Iraqi Journal of Hematology最新文献

{"title":"Incidence of QT interval prolongation during arsenic trioxide-based therapy in a sample of Iraqi adult patients with acute promyelocytic leukemia (a single-center experience)","authors":"Aseel Abd Ul Sahib Hassan, A. Almothaffar","doi":"10.4103/ijh.ijh_90_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_90_23","url":null,"abstract":"\u0000 \u0000 \u0000 Arsenic trioxide (ATO) regimen is now the standard of care for acute promyelocytic leukemia (APL). The complete remission and possible cure are reported to be 50%–80% of APL patients. Prolongation of the QT interval has been consistently observed in clinical trials with ATO, which is known to have a direct effect on cardiac repolarization with the recommendations for management include electrocardiogram (ECG) monitoring, discontinuation of drugs that prolong the QT interval, and careful repletion of serum potassium and magnesium.\u0000 \u0000 \u0000 \u0000 To study the incidence and clinical consequences of QT prolongation in a sample of Iraqi APL patients treated with ATO.\u0000 \u0000 \u0000 \u0000 A prospective, cross-sectional study was conducted on 24 adult patients with newly diagnosed APL at Baghdad Teaching Hospital. ECG was performed at baseline and twice weekly till the end of induction treatment course. Corrected QT interval was calculated based on Bazett and Fridericia formulas (QTc interval of more than 500 ms is considered dangerous): Serum potassium, calcium, and magnesium levels were also measured simultaneously.\u0000 \u0000 \u0000 \u0000 The mean QT at baseline was 424 ± 18 ms and 402 ± 15 ms by Bazett and Fridericia, respectively, and at the end of induction, the mean QT was 436 ± 20 ms and 418 ± 20 ms by Bazett and Fridericia, respectively. The rate of developing prolonged QT was 62.5% by Bazet, in which 15 patients developed prolonged QT (at any time point). The comparison between prolonged and dangerous QT groups by Bazet showed significant difference, in which QT-related complications were associated with dangerous QT (>500 ms) prolongation significantly, while Fridrica method did not label these patients as having dangerous QT prolongation. The change in QT started as early as 1 week after treatment, the comparison between baseline QT and QT at week 1 showed that there was significant increase in QT. The electrolytes analysis and comparison with baseline results for potassium, magnesium, and calcium showed that there were no significant differences over time for tested electrolytes.\u0000 \u0000 \u0000 \u0000 Bazett formula is useful to monitor Iraqi patients with APL who are treated with ATO for the detection of dangerous prolongation of QT.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of plasma soluble interleukin-2 receptor alpha chain level in adults with acute myeloid leukemia","authors":"Yusur Zaher Abd-Alabass, Najlaa Bader Mohammed","doi":"10.4103/ijh.ijh_95_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_95_23","url":null,"abstract":"\u0000 \u0000 \u0000 Acute myeloid leukemia (AML) is a clonal malignant condition of immature hematopoietic cells, characterized by clonal proliferation of abnormal cells (blasts) in the marrow leading to impairment of the normal blood cell production giving rise to failure of the bone marrow. Soluble interleukin-2 (IL-2) receptor alpha chain is a protein that is involved in the assembly of the high-affinity IL-2 receptor, and it has a critical role in controlling immune system homeostasis. The overexpression of sIL-2RA was investigated in many hematopoietic malignancies, and it was correlated with poor outcome.\u0000 \u0000 \u0000 \u0000 The aim of this study was to assess the sIL-2RA level as a prognostic factor and assess its impact on survival and if it can be used as a targeted treatment for a better outcome.\u0000 \u0000 \u0000 \u0000 Sixty newly diagnosed adults with AML before starting therapy were included in the study, and they were followed up for 6 months to document survival status. Thirty healthy adults were taken as a control group. Using an enzyme-linked immunosorbent assay, the plasma sIL-2RA level was measured. Statistical analysis was done using Microsoft Excel 2019 and version 26 SPSS statistical software. P <0.05 was considered statistically significant.