Revista Brasileira De Cirurgia Cardiovascular最新文献

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Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats 模拟地磁活动对大鼠心肌缺血再灌注损伤的影响
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0306
Huisheng Wu, Weiyu Chang, Yanglin Deng, Xinli Chen, Yongli Ding, Xuesong Li, Liang Dong
{"title":"Effect of Simulated Geomagnetic Activity on Myocardial Ischemia/Reperfusion Injury in Rats","authors":"Huisheng Wu, Weiyu Chang, Yanglin Deng, Xinli Chen, Yongli Ding, Xuesong Li, Liang Dong","doi":"10.21470/1678-9741-2018-0306","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0306","url":null,"abstract":"Objective To study the response of myocardial ischemia/reperfusion injury (MI/RI) in rats to simulated geomagnetic activity. Methods In a simulated strong geomagnetic outbreak, the MI/RI rat models were radiated, and their area of myocardial infarction, hemodynamic parameters, creatine kinase (CK), lactate dehydrogenase (LDH), melatonin, and troponin I values were measured after a 24-hour intervention. Results Our analysis indicates that the concentrations of troponin I in the geomagnetic shielding+operation group were lower than in the radiation+operation group (P<0.05), the concentrations of melatonin in the shielding+operation group and normal+operation group were higher than in the radiation + operation group (P<0.01), and the concentrations of CK in the shielding + operation group were lower than in the radiation + operation group and normal + operation group (P<0.05). Left ventricular developed pressure (LVDP) and ± dP/dtmax in the radiation+operation group were lower than in the shielding + operation group and normal+operation group (P<0.01). Left ventricular end-diastolic pressure (LEVDP) in the shielding + operation group was higher than in the normal + operation group (P<0.05). There was no significant difference in area of myocardial infarction and LDH between the shielding + operation group and the radiation + operation group. Conclusion Our data suggest that geomagnetic activity is important in regulating myocardial reperfusion injury. The geomagnetic shielding has a protective effect on myocardial injury, and the geomagnetic radiation is a risk factor for aggravating the cardiovascular and cerebrovascular diseases.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"674 - 679"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43477956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Scientific Transparency: a New Horizon for Scientific Publication and the “New Cardiovascular Surgeon” 科学透明:科学出版的新视野与“新型心血管外科医生”
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2019-0608
D. Braile, P. Evora
{"title":"Scientific Transparency: a New Horizon for Scientific Publication and the “New Cardiovascular Surgeon”","authors":"D. Braile, P. Evora","doi":"10.21470/1678-9741-2019-0608","DOIUrl":"https://doi.org/10.21470/1678-9741-2019-0608","url":null,"abstract":"there are several publications in national and international journals that show the field’s rich tradition in the development of surgical techniques and medicines, among other products. However, in recent years, information technology has significantly impacted medical practice, and with this, several challenges have emerged, such as the provision and dissemination of health care information. With the constant growth of health research, falsification, plagiarism, and data fabrication have been having a deleterious effect on the results presented. Unethical conduct in research drains the foundations of science which, by their very nature, are built on previous evidences, and if these are false, these foundations are logically weakened. In this context, it is up to the hard work of the editors of major scientific publications to ensure to the researchers and the society the dissemination of papers with reliable and transparent results. Research misconduct means fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results[1]. It is important to point out that misconduct does not include honest mistakes or differences of opinion. Scientific integrity consists in sticking to strategies that allow the promotion and development of ethical and honest scientific standards that guarantee objectivity, clarity, reproducibility, openness, and accessibility, the caring duty, fairness in providing references and giving credit, and responsibility to future scientists and researchers. This is one of the main concerns that scientific editors face daily, and this topic has been included in the Brazilian Journal of Cardiovascular Surgery’s (BJCVS) new instructions. Plagiarism consists in the appropriation of someone else’s ideas, processes, results, or words, without giving the appropriate credits. The authors are responsible for the content and the information in their manuscripts. BJCVS uses the Similarity Check software, which allows to detect similarities in the submitted EDITORIAL","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":" ","pages":"I - II"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48337426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anesthesia Management for a Patient Undergoing Pulmonary Endarterctomy without Cardiopulmonary Bypass 非体外循环肺动脉内膜切除术患者的麻醉管理
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0245
