Pediatric Rheumatology最新文献

{"title":"Enhancing the precision of clinical assessment in juvenile idiopathic arthritis through the JADAS.","authors":"Alessandro Consolaro, Roberta Naddei, Silvia Maria Orsi, Marco Burrone, Silvia Rosina, Angelo Ravelli","doi":"10.1186/s12969-026-01226-3","DOIUrl":"https://doi.org/10.1186/s12969-026-01226-3","url":null,"abstract":"<p><p>The use of composite disease activity scores enables a pragmatic approach to the measurement of the level of disease activity in children with juvenile idiopathic arthritis (JIA). These tools are constructed through the combination of individual measures and provide a quantification of the absolute level of disease activity in one summary number on a continuous scale. The first composite score for JIA, named Juvenile Arthritis Disease Activity Score (JADAS), was published in 2009. It includes the following four variables: physician global assessment, parent/patient global assessment, active joints count, and an acute phase reactant. Its score is calculated as the arithmetic sum of the scores of its four items. Additional versions of the JADAS, which lack the acute phase reactant (clinical JADAS, cJADAS) or are specific to systemic JIA (systemic JADAS, sJADAS), were developed over the years. An important progress in the field has been represented by the definition of the cutoff values in the JADAS that distinguish the states of inactive disease or minimal, moderate, and high disease activity in JIA. These cutoffs may serve as therapeutic targets in the treat-to-target strategy. Recently, a JADAS version entirely composed of parent/patient-reported outcome measures has been developed and validated. This tool is well suited to implement remote patient monitoring, a form of telemedicine that may help to optimize disease control and reduce the pressure on healthcare systems. This review is aimed to describe the different versions of the JADAS and the main aspects of their developmental process.</p>","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporo-mandibular joint alterations in juvenile idiopathic arthritis and young-onset inflammatory arthropathies: a magnetic resonance imaging study with ultrasound comparison.","authors":"Adriano Lercara, Silvana Martino, Gloria Crepaldi, Stefano Cirillo, Marco Davico, Sarah Marouen, Enrica Vandelli, Claudia Lomater, Yves-Marie Pers, Francesco Licciardi","doi":"10.1186/s12969-026-01218-3","DOIUrl":"https://doi.org/10.1186/s12969-026-01218-3","url":null,"abstract":"<p><strong>Background: </strong>To assess temporomandibular joint (TMJ) alterations using magnetic resonance imaging (MRI) in pediatric and young adult patients with juvenile idiopathic arthritis (JIA) and non-JIA inflammatory arthropathies, and to evaluate the added value of ultrasound (US).</p><p><strong>Methods: </strong>The study prospectively included three groups of patients: children with JIA; young adults under 35 years with JIA, and young adults under 35 years with non-JIA inflammatory arthropathies. All patients underwent joint count assessment, clinical examination of the TMJs, evaluation of global disease activity and TMJ MRI to identify inflammation or structural damage. TMJ US was additionally performed in the two young adult patient groups. Associations between clinical findings and MRI results were then analyzed using appropriate group comparison tests. Concordance between MRI and US findings was also calculated.</p><p><strong>Results: </strong>A total of 41 patients were enrolled: 14 in the pediatric JIA group, 19 in the adult JIA group, and 8 in the adult non-JIA group. MRI analysis revealed significantly greater joint damage in adults compared to pediatric patients (p = 0.05). Tenderness on physical examination was significantly associated with MRI-detected joint damage (p = 0.01), whereas retrognathia was associated with MRI evidence of inflammation (p = 0.02) in all patients. The negative predictive value of clinical examination for detecting TMJ alterations was low (47.8%). US, performed in 18 out of the 27 adults, was compared with MRI findings and demonstrate poor concordance, with a sensitivity of 48% (95%CI 0.28-0.68), and a specificity of 73% (95%CI 0.47-0.99).