Journal of Thermal Stresses最新文献_第9页

A variational inequality approach for the numerical simulation of steel solidification of two-phase continuous casting process 用变分不等式方法模拟两相连铸过程中钢的凝固过程

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-09-08 DOI: 10.1080/01495739.2023.2231988

G. Khenniche, Hocine Sissaoui, Lamine Bouzettouta, Salah Bouhouche

引用次数: 0

Multiple fields generated by two dissimilar conductive punches on thermoelectric material 两种不同导电冲头在热电材料上产生的多场

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-09-08 DOI: 10.1080/01495739.2023.2246521

Yali Zhang, Yueting Zhou, Juan Yang, Shenghu Ding

引用次数: 0

Mathematical significance of strain rate and temperature rate on heat conduction in thermoelastic material due to line heat source 线热源下热弹性材料应变速率和温度率对热传导的数学意义

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-09-06 DOI: 10.1080/01495739.2023.2246523

Robinderpal Singh, Santwana Mukhopadhyay

{"title":"Mathematical significance of strain rate and temperature rate on heat conduction in thermoelastic material due to line heat source","authors":"Robinderpal Singh, Santwana Mukhopadhyay","doi":"10.1080/01495739.2023.2246523","DOIUrl":"https://doi.org/10.1080/01495739.2023.2246523","url":null,"abstract":"Abstract The primary purpose of the present article is to investigate the effect of strain rate and temperature rate factors on a homogeneous, unbounded isotropic elastic medium originating due to continuous line heat source. This study is based on the modified Green-Lindsay Model (MGL) theory proposed by Yu et al. (2018). This model eliminates the discontinuous nature of the displacement field reported under the temperature-rate-dependent thermoelasticity theory (GL) established by Green and Lindsay. The present work obtains the analytical solution for the distributions of stress components, temperature and displacement through the potential function approach accompanied by the Laplace transform method. The inverse Laplace transformation is performed by using short-time approximation method to find the approximated analytical solution of the problem in space-time domain. A detailed analysis of solution is discussed for MGL model and compared to the results predicted by other existing generalized thermoelastic models. The effect of strain-rate and temperature-rate-terms is acknowledged explicitly in mathematical formulation and other significant effects are notified. However, this new model predicts the infinite speed of disturbance analogous to classical theory.","PeriodicalId":54759,"journal":{"name":"Journal of Thermal Stresses","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43252234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory Effects of GPR158 Overexpression in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways GPR158过表达在眼水流出通路小梁网细胞中的调控作用

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-09-01 DOI: 10.3390/stresses3030044

Maria Fernanda Suarez, Tatsuo Itakura, Satyabrata Pany, Shinwu Jeong, S. Chintala, Michael B. Raizman, Steven Riesinger, Tsvetelina Lazarova, José Echenique, Horacio M. Serra, W. D. Stamer, M. Fini