A. Saraçoğlu, Onur Ermerak, Esra Yaman Savci Sirzai, M. Yuksel, Z. Aykaç, B. Yıldızeli
{"title":"Anesthesia Management for a Patient Undergoing Pulmonary Endarterctomy without Cardiopulmonary Bypass","authors":"A. Saraçoğlu, Onur Ermerak, Esra Yaman Savci Sirzai, M. Yuksel, Z. Aykaç, B. Yıldızeli","doi":"10.21470/1678-9741-2018-0245","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0245","url":null,"abstract":"Pulmonary endarterectomy is a curative procedure for chronic thromboembolic Pulmonary Hypertension. As usual, cardiopulmonary bypass circuit is required. However, there are several complications attributed to extracorporeal circulation. Hemodilution, systemic inflammatory response syndrome and leukocyte sequestration are circulation related complications. The severe forms include Acute Respiratory Distress Syndrome, Acute Lung Injury, myocardial stunning, dysfunction of the right ventricle, coagulopathy, postoperative stroke or renal dysfunction. In this case report, we aimed to give information about perioperative anesthesia and surgical management of pulmonary endarterectomy which was successfully managed without Cardiopulmonary Bypass.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"783 - 787"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42984699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quadricuspid Aortic Valve: Three Cases Report and Literature Review 四尖瓣主动脉瓣:3例报告并文献复习
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0125
Elinthon T Veronese, C. Brandão, S. Steffen, P. Pomerantzeff, F. Jatene
{"title":"Quadricuspid Aortic Valve: Three Cases Report and Literature Review","authors":"Elinthon T Veronese, C. Brandão, S. Steffen, P. Pomerantzeff, F. Jatene","doi":"10.21470/1678-9741-2018-0125","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0125","url":null,"abstract":"Quadricuspid aortic valve (QAV) is a rare cardiac malformation. Many cases are incidentally diagnosed in aortic surgeries or autopsies and it usually appears as an isolated anomaly. The most widely classification used is the one by Hurwitz and Roberts[1], which divides 7 alphabetical subtypes based on the cusps size. The aim of this report is to describe three different anatomic presentations of this rare aortic valve anomaly.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"637 - 639"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47036476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Botulinum Toxin Injection into Epicardial Fat Pads: A Promising Potential Modality for Prevention of Postoperative Atrial Fibrillation After Cardiac Surgery 肉毒毒素注射心外膜脂肪垫:预防心脏手术后房颤的一种有前景的潜在方式
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2019-0309
A. Fatahian
{"title":"Botulinum Toxin Injection into Epicardial Fat Pads: A Promising Potential Modality for Prevention of Postoperative Atrial Fibrillation After Cardiac Surgery","authors":"A. Fatahian","doi":"10.21470/1678-9741-2019-0309","DOIUrl":"https://doi.org/10.21470/1678-9741-2019-0309","url":null,"abstract":"Despite developing new standards and advances in anesthetic and surgical techniques, postoperative atrial fibrillation (POAF) is one of the most frequent complications and a significant unsolved clinical problem after cardiac surgery[1]. Occurrence of POAF is associated with significant increased risk of long-term mortality, morbidity, and long intensive care unit (ICU) and hospital stays, which consequently impose additional cost on both health system and patient[2]. Considering the potential significant adverse effects of POAF in patients undergoing cardiac surgery and the limited efficacy of current preventive strategies, concerted efforts to identify and implement new preventive strategies are necessary[1,2]. Recently, injection of botulinum toxin into epicardial fat pads in patients undergoing cardiac surgery has been suggested as a promising modality for prevention of POAF. In a study by Pokushalov et al.[3], it has been shown that 50 U botulinum toxin injection, at four major epicardial fat pads, during surgery in patients undergoing coronary artery bypass grafting (CABG) provided considerable atrial tachyarrhythmia suppression, in both early and one-year followups[3]. Also, a three-year follow-up of this study indicates a sustained and significant reduction in atrial fibrillation (AF) incidence and burden, along with reduction in patients' hospitalizations. Besides, no serious adverse events related to injection of botulinum toxin for prevention of POAF after CABG have been reported[4]. Suppression of atrial autonomic remodeling has been suggested as a potential mechanism of botulinum toxin injection for prevention of POAF[34]. Another study by Waldron et al.[5] showed that injection of 50 U of botulinum toxin into each five epicardial fat pads (immediately after beginning of cardiopulmonary bypass) in patients undergoing cardiac surgery reduced the incidence of POAF compared to placebo (36.5% and 47.8%, respectively), however this difference was not statistically significant. Also, no significant differences were seen between length of hospital stay and occurrence of adverse effects in patients who received botulinum toxin injection or placebo[5]. In this study, patients who underwent CABG or valve surgery or combined CABG and valve surgery were included; whereas in Pokushalov et al.