\u0000 \u0000 \u0000 \u0000 A considerable difference in the plasma sIL-2RA level between AML patients and controls also was more elevated in patients who died after 6-month follow-up. According to the blast percentage, total white blood cell count, and M0-M2 subgroups, the sIL-2RA level correlated positively. Irrelevant association was found regarding the patients’ age, the count of platelet, and the hemoglobin.\u0000 \u0000 \u0000 \u0000 Plasma sIL-2RA level is higher in AML patients than the control group at the time of diagnosis. Patients with a high level of plasma sIL-2RA have an inferior (overall survival) and poor outcome. SIL-2RA level is higher in M0-M2 subgroups than other subtypes. There is a significant association between sIL-2RA level and the absolute count of leukemic blasts.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of the t(11; 14)(q13; q32) immunoglobulin H/CCND1 in Mexican mestizos with multiple myeloma: A single institution experience","authors":"Olivia Lira-Lara, M. Gallardo-Pérez, S. Garcés-Eisele, Virginia Adriana Reyes-Núñez, M. A. López-Trujillo, Miranda Melgar-de-la-Paz, Paola Negrete-Rodríguez, Luis Enrique Hamilton-Avilés, Guillermo Ocaña-Ramm, Max Robles-Nasta, Daniela Sánchez-Bonilla, J. Olivares-Gazca, Guillermo J. Ruiz-Delgado, G. Ruiz-Argüelles","doi":"10.4103/ijh.ijh_93_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_93_23","url":null,"abstract":"\u0000 \u0000 \u0000 Multiple myeloma (MM) is a hematologic malignancy resulting from clonal proliferation of plasma cells in which significant heterogeneity has been demonstrated, both cytogenetically and molecularly. Translocation (11;14)(q13;q32), involving the CCND1 gene, has been described as the most common one, its estimated prevalence being around 15%–24%.\u0000 \u0000 \u0000 \u0000 The objective of the study was to report the prevalence of t(11;14) in Mexican individuals with MM in a single institution.\u0000 \u0000 \u0000 \u0000 A descriptive cross-sectional study in 26 patients with MM undergoing a fluorescence in situ hybridization study with fluorescent probes for the detection of t(11;14) employing a fluorescence microscope and studying 200 interphase nuclei, referred to Laboratorios Ruiz and Synlab, Puebla, México from 2017 to 2021.\u0000 \u0000 \u0000 \u0000 The t(11;14) was found in 5 (19%) of the cases. Data on the clinical evolution of the patients was not available. In the 26 subjects, serum immunofixation was performed to identify the type of monoclonal gammopathy (MG), 13 (50%) were compatible with MG immunoglobulin (Ig) G-Lambda, 8 (30.7%) with IgG-Kappa, 4 (15.3%) with IgA-Lambda, and 1 (4%) with IgA-Kappa. Of the five individuals positive for t(11;14), four were IgG Lambda and one IgG Kappa.\u0000 \u0000 \u0000 \u0000 The presence of t(11;14) in our cohort is similar to that reported in other populations. The clinical implications of the t(11;14) translocation in MM have been observed in various populations, but further studies are needed to comprehensively assess its relationship to the clinical course of the disease.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139778037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of the t(11; 14)(q13; q32) immunoglobulin H/CCND1 in Mexican mestizos with multiple myeloma: A single institution experience","authors":"Olivia Lira-Lara, M. Gallardo-Pérez, S. Garcés-Eisele, Virginia Adriana Reyes-Núñez, M. A. López-Trujillo, Miranda Melgar-de-la-Paz, Paola Negrete-Rodríguez, Luis Enrique Hamilton-Avilés, Guillermo Ocaña-Ramm, Max Robles-Nasta, Daniela Sánchez-Bonilla, J. Olivares-Gazca, Guillermo J. Ruiz-Delgado, G. Ruiz-Argüelles","doi":"10.4103/ijh.ijh_93_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_93_23","url":null,"abstract":"\u0000 \u0000 \u0000 Multiple myeloma (MM) is a hematologic malignancy resulting from clonal proliferation of plasma cells in which significant heterogeneity has been demonstrated, both cytogenetically and molecularly. Translocation (11;14)(q13;q32), involving the CCND1 gene, has been described as the most common one, its estimated prevalence being around 15%–24%.\u0000 \u0000 \u0000 \u0000 The objective of the study was to report the prevalence of t(11;14) in Mexican individuals with MM in a single institution.