{"title":"Regulatory Effects of GPR158 Overexpression in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways","authors":"Maria Fernanda Suarez, Tatsuo Itakura, Satyabrata Pany, Shinwu Jeong, S. Chintala, Michael B. Raizman, Steven Riesinger, Tsvetelina Lazarova, José Echenique, Horacio M. Serra, W. D. Stamer, M. Fini","doi":"10.3390/stresses3030044","DOIUrl":"https://doi.org/10.3390/stresses3030044","url":null,"abstract":"Elevated intraocular pressure (IOP), the major risk factor for glaucoma, is caused by decreased outflow through the trabecular meshwork (TM). The pathophysiology of ocular hypertension has been linked to stress pathways, including fibrosis, calcification and the unfolded protein response (UPR). In a pharmacogenomic screen, we previously identified the novel G-protein-coupled receptor (GPCR), GPR158, showed that expression is upregulated in TM cells by glucocorticoid stress hormones, and showed that overexpression protects against oxidative stress. We also found that loss of Gpr158 in knockout mice negates IOP reduction due to treatment with the catecholamine stress hormone, epinephrine. An increase in GPR158 would be expected to alter the activity of GPR158-regulated pathways. Here, we profiled gene expression changes due to GPR158 overexpression by microarray, then conducted pathway analysis. We identified five upstream stress regulators relevant to ocular hypertension: dexamethasone and TGFB1 (fibrosis), XBP1 and ATF4 (UPR), and TP53 (cell cycle arrest). Key genes in the first three pathways were downregulated by GPR158 overexpression, but not enough to inhibit dexamethasone-induced fibrosis or calcification in TM cells, and loss of Gpr158 in knockout mice only minimally protected against dexamethasone-induced ocular hypertension. Depending on dose, GPR158 overexpression down- or upregulated the TP53 pathway, suggesting the mechanism for previously observed effects on cell proliferation. A sixth upstream regulator we identified was a GPCR: the beta-adrenergic receptor ADRB1. Adrenergic receptors serve as targets for IOP-lowering drugs, including epinephrine. These data provide new information about pathways regulated by GPR158.","PeriodicalId":54759,"journal":{"name":"Journal of Thermal Stresses","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80645041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paradigm of Well-Orchestrated Pharmacokinetic Properties of Curcuminoids Relative to Conventional Drugs for the Inactivation of SARS-CoV-2 Receptors: An In Silico Approach 姜黄素相对于传统药物在灭活SARS-CoV-2受体方面的精心安排的药代动力学特性范式:一种计算机方法

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-08-30 DOI: 10.3390/stresses3030043

A. Srivastava, Divya Singh, P. Yadav, Monika Singh, Sandeep K. Singh, Ajay Mahaputra Kumar

{"title":"Paradigm of Well-Orchestrated Pharmacokinetic Properties of Curcuminoids Relative to Conventional Drugs for the Inactivation of SARS-CoV-2 Receptors: An In Silico Approach","authors":"A. Srivastava, Divya Singh, P. Yadav, Monika Singh, Sandeep K. Singh, Ajay Mahaputra Kumar","doi":"10.3390/stresses3030043","DOIUrl":"https://doi.org/10.3390/stresses3030043","url":null,"abstract":"To cure SARS-CoV-2 infection, the repurposing of conventional antiviral drugs is currently advocated by researchers, though their action is not very effective. The present study, based on in silico methods, was intended to increase the therapeutic potential of conventional drugs: hydroxychloroquine (HCQ), favipiravir (FAV), and remdesivir (REM) by using curcuminoids like curcumin (CUR), bisdemethoxycurcumin (BDMC), and demethoxycurcumin (DMC) as adjunct drugs against SARS-CoV-2 receptor proteins, namely main protease (Mpro) and the S1 receptor-binding domain (RBD). The curcuminoids exhibited similar pharmacokinetic properties to the conventional drugs. The webserver (ANCHOR) predicted greater protein stability for both receptors with a disordered score (<0.5). The molecular docking study showed that the binding energy was highest (−27.47 kcal/mol) for BDMC toward Mpro receptors, while the binding energy of CUR (−20.47 kcal/mol) and DMC (−20.58 kcal/mol) was lower than that of HCQ (−24.58 kcal/mol), FAV (−22.87 kcal/mol), and REM (−23.48 kcal/mol). In the case of S1-RBD, CUR had the highest binding energy (−38.84 kcal/mol) and the lowest was in FAV (−23.77 kcal/mol), whereas HCQ (−35.87 kcal/mol) and REM (−38.44 kcal/mol) had greater binding energy than BDMC (−28.07 kcal/mol) and DMC (−30.29 kcal/mol). Hence, this study envisages that these curcuminoids could be employed in combination therapy with conventional drugs to disrupt the stability of SARS-CoV-2 receptor proteins.","PeriodicalId":54759,"journal":{"name":"Journal of Thermal Stresses","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89028045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surprising Effects of Rocking Motion on Leishmania tarentolae Behavior in Culture and Implications for Cell Stress 摇摆运动对培养利什曼原虫行为的惊人影响及其对细胞应激的影响