[3] one-year and three-year follow-up studies[4], only CABG patients were included and evaluated. Additionally, the left atrial sizes, as a marker of atrial structural remodeling, which commonly is associated with increased risk for AF, were considerably different between these studies (3.9±0.6 and 3.9±0.7 cm vs. 4.7±0.8 and 4.8±0.6, respectively). These issues may be possible explanations for the inconsistent results between studies. In sum, it seems that botulinum toxin injection into epicardial fat pads may be considered as a potentially promising and safe modality for prevention of POAF after cardiac surgery. However, further well-designed studies will be","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"643 - 643"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49209640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
"Overtime Hours Effect" on Emergency Surgery of Acute Type A Aortic Dissection 急性A型主动脉夹层急诊手术的“加班效应
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0350
O. Gokalp, L. Yılık, Y. Beşir, H. Iner, Nihan KarakasYesilkaya, Erturk Karaagac, Yasar Gokkurt, S. Iscan, A. Gurbuz
{"title":"\"Overtime Hours Effect\" on Emergency Surgery of Acute Type A Aortic Dissection","authors":"O. Gokalp, L. Yılık, Y. Beşir, H. Iner, Nihan KarakasYesilkaya, Erturk Karaagac, Yasar Gokkurt, S. Iscan, A. Gurbuz","doi":"10.21470/1678-9741-2018-0350","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0350","url":null,"abstract":"Objective Treatment of acute diseases of the aorta is still associated with high mortality and morbidity. It is believed that interventions for these diseases on overtime hours (night shifts or weekend shifts) may increase mortality. In this study, we investigated the effect of performing acute type A aortic dissection surgery on overtime hours in terms of postoperative outcomes. Methods 206 patients who underwent emergency surgery for acute type A aortic dissection were retrospectively evaluated. Two groups were constituted: patients operated on daytime working hours (n=61), and patients operated on overtime hours (n=145), respectively. Results Chronic obstructive pulmonary disease and repeat surgery were higher in group 1. There was no statistically significant difference between the two groups in terms of operative and postoperative results. Mortality rates and postoperative neurological complications in group 1 were 9.8% and 13.1%, respectively. In group 2, these rates were 13.8% and 12.4%, respectively (P=0.485 - P=0.890). Multivariate analysis identified that cross-clamp time, amount of postoperative drainage, preoperative loss of consciousness and postoperative neurological complications are the independent predictors of mortality. Conclusions As the surgical experience of the clinics improves, treatment of acute type A aortic dissections can be successfully performed both overtime and daytime working hours.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"680 - 686"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47799663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
A Mass Causing Right Ventricular Outflow Obstruction - A Dreadful Complication 一个肿块引起右心室流出梗阻——一个可怕的并发症
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0314
Rupesh Kumar, Javid Raja
{"title":"A Mass Causing Right Ventricular Outflow Obstruction - A Dreadful Complication","authors":"Rupesh Kumar, Javid Raja","doi":"10.21470/1678-9741-2018-0314","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0314","url":null,"abstract":"The most common cardiac tumour in the pediatric age group is rhabdomyoma. These are usually located in the ventricles, either in the ventricular septum or free wall. Cardiac tumours in early infancy may lead to severely compromised blood flow due to inflow or outflow tract obstruction. The diagnosis of cardiac rhabdomyoma can be established by transthoracic echocardiography (TTE). Rhabdomyomas have a natural history of spontaneous regression; surgical intervention is reserved for patients with symptoms of severe obstruction or hemodynamic instability. In this study, a case of two-year old child who presented with failure to thrive and underwent excision of pedunculated mass from the right ventricular outflow tract was reported.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"772 - 774"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42157346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syntax Score I and II for Predicting Carotid Artery Stenosis in Patients with Multivessel Coronary Artery Disease: A Propensity Score Matching Analysis 预测多支冠状动脉疾病患者颈动脉狭窄的语法评分I和II:倾向评分匹配分析
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2019-0067
S. Ozturk, M. Şahin
