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[Acute porphyrias viewed differently]. [对急性卟啉症的不同看法]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2021-11-11 DOI: 10.1007/s00108-021-01203-w
Jasmin Barman-Aksözen, Anna-Elisabeth Minder
{"title":"[Acute porphyrias viewed differently].","authors":"Jasmin Barman-Aksözen,&nbsp;Anna-Elisabeth Minder","doi":"10.1007/s00108-021-01203-w","DOIUrl":"https://doi.org/10.1007/s00108-021-01203-w","url":null,"abstract":"<p><p>The acute porphyrias are a group of four metabolic defects in which the heme synthesis in the liver is disrupted. They are characterized by massively painful acute attacks, which can be life-threatening if not diagnosed. To raise the awareness for these rare disorders, a heme molecule in cartoon style is introduced, which accurately explains the basic biochemical processes in the body and mediates important information on the acute hepatic porphyrias in a simplified and attractive way. The article is complemented by a case report.</p>","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 2","pages":"224-229"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[29/f-Abdominal pain, distended abdomen and occasionally diarrhea : Preparation for the medical specialist examination: part 120]. [29/f]腹痛、腹胀和偶尔腹泻:为医学专家检查做准备:第120部分]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2022-01-20 DOI: 10.1007/s00108-021-01245-0
H Fehrendt
{"title":"[29/f-Abdominal pain, distended abdomen and occasionally diarrhea : Preparation for the medical specialist examination: part 120].","authors":"H Fehrendt","doi":"10.1007/s00108-021-01245-0","DOIUrl":"https://doi.org/10.1007/s00108-021-01245-0","url":null,"abstract":"","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 Suppl 1","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39845518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Food sensitivities of the digestive tract-Part 1: Food allergies]. [消化道食物过敏-第1部分:食物过敏]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2022-01-26 DOI: 10.1007/s00108-021-01256-x
Stephan C Bischoff
{"title":"[Food sensitivities of the digestive tract-Part 1: Food allergies].","authors":"Stephan C Bischoff","doi":"10.1007/s00108-021-01256-x","DOIUrl":"https://doi.org/10.1007/s00108-021-01256-x","url":null,"abstract":"<p><p>Adverse reactions to food affect approximately one third of the population. They are based on very different mechanisms and are divided into food intolerances, which manifest mainly in the gastrointestinal tract, and food allergies, which can also cause extraintestinal symptoms and have an immunological genesis. The most common food allergies in adults are pollen-associated allergies to cereals or pome and stone fruits, while allergies to peanut, milk and egg are particularly common in children. The diagnostics of food allergies are complex and therapy is primarily based on targeted elimination diets. This advanced education article focuses on food allergies with gastrointestinal symptoms.</p>","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 2","pages":"171-184"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39860588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[35/m-Skin rash : Preparation for the medical specialist examination: part 105]. [35/m-皮疹:准备医学专家检查:第105部分]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2021-08-31 DOI: 10.1007/s00108-021-01132-8
H Matthews, S Schmiedel
{"title":"[35/m-Skin rash : Preparation for the medical specialist examination: part 105].","authors":"H Matthews,&nbsp;S Schmiedel","doi":"10.1007/s00108-021-01132-8","DOIUrl":"https://doi.org/10.1007/s00108-021-01132-8","url":null,"abstract":"","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 Suppl 1","pages":"27-30"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39372045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[93/f-Sudden indisposition, confusion and cold sweat : Preparation for the medical specialist examination: part 119]. [93/f]突然不适、神志不清和出冷汗:准备医学专家检查:第119部分]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2022-01-13 DOI: 10.1007/s00108-021-01254-z
S Meyhöfer
{"title":"[93/f-Sudden indisposition, confusion and cold sweat : Preparation for the medical specialist examination: part 119].","authors":"S Meyhöfer","doi":"10.1007/s00108-021-01254-z","DOIUrl":"https://doi.org/10.1007/s00108-021-01254-z","url":null,"abstract":"","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 Suppl 1","pages":"95-98"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39820348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[23/f-Arm swelling after physical exercise : Preparation for the medical specialist examination: part 109]. [23/f]体育锻炼后手臂肿胀:医学专家检查的准备:第109部分]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2022-01-11 DOI: 10.1007/s00108-021-01238-z
E Stegemann, B Krabbe
{"title":"[23/f-Arm swelling after physical exercise : Preparation for the medical specialist examination: part 109].","authors":"E Stegemann,&nbsp;B Krabbe","doi":"10.1007/s00108-021-01238-z","DOIUrl":"https://doi.org/10.1007/s00108-021-01238-z","url":null,"abstract":"","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 Suppl 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39810073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biologics in inflammatory bowel diseases]. [炎症性肠病的生物制剂]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2022-01-17 DOI: 10.1007/s00108-021-01255-y
Philip Esters, Christopher Hackenberg, Herrmann Schulze, Axel U Dignass
