, as well as the presence of metastases in peripheral lymph nodes are important. As a rule, such patients cannot be timely cured.\u0000\u0000Key words: multiple endocrine neoplasia, endocrine tumors, genetic analysis, family history.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":"11-15"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48550722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF EXPEDIENCY TO USE PLATELET-ENRICHED PLASMA FOR TREATMENT OF ANDROGENETIC ALOPECIA","authors":"Y. Ovcharenko, O. Salyenkova","doi":"10.37436/2308-5274-2020-1-14","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-14","url":null,"abstract":"A detailed analysis of the published data on the use of platelet−enriched plasma for the treatment of androgenetic alopecia has been performed. Based on the results, it has been suggested that platelet−rich plasma may be considered as a new treatment for pathological hair−related conditions, including androgenetic alopecia. Information on platelet morphology, characteristics of biologically active substances released from activated platelets have been provided. It has been substantiated that platelets play a crucial role in hemostasis and tissue regeneration by stimulating the cell chemotaxis, proliferation, differentiation, angiogenesis and deposition of the extracellular matrix. Among the many active components of platelets involved into the recovery of damaged tissue, the growth factors have been particularly noted. The influence of growth factors on the regulation of hair growth cycles has been established. Based on the analysis of their biological effects, the diversity of their action in the regulation of hair growth has been emphasized. Characteristic features of some growth factors, insulin−like growth factor (IGF), have been determined and described, their role in damaged tissue repair, angiogenesis, proliferation and cell differentiation has been noted. The practical experience of application of platelet−enriched plasma in various branches of medicine is summarized, proposals concerning the use of this method as a new way of treatment of androgenetic alopecia have been provided. The question of standardization of this method, study and substantiation of differentiated use of platelet−enriched plasma depending on the stage of androgenetic alopecia in men and women remains debatable.\u0000\u0000Key words: androgenetic alopecia, platelet−enriched plasma, platelets, growth factors.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"64-67"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47305845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL PARALLELS IN INFECTIOUS DISEASES OF THE CENTRAL NERVOUS SYSTEM IN PATIENTS WITH HIV","authors":"K. Lytvyn, L. Shostakovych-Koretska, Z. Chykarenko, O. Kushnierova, I. Budaeva, O. Bilokon","doi":"10.37436/2308-5274-2020-1-18","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-18","url":null,"abstract":"A retrospective analysis of medical records of 451 patients with HIV infection showed that the most common clinical manifestations of cerebral tuberculosis are as follows: headache, fever ≥ 38.0 °C, meningeal symptoms; in toxoplasmosis encephalitis these are headache, paresis of cranial nerves and extremities, incoordination, cognitive disorders, dysarthria, fever ≥ 38.0 °C and convulsions; in mycotic lesions of the CNS they are headache, coordination disorders, positive meningeal symptoms, disturbances of consciousness, cognitive disorders, visual disorders, cranial nerve deficiency, convulsions and dysarthria. The clinical picture of bacterial (exacted) meningitis was dominated by positive meningeal symptoms, headache, fever, impaired consciousness. At the same time, in such neurological manifestations of central nervous system lesions as cranial nerve paresis, mono− and hemiparesis, visual, coordination and speech disorders, which mostly accompany cerebral toxoplasmosis, cerebrovascular diseases, brain tumors, encephalitis of unspecified etiology. Thus, the analysis suggests that the clinical manifestations of various etiologies of lesions of the central nervous system are often nonspecific and probably are stipulated with common morphological changes in brain tissue, which may be associated with the neuropathological effects of HIV, as well as a large impact co−infection.\u0000\u0000Key words: HIV infection, opportunistic infections, central nervous system, main symptoms.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"83-87"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41383583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMMUNE CHECKPOINT BLOCKADE IN BREAST CANCER THERAPY","authors":"I. Hromakova, P. Sorochan, N. Prokhach, I. N. Ponamarov, I. S. Hromakova, M. V. Polozova","doi":"10.37436/2308-5274-2020-1-7","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-7","url":null,"abstract":"Despite advances in early detection and treatment, breast cancer remains the deadliest oncopathology for women worldwide. Today there is an urgent need for new approaches to this disease treatment. Recently, immune therapy, especially inhibitors of immune checkpoints, has taken the lead when fighting against cancer. Blocking immune checkpoints is an effective approach to enhance the effector T cell function. Immune checkpoint blockers, namely inhibitors of cytotoxic T−lymphocyte−associated antigen 4 (CTLA−4), programmed cell death protein 1 (PD−1) and ligand 1 of programmed cell death protein 1 (PD−L1) are approved by the US Food and Drug Association (FDA) to be used in various solid tumors, refractory cancers with microsatellite instability, classical Hodgkin's lymphoma. In March 2019, the first inhibitor for the treatment of breast cancer was approved, i.e. atezolizumab (anti−PD−L1) in combination with nab−paclitaxel in the patients with metastatic triple−negative breast cancer, which aroused the interest of experts in the study of immunotherapeutic agents for the treatment of these patients. The review presents the results of using the inhibitors of immune control points in monotherapy and in combination with standard methods of antitumor treatment (chemotherapy and radiotherapy, targeted therapy) in patients with breast cancer. Information on potential biomarkers of response to immunotherapy in breast cancer is presented.\u0000\u0000Key words: breast cancer, checkpoint inhibitors, biomarkers of response.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43930485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES IN SMALL INTESTINE MICROFLORA IN PATIENTS WITH ACUTE INTESTINAL OBSTRUCTION","authors":"V. M. Lykhman, O. Shevchenko, Ye. O. Bilodid, I. Volchenko, I. Kulyk, A. Tokarev","doi":"10.37436/2308-5274-2020-1-3","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-3","url":null,"abstract":"Among urgent surgical diseases of abdominal cavity, an acute intestinal obstruction is the most difficult to be diagnosed and treated. Leading factor, determining the development of pathophysiological processes is considered to be the progressive manifestations of enteric insufficiency syndrome, resulting in intestinal barrier impairment, negative changes in ecology of intestinal flora, increased endotoxins. To identify the small intestine microflora in acute intestinal obstruction and determine the role of dysbiotic disorders in clinical manifestations of main pathological process, a study was conducted in 60 patients with mechanical intestinal obstruction. The small intestine has a relatively rare microflora, consisting mainly of gram−positive facultative aerobic microorganisms, streptococci, lactobacilli. The distal ileum in nearly 30−55 % of healthy people contains scanty microflora, and yet the flora of this area differs from the microbial population of the higher gastrointestinal tract due to higher concentration of gram−negative bacteria. Optional−anaerobic coliform bacilli, anaerobic bifidobacteria and fusobacteria, bacteroids, the number of which starts exceeding the one of gram−positive species, are presented in significant quantities. Distal to the ileocecal valve there are significant changes in the microflora quantitative and species composition. Obligatory anaerobic bacteria become the predominant part of microflora, exceeding the number of aerobic and facultative anaerobic bacteria. The bacterial flora in different parts of gastrointestinal tract has its own specifics and is quite constant, as a result of the interaction of many factors, regulating the bacterial population in small intestine. The most important among them are: acidity of gastric juice, normal peristaltic activity of the intestine, bacterial interactions and immune mechanisms. Disorders of the intestine motor and evacuation function with its obstruction lead to slow passage of the chyme and contamination of the upper gastrointestinal tract with new types of microbes. There is a syndrome of small intestine excessive colonization, which means an increased concentration of bacterial populations in it, similar in species composition to the colon microflora. Pathological intra−intestinal contents become a source of endogenous infection and re−infection of the patient, leads to internal digestive disorders, which is manifested by syndrome of malabsorption of proteins, carbohydrates and vitamins.\u0000\u0000Key words: acute intestinal obstruction, small intestinal microflora, conditionally pathogenic microorganisms, intestinal biocenosis.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"16-18"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43747949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONCEPT OF INFORMATION PROCESSES ORGANIZATION IN HUMAN VISUAL SYSTEM","authors":"M. Kochina, O. Yavorsky, N. M. Maslova","doi":"10.37436/2308-5274-2020-1-12","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-12","url":null,"abstract":"Recent studies have shown that both traditional and modern (electronic) visual media significantly affect the processes occurring in the visual system of children and adolescents, iin the development of which the concept of controlled and uncontrolled elements is used. When studying the adaptation of the visual system to a visual load, ensuring the uptake, transmission and processing of visual information, its structural and functional organization is taken into account. The proposed summarized scheme of information processes in the visual system takes into account and significantly supplements the main provisions of the object−oriented model of selective visual attention, based on current methods of intelligent data processing. The results of the study indicate the complexity of the visual information transformation path from a visual stimulus to the creation and awareness of the image, occurring in the higher parts of the brain. The whole apparatus of encoding, transmitting, processing and perceiving visual information is useless if the guidance and focusing unit does not provide