{"title":"Syntax Score I and II for Predicting Carotid Artery Stenosis in Patients with Multivessel Coronary Artery Disease: A Propensity Score Matching Analysis","authors":"S. Ozturk, M. Şahin","doi":"10.21470/1678-9741-2019-0067","DOIUrl":"https://doi.org/10.21470/1678-9741-2019-0067","url":null,"abstract":"Objective To evaluate the predictive accuracy of SYNTAX score (SS) I and II for detecting significant carotid artery stenosis (CAS) in patients with multivessel coronary artery disease undergoing coronary artery bypass grafting (CABG) surgery. Methods The study population consisted of 416 patients. Clinical, demographic, and radiological records were retrospectively reviewed. Characteristics of patients with CAS (n=66) and patients without CAS (n=350) were compared before and after propensity score matching analysis. Results Patients with significant CAS were older compared to those without significant CAS [(60 (53-65) vs. 63 (59-67); P=0.01]. However, atherosclerotic risk factors and SS I were similar between groups. SS II CABG and percutaneous coronary intervention (PCI) were significantly higher in patients with CAS [37.4 (30.9-43.5) vs. 33.8 (29.9-38.9); P=0.02]. After propensity score matching analysis (66 vs. 66), age, SS II PCI and CABG were significantly higher in patients with CAS than those without CAS [37.4 (30.9-43.5) vs. 33 (29.3-36.9); P=0.03]. Age, SS II PCI and CABG were associated with CAS in logistic regression analysis [OR=1.086, 95% CI (1.032-1.143), P<0.001; OR=1.054, 95% CI (1.010-1.101), P=0.02; OR=1.078, 95% CI (1.029-1.129), P<0.01]. In ROC curve analysis, SS II PCI >33.1 had 68.2% sensitivity and 54.6% specificity [AUC=0.624, P=0.01, 95% CI (0.536-0.707)] whereas SS II CABG >26.1 had 81.8% sensitivity and 54.6% specificity [AUC=0.670, P<0.01, 95% CI (0.583-0.749)] to predict CAS. Pairwise comparison of ROC curves revealed similar statistical accuracy for prediction of CAS (z statistic: 0.683, P=0.49) Conclusion SS II is useful to predict asymptomatic CAS in patients with multivessel coronary artery disease.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"653 - 658"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47827655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Challenges in Diagnosis and Management of Spontaneous Coronary Artery Dissection in a Young Patient 一例年轻自发性冠状动脉夹层的诊断和治疗挑战
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0198
Beatriz J. S. Branco, Cesar Sanchez, C. Mendoza, M. Magarakis, Alejandro E. Macias, T. Salerno
{"title":"Challenges in Diagnosis and Management of Spontaneous Coronary Artery Dissection in a Young Patient","authors":"Beatriz J. S. Branco, Cesar Sanchez, C. Mendoza, M. Magarakis, Alejandro E. Macias, T. Salerno","doi":"10.21470/1678-9741-2018-0198","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0198","url":null,"abstract":"Spontaneous coronary artery dissection (SCAD) is characterized by tear of the inner layer in the coronary artery, creating a false lumen between the inner and central layer. Its infrequent incidence often leads to delay in diagnosis posing challenges in management. There are currently no guidelines for the treatment of this condition. We describe an adult patient who presented with multiple episodes of ventricular fibrillation, in whom cardiac catheterization showed SCAD, treated by off-pump coronary artery bypass.","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"779 - 782"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44974274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery 大剂量维生素C对冠状动脉搭桥术心肌损伤生化指标的影响
4区 医学
Revista Brasileira De Cirurgia Cardiovascular Pub Date : 2019-12-01 DOI: 10.21470/1678-9741-2018-0312
Nafiseh Emadi, M. Nemati, M. Ghorbani, E. Allahyari
{"title":"The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery","authors":"Nafiseh Emadi, M. Nemati, M. Ghorbani, E. Allahyari","doi":"10.21470/1678-9741-2018-0312","DOIUrl":"https://doi.org/10.21470/1678-9741-2018-0312","url":null,"abstract":"Objective To evaluate the effect of high-dose vitamin C on cardiac reperfusion injury and plasma levels of creatine kinase-muscle/brain (CK-MB), troponin I, and lactate dehydrogenase (LDH) in patients undergoing coronary artery bypass grafting (CABG). Methods This is a double-blind randomized clinical trial study. Fifty patients (50-80 years old) who had CABG surgery were selected. The intervention group received 5 g of intravenous vitamin C before anesthesia induction and 5 g of vitamin C in cardioplegic solution. The control group received the same amount of placebo (normal saline). Arterial blood samples were taken to determine the serum levels of CK-MB, troponin I, and LDH enzymes. Left ventricular ejection fraction was measured and hemodynamic parameters were recorded at intervals. Results High doses of vitamin C in the treatment group led to improvement of ventricular function (ejection fraction [EF]) and low Intensive Care Unit (ICU) stay. The cardiac enzymes level in the vitamin C group was lower than in the control group. These changes were not significant between the groups in different time intervals (anesthesia induction, end of bypass, 6 h after surgery, and 24 h after surgery) for CK-MB, LDH, and troponin I. Hemodynamic parameters, hematocrit, potassium, urinary output, blood transfusion, arrhythmia, and inotropic support showed no significant difference between the groups. Conclusion Vitamin C has significantly improved the patients’ ventricular function (EF) 72 h after surgery and reduced the length of ICU stay. No significant changes in cardiac biomarkers, including CK-MB, troponin I, and LDH, were seen over time in each group. IRCT code IRCT2016053019470N33","PeriodicalId":54481,"journal":{"name":"Revista Brasileira De Cirurgia Cardiovascular","volume":"34 1","pages":"517 - 524"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47469278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
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