Journal of Nutrigenetics and Nutrigenomics最新文献

{"title":"Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk.","authors":"Raffaele De Caterina,&nbsp;Ahmed El-Sohemy","doi":"10.1159/000446801","DOIUrl":"https://doi.org/10.1159/000446801","url":null,"abstract":"<p><p>Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 2-4","pages":"106-115"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446801","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34711268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The FTO Gene, Browning of Adipose Tissue and Omega-3 Fatty Acids.","authors":"Artemis Simopoulos","doi":"10.1159/000448617","DOIUrl":"https://doi.org/10.1159/000448617","url":null,"abstract":"Body mass index (BMI) is a complex trait with high heritability. In population studies, it is considered a surrogate for obesity [1] . In large genome-wide association studies, the strongest genetic signal for BMI has been the fat mass and obesity-associated (FTO) locus [2] . Eighty-nine genetic variants within introns 1 and 2 of the FTO have been associated with BMI. Browning of adipose tissue has physiological relevance, and disorders of mitochondrial function and brown fat may play a role in pathophysiological aspects of obesity [3] . Browning adipocytes are a key site of energy expenditure; therefore, shifting adipocyte differentiation towards a brown adipocyte-like phenotype may increase energetic efficiency in mammals. Mammals have two types of adipose tissue: white adipose tissue (WAT), which is the most abundant, stores extra calories, and brown adipose tissue, which dissipates energy through mitochondrial uncoupling and the production of heat. Recently, a number of investigators have shown that there is a third type of fat cell, the ‘beige’ adipocyte. This beige cell transitions between states of energy storage and dissipation. It can be induced and is found in adult humans [4] . The potential importance of the fatty acid composition of dietary fats as a factor that plays a role in adipose tissue development and function has been actively investigated. Over the years, Ailhaud et al. [5] , Massiera et al. [6] and Pisani et al. [8] have contributed enormously to understanding the role of arachidonic acid (AA) and its metabolites derived from the cyclooxygenase pathway in increasing WAT proliferation and decreasing browning of WAT. Under isoenergetic isolipidic conditions, inclusion of AA in the diet impaired brite adipocyte recruitment in the subcutaneous WAT compared to mice fed a standard diet [7] . The data of Massiera et al. [6] regarding the fat mass show that perinatal exposure of mice to a high omega-6 [linoleic acid (LA)] fatty acid diet, as it is today in Western diets, results in a progressive accumulation of body fat across generations. This is consistent with the data showing that in humans, overweight and obesity have steadily increased over the last 30–40 years, in addition to occurring earlier in life. Today, there is more obesity in children worldwide than ever before. The inhibitory role of the omega-6 fatty acids (LA + AA) in the browning process of white fat cells has been precisely investigated. Prostaglandin E 2 (PGE2), a metabPublished online: August 20, 2016","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 2-4","pages":"123-126"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000448617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34322492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Lactase Persistence Genotypes with High Intake of Dairy Saturated Fat and High Prevalence of Lactase Non-Persistence among the Mexican Population.","authors":"Claudia Ojeda-Granados,&nbsp;Arturo Panduro,&nbsp;João Renato Rebello Pinho,&nbsp;Omar Ramos-Lopez,&nbsp;Ketti Gleyzer,&nbsp;Fernanda de Mello Malta,&nbsp;Karina Gonzalez-Aldaco,&nbsp;Sonia Roman","doi":"10.1159/000446241","DOIUrl":"https://doi.org/10.1159/000446241","url":null,"abstract":"Background/Aim: Lactase (LCT) -13910 C>T and -22018 G>A polymorphisms associated with the lactase non-persistence (LNP)/persistence (LP) phenotypes vary globally. LP has been associated with obesity in Europeans. However, it has not been genetically evaluated in Mexico, a country with admixed population, recent introduction of dairy, and a high prevalence of obesity. Thus, we aimed to determine the distribution of the LCT polymorphisms and their association with the nutritional profile of West Mexico's populations. Methods: Genotyping of 1,196 individuals (natives and mestizos) was carried out by a Taqman allelic discrimination assay. Descriptive statistics and interpopulation analyzes were performed by SPSS, Arlequin, and Structure software. Demographic, anthropometric, biochemical and dietary data were analyzed in 212 mestizos. Results: LNP genotypes mainly