a clear and undistorted image of the objects of the outside world on the retina. In case of any malfunctions of the first unit or in the presence of defects in the visual system, the processes of finding compensation for this condition and modes of operation are started, which allows to obtain the most complete and high−quality perception of visual objects. These processes can lead to the formation of a visual system with sufficiently high visual functions or monocular one, if the compensation of existing problems will have a high \"price\". With the help of the proposed concept of organization of information processes in the visual system it is possible to assess the role of each of its considered blocks not only in the perception of visual information, but also the formation of this system in children and adolescents.\u0000\u0000Key words: visual system, information processes, visual information.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46160222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT ASPECTS OF CORONARY HEART DISEASE DIAGNOSIS AND TREATMENT","authors":"O. Korzh","doi":"10.37436/2308-5274-2020-1-1","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-1","url":null,"abstract":"Among the cardiovascular diseases associated with atherosclerosis, chronic coronary heart disease, including angina, is the most common form. It is the myocardium lesion that develops as a result of an imbalance between the coronary circulation and metabolic needs of heart muscle. The presence of angina symptoms often indicates a pronounced narrowing of one or more coronary arteries, but also occurs in non−obstructive arterial impairment and even in normal coronary arteries. Factors of functional damage to the coronary arteries are spasm, temporary platelet aggregation and intravascular thrombosis. Today there are opportunities not only to use the therapy with proven effectiveness, aimed at reducing the risk of complications, including fatal, but also to treat angina (ischemia), which improves the patient's life quality. The drug protocol includes the ones with a proven positive effect on this disease prognosis, which are mandatory if there are no direct contraindications to use, as well as a large group of antianginal or anti−ischemic drugs. The choice of a particular drug or its combinations with other drugs is carried out in accordance with generally accepted recommendations: taking into account the individual approach, the severity of angina, hemodynamic parameters (heart rate and blood pressure, presence of comorbid conditions). If drug therapy is ineffective, the option of coronary myocardial revascularization (percutaneous coronary angioplasty or coronary artery bypass grafting) is considered. Due to the high mortality and morbidity rates of coronary heart disease worldwide, one of the priorities of practical health care is the prevention of diseases caused by atherosclerosis.\u0000\u0000Key words: coronary heart disease, angina, family physician, prognosis, drug therapy.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":" ","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47876414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POSSIBILITIES OF IMMUNOLOGY STUDIES IN ESTIMATION OF VALIDITY OF BURN WOUNDS FOR SKIN PLASTICITY","authors":"O. Kravtsov, O. Klimova, L. Drozdova, T. Kurbanov, A. Hopko","doi":"10.37436/2308-5274-2020-1-4","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-4","url":null,"abstract":"Immunological features of burn disease largely reflect the state of general and local changes caused by the action of thermal factors. They are fundamental in formation of physiological repair of damaged tissue and disorders of the local immune system, lead to disruption of protective mechanisms with increased risk of occurrence and progression of local and systemic complications. It is the period of burn shock that is one of the main ones in the course and consequences of burn disease. In patients, the burn septicemia period even starting from the third day is characterized by severe immune changes, frequent generalization of inflammation and infection. Since one of the main tasks in treatment of patients with thermal trauma is the earliest possible recovery of lost skin, which consists in early surgical treatment (excision of necrotized tissues followed by simultaneous or delayed autodermoplasty), it is necessary to take into account metabolic disorders and changes in immune reactivity, affecting reparation of damaged tissues. To study the main immunological parameters in treatment of skin burn defects and their impact on the results of skin grafting, 17 patients with deep burns were examined. The main indices of metabolic status and immune reactivity in t surgical treatment of skin lesions, namely, innate immunity, humoral and cell components of immunity, metabolism (phagocytic activity of neutrophils, oxygen−dependent metabolism of neutrophils, concentration of peptides) differentiation clusters CD22 +, CD25 +, HLA−DR +) were examined. It is established that the corresponding changes in the indices can be the markers to predict the results of skin grafting. In this research it was found that with an unfavorable result of autodermoplasty in the patients with deep burns significant changes in immune reactivity and metabolic disorders were revealed. Altered immune reactivity due to increased circulating immune complexes and medium molecular weight peptides that provide opsonization and elimination of cytotoxic antigens in patients with deep burns may affect the results of skin grafting in surgical treatment of skin defects.