Operative Techniques in Sports Medicine最新文献_第10页

A Biphasic Aragonite off the Shelf Implant for Articular Cartilage Restoration in Early OA 双相现成霰石种植体修复早期OA关节软骨

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150960

Enrico Maria Bertolino , Berardo Di Matteo , Daniele Altomare , Elizaveta Kon

{"title":"A Biphasic Aragonite off the Shelf Implant for Articular Cartilage Restoration in Early OA","authors":"Enrico Maria Bertolino , Berardo Di Matteo , Daniele Altomare , Elizaveta Kon","doi":"10.1016/j.otsm.2022.150960","DOIUrl":"10.1016/j.otsm.2022.150960","url":null,"abstract":"<div>Osteoarthritis (OA) refers to a group of mechanically induced joint disorders characterized by an epigenetic nature. It has been defined as a disease of the entire joint. Articular chondrocytes and subchondral osteocytes are constantly subject to stress, strain and load and, if homeostatic and reparative processes are unable to compensate for the destructive processes, the joint environment will suffer and present with structural damage and clinical symptoms. The lack of drugs able to cure patients from OA has resulted in the use of intra-articular infiltrations and surgical procedures among which the implantation of biomimetic scaffolds. Biomimetic scaffolds are innovative materials created with the aim of encouraging bone and cartilage regeneration. The latest generation of scaffolds has been developed with the aim of increasing the healing abilities of the human body's own cells and signaling factors to achieve a superior tissue quality and better clinical outcomes. The present paper presents the in vivo performance of biphasic aragonite scaffolds on knees affected by early OA. The implantation of bioscaffolds has been been evaluated with MRIs, KOOS scores at follow up and histologically. The Agili-C scaffold's analysis has revealed it to be a viable option in the use of patients with mild to moderate OA.</div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48049206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Next Generation Cartilage Repair and the Pre-arthroplasty Patient. Pre-arthroplasty artificial Implants Part B: Metallic 下一代软骨修复和关节置换术前患者。关节置换术前人工植入物B部分:金属

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150965

Tim Spalding , Iswadi Damasena

{"title":"Next Generation Cartilage Repair and the Pre-arthroplasty Patient. Pre-arthroplasty artificial Implants Part B: Metallic","authors":"Tim Spalding , Iswadi Damasena","doi":"10.1016/j.otsm.2022.150965","DOIUrl":"10.1016/j.otsm.2022.150965","url":null,"abstract":"<div>Mini-metal implants are indicated for the treatment of symptomatic focal chondral or osteochondral defects in patients considered too old for biological reconstruction or too young with limited cartilage defects for knee arthroplasty. Precise surgical techniques are required to ensure optimal positioning with recession below the articular cartilage surface. Partial resurfacing for femoral or trochlea surfaces using the HemiCAP and UniCAP implants or the Episealer system has shown good short-term outcomes for middle-aged patients. In some series, however, quantification of tibial articular surface wear was not reported making interpretation of the clinical benefit difficult. When successful, clinical function is high and results appear durable. Favorable outcomes are seen with well-defined indications of: isolated defect, healthy opposing articular cartilage, and >50% volume meniscus. Indications also include patients with failed previous cartilage repair and those facing revision articular cartilage repair. Extended indications may include multiple lesions and the requirement for concomitant osteotomy or ligament reconstruction.</div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42498003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Allogeneic Mesenchymal Signaling Cells (MSCs) to Augment Cartilage Repair 利用同种异体间充质信号细胞(MSCs)增强软骨修复

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150962

Tim F.F. Saris , Tommy S. de Windt , Roel J.H. Custers , Daniël B.F. Saris

{"title":"Use of Allogeneic Mesenchymal Signaling Cells (MSCs) to Augment Cartilage Repair","authors":"Tim F.F. Saris , Tommy S. de Windt , Roel J.H. Custers , Daniël B.F. Saris","doi":"10.1016/j.otsm.2022.150962","DOIUrl":"10.1016/j.otsm.2022.150962","url":null,"abstract":"<div>Preserving articular cartilage extends the life span and functional capabilities of a joint, and prevents early joint arthroplasty. Mesenchymal signaling cells (MSCs) induce chondrocytes and stimulate the innate capacity to regenerate and restore damaged cartilage. Preserving the pericellular matrix of chondrocytes boosts the ability of MSC to stimulate chondrocytes. The ability to augment joint homeostasis and induce cartilage regeneration with the use of allogenic MSCs unlocks the possibility of a single stage cell based surgical therapy for medium to large cartilage defects. The results of cell therapy with recycled autologous chondrons mixed with allogeneic (bone-marrow or adipose derived) mesenchymal signaling cells (IMPACT/RECLAIM) after 7 years have supported the safety and clinical efficacy of this treatment. Patients have shown clinically relevant and statistically significant improvement in multiple validated patient reported outcome measures for knee pain and quality of life. Once fully industrialized the single stage approach, compared to conventional 2 stage procedures, should also provide a more economical and logistically friendly treatment option. Low failure rates and similar results compared to the current golden standard reinforce the longevity of this proof of concept. The phase III randomized controlled trial comparing results of the treatment after a non-surgical approach will conclude in 2024. As for now, research supports this unique first in man one stage cartilage repair to be safe, feasible, and have good clinical outcomes when combining recycled cartilage with allogeneic MSCs.</div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43458549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmented Marrow Stimulation: Drilling Techniques and Scaffold Options 增强骨髓刺激:钻孔技术和支架选择。