prevailed (CC 68.7% and GG 68.2%); both predominated in native Huicholes and Nahuas (>97.7%). Among the mestizos, the LP genotypes were associated with a higher intake of saturated fat (9.9 ± 3.9% vs. 8.5 ± 4.0%, p = 0.018; OR = 2.55, 95% CI 1.29-5.03, p = 0.006) and a daily/more frequent consumption of dairy (88.8 vs. 78.0%; p = 0.049) than LNP genotypes. Conclusion: The LNP trait was predominant in Mexicans with a major Amerindian ancestry. A daily consumption of dairy was associated with a higher intake of saturated fat in LP individuals.","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 2-4","pages":"83-94"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34632633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Variation in CD36 Is Associated with Decreased Fat and Sugar Intake in Obese Children and Adolescents.","authors":"Marina B Pioltine,&nbsp;Maria Edna de Melo,&nbsp;Aritânia Santos,&nbsp;Alisson D Machado,&nbsp;Ariana E Fernandes,&nbsp;Clarissa T Fujiwara,&nbsp;Cintia Cercato,&nbsp;Marcio C Mancini","doi":"10.1159/000455915","DOIUrl":"https://doi.org/10.1159/000455915","url":null,"abstract":"<p><strong>Background/aims: </strong>Taste is recognized as an important predictor of food choices. Thus, polymorphisms in genes encoding taste receptors may explain the variability in food preference and intake. Here, we aimed to determine whether genetic variation in the CD36 gene affects food intake and risk of obesity.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with obese Brazilian children and adolescents (n = 466; BMI-for-age z-score [zBMI] 3.29 ± 0.61) and normal-weight children (n = 114; zBMI -0.11 ± 0.7). To assess the obesity risk according to genotypes, a logistic regression adjusted for age and gender was performed. Two 24-h food recalls assessed total energy (kcal/day) and macronutrient (% kcal and g/day) intake, consumption of sweet and fatty tasting foods (portion and g/day), as well as the most commonly consumed foods (mL or g/day). The food portion sizes were measured according to Brazilian guidelines. The genetic variant rs1761667 (A/G) in CD36 was genotyped by real-time PCR.</p><p><strong>Results: </strong>We found no relationship between rs1761667 genotypes and obesity risk. A significant genetic association between CD36 genotype and fat intake was observed for the A allele of rs1761667, which was associated with a decreased intake of total fat (g/day) (p = 0.01), polyunsaturated and monounsaturated fatty acids (% kcal and g/day), total sugars (g/day) (p = 0.01), fatty foods (portion and g/day) (p < 0.001 for both), and vegetable oils (mL/day) (p = 0.02) only in obese subjects. No differences were found between normal-weight children.</p><p><strong>Conclusion: </strong>The A allele of the rs1761667 single nucleotide polymorphism in CD36 is associated with decreased fat and sugar intake in obese children and adolescents.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 5-6","pages":"300-305"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000455915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34764671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bovine Mammary Nutrigenomics and Changes in the Milk Composition due to Rapeseed or Sunflower Oil Supplementation of High-Forage or High-Concentrate Diets.","authors":"Christine Leroux,&nbsp;Laurence Bernard,&nbsp;Yannick Faulconnier,&nbsp;Jacques Rouel,&nbsp;Anne de la Foye,&nbsp;Jordann Domagalski,&nbsp;Yves Chilliard","doi":"10.1159/000445996","DOIUrl":"https://doi.org/10.1159/000445996","url":null,"abstract":"<p><strong>Background: </strong>Fatty acid (FA) composition plays a crucial role in milk nutritional quality. Despite the known nutritional regulation of ruminant milk composition, the overall mammary mechanisms underlying this regulation are far from being understood. The aim of our study was to determine nutritional regulation of mammary transcriptomes in relation to the cow milk composition.</p><p><strong>Methods: </strong>Twelve cows received diets differing in the forage-to-concentrate ratio [high forage (HF) and low forage (LF)] supplemented or not with lipids [HF with whole intact rapeseeds (RS) and LF sunflower oil (SO)] in a 4 × 4 Latin square design. Milk production and FA composition were determined. The gene expression profile was studied using RT-qPCR and a bovine microarray.</p><p><strong>Results: </strong>Our results showed a higher amplitude of milk composition and mammary transcriptome responses to lipid supplementation with the LF-SO compared with the LF diet than with the HF-RS compared with the HF diet. Forty-nine differentially expressed genes, including genes involved in lipid metabolism, were identified with LF-SO versus LF, whereas RS supplementation to the HF diet did not affect the mammary transcriptome.