Quarterly Journal of Studies on Alcohol最新文献

Glyphosate and neurological outcomes: A systematic literature review of animal studies. 草甘膦与神经系统疾病：动物研究的系统文献综述。

IF 7.2

Quarterly Journal of Studies on Alcohol Pub Date : 2022-05-19 Epub Date: 2022-06-08 DOI: 10.1080/10937404.2022.2083739

Virginia C Moser, Keith Morris-Schaffer, Jason R Richardson, Abby A Li

{"title":"Glyphosate and neurological outcomes: A systematic literature review of animal studies.","authors":"Virginia C Moser, Keith Morris-Schaffer, Jason R Richardson, Abby A Li","doi":"10.1080/10937404.2022.2083739","DOIUrl":"10.1080/10937404.2022.2083739","url":null,"abstract":"Studies of nervous system effects of glyphosate, a widely used herbicide, have not been critically examined. The aim of this paper was to systematically review glyphosate-induced neurotoxicity literature to determine its usefulness in regulatory decision-making. The review was restricted to mammalian studies of behavior, neuropathology, and neuropharmacology; in vitro and other biochemical studies were considered supplementary information. Glyphosate formulation studies were also considered, despite uncertainties regarding toxicities of the formulated products; no studies used a formulation vehicle as the control. Inclusion criteria were developed a priori to ensure consistent evaluation of studies, and in vivo investigations were also ranked using ToxRTool software to determine reliability. There were 27 in vivo studies (open literature and available regulatory reports), but 11 studies were considered unreliable (mostly due to critical methodological deficiencies). There were only seven acceptable investigations on glyphosate alone. Studies differed in terms of dosing scenarios, experimental designs, test species, and commercial product. Limitations included using only one dose and/or one test time, small sample sizes, limited data presentation, and/or overtly toxic doses. While motor activity was the most consistently affected endpoint (10 of 12 studies), there were considerable differences in outcomes. In six investigations, there were no marked neuropathological changes in the central or peripheral nervous system. Other neurological effects were less consistent, and some outcomes were less convincing due to influences including high variability and small effect sizes. Taken together, these studies do not demonstrate a consistent impact of glyphosate on the structure or function of the mammalian nervous system.","PeriodicalId":54519,"journal":{"name":"Quarterly Journal of Studies on Alcohol","volume":"6 1","pages":"162-209"},"PeriodicalIF":7.2,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89279844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Structure-based analysis and evolution of a monomerized red-colored chromoprotein from the Olindias formosa jellyfish. 基于结构的分析和福尔马林水母单体红色色素蛋白的进化。

IF 4.5

Quarterly Journal of Studies on Alcohol Pub Date : 2022-05-01 DOI: 10.1002/pro.4285

Le Zhai, Ryosuke Nakashima, Hajime Shinoda, Yoshimasa Ike, Tomoki Matsuda, Takeharu Nagai

{"title":"Structure-based analysis and evolution of a monomerized red-colored chromoprotein from the Olindias formosa jellyfish.","authors":"Le Zhai, Ryosuke Nakashima, Hajime Shinoda, Yoshimasa Ike, Tomoki Matsuda, Takeharu Nagai","doi":"10.1002/pro.4285","DOIUrl":"10.1002/pro.4285","url":null,"abstract":"GFP-like chromoproteins (CPs) with non-fluorescence ability have been used as bioimaging probes. Existing CPs have voids in the optical absorption window which limits their extensibility. The development of new CP color is therefore ongoing. Here, we cloned CPs from the jellyfish, Olindias formosa, and developed a completely non-fluorescent monomeric red CP, R-Velour, with an absorption peak at 528 nm. To analyze the photophysical properties from a structural aspect, we determined the crystal structure of R-Velour at a 2.1 Å resolution. R-Velour has a trans-chromophore similar to the green fluorescence protein, Gamillus, derived from the same jellyfish. However, in contrast to the two coplanar chromophoric rings in Gamillus, R-Velour has a large torsion inducing non-fluorescence property. Through site-directed mutagenesis, we surveyed residues surrounding the chromophore and found a key residue, Ser155, which contributes to the generation of four-color variants with the bathochromic and hypsochromic shift of the absorption peak, ranging from 506 to 554 nm. The recently proposed spectrum shift theory, based on the Marcus-Hush model, supports the spectrum shift of these mutants. These findings may support further development of R-Velour variants with useful absorption characteristics for bioimaging, including fluorescence lifetime imaging and photoacoustic imaging.","PeriodicalId":54519,"journal":{"name":"Quarterly Journal of Studies on Alcohol","volume":"12 1 1","pages":"e4285"},"PeriodicalIF":4.5,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89283417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Internationalisation of Tobacco Control, 1950-2010. 烟草控制的国际化，1950-2010 年。

Quarterly Journal of Studies on Alcohol Pub Date : 2016-10-01 DOI: 10.1017/mdh.2016.97

David Reubi, Virginia Berridge

{"title":"The Internationalisation of Tobacco Control, 1950-2010.","authors":"David Reubi, Virginia Berridge","doi":"10.1017/mdh.2016.97","DOIUrl":"10.1017/mdh.2016.97","url":null,"abstract":"This article explores the internationalisation of tobacco control as a case study in the history of international health regulation. Contrary to the existing literature on the topic, it argues that the history of international anti-smoking efforts is longer and richer than the making of the World Health Organisation's Framework Convention on Tobacco Control in the early twenty-first century. It thereby echoes the point made by other scholars about the importance of history when making sense of contemporary global health. Specifically, the article shows how the internationalisation of tobacco control started in the 1950s through informal contacts between scientists working on cancer research and how these initial interactions were followed by a growing number of more formal initiatives, from the World Conferences on Tobacco or Health to the Bloomberg Initiative to Reduce Tobacco Use. Rather than arranging these efforts in a linear narrative of progress culminating with the Framework Convention on Tobacco Control, we take anthropological claims about global health's uneven terrain seriously and portray a history of international tobacco control marked by ruptures and discontinuities. Specifically, we identify three successive periods, with each of them characterised by specific understandings of international action, tobacco control expertise, advocacy networks and funding strategies. ","PeriodicalId":54519,"journal":{"name":"Quarterly Journal of Studies on Alcohol","volume":"23 1","pages":"453-72"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89299673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive style and intellectual performance in relation to the progress of alcoholism. 认知方式和智力表现与酒精中毒进展的关系。

Quarterly Journal of Studies on Alcohol Pub Date : 1974-12-01

H Bergman, G Agren

引用次数: 0

Observations of barroom drinking; methodology and preliminary results. 酒吧间饮酒观察;方法和初步结果。

Quarterly Journal of Studies on Alcohol Pub Date : 1974-12-01

M Kessler, C Gomberg

引用次数: 0

Effect of acute and prolonged ethanol administration on serotonin metabolism and excretion in urine and bile of rats. 急性和长期乙醇给药对大鼠尿胆血清素代谢和排泄的影响。

Quarterly Journal of Studies on Alcohol Pub Date : 1974-12-01 DOI: 10.15288/QJSA.1974.35.1195

M. Kekki, P. Pentikäinen, O. Mustala