{"title":"[Biologics in inflammatory bowel diseases].","authors":"Philip Esters,&nbsp;Christopher Hackenberg,&nbsp;Herrmann Schulze,&nbsp;Axel U Dignass","doi":"10.1007/s00108-021-01255-y","DOIUrl":"https://doi.org/10.1007/s00108-021-01255-y","url":null,"abstract":"<p><strong>Background: </strong>In addition to conventional anti-inflammatory treatment for chronic inflammatory bowel disease (IBD), there has been an evolution of new treatment options over the past 20 years. Already approved biologics provide multiple treatment alternatives but also make the treatment algorithms more complex. This development results in a substantial improvement in patient care. The ambitious treatment targets are associated with a higher quality of life and the reduction of long-term disability and morbidity.</p><p><strong>Objective: </strong>The aim of this article is to give an overview of how biologics can currently be implemented in IBD. In particular, the current clinical management is presented and an outlook on future treatment options with biologics for IBD is provided.</p><p><strong>Material and methods: </strong>A search was carried out in PubMed and ClinicalTrials.gov and the current German and European guidelines and expert recommendations were evaluated.</p><p><strong>Results: </strong>Since the late 1990s there have been a continuously increasing number of treatment options for IBD. All substances have proven safety and efficacy in large randomized clinical studies and enable increasingly more individualized treatment for patients with IBD. Biologics are currently the standard treatment of choice for moderate to severe inflammatory activity as well as for steroid-refractory or steroid-dependent courses of disease after failure of conventional treatment.</p><p><strong>Conclusion: </strong>The diversity of IBD treatment offers increasing treatment options and thus improved patient care; however, as the number of new substances increases treatment becomes more complex. This article summarizes the current and future treatment options for IBD and their integration into current treatment algorithms.</p>","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 2","pages":"155-164"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39916964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[53/f-Nausea, vomiting, polydipsia and polyuria : Preparation for the medical specialist examination: part 102]. [53/f]恶心、呕吐、烦渴和多尿:为医学专家检查做准备:第102部分]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2021-10-14 DOI: 10.1007/s00108-021-01178-8
S Meyhöfer
{"title":"[53/f-Nausea, vomiting, polydipsia and polyuria : Preparation for the medical specialist examination: part 102].","authors":"S Meyhöfer","doi":"10.1007/s00108-021-01178-8","DOIUrl":"https://doi.org/10.1007/s00108-021-01178-8","url":null,"abstract":"","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 Suppl 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39519399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[84/f with spondylodiscitis and multiple medications : Preparation for the medical specialist examination: part 110]. [84/f伴有脊椎椎间盘炎和多种药物:为医学专家检查做准备:第110部分]。
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2021-10-20 DOI: 10.1007/s00108-021-01174-y
K Faehling, M Denkinger
{"title":"[84/f with spondylodiscitis and multiple medications : Preparation for the medical specialist examination: part 110].","authors":"K Faehling,&nbsp;M Denkinger","doi":"10.1007/s00108-021-01174-y","DOIUrl":"https://doi.org/10.1007/s00108-021-01174-y","url":null,"abstract":"","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 Suppl 1","pages":"52-56"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39535257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Atrial fibrillation and the limits of oral anticoagulation: for whom are left atrial appendage occluders suitable?] 心房颤动与口服抗凝的限度:左心房附件封堵器适合于谁?］
4区 医学
Internist Pub Date : 2022-02-01 Epub Date: 2021-11-11 DOI: 10.1007/s00108-021-01206-7
Sebastian Feickert, Niels Christian Ewertsen, Giuseppe D'Ancona, Alper Öner, Hüseyin Ince, Jasmin Ortak
{"title":"[Atrial fibrillation and the limits of oral anticoagulation: for whom are left atrial appendage occluders suitable?]","authors":"Sebastian Feickert,&nbsp;Niels Christian Ewertsen,&nbsp;Giuseppe D'Ancona,&nbsp;Alper Öner,&nbsp;Hüseyin Ince,&nbsp;Jasmin Ortak","doi":"10.1007/s00108-021-01206-7","DOIUrl":"https://doi.org/10.1007/s00108-021-01206-7","url":null,"abstract":"<p><strong>Background: </strong>Patients with atrial fibrillation are at a significantly increased risk of thromboembolic events, especially ischemic strokes. Oral anticoagulation reduces this risk, but cannot be used in some patients for various reasons and is associated with a relevantly increased risk of bleeding. As an alternative for prophylaxis of thromboembolic events in patients with atrial fibrillation, there are different options of left atrial appendage closure.</p><p><strong>Aim: </strong>This article explains the possibilities of interventional atrial occlusion as well as the suitable patient clientele using an overview of the currently available systems for atrial occlusion, a guideline for patient selection and a summary of the current scientific data.</p><p><strong>Conclusion and available scientific data: </strong>In carefully selected patients suffering from atrial fibrillation with relative or absolute contraindications for oral anticoagulation, interventional closure of the atrial appendage is a safe alternative for prophylaxis against thromboembolic events. The currently available scientific evidence from randomized controlled trials is sparse. Nevertheless, extensive amounts of registry study data suggest a benefit, while the results of several large randomized controlled trials are expected in the coming years.</p>","PeriodicalId":54924,"journal":{"name":"Internist","volume":"63 2","pages":"230-237"},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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