Missouri Review最新文献

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Platelet transfusions in a murine model of neonatal polymicrobial sepsis: Divergent effects on inflammation and mortality. 在新生儿多微生物败血症小鼠模型中输注血小板:对炎症和死亡率的不同影响
IF 2.5 4区 文学
Missouri Review Pub Date : 2022-06-01 Epub Date: 2022-05-06 DOI: 10.1111/trf.16895
Patricia Davenport, Hsuan-Hao Fan, Emily Nolton, Henry A Feldman, Viola Lorenz, Jorge Canas, Maikel Acosta-Zaldívar, William Yakah, Connie Arthur, Camilia Martin, Sean Stowell, Julia Koehler, Donald Mager, Martha Sola-Visner
{"title":"Platelet transfusions in a murine model of neonatal polymicrobial sepsis: Divergent effects on inflammation and mortality.","authors":"Patricia Davenport, Hsuan-Hao Fan, Emily Nolton, Henry A Feldman, Viola Lorenz, Jorge Canas, Maikel Acosta-Zaldívar, William Yakah, Connie Arthur, Camilia Martin, Sean Stowell, Julia Koehler, Donald Mager, Martha Sola-Visner","doi":"10.1111/trf.16895","DOIUrl":"10.1111/trf.16895","url":null,"abstract":"<p><strong>Background: </strong>Platelet transfusions (PTxs) are often given to septic preterm neonates at high platelet count thresholds in an attempt to reduce bleeding risk. However, the largest randomized controlled trial (RCT) of neonatal transfusion thresholds found higher mortality and/or major bleeding in infants transfused at higher thresholds. Using a murine model, we investigated the effects of adult PTx on neonatal sepsis-induced mortality, systemic inflammation, and platelet consumption.</p><p><strong>Study design and methods: </strong>Polymicrobial sepsis was induced via intraperitoneal injection of cecal slurry preparations (CS1, 2, 3) into P10 pups. Two hours after infection, pups were transfused with washed adult Green Flourescent Protein (GFP+) platelets or control. Weights, platelet counts, and GFP% were measured before 4 and 24 h post-infection. At 24 h, blood was collected for quantification of plasma cytokines.</p><p><strong>Results: </strong>The CS batches varied in 24 h mortality (11%, 73%, and 30% in CS1, 2, and 3, respectively), due to differences in bacterial composition. PTx had differential effects on sepsis-induced mortality and systemic inflammatory cytokines, increasing both in mice infected with CS1 (low mortality) and decreasing both in mice infected with CS2 and 3. In a mathematical model of platelet kinetics, the consumption of transfused adult platelets was higher than that of endogenous neonatal platelets, regardless of CS batch.</p><p><strong>Discussion: </strong>Our findings support the hypothesis that transfused adult platelets are consumed faster than endogenous neonatal platelets in sepsis and demonstrate that PTx can enhance or attenuate neonatal inflammation and mortality in a model of murine polymicrobial sepsis, depending on the composition of the inoculum and/or the severity of sepsis.</p>","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"30 1","pages":"1177-1187"},"PeriodicalIF":2.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88512027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The New Realism 新现实主义
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0014
Speer Morgan
{"title":"The New Realism","authors":"Speer Morgan","doi":"10.1353/mis.2022.0014","DOIUrl":"https://doi.org/10.1353/mis.2022.0014","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"5 - 9"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42258739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breathe for Me 为我呼吸
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0024
D. Waters
{"title":"Breathe for Me","authors":"D. Waters","doi":"10.1353/mis.2022.0024","DOIUrl":"https://doi.org/10.1353/mis.2022.0024","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"126 - 146"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43986265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Last Summer 最后的夏天
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0015
A. Stuber
{"title":"The Last Summer","authors":"A. Stuber","doi":"10.1353/mis.2022.0015","DOIUrl":"https://doi.org/10.1353/mis.2022.0015","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"10 - 20"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48238039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Wind and the Rain, and: Conservation Theory, and: Vespers, and: Shutdown, and: The "I Want" Song 《风与雨》《保护理论》《晚祷》《关机》《我想要》这首歌
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0023
Rachel M. Richardson
{"title":"The Wind and the Rain, and: Conservation Theory, and: Vespers, and: Shutdown, and: The \"I Want\" Song","authors":"Rachel M. Richardson","doi":"10.1353/mis.2022.0023","DOIUrl":"https://doi.org/10.1353/mis.2022.0023","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"119 - 124"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44486956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Felling, and: Supper Poem, and: His Body Cut through the World like a Cold Wind, and: Love Poem 《感觉》,《晚餐诗》,《他的身体像寒风一样穿过世界》,《情诗》
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0021
Kelan Nee
{"title":"Felling, and: Supper Poem, and: His Body Cut through the World like a Cold Wind, and: Love Poem","authors":"Kelan Nee","doi":"10.1353/mis.2022.0021","DOIUrl":"https://doi.org/10.1353/mis.2022.0021","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"101 - 95"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43280364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sneaker Waves 运动鞋波浪
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0019
Caroline Casper
{"title":"Sneaker Waves","authors":"Caroline Casper","doi":"10.1353/mis.2022.0019","DOIUrl":"https://doi.org/10.1353/mis.2022.0019","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":" ","pages":"68 - 82"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49664626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Number of Things in the City at Night 夜间城市里事物的数量
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0026
S. Dunnington
{"title":"The Number of Things in the City at Night","authors":"S. Dunnington","doi":"10.1353/mis.2022.0026","DOIUrl":"https://doi.org/10.1353/mis.2022.0026","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"158 - 172"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48845162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selling Amelia Earhart 出售Amelia Earhart
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0020
Curio Cabinet
{"title":"Selling Amelia Earhart","authors":"Curio Cabinet","doi":"10.1353/mis.2022.0020","DOIUrl":"https://doi.org/10.1353/mis.2022.0020","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"83 - 94"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43461652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rich Bright Days: Six Writers on Nature and Life 六位作家谈自然与生命
4区 文学
Missouri Review Pub Date : 2022-06-01 DOI: 10.1353/mis.2022.0027
S. Pickering
{"title":"Rich Bright Days: Six Writers on Nature and Life","authors":"S. Pickering","doi":"10.1353/mis.2022.0027","DOIUrl":"https://doi.org/10.1353/mis.2022.0027","url":null,"abstract":"","PeriodicalId":53743,"journal":{"name":"Missouri Review","volume":"45 1","pages":"173 - 187"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41643796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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