\u0000 \u0000 \u0000 \u0000 A descriptive cross-sectional study in 26 patients with MM undergoing a fluorescence in situ hybridization study with fluorescent probes for the detection of t(11;14) employing a fluorescence microscope and studying 200 interphase nuclei, referred to Laboratorios Ruiz and Synlab, Puebla, México from 2017 to 2021.\u0000 \u0000 \u0000 \u0000 The t(11;14) was found in 5 (19%) of the cases. Data on the clinical evolution of the patients was not available. In the 26 subjects, serum immunofixation was performed to identify the type of monoclonal gammopathy (MG), 13 (50%) were compatible with MG immunoglobulin (Ig) G-Lambda, 8 (30.7%) with IgG-Kappa, 4 (15.3%) with IgA-Lambda, and 1 (4%) with IgA-Kappa. Of the five individuals positive for t(11;14), four were IgG Lambda and one IgG Kappa.\u0000 \u0000 \u0000 \u0000 The presence of t(11;14) in our cohort is similar to that reported in other populations. The clinical implications of the t(11;14) translocation in MM have been observed in various populations, but further studies are needed to comprehensively assess its relationship to the clinical course of the disease.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139837555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of iron overload on prevalence of common bacterial infection in thalassemia patients","authors":"Fatma Abdulhamza Obed, Ali Mohammad Omran, Khalid Sh. Jebur","doi":"10.4103/ijh.ijh_84_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_84_23","url":null,"abstract":"\u0000 \u0000 \u0000 Thalassemia is the most common human monogenic disease in the world, associated with several consequences, including recurrent infections, many studies have demonstrated a high prevalence of infection among individuals with thalassemia accounting for about 10% of cases.\u0000 \u0000 \u0000 \u0000 This study aimed to detect the effect of serum iron imbalance on the prevalence of infection in thalassemia patients.\u0000 \u0000 \u0000 \u0000 This research was conducted in the Thalassemia Teaching Department at Al Karama Hospital, between March and October 2023. The case–control study was conducted by comparing 60 people with thalassemia with 60 other people who were not thalassemic but suffering from fever and similar symptoms. Through examining urine, sputum, blood, and skin swab samples, samples with a positive result for the bacteria were identified, their sensitivity to antibiotics was examined, and these results were compared with the control group. Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus, three types of the most common bacteria were chosen for testing due to the limited resources.\u0000 \u0000 \u0000 \u0000 Control groups of 20 males and 30 females with a mean age of 20 ± 4.5 years compared to 60 nonthalassemia febrile patients classified into 34 males and 26 females with the same age range as control groups. It was discovered that the majority of thalassemia patients are infected with E. coli bacteria. It also depends in its infection rate on an imbalance in the level of iron in the blood, whether it is increased, as in thalassemia, or decreased in cases of iron deficiency anemia that E. coli bacteria is the type that most infects thalassemia patients.\u0000 \u0000 \u0000 \u0000 Common species of bacteria responsible for infection in thalassemia patients represented by E. coli, K. pneumoniae, and Staphylococcus aureus associated with serum iron level changes highlighting the need for additional research into the impact of iron imbalance on infections. The study found that imipenem and meropenem had a profound effect on the vast majority of bacterial species involved in thalassemia.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of iron overload on prevalence of common bacterial infection in thalassemia patients","authors":"Fatma Abdulhamza Obed, Ali Mohammad Omran, Khalid Sh. Jebur","doi":"10.4103/ijh.ijh_84_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_84_23","url":null,"abstract":"\u0000 \u0000 \u0000 Thalassemia is the most common human monogenic disease in the world, associated with several consequences, including recurrent infections, many studies have demonstrated a high prevalence of infection among individuals with thalassemia accounting for about 10% of cases.\u0000 \u0000 \u0000 \u0000 This study aimed to detect the effect of serum iron imbalance on the prevalence of infection in thalassemia patients.