\u0000\u0000Key words: burns, immune reactivity, dermatoplasty, metabolic state, autological skin transplantation.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43771572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WAYS TO SOLVE THE PROBLEM OF PREVENTION AND MAIN REHABILITATION MEASURES IN TOXOPLASMOSIS IN UKRAINE","authors":"O. Bobrova, P. Nartov, K. Kryvonos, O. V. Zagorodnieva","doi":"10.37436/2308-5274-2020-1-17","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-17","url":null,"abstract":"One of the most pressing health problems worldwide is the fight against such common and socially significant parasites as toxoplasmosis. Epidemiology, prevention and rehabilitation of patients require careful study, as this invasion can lead to termination of pregnancy, stillbirth or birth of children with abnormalities of the central nervous system and visual organ, as toxoplasmosis chorioretinitis can result in complete loss of vision. It is known that congenital toxoplasmosis can be detected in decades by multifocal lesions of the central nervous system, auditory analyzer. Toxoplasmosis is characterized by polymorphism of clinical manifestations, which complicates the diagnosis of this disease; so far there are no specific methods of its prevention and rehabilitation programs. The causative agents of many parasitosis are potential biological threats, a number of these diseases, including toxoplasmosis, are associated with many immunodeficiency conditions, including HIV. The research aim was to improve the monitoring, regulation and improvement of the parasitological situation regarding toxoplasmosis in Ukraine by introducing a system of preventive measures against this invasion; development and use in the practice of medical institutions of methods of rehabilitation of patients with various forms of toxoplasmosis. Recommendations have been given to women on the prevention of congenital toxoplasmosis when planning a pregnancy. The need to improve the monitoring system and main ways to solve problems in diagnosis, prevention and rehabilitation of patients with toxoplasmosis, especially for the population at high risk has been demonstrated. The priority tasks are the development of leading parasitologists of Ukraine methodological recommendations, protocols and algorithms of actions for diagnosis, treatment, prevention and rehabilitation of patients with toxoplasmosis, the creation of appropriate regional centers, establishing a comprehensive national program to combat toxoplasmosis.\u0000\u0000Key words: toxoplasmosis, parasitosis, prophylaxis, rehabilitation.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44289909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIFE QUALITY OF PATIENTS WITH NEWLY DIAGNOSED PULMONARY TUBERCULOSIS WHEN USING ALCOHOL","authors":"I. Hrek, A. Rohozhyn, V. Kushnir, Yulia Zaikina, M. Kochuieva","doi":"10.37436/2308-5274-2020-1-19","DOIUrl":"https://doi.org/10.37436/2308-5274-2020-1-19","url":null,"abstract":"Interest to the studies of life quality by scientists and practitioners is constantly growing, as this unique approach allows to fundamentally change the traditional view of the problem of the disease and the patient. By investigating the quality of life as an integral index of the patient's condition, it is possible to assess the complex impact of the disease on the patient's life, to compare the effectiveness of various interventions, to predict the disease course. However, the problem of assessing the quality of life in patients with tuberculosis under conditions of alcohol consumption remains poorly understood. To establish the level of quality of life in patients, 102 men with newly diagnosed tuberculosis, with preserved sensitivity to anti−tuberculosis drugs were examined. The AUDIT test was used to assess their alcohol consumption, and the MOS SF−36 questionnaire was used to analyze the quality of life parameters. The study also assessed quality of life parameters and alcohol consumption in groups with varying prevalence of tuberculosis and the presence of mycobacteria or no bacterial excretion. According to the findings, the following conclusions can be drawn: pulmonary tuberculosis leads to a decrease in quality of life with the greatest depression in the group of patients who abuse alcohol; quality of life indices are significantly lower in patients with advanced tuberculosis and bacterial excretion, while the level of alcohol consumption in these groups is significantly higher than in patients with localized forms and lack of bacterial excretion. Interestingly, when interviewing patients, none of them rated their health as \"excellent\", answering the first question of the SF−36 questionnaire, and 100 % of respondents to question 11 answered \"definitely not\" to the statement \"I expect my health to deteriorate\". The obtained research data on the parameters of quality of life in patients with tuberculosis can be used to achieve the highest effectiveness of therapy and targeted psychosocial rehabilitation.\u0000\u0000Key words: tuberculosis, alcohol, quality of life, bacterial excretion.","PeriodicalId":54933,"journal":{"name":"International Medical Journal","volume":"1 1","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45058371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}