</p><p><strong>Conclusions: </strong>This study highlights different responses to lipid supplementation of milk production and composition and mammary transcriptomes depending on the nature of lipid supplementation and the percentage of dietary concentrate.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 2-4","pages":"65-82"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000445996","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34492833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalized Nutrition: Part 2 - Ethics, Challenges and Endeavors of Precision Nutrition.","authors":"Martin Kohlmeier,&nbsp;Raffaele De Caterina,&nbsp;Lynnette R Ferguson,&nbsp;Ulf Görman,&nbsp;Hooman Allayee,&nbsp;Chandan Prasad,&nbsp;Jing X Kang,&nbsp;Carolina Ferreira Nicoletti,&nbsp;J Alfredo Martinez","doi":"10.1159/000446347","DOIUrl":"https://doi.org/10.1159/000446347","url":null,"abstract":"<p><p>Nutrigenetics considers the influence of individual genetic variation on differences in response to dietary components, nutrient requirements and predisposition to disease. Nutrigenomics involves the study of interactions between the genome and diet, including how nutrients affect the transcription and translation process plus subsequent proteomic and metabolomic changes, and also differences in response to dietary factors based on the individual genetic makeup. Personalized characteristics such as age, gender, physical activity, physiological state and social status, and special conditions such as pregnancy and risk of disease can inform dietary advice that more closely meets individual needs. Precision nutrition has a promising future in treating the individual according to their phenotype and genetic characteristics, aimed at both the treatment and prevention of disease. However, many aspects are still in progress and remain as challenges for the future of nutrition. The integration of the human genotype and microbiome needs to be better understood. Further advances in data interpretation tools are also necessary, so that information obtained through newer tests and technologies can be properly transferred to consumers. Indeed, precision nutrition will integrate genetic data with phenotypical, social, cultural and personal preferences and lifestyles matters to provide a more individual nutrition, but considering public health perspectives, where ethical, legal and policy aspects need to be defined and implemented.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 1","pages":"28-46"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34632454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2nd European Summer School on Nutrigenomics. September 5-9, 2016, Camerino, Italy: Abstracts.","authors":"","doi":"10.1159/000448866","DOIUrl":"https://doi.org/10.1159/000448866","url":null,"abstract":"s of the 2nd European Summer School on Nutrigenomics September 5–9, 2016, Camerino, Italy Guest Editors Rosita Gabbianelli, Camerino J. Alfredo Martínez, Navarra Raffaele De Caterina, Chieti Basel • Freiburg • Paris • London • New York • Chennai • New Delhi • Bangkok • Beijing • Shanghai • Tokyo • Kuala Lumpur • Singapore • Sydney J Nutrigenet Nutrigenomics 2016;9:127–149 © 2016 S. Karger AG, Basel 1661–6499/16/0094–0127$39.50/0 Published online: August 24, 2016 www.karger.com/jnn DOI: 10.1159/000448866","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 2-4","pages":"127-149"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000448866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34330068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPV1 Gene Polymorphisms Are Associated with Type 2 Diabetes by Their Interaction with Fat Consumption in the Korean Genome Epidemiology Study.","authors":"Sunmin Park,&nbsp;Xin Zhang,&nbsp;Na Ra Lee,&nbsp;Hyun-Seok Jin","doi":"10.1159/000446499","DOIUrl":"https://doi.org/10.1159/000446499","url":null,"abstract":"<p><strong>Background: </strong>Different transient receptor potential vanilloid 1 (TRPV1) variants may be differently activated by noxious stimuli.</p><p><strong>Aim: </strong>We investigated how TRPV1 variants modulated the prevalence of type 2 diabetes and specific gene-nutrient interactions.</p><p><strong>Methods: </strong>Among 8,842 adults aged 40-69 years in the Korean Genome Epidemiology Study, the associations between TRPV1 genotypes and the prevalence of type 2 diabetes as well as their gene-nutrient interactions were investigated after adjusting for the covariates of age, gender, residence area, body mass index, daily energy intake, and total activity.