\u0000 \u0000 \u0000 \u0000 This research was conducted in the Thalassemia Teaching Department at Al Karama Hospital, between March and October 2023. The case–control study was conducted by comparing 60 people with thalassemia with 60 other people who were not thalassemic but suffering from fever and similar symptoms. Through examining urine, sputum, blood, and skin swab samples, samples with a positive result for the bacteria were identified, their sensitivity to antibiotics was examined, and these results were compared with the control group. Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus, three types of the most common bacteria were chosen for testing due to the limited resources.\u0000 \u0000 \u0000 \u0000 Control groups of 20 males and 30 females with a mean age of 20 ± 4.5 years compared to 60 nonthalassemia febrile patients classified into 34 males and 26 females with the same age range as control groups. It was discovered that the majority of thalassemia patients are infected with E. coli bacteria. It also depends in its infection rate on an imbalance in the level of iron in the blood, whether it is increased, as in thalassemia, or decreased in cases of iron deficiency anemia that E. coli bacteria is the type that most infects thalassemia patients.\u0000 \u0000 \u0000 \u0000 Common species of bacteria responsible for infection in thalassemia patients represented by E. coli, K. pneumoniae, and Staphylococcus aureus associated with serum iron level changes highlighting the need for additional research into the impact of iron imbalance on infections. The study found that imipenem and meropenem had a profound effect on the vast majority of bacterial species involved in thalassemia.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139843756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast lymphoma mimicking benign breast lesions: A diagnostic challenge","authors":"Divya Mahajan, Bhupender Saini, Theepanraj Kamaraj, A. Pandey","doi":"10.4103/ijh.ijh_79_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_79_23","url":null,"abstract":"\u0000 NHL Primary of the breast is rare accounting 0.1% of the total malignancy. DLBCL is the most common histology for Primary NHL breast. It presentation is similar to carcinoma breast so biopsy followed by IHC is only method to differentiate between both. Due to rarity of the tumor there is lack of literature on proper diagnosis and treatment. RCHOP is the chemotherapy regime used and radiotherapy role is not clear. Some studies suggest role of CNS irradiation in high risk patient because of high chances of CNS spread in advance stage patient. In this paper we aim to highlight the diagnostic difficulties we faced and the treatment we followed. Here we bring to the knowledge of the reader about the review over diagnosis, clinical feature and treatment of NHL breast along side with two clinical cases to enhance clinical interest of the reviewer.","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast lymphoma mimicking benign breast lesions: A diagnostic challenge","authors":"Divya Mahajan, Bhupender Saini, Theepanraj Kamaraj, A. Pandey","doi":"10.4103/ijh.ijh_79_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_79_23","url":null,"abstract":"\u0000 NHL Primary of the breast is rare accounting 0.1% of the total malignancy. DLBCL is the most common histology for Primary NHL breast. It presentation is similar to carcinoma breast so biopsy followed by IHC is only method to differentiate between both. Due to rarity of the tumor there is lack of literature on proper diagnosis and treatment. RCHOP is the chemotherapy regime used and radiotherapy role is not clear. Some studies suggest role of CNS irradiation in high risk patient because of high chances of CNS spread in advance stage patient. In this paper we aim to highlight the diagnostic difficulties we faced and the treatment we followed. Here we bring to the knowledge of the reader about the review over diagnosis, clinical feature and treatment of NHL breast along side with two clinical cases to enhance clinical interest of the reviewer.","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of tissue inhibitor of matrix metalloproteinase-1 in Iraqi patients with acute myeloid leukemia","authors":"Hassnien Samir AlHashemi, Z. Shabeeb","doi":"10.4103/ijh.ijh_82_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_82_23","url":null,"abstract":"\u0000 \u0000 \u0000 Leukemia is characterized by an uncontrolled expansion or proliferation of hematopoietic cells that are unable to develop appropriately into mature blood cells. Tissue inhibitor of metalloproteinases (TIMP) is glycoprotein with 28 Da Molecular weight. It has proteolytic and proliferative activity show pleiotropic effects in the bone marrow regulates cell responsible for survival and growth also healthy hematopoietic progenitor cells and involve in cancer progression.