Kosin Medical Journal最新文献_第10页

How to write an original article in medicine and medical science 如何在医学和医学科学领域撰写原创文章

Kosin Medical Journal Pub Date : 2022-06-24 DOI: 10.7180/kmj.22.105

Gwansuk Kang, Sung Eun Kim

引用次数: 1

Incidence of arterial steno-occlusive disease and related factors in patients undergoing coronary artery bypass graft surgery 冠状动脉搭桥术患者动脉狭窄闭塞性疾病的发生率及相关因素分析

Kosin Medical Journal Pub Date : 2022-06-24 DOI: 10.7180/kmj.22.104

Seong Gyu Kim, Geun Woo Lee, C. Lee

{"title":"Incidence of arterial steno-occlusive disease and related factors in patients undergoing coronary artery bypass graft surgery","authors":"Seong Gyu Kim, Geun Woo Lee, C. Lee","doi":"10.7180/kmj.22.104","DOIUrl":"https://doi.org/10.7180/kmj.22.104","url":null,"abstract":"Background: Patients who undergo coronary artery bypass graft (CABG) surgery receive regular physical examinations and medications on an outpatient basis. However, these patients are at risk of developing other vascular diseases, such as postoperative arterial steno-occlusive disease (SOD). This study investigated the incidence of SOD and related factors. Methods: In total, 246 patients who underwent CABG surgery from January 1, 2017 to December 31, 2021 were investigated. The incidence and risk factors of vascular disease were analyzed by dividing the included patients into SOD and non-SOD groups. Laboratory tests, medical history, surgical information, and family history were investigated through an electronic chart review. Results: Data from 193 patients who met the criteria were analyzed. SOD occurred in 19.1% of patients, and the cerebral artery (38%) was the most common artery involved, followed by the peripheral artery (32%), the coronary artery (22%), and the retinal artery (8%). Risk factors for the development of SOD included estimated glomerular filtration rate (eGFR; odds ratio [OR]=0.977, p=0.008), cholesterol (OR=1.020, p=0.001), and patients with diabetes complications (OR=5.077, p=0.010). The 3-year cumulative incidence rate was 21.6%, and the risk factors for cumulative occurrence were a low eGFR, elevated cholesterol, and complications of diabetes. Conclusion: Low eGFR, high cholesterol, and the presence of diabetic complications before CABG surgery may be associated with postoperative vascular disease. In these cases, close monitoring, proper drug administration, and patient warnings may be required.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43932100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of ultradian rest-activity rhythms using locomotor activity in mice 利用小鼠运动活动分析超昼夜静息活动节律

Kosin Medical Journal Pub Date : 2022-06-24 DOI: 10.7180/kmj.22.023

Jung Hyun Lee, E. Moon, Jeonghyun Park, Yoo Rha Hong, Min-Soo Yoon

{"title":"Analysis of ultradian rest-activity rhythms using locomotor activity in mice","authors":"Jung Hyun Lee, E. Moon, Jeonghyun Park, Yoo Rha Hong, Min-Soo Yoon","doi":"10.7180/kmj.22.023","DOIUrl":"https://doi.org/10.7180/kmj.22.023","url":null,"abstract":"circadian patterns a 12/12-hour dark/light Noc-turnal mice are likely to be less active during the light phase Background: Locomotor activity in mice may have an ultradian rest-activity rhythm. However, to date, no study has shown how locomotor activity can be explained statistically using fitted cosine curves. Therefore, this study explored whether the ultradian rhythm of locomotor activity in mice could be analyzed using cosine fitting analysis. Methods: The locomotor activity of 20 male mice under a 12/12-hour dark/light cycle for 2 days was fitted to a cosine function to obtain the best fit. The mean absolute error (MAE) values were used to determine the explanatory power of the calculated cosine model for locomotor activity. The cosine fitting analysis was performed using R statistical software (version 4.1.1). Results: The mean MAE was 0.2944, whereas the mean MAE for integrating the individual analyses in the two experimental groups was 0.3284. The periods of the estimated ultradian rest-activity rhythm ranged from 1.602 to 4.168 hours. Conclusion: These results suggest that locomotor activity data reflect an ultradian rhythm better than a circadian rhythm. Locomotor activity can be statistically fitted to a cosine curve under well-controlled conditions. In the future, it will be necessary to explore whether this cosine-fitting analysis can be used to analyze ultradian rhythms under different experimental conditions.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46164723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of pure-type embryonal carcinoma in a 75-year-old woman mimicking epithelial ovarian carcinoma 一例罕见的模仿卵巢上皮癌的75岁女性纯型胚胎癌