</p><p><strong>Results: </strong>The TRPV1 rs161364 and rs8065080 minor alleles lowered HOMA-IR and the risk of type 2 diabetes after adjusting for covariates. There were gene-nutrient interactions between TRPV1 variants rs161364 and rs8065080 and preference for oily taste, intake of oily foods, and fat intake after adjusting for covariates. Among subjects with the minor alleles of TRPV1 rs161364 and rs8065080, the group with a high preference for oily foods had a lower odds ratio for type 2 diabetes. Consistent with the preference for taste, among subjects with the minor alleles, the group with high fat intake from oily foods also exhibited a lower risk of type 2 diabetes than subjects with the major alleles.</p><p><strong>Conclusions: </strong>People with the minor alleles of the TRPV1 single nucleotide polymorphisms rs161364 and rs8065080 have a lower risk of diabetes with a high-fat diet, but people with the major alleles are at a higher risk of type 2 diabetes when consuming high-fat diets. The majority of people should be careful about a high fat intake.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 1","pages":"47-61"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34458532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation.","authors":"Bastien Vallée Marcotte,&nbsp;Hubert Cormier,&nbsp;Frédéric Guénard,&nbsp;Iwona Rudkowska,&nbsp;Simone Lemieux,&nbsp;Patrick Couture,&nbsp;Marie-Claude Vohl","doi":"10.1159/000446024","DOIUrl":"https://doi.org/10.1159/000446024","url":null,"abstract":"<p><strong>Background: </strong>A recent genome-wide association study (GWAS) by our group identified 13 loci associated with the plasma triglyceride (TG) response to omega-3 (n-3) fatty acid (FA) supplementation. This study aimed to test whether single-nucleotide polymorphisms (SNPs) within the IQCJ, NXPH1, PHF17 and MYB genes are associated with the plasma TG response to an n-3 FA supplementation.</p><p><strong>Methods: </strong>A total of 208 subjects followed a 6-week n-3 FA supplementation of 5 g/day of fish oil (1.9-2.2 g of eicosapentaenoic acid and 1.1 g of docosahexaenoic acid). Measurements of plasma lipids were made before and after the supplementation. Sixty-seven tagged SNPs were selected to increase the density of markers near GWAS hits.</p><p><strong>Results: </strong>In a repeated model, independent effects of the genotype and the gene-supplementation interaction were associated with plasma TG. Genotype effects were observed with two SNPs of NXPH1, and gene-diet interactions were observed with ten SNPs of IQCJ, four SNPs of NXPH1 and three SNPs of MYB. Positive and negative responders showed different genotype frequencies with nine SNPs of IQCJ, two SNPs of NXPH1 and two SNPs of MYB.</p><p><strong>Conclusion: </strong>Fine mapping in GWAS-associated loci allowed the identification of SNPs partly explaining the large interindividual variability observed in plasma TG levels in response to an n-3 FA supplementation.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000446024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34531650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of apoM Polymorphism Associated with HDL Metabolism on Obese Korean Adults.","authors":"Myoungsook Lee,&nbsp;Jung-Im Kim,&nbsp;Seojin Choi,&nbsp;Yangsoo Jang,&nbsp;Sungbin Richard Sorn","doi":"10.1159/000455948","DOIUrl":"https://doi.org/10.1159/000455948","url":null,"abstract":"<p><strong>Background: </strong>Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported.</p><p><strong>Aim: </strong>To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults.</p><p><strong>Methods: </strong>A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups. Anthropometric variables, lipid profiles, insulin-resistant profiles, reverse cholesterol transport (RCT) enzymes, HDL subfraction, and apoM polymorphism were determined.</p><p><strong>Results: </strong>In OB with T-855C polymorphism, TT genotype carriers significantly showed 6.2% higher diastolic blood pressure (DBP), 1.3% lower amount of HDL2b subfraction, and 19.7% higher lecithin-cholesterol acyltransferase (LCAT) mass than TC+CC carriers. OB subjects with the T allele of T-778C polymorphism significantly demonstrated 43% higher plasma insulin, 17.7% higher total cholesterol, 26.7% higher triglyceride, 40.7% higher leptin, 1.6% lower HDL2b, and 12.6% higher LCAT mass than those with the C allele. These results were reversed in non-OB with T-778C polymorphism regarding HDL subfractions and RCT enzymes.</p><p><strong>Conclusion: </strong>apoM T-855C and T-778C polymorphisms were found to be associated with obesity by regulating HDL metabolism, and the T alleles of apoM T-778C were shown to be more strongly correlated.</p>","PeriodicalId":54779,"journal":{"name":"Journal of Nutrigenetics and Nutrigenomics","volume":"9 5-6","pages":"306-317"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000455948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34770918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}