\u0000 \u0000 \u0000 \u0000 The aim of this study was to measure TIMP in Iraqi acute myeloid leukemia patients as well as the correlation between tissue inhibitor of matrix metalloproteinase-1 and blast cells.\u0000 \u0000 \u0000 \u0000 The study involved 50 patients from Iraqi National Hematology Center/Al-Mustansiriyah University and Baghdad Teaching Hospital with acute myeloid leukemia and 50 control participants who were physically similar. The patients’ ages ranged from 20 to 70 years. Tissue inhibitor of matrix metalloproteinase concentration in plasma was measured using a sandwich enzyme immunoassay approach that is quantitative.\u0000 \u0000 \u0000 \u0000 The present study demonstrates a statistically significant increase in the level of tissue inhibitor of matrix metalloproteinase-1 patients with acute myeloid leukemia. The level of TIMP-1 in serum AML patients was 443.7 ± 0.3 pg/mL while in healthy control serum was 149.5 ± 0.088 pg/mL. The current result showed a positive significant correlation between TIMP-1 level and blast Cells percentage (r = 0.495; P = 0.031), while the correlation between leukocytes number and platelets number was insignificant (r = 0.388; P = 0.078, r = −0.444; P = 0.155).\u0000 \u0000 \u0000 \u0000 TIMP-1 levels increased in the CML patient compared with healthy control also there was a significant correlation between TIMP-1 and Blast cell level while no correlation between level of TIMP-1 and number of leukocytes and platelets. The level of TIMP in patients untreated and undergoing chemotherapy does not change.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FMS-like tyrosine kinase 3 internal tandem duplication mutation in patients with acute myeloid leukemia in Kurdistan region/Iraq","authors":"Sarween Sherzad Rasool, N. Mohammad, Hiwa Hassan Hamza, Sarah Laith Alnuaimy","doi":"10.4103/ijh.ijh_66_23","DOIUrl":"https://doi.org/10.4103/ijh.ijh_66_23","url":null,"abstract":"\u0000 \u0000 \u0000 Mutations in the FLT3 gene are very common in acute myeloid leukemia (AML). These mutations are linked to a high chance of the disease relapse and decrease overall survival. This study aimed to investigate this mutation in AML cases and to correlate it with the clinicopathological presentation and their response to induction therapy.\u0000 \u0000 \u0000 \u0000 This study aimed to investigate this mutation in AML cases and to correlate it with the clinicopathological presentation and their response to induction therapy.\u0000 \u0000 \u0000 \u0000 This study was done on 63 AML cases; for each patient, the clinical presentation and the hematological lab parameters were recorded. The results of FLT3 internal tandem duplication (ITD) mutation were recorded and the mutation was detected by conventional polymerase chain reaction technology. Postinduction assessment was recorded for each patient.\u0000 \u0000 \u0000 \u0000 The mean age of the studied group was 36.06 (22.42), with a male to female ratio of 1:1.6. Out of 63 AML patients, 16 (25.4%) had FLT3-ITD mutation. The highest incidence of the mutation was found among the age group of 10–19 years (40%). The highest incidence of FLT3 mutation was among M3 (45.5%). The blast count was significantly higher in patients with than without the mutation (P = 0.04). The remission rate was significantly lower in FLT3 AML patients than in those lacking the mutation (P = 0.45).\u0000 \u0000 \u0000 \u0000 FLT3-ITD mutation was common in our AML patients. This mutation was associated with significantly higher counts of blast and poorer response to induction therapy; thus, it is considered one of the poor prognostic factors.\u0000","PeriodicalId":53847,"journal":{"name":"Iraqi Journal of Hematology","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138591627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}