Kosin Medical Journal Pub Date : 2022-06-16 DOI: 10.7180/kmj.22.026

Hyun Been Jo, Eun Taeg Kim, N. Lee, K. Choi, Eon Jin Kim, Yunjoo Shin, K. Kim, D. Suh

引用次数: 0

Identification of the transcriptome profile of Miamiensis avidus after mebendazole treatment 灭蚁灭蚁在甲苯咪唑处理后转录组图谱的鉴定

Kosin Medical Journal Pub Date : 2022-05-16 DOI: 10.7180/kmj.22.003

Hyunsu Kim, A-Reum Lee, Kyung-Yoon Jeon, Eun-Ji Ko, H. Cha, M. Ock

{"title":"Identification of the transcriptome profile of Miamiensis avidus after mebendazole treatment","authors":"Hyunsu Kim, A-Reum Lee, Kyung-Yoon Jeon, Eun-Ji Ko, H. Cha, M. Ock","doi":"10.7180/kmj.22.003","DOIUrl":"https://doi.org/10.7180/kmj.22.003","url":null,"abstract":"Background: The scuticociliate Miamiensis avidus is a major pathogenic agent that causes significant economic losses in the flounder aquaculture industry. Many different types of drugs are being tested to control this disease, including mebendazole, which is a broad-spectrum antiprotozoal agent. The purpose of this study was to determine whether mebendazole worked in vitro against M. avidus and to explore its mechanism of action. Methods: Transcriptome and gene ontology analyses were conducted to investigate the specifically expressed gene profile. We confirmed the cytotoxic effect of mebendazole against M. avidus when it was applied intermittently for a total of three times. We also identified differentially expressed genes using transcriptome analysis. Results: Most of the upregulated genes were membrane transport-related genes, including Na + /K + -ATPase. Most of the downregulated genes were categorized into three groups: tubulin-related, metabolism-related, and transport-related genes. The expression levels of glucose uptake-related genes decreased due to the inhibition of tubulin polymerization, but this was not statistically significant. Conclusion: Our results demonstrate that intermittent treatment with mebendazole has a significant cytotoxic effect on M. avidus . Furthermore, mebendazole induces downregulation of the tubulin-alpha chain and metabolism-related genes. It is presumed that this leads to a glucose shortage and the death of M. avidus . Transcriptome analysis will provide useful clues for further studies on mebendazole applications for scutica control.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48604690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of pure-type embryonal carcinoma mimicking epithelial ovarian carcinoma in a 75-year-old woman 一例罕见的纯型胚胎癌模仿上皮性卵巢癌的75岁妇女

Kosin Medical Journal Pub Date : 2022-05-03 DOI: 10.7180/kmj.21.050

Hyun Been Jo, Eun Taeg Kim, N. Lee, K. Choi, Eon Jin Kim, Yunjoo Shin, K. Kim, D. Suh

{"title":"A rare case of pure-type embryonal carcinoma mimicking epithelial ovarian carcinoma in a 75-year-old woman","authors":"Hyun Been Jo, Eun Taeg Kim, N. Lee, K. Choi, Eon Jin Kim, Yunjoo Shin, K. Kim, D. Suh","doi":"10.7180/kmj.21.050","DOIUrl":"https://doi.org/10.7180/kmj.21.050","url":null,"abstract":"Embryonal carcinoma, a very rare ovarian germ cell tumor, has pure and mixed phenotypes. Pure-type embryonal carcinoma has nev-er been reported in postmenopausal women. The current case was, thus, misdiagnosed as an epithelial ovarian carcinoma based on radiological findings. Herein, we describe the case of ovarian embryonal carcinoma in a 75-year-old woman along with a literature review. Magnetic resonance imaging findings were suggestive of an epithelial ovarian malignancy associated with endometrioma, including ureteral invasion. The patient underwent complete surgical staging. A pathological diagnosis of pure-type embryonal carcinoma was made. The patient’s postoperative course was uneventful, and adjuvant chemotherapy was administered. Embryonal carcinoma in postmenopausal women is a clinical challenge owing to the possibility of its misdiagnosis as epithelial ovarian carcinoma. To the best of our knowledge, this is the first report on pure-type ovarian embryonal carcinoma in a postmenopausal woman, with a de-scription of the clinicopathological characteristics and review of the relevant literature.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42645015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracheostomy with aortic debranching: a case report 气管造口术伴主动脉断支1例