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-08-28 DOI: 10.3390/stresses3030042

Linda M. Ferrence, Akshata Gajula, Marjorie A. Jones

{"title":"Surprising Effects of Rocking Motion on Leishmania tarentolae Behavior in Culture and Implications for Cell Stress","authors":"Linda M. Ferrence, Akshata Gajula, Marjorie A. Jones","doi":"10.3390/stresses3030042","DOIUrl":"https://doi.org/10.3390/stresses3030042","url":null,"abstract":"Leishmania are an understudied genus of parasitic protozoans causing significant health problems for people, particularly in tropical climates. To better understand the growth of Leishmania and potential drug sensitivity implications, the effects of motion on cells grown in vitro were probed. Using a stock Leishmania tarentolae cell culture, cells were placed in 10 mL of a Brain–Heart Infusion medium in either a non-moving (static) environment or on a flat platform of one of two lab rockers (set at a minimal speed) in a dark environment for 13 days. Also, the addition of 0.5 M of L-Proline was evaluated. Microscopy, cell clumping, cell viability, and secreted acid phosphatase (SAP) activity data were collected. Results show that a constant slow rocking motion changed cell growth, clumping behavior, and detectable SAP activity relative to the no-motion cultures, but this change was dependent on which rocker was used, indicating a complexity in the growth of these cells in culture. Thus, continuous motion affects the stresses placed on the cells during a growth curve under some conditions. The implications of this study lead to questions about the effects of motion on the efficacy of pharmaceutical testing in vitro. Further study of the effects of motion on Leishmania is important.","PeriodicalId":54759,"journal":{"name":"Journal of Thermal Stresses","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89470377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Combining Abilities of Popcorn Inbred Lines for Agronomic and Root Traits under Contrasting Water Conditions: Towards Developing Drought-Tolerant Genotypes 对比水分条件下爆米花自交系农艺性状和根系性状配合力评价:培育耐旱基因型

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-08-10 DOI: 10.3390/stresses3030041

R. Bispo, A. T. A. Junior, S. Kamphorst, V. J. Lima, G. Pena, T. D. O. Santos, J. T. Leite, Flávia Nicácio Viana, Divino Rosa dos Santos Júnior, Danielle Leal Lamêgo, Uéliton Alves de Oliveira, Rodrigo Moreira Ribeiro, T. Pereira, Shahid Khan

{"title":"Assessing Combining Abilities of Popcorn Inbred Lines for Agronomic and Root Traits under Contrasting Water Conditions: Towards Developing Drought-Tolerant Genotypes","authors":"R. Bispo, A. T. A. Junior, S. Kamphorst, V. J. Lima, G. Pena, T. D. O. Santos, J. T. Leite, Flávia Nicácio Viana, Divino Rosa dos Santos Júnior, Danielle Leal Lamêgo, Uéliton Alves de Oliveira, Rodrigo Moreira Ribeiro, T. Pereira, Shahid Khan","doi":"10.3390/stresses3030041","DOIUrl":"https://doi.org/10.3390/stresses3030041","url":null,"abstract":"Developing popcorn genotypes that are adapted to water-deficit conditions is crucial due to the significant impact of this abiotic stress on grain yield. This study aimed to assess the combining abilities of preselected popcorn lines for agronomic and root traits under well-watered and water-stressed conditions. A circulating diallel analysis was conducted to investigate the effects of the general and specific combining abilities of 10 lines and their respective hybrids for various traits, including productivity, popping expansion, expanded popcorn volume, 100-grain weight, ear length, ear width, support root angle, crown root angle, number of support roots, number of crown roots, density of support roots, and density of crown roots. Non-additive action genes predominantly influenced the agronomic traits under both water conditions. In contrast, the root traits displayed a greater proportion of additive action gene expression under both conditions, despite being significantly affected by the environment. Lines L61, L71, and L76 demonstrated positive and high effects for general combining ability. The hybrids L65/L76, L71/L76, and L61/L75, in addition to exhibiting satisfactory effects of their specific combining ability, also displayed the most favorable phenotypic responses for most agronomic and root traits, making them ideal candidates for inclusion in popcorn breeding programs aiming to develop drought-tolerant genotypes.","PeriodicalId":54759,"journal":{"name":"Journal of Thermal Stresses","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80981202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoelastic diffusion system of type II with nonlocal delay 具有非局部延迟的II型热弹性扩散系统