</p><p><strong>Conclusions: </strong>TMJs alterations were common across all three patient groups. Clinical examination showed limited association with MRI-detected morphological lesions. MRI remains the gold standard for TMJ assessment, while the diagnostic performance of US requires optimization to enhance both sensitivity and specificity.</p><p><strong>Trail registration: </strong>\"Comité Local d'Ethique Recherche (IRB) du CHU de Montpellier\" no. IRB-MTP_2022_06_202201149.</p>","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markerless gait analysis for children and adolescents with juvenile idiopathic arthritis using a machine learning pipeline.","authors":"Aseem Behl, Dominik Papies, Winfried Ilg, Mareen Kraft, Andrea Bevot, Sandra Hansmann","doi":"10.1186/s12969-026-01211-w","DOIUrl":"10.1186/s12969-026-01211-w","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anakinra use in pediatric kawasaki disease: inflammation control, coronary artery outcomes, and safety.","authors":"Melika Kolahdoozan, Fatemeh Kabiri, Aylin Biyabanaki, Fatemeh Shafiee","doi":"10.1186/s12969-026-01205-8","DOIUrl":"https://doi.org/10.1186/s12969-026-01205-8","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-adalimumab antibodies are associated with loss of response in juvenile idiopathic arthritis.","authors":"Mikhail Carrim, Muhammad R A Shipa, Aicha Bouraoui, Toka AlSulaim, Corinne Fisher, James R W Glanville, Maria Leandro, Debajit Sen","doi":"10.1186/s12969-026-01213-8","DOIUrl":"https://doi.org/10.1186/s12969-026-01213-8","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morning stiffness duration is associated with physician active joint count in juvenile idiopathic arthritis.","authors":"Nikki Ruhof, Sebastiaan J Vastert, Annet van Royen, Marc H A Jansen, Erika van Nieuwenhove, Joost F Swart, Sytze de Roock","doi":"10.1186/s12969-026-01210-x","DOIUrl":"https://doi.org/10.1186/s12969-026-01210-x","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expert collaborative evidence-based consensus for childhood lupus nephritis diagnosis and treatment: unifying clinical approach in Saudi Arabia.","authors":"Abdulaziz AlMutairi, Abdulaziz Bahassan, Ibrahim Sandokji, Emtenan Basahl, Sulaiman M Al-Mayouf, Khalid Alhasan, Khalid Alsaran, Mahmoud Majeed, Jameela A Kari, Wafaa AlSuwairi, Abdulkarim AlAnazi, Abdullatif Alenazi, Naif Abdulmajeed, Sajdi AlMutairi, Weiam AlMaiman, Mohammed Olfat, Mohmmad AlTuwigri, Muneera Alabdulqader, Abdurhman Asiri, Alaa Hakami, Khairiyah AlSufyani, Khamisa AlMokali, Hosam AlThagafi, Khalid Al Alsheikh, Emad Anam, Samah Zahran, Hanan Al Rayes, Ghada Ankawi, Mohammed Nashawi","doi":"10.1186/s12969-026-01215-6","DOIUrl":"10.1186/s12969-026-01215-6","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the utility of sarcopenia associated SARC-F and MSRA questionnaires in identifying falls and self-reported functional impairment in juvenile idiopathic arthritis.","authors":"Amaani Ahmad, Sameera Oruganti, Zahra Ladan, Nicole Y Zhang, Louise Willoughby, Fatima Yousaf, Vithushi Karunakaran, Souraya Sayegh, Charalambos Hadjicharalambous, James Glanville, Madhura Castelino, Corinne Fisher, Maria Leandro, Venkat R Reddy, Debajit Sen","doi":"10.1186/s12969-026-01212-9","DOIUrl":"https://doi.org/10.1186/s12969-026-01212-9","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-phenotype correlations in pediatric CAPS with predominantly low-penetrance NLRP3 variants among Turkish patients in Germany and Turkey: beyond borders.","authors":"Yagmur Bayindir, Özlem Satirer, Veysel Cam, Seyma Turkmen, Betul Sozeri, Jasmin B Kuemmerle-Deschner, Seza Ozen","doi":"10.1186/s12969-026-01214-7","DOIUrl":"10.1186/s12969-026-01214-7","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic steroidophobia scale for pediatric rheumatology (SSS-PR): development and validation of a novel psychometric tool measuring clinician steroidophobia.","authors":"Sema Nur Taşkın, Sevil Aydoğan Gedik, Emrah Atay, Zeynep Kasap Acungil, Nuray Aktay Ayaz","doi":"10.1186/s12969-026-01200-z","DOIUrl":"10.1186/s12969-026-01200-z","url":null,"abstract":"","PeriodicalId":54630,"journal":{"name":"Pediatric Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}