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Current Controlled Trials in Cardiovascular Medicine最新文献

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Are there fundamental deficiencies in the megatrial methodology? 巨心房方法学是否存在根本性缺陷?
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-02-09 DOI: 10.1186/cvm-2-1-001
D. Julian, C. Furberg
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引用次数: 4
New immunosuppressive drugs in heart transplantation 新型免疫抑制药物在心脏移植中的应用
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-02-08 DOI: 10.1186/cvm-2-1-045
M. Costanzo
{"title":"New immunosuppressive drugs in heart transplantation","authors":"M. Costanzo","doi":"10.1186/cvm-2-1-045","DOIUrl":"https://doi.org/10.1186/cvm-2-1-045","url":null,"abstract":"","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"24 1","pages":"45 - 53"},"PeriodicalIF":0.0,"publicationDate":"2001-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88353516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Experience collecting interim data on mortality: an example from the RALES study 收集死亡率临时数据的经验:以RALES研究为例
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-02-07 DOI: 10.1186/cvm-2-1-059
J. Wittes, J. Palensky, Debra J. Asner, D. Julian, J. Boissel, C. Furberg, H. Kulbertus, S. Pocock, B. Roniker
{"title":"Experience collecting interim data on mortality: an example from the RALES study","authors":"J. Wittes, J. Palensky, Debra J. Asner, D. Julian, J. Boissel, C. Furberg, H. Kulbertus, S. Pocock, B. Roniker","doi":"10.1186/cvm-2-1-059","DOIUrl":"https://doi.org/10.1186/cvm-2-1-059","url":null,"abstract":"","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"29 1","pages":"59 - 62"},"PeriodicalIF":0.0,"publicationDate":"2001-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75759262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
The Proliferation REduction with Vascular ENergy Trial (PREVENT) 血管能量抑制增殖试验(PREVENT)
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-02-01 DOI: 10.1186/cvm-2-1-016
A. Raizner, G. Kaluza
{"title":"The Proliferation REduction with Vascular ENergy Trial (PREVENT)","authors":"A. Raizner, G. Kaluza","doi":"10.1186/cvm-2-1-016","DOIUrl":"https://doi.org/10.1186/cvm-2-1-016","url":null,"abstract":"","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"5 1","pages":"16 - 19"},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74813137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Fundamental deficiencies in the megatrial methodology 巨心房方法学的根本缺陷
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-01-30 DOI: 10.1186/cvm-2-1-002
B. Charlton
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引用次数: 31
Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials 磁共振扩散和灌注成像在急性脑卒中临床试验中的应用
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-01-30 DOI: 10.1186/cvm-2-1-038
S. Warach
{"title":"Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials","authors":"S. Warach","doi":"10.1186/cvm-2-1-038","DOIUrl":"https://doi.org/10.1186/cvm-2-1-038","url":null,"abstract":"","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"14 1","pages":"38 - 44"},"PeriodicalIF":0.0,"publicationDate":"2001-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87178425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
The current status of primary prevention in coronary heart disease. 冠心病一级预防的现状。
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-01-01 DOI: 10.1186/cvm-2-1-024
Cornel Pater
{"title":"The current status of primary prevention in coronary heart disease.","authors":"Cornel Pater","doi":"10.1186/cvm-2-1-024","DOIUrl":"https://doi.org/10.1186/cvm-2-1-024","url":null,"abstract":"<p><p>During the second part of the twentieth century, research advances caused a substantial decline in the rate of coronary heart disease. The decline lasted from the mid-1960s until the early 1990s and occurred primarily in Western countries. However, an unfavourable trend in coronary heart disease related mortality has gradually developed during the 1990s, with cardiovascular diseases anticipated to remain the main cause of overall mortality for the foreseeable future. The present paper aims at analyzing the current status of the main determinants of population-wide coronary heart disease prevention.</p>","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"2 1","pages":"24-37"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/cvm-2-1-024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Arterial indications for the low molecular weight heparins. 低分子肝素的动脉适应症。
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-01-01 DOI: 10.1186/cvm-2-5-233
Walter Ageno, Menno V Huisman
{"title":"Arterial indications for the low molecular weight heparins.","authors":"Walter Ageno,&nbsp;Menno V Huisman","doi":"10.1186/cvm-2-5-233","DOIUrl":"https://doi.org/10.1186/cvm-2-5-233","url":null,"abstract":"<p><p>Antithrombotic treatment is of proven importance in patients with acute coronary syndromes. There is now accumulating evidence from several clinical trials in patients with unstable angina pectoris that the low molecular weight heparins (LMWHs) are at least as effective as unfractionated heparin. The LMWHs are easier to use, with the potential to facilitate long-term outpatient treatment. The results of the trials have actually failed to show any clear advantage, however, of the LMWHs over the standard antiplatelet treatment, despite the evidence of a sustained hypercoagulability. Potentially, the use of higher doses of LMWHs could improve the outcomes, but this is as yet unproven and could be associated with unacceptably increased risk of bleeding. During the acute phase of a stroke, aspirin is the first choice of antithrombotic drug because it reduces the risk of recurrent stroke. LMWH cannot be recommended as an antithrombotic agent for the acute treatment of stroke. Prophylactic use of low dose LMWH for the prevention of venous thromboembolism should be considered in every patient with a stroke.</p>","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"2 5","pages":"233-239"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/cvm-2-5-233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dose response of ACE inhibitors: implications of the SECURE trial. ACE抑制剂的剂量反应：SECURE试验的意义。
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2001-01-01 DOI: 10.1186/cvm-2-4-155
Eva Lonn
{"title":"Dose response of ACE inhibitors: implications of the SECURE trial.","authors":"Eva Lonn","doi":"10.1186/cvm-2-4-155","DOIUrl":"10.1186/cvm-2-4-155","url":null,"abstract":"<p><p>The choice of the appropriate dosage of ACE inhibitor in clinical practice is an important one. The available evidence suggests that in chronic heart failure as well as in chronic coronary artery disease, high doses of angiotensin-converting enzyme (ACE) inhibitor are more effective than low ones. The current recommended clinical approach is to target ACE inhibitor dosing regimens to be similar to those used in the clinical trials, which demonstrated mortality and morbidity benefits. When titrated appropriately, ACE inhibitors are generally well tolerated and target doses can be achieved and maintained in the majority of patients with atherosclerotic vascular disease, with or without heart failure.</p>","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"2 4","pages":"155-159"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'No independent link' between diabetes and poor outcomes after CABG/PTCA CABG/PTCA术后不良预后与糖尿病之间无独立联系
Current Controlled Trials in Cardiovascular Medicine Pub Date : 2000-12-07 DOI: 10.1186/CVM-2001-72154
J. Lyford
{"title":"'No independent link' between diabetes and poor outcomes after CABG/PTCA","authors":"J. Lyford","doi":"10.1186/CVM-2001-72154","DOIUrl":"https://doi.org/10.1186/CVM-2001-72154","url":null,"abstract":"","PeriodicalId":53230,"journal":{"name":"Current Controlled Trials in Cardiovascular Medicine","volume":"19 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2000-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82534073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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