Kosin Medical Journal Pub Date : 2022-04-27 DOI: 10.7180/kmj.21.046

J. Choi, Haeyoung Lee

引用次数: 0

Role of biomarkers in the heart failure clinic 生物标志物在心力衰竭临床中的作用

Kosin Medical Journal Pub Date : 2022-03-31 DOI: 10.7180/kmj.22.019

B. Kim, Jae-Hyeong Park

引用次数: 0

Hepatic steatosis changes after early gastric cancer surgery 早期胃癌手术后肝脂肪变性的改变

Kosin Medical Journal Pub Date : 2022-03-31 DOI: 10.7180/kmj.22.008

Ki Hyun Kim, S. Ock, Dohyung Lee, Yoon-Ji Kim, Jihoon Jo, K. Seo, K. Yoon, S. Kwon, Y. Choi, Bukyung Kim

{"title":"Hepatic steatosis changes after early gastric cancer surgery","authors":"Ki Hyun Kim, S. Ock, Dohyung Lee, Yoon-Ji Kim, Jihoon Jo, K. Seo, K. Yoon, S. Kwon, Y. Choi, Bukyung Kim","doi":"10.7180/kmj.22.008","DOIUrl":"https://doi.org/10.7180/kmj.22.008","url":null,"abstract":"Background: Nonalcoholic fatty liver disease dramatically improves after bariatric surgery, primarily due to improvements in hepatic insulin sensitivity. Since the procedure for gastric cancer surgery is very similar to that for bariatric surgery, we investigated changes in fatty liver following gastrectomy for gastric cancer according to the type of surgery.Methods: We evaluated hepatic steatosis in 212 early gastric cancer patients using Hounsfield units (HUs) on non-contrast computed tomography preoperatively and 6, 12, and 24 months after surgery. We compared the preoperative and postoperative liver-to-spleen HU ratio according to the type of surgery: Billroth I, Billroth II, and total gastrectomy with Roux-en-Y reconstruction. Results: The initial results (liver/spleen HUs and the liver-to-spleen HU ratio) did not significantly differ according to surgical group. After surgery, only patients who underwent total gastrectomy with Roux-en-Y exhibited significant changes in the liver-to-spleen HU ratio at 6 months. In 26 patients who had higher initial HU levels of the spleen than the liver, the liver-to-spleen HU ratio significantly increased from 0.836 to 1.115 at 6 months, 1.109 at 12 months, and 1.102 at 24 months (P<0.01). Conclusion: Significant changes in hepatic steatosis were found in even normal patients (with higher liver than spleen HU values) who underwent total gastrectomy with Roux-en-Y. Patients who initially had fatty liver also showed a significant increase in the liver-to-spleen HU ratio. These results suggest that total gastrectomy with Roux-en-Y reconstruction can have a positive effect on the improvement of hepatic steatosis.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41761602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and vaccine administration time as factors influencing vaccine immunogenicity 睡眠和接种时间是影响疫苗免疫原性的因素

Kosin Medical Journal Pub Date : 2022-03-31 DOI: 10.7180/kmj.22.014

Eun Seok Kim, C. Oh

{"title":"Sleep and vaccine administration time as factors influencing vaccine immunogenicity","authors":"Eun Seok Kim, C. Oh","doi":"10.7180/kmj.22.014","DOIUrl":"https://doi.org/10.7180/kmj.22.014","url":null,"abstract":"The immunogenicity of vaccines is affected by host, external, environmental, and vaccine factors; in addition, sleep or circadian rhythms may also have effects. With the use of vaccines to mitigate the coronavirus disease 2019 (COVID-19) pandemic, research is underway to clarify what time of the day is optimal for COVID