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150958

Joshua T. Kaiser, Mario Hevesi, Kyle R. Wagner, Zachary D. Meeker, Brian J. Cole

引用次数: 0

Editorial Board (pick up from previous issue) 编辑委员会(选自上一期)

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1053/S1060-1872(22)00083-1

引用次数: 0

Orthobiologics: Optimizing the Joint for Restoration or Delaying Arthroplasty 骨科:优化关节修复或延迟关节置换术

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150957

Bert Mandelbaum , Eric Chen

{"title":"Orthobiologics: Optimizing the Joint for Restoration or Delaying Arthroplasty","authors":"Bert Mandelbaum , Eric Chen","doi":"10.1016/j.otsm.2022.150957","DOIUrl":"10.1016/j.otsm.2022.150957","url":null,"abstract":"<div>New medical interventions have helped people live longer and healthier lives, which has been accompanied by the expectation of patients remaining active even into their eighth decade and beyond. Unfortunately, advances in the orthopaedic literature for joint preservation have lagged behind. Research into techniques for joint preservation with the goal of delaying arthroplasty have risen to the forefront due to the tremendous physical and economic burden associated with osteoarthritis. One component has been the field of orthobiologics, the class of therapies that utilize biological products to enhance the body's natural healing process. Several potential candidates have emerged and entered the public consciousness, which portends increasing interest into these therapeutics. Among these possibilities include hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrate, and mesenchymal stem cells (MSC's). Despite concerns regarding the efficacy and cost-benefit ratio, both the basic science and the clinical data have supported their use to varying degrees. Further research remains to provide concrete guidelines for clinicians to provide optimal care for their patients.</div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46494891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous Stem Cells for the Treatment of Chondral Injury and Disease 自体干细胞治疗软骨损伤和疾病

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150963

Eric A. Branch , Travis J. Dekker , Adam W. Anz

引用次数: 0

Table of Contents (pick up from previous issue w/updates) 目录(选自上一期的内容和更新)

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1053/S1060-1872(22)00082-X

引用次数: 0

Autologous Chondrocyte Implantation (ACI) for Cartilage Defects of the Knee Using Novocart 3D and Novocart Inject 自体软骨细胞植入术治疗膝关节软骨缺损的研究

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-12-01 DOI: 10.1016/j.otsm.2022.150959

Philipp Niemeyer MD, PhD , Peter Angele MD, PhD

{"title":"Autologous Chondrocyte Implantation (ACI) for Cartilage Defects of the Knee Using Novocart 3D and Novocart Inject","authors":"Philipp Niemeyer MD, PhD , Peter Angele MD, PhD","doi":"10.1016/j.otsm.2022.150959","DOIUrl":"10.1016/j.otsm.2022.150959","url":null,"abstract":"<div>Ever since autologous chondrocyte implantation (ACI) has been introduced, there have been important advancements and progress leading to a more reliable and more standardized application of this technology. While first-generation ACI followed the principle of a cell-suspension being injected under an autologous periosteum patch, second and third generation ACI are characterized by the use of biomaterials, either using a cell-suspension (second generation) or a combination of cells and the biomaterial (third generation). Due to easier handling and improved clinical outcome, third generation ACI has become the gold standard for the use of ACI at this time. The present chapter focuses on the Novocart third generation ACI products. While Novocart 3D uses a collagen membrane and therefore an implantable biomaterial, Novocart Inject is a hydrogel-based ACI product that can be injected into cartilage defects. Both products are currently underway for central European market authorization by the European Medicinal Agency (EMA), additionally, an FDA-approval trial is underway for Novocart 3D. Product characteristics, indications, surgical techniques, and clinical outcomes are summarized in the present chapter.</div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49615381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Use of 3D-Printed Patient Specific Guides in Osteotomies around the Knee 3D打印患者专用导向器在膝关节周围截骨术中的应用

IF 0.3 4区医学

Operative Techniques in Sports Medicine Pub Date : 2022-09-01 DOI: 10.1016/j.otsm.2022.150936

Suhas P. Dasari MD , Luc M. Fortier MD, Bhargavi Maheshwer MD, Mario Hevesi MD, PhD, Safa Gursoy MD, PhD, Jorge Chahla MD, PhD

{"title":"Use of 3D-Printed Patient Specific Guides in Osteotomies around the Knee","authors":"Suhas P. Dasari MD , Luc M. Fortier MD, Bhargavi Maheshwer MD, Mario Hevesi MD, PhD, Safa Gursoy MD, PhD, Jorge Chahla MD, PhD","doi":"10.1016/j.otsm.2022.150936","DOIUrl":"10.1016/j.otsm.2022.150936","url":null,"abstract":"<div>High tibial osteotomies are challenging procedures that have traditionally implemented two-dimensional planning (2D) for a complex three-dimensional surgery (3D). In an effort to improve the accuracy and precision of the technique, there has been a growing interest in the use of patient specific instrumentation (PSI). The implementation of PSI in osteotomies has demonstrated consistent and reliable results in the correction of the hip-knee-ankle angle, proximal tibial angle, and the posterior tibial slope. Initial clinical studies describing the implementation of this technology have reported superior accuracy in both the coronal and sagittal planes as compared to free-hand techniques. Additionally, these studies reported a fast surgeon learning curve, short operative times, and minimal fluoroscopy exposure. The senior author's preferred closing wedge HTO technique utilizes a patient specific cutting guide with osteotomy fixation provided by an extra-cortical titanium alloy locking plate. This technique is designed to provide reliable and accurate HTOs while minimizing the risk of major complications such as hinge fractures on the contralateral cortex.</div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41661402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1