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Creating a culture of wellness 创造健康文化

Power Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-817872-0.00010-0

Felipe Rubim, Lucas Rubim, A. Thornton

引用次数: 0

Promoting wellness 促进健康

Power Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-817872-0.00011-2

S. Creighton, Chuck Kaye

引用次数: 7

Copyright 版权

Power Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-817872-0.12001-4

引用次数: 0

The Efficacy and Evidence-Based Use of Biologics in Children and Adolescents: Using Monoclonal Antibodies and Fusion Proteins as Treatments. 生物制剂在儿童和青少年中的疗效和循证使用：使用单克隆抗体和融合蛋白进行治疗。

IF 6.5

Power Pub Date : 2019-10-18 DOI: 10.3238/arztebl.2019.0703

Tim Niehues, Tuba Turul Özgür

{"title":"The Efficacy and Evidence-Based Use of Biologics in Children and Adolescents: Using Monoclonal Antibodies and Fusion Proteins as Treatments.","authors":"Tim Niehues, Tuba Turul Özgür","doi":"10.3238/arztebl.2019.0703","DOIUrl":"10.3238/arztebl.2019.0703","url":null,"abstract":"Background: Monoclonal antibodies (mAb) and fusion proteins (FP) are increasingly being used in children and adolescents. In this review, we analyze the evidence for their safety and efficacy in the treatment of the most common chronic inflammatory diseases.Methods: We systematically searched PubMed, AWMF.org, and other databases for high-quality trials (i.e., randomized controlled trials with clinical primary endpoints) and guidelines published at any time up to 10 December 2018 that dealt with mAb and FP that are approved for pediatric use. The search term was \"monoclonal anti- body/fusion protein [e. g. adalimumab] AND children.\"Results: The 620 hits included 25 high-quality trials (20 of them manufacturer- sponsored) on 9 mAb/FP (omalizumab, adalimumab, etanercept, ustekinumab, infliximab, golimumab, anakinra, canakinumab, tocilizumab, and abatacept), as well as 6 guidelines (3 each of levels S3 and S2k) on the treatment of bronchial asthma, psoriasis, juvenile idopathic arthritis, and chronic inflammatory bowel diseases. For none of these conditions are mAb and FP the drugs of first choice. Adverse drug effects are rare but sometimes severe (infection, immune dysregulation, tumors).Conclusion: The retrieved trials have deficiencies that make it difficult to reliably evaluate the efficacy, safety, and utility of mAb/FP for children and adolescents with chronic inflammatory diseases. mAb/FP nonetheless represent a treatment option to be considered in case conventional immune-modulating drugs are ineffective. Researcher-initiated, high-quality trials and manufacturer-independent, systematic long-term evaluations of adverse effects (e.g., tumors) are sorely needed.","PeriodicalId":54593,"journal":{"name":"Power","volume":"139 1","pages":"703-710"},"PeriodicalIF":6.5,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75124439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Model of Protests, Revolution, and Information 抗议、革命和信息的模型

Power Pub Date : 2019-10-01 DOI: 10.2139/ssrn.2732864

S. Barberà, M. Jackson

{"title":"A Model of Protests, Revolution, and Information","authors":"S. Barberà, M. Jackson","doi":"10.2139/ssrn.2732864","DOIUrl":"https://doi.org/10.2139/ssrn.2732864","url":null,"abstract":"A revolt or protest succeeds only if sufficient people participate. We study how potential participants' ability to coordinate is affected by their information. We distinguish four phenomena that affect whether information either encourages or inhibits protests and revolutions: (i) Unraveling: When agents learn about each others' types, some are discouraged by meeting partisans of the status quo. This can unravel, as even confident agents realize that enough supporters will be discouraged to preclude a successful revolution. (ii) Homophily: Learning someone else's type under homophily is less informative since that individual is more likely to be similar to the learner. This can lead people to be less confident of a revolution, but can also stop potential unraveling. (iii) Extremism: Meeting other protestors, and seeing pilot demonstrations or outcomes in similar countries, reveal not only how much support for change exists, but also from which constituencies it emerges. This can undercut a revolution if factions differ sufficiently in their preferred changes. (iv) Counter Demonstrations: partisans for the status quo can hold counter-demonstrations to signal their strength. We also discuss why holding mass demonstrations before a revolution may provide better signals of peoples willingness to actively participate than other less costly forms of communication (e.g., via social media), and how governments use redistribution and propaganda to avoid a revolution.","PeriodicalId":54593,"journal":{"name":"Power","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2139/ssrn.2732864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41324552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 50

Human Resource-Based View of the Organisation 基于人力资源的组织观

Power Pub Date : 2019-06-12 DOI: 10.2139/ssrn.3403098

J. Mathews

引用次数: 1

Passing Marx 通过马克思

Power Pub Date : 2019-04-11 DOI: 10.22459/csy.2019.08c

W. Sima