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-08-08 DOI: 10.1080/01495739.2023.2240862

Carlos Alberto Raposo da Cunha, B. Feng, J. Ribeiro, Edson A. Coayla-Teran

引用次数: 0

An Overview of Plant Phenolics and Their Involvement in Abiotic Stress Tolerance 植物酚类物质及其在非生物逆境抗性中的作用综述

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-08-08 DOI: 10.3390/stresses3030040

K. Kumar, P. Debnath, S. Singh, Navin Kumar

引用次数: 3

Algae Polysaccharides (Carrageenan and Alginate)—A Treasure-Trove of Antiviral Compounds: An In Silico Approach to Identify Potential Candidates for Inhibition of S1-RBD Spike Protein of SARS-CoV2 藻类多糖(卡拉胶和海藻酸盐)-抗病毒化合物的宝库:一种识别抑制SARS-CoV2 S1-RBD刺突蛋白的潜在候选物的计算机方法

IF 2.8 3区工程技术

Journal of Thermal Stresses Pub Date : 2023-07-31 DOI: 10.3390/stresses3030039

Dikshansha Rohilla, A. Srivastava, R. Singh, P. Yadav, Sandeep K. Singh, Dharmendra Kumar, Nikunj Bhardwaj, Mahipal Singh Kesawat, K. D. Pandey, Ajay Mahaputra Kumar

{"title":"Algae Polysaccharides (Carrageenan and Alginate)—A Treasure-Trove of Antiviral Compounds: An In Silico Approach to Identify Potential Candidates for Inhibition of S1-RBD Spike Protein of SARS-CoV2","authors":"Dikshansha Rohilla, A. Srivastava, R. Singh, P. Yadav, Sandeep K. Singh, Dharmendra Kumar, Nikunj Bhardwaj, Mahipal Singh Kesawat, K. D. Pandey, Ajay Mahaputra Kumar","doi":"10.3390/stresses3030039","DOIUrl":"https://doi.org/10.3390/stresses3030039","url":null,"abstract":"For the last three years, the world has faced the unexpected spread of the pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The high mortality rate and ever-changing shape of the virus are the challenging factors in the effective management of SARS-CoV-2. However, in last three years, research communities have made significant progress in developing vaccines and controlling the spread of the pandemic to a certain extent. These vaccines contain the attenuated pathogens, which after application did not kill the virus but protected the human by enhancing the immune system response during pandemic exposure. However, the negative side effects and the high cost of the synthetic vaccines are always of concern for researchers, consumers, and the government. Therefore, as an alternative to synthetic drugs, natural medicines or natural plant products have piqued researchers’ interest. Algae are considered as a treasure house of bioactive compounds such as carotenoids, vitamins, polysaccharides, proteins, etc. These bioactive compounds have been well documented for the treatments of various human ailments such as cancer and cardiovascular diseases. Furthermore, sulfated polysaccharides such as alginate and carrageenan have been reported as having antiviral and immunomodulating properties. Therefore, this review addresses algal polysaccharides, especially alginate and carrageenan, and their application in the treatment of COVID-19. In addition, in silico approaches are discussed for the inhibition of the S1-RBD (receptor-binding domain) of SARS-CoV-2, which attaches to the host receptor ACE2 (angiotensin-converting enzyme 2), and the interaction with the network of relative proteins is also explored, which will help in drug discovery and drug design.","PeriodicalId":54759,"journal":{"name":"Journal of Thermal Stresses","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85960005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0