Libri Oncologici最新文献_第9页

Association of inflammatory status of patients with histopathological characteristics of colorectal tumors and perioperative transfusion requirements 结直肠肿瘤患者炎症状态与组织病理学特征及围手术期输血要求的关系

Libri Oncologici Pub Date : 2019-01-29 DOI: 10.20471/lo.2018.46.02-03.07

Anita Štefić, M. Skoko, Irena Mihić-Lasan, I. Kirac, K. Bilić, T. Vučemilo

{"title":"Association of inflammatory status of patients with histopathological characteristics of colorectal tumors and perioperative transfusion requirements","authors":"Anita Štefić, M. Skoko, Irena Mihić-Lasan, I. Kirac, K. Bilić, T. Vučemilo","doi":"10.20471/lo.2018.46.02-03.07","DOIUrl":"https://doi.org/10.20471/lo.2018.46.02-03.07","url":null,"abstract":"Glasgow Prognostic Score (GPS) is such an infl ammation-based factor, defi ned by the combination of the level of serum C-reactive protein (CRP) and albumin, which are indicators of systematic infl ammatory response and nutritional status. A higher score is associated with a worse prognosis of diff erent tumor sites. The score is based on the immunomodulatory and infl ammatory status found in patients with elevated CRP. We hypothesized that there is a correlation between GPS and histopathological tumor characteristics and GPS and perioperative administration of erythrocyte concentrates in patients undergoing curative tumor resection. We retrospectively revied the data of fi fty-one consecutive patient who underwent elective colorectal surgery. We extracted the values of preoperative C-reactive protein(CRP) and albumin and calculated the GPS. We correlated the histopathology of cancer and perioperative transfusion with the outcome. GPS 0 and 2 having a tumor localized in the colon, with GPS 1 in the rectum. T4 tumor stage had patients only in the group of GPS 2 which was statistically signifi cant from the GPS 0 group. The GPS was not associated with the presence of metastases in the lymph nodes, lymphatic and perineural invasions, while a statistically signifi cant diff erence was present comparing GPS with tumor deposits between GPS 0 and GPS 1 and GPS 0 and GPS 2. Transfusions were statistically signifi cantly higher in GPS 2 group compared to GPS 0 and 1. A higher GPS score is associated with the changes of immune status of the tumor environment which can aff ect the recurrence of the disease and survival. GPS should be considered when recommending the frequency of follow up and therapy after curative tumor resection. We have shown that there is an increased risk for perioperative blood consumption, which may independently result in a worse prognosis of the underlying disease.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42179911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of tumor cells chemoresistance mechanisms and suboptimal systemic cytotoxic treatment results 肿瘤细胞化学耐药性机制与次优全身细胞毒性治疗结果的相关性

Libri Oncologici Pub Date : 2019-01-29 DOI: 10.20471/lo.2018.46.02-03.11

L. Vazdar, R. Šeparović, Ana Tečić-Vuger, M. Pavlovic, Nikolina Lonjak, C. Krstić

{"title":"Association of tumor cells chemoresistance mechanisms and suboptimal systemic cytotoxic treatment results","authors":"L. Vazdar, R. Šeparović, Ana Tečić-Vuger, M. Pavlovic, Nikolina Lonjak, C. Krstić","doi":"10.20471/lo.2018.46.02-03.11","DOIUrl":"https://doi.org/10.20471/lo.2018.46.02-03.11","url":null,"abstract":"Systemic cytotoxic chemotherapeutic treatment of malignant tumors does not fully meet its goal due to the resistance of present tumor cells to the applied therapy. Chemoresistance is complex and multifactorial, caused by numerous mechanisms that alter drug concentration in the cell, by changes in expression of the epidermal growth factor and by activation of intracellular signaling pathways PI3K / Akt and MAPK. The factor of chemoresistance is also an increased level of antioxidative glutathione and glutathione transferase – S enzyme and the presence of tumor stem cells that signifi cantly improve protection of DNA from damage. Apart from cellular factors, resistance is infl uenced by extracellular hypoxia and acidosis and autophagy. Overcoming the chemoresistance is possible by using nanomechanisms for delivery of drugs to tumor cells, autophagy inhibitors like antimalarials chloroquine and hydroxychloroquine and plant polyphenols. By bett er understanding the mechanisms of chemoresistance and it’s overcoming it can be possible to achieve improvement in antitumor treatment.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46441844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-induced angiosarcoma of the breast - four case reports 辐射诱发乳腺血管肉瘤4例报告

Libri Oncologici Pub Date : 2019-01-29 DOI: 10.20471/lo.2018.46.02-03.19

Katarina Antunac

引用次数: 0

Adjuvant radiotherapy of breast cancer - is partial breast irradiation sufficient? 乳腺癌辅助放疗——部分乳房放疗是否足够?

Libri Oncologici Pub Date : 2019-01-29 DOI: 10.20471/LO.2018.46.02-03.12

Martina Mikulandra, L. Beketić-Orešković

引用次数: 0

Management of young women with early breast cancer – focus on fertility preservation 早期患有癌症的年轻女性的管理——专注于保持生育能力

Libri Oncologici Pub Date : 2019-01-29 DOI: 10.20471/LO.2018.46.02-03.13

P. Vuković, J. Raguž, L. Beketić-Orešković

{"title":"Management of young women with early breast cancer – focus on fertility preservation","authors":"P. Vuković, J. Raguž, L. Beketić-Orešković","doi":"10.20471/LO.2018.46.02-03.13","DOIUrl":"https://doi.org/10.20471/LO.2018.46.02-03.13","url":null,"abstract":"Management of young women with breast cancer is complex and has several particularities, one of which is fertility preservation, a very important quality of life issue for young breast cancer survivors. Chemotherapy can be gonadotoxic and signifi cantly reduce woman`s reproductive potential and cause premature ovarian insuffi ciency while endocrine therapy requires a delay of pregnancy and indirectly aff ects fertility. Therefore every woman of reproductive age diagnosed with breast cancer should be informed about potential gonadotoxic eff ect of cancer treatment, the risk of premature ovarian insuffi ciency and associated symptoms, available fertility preservation methods, delay of cancer treatment and chances of subsequent pregnancy. If interested in fertility preservation breast cancer patients should be referred as early as possible to a reproductive specialist to further discuss the risk of infertility and available fertility preservation options. Currently established methods for fertility preservation are embryo and oocyte cryopreservation, while ovarian tissue cryopreservation, cryopreservation of immature oocytes and ovarian suppression with gonadotropin-releasing hormone agonists are still considered experimental. The aim of this review is to highlight the importance of fertility preservation as an important quality of life issue for young breast cancer survivors.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43563465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uveal melanoma: an overview of management and prognosis 葡萄膜黑色素瘤:管理和预后概述

Libri Oncologici Pub Date : 2019-01-29 DOI: 10.20471/LO.2018.46.02-03.16

S. Kaštelan, Antonela Gverović-Antunica, L. Beketić-Orešković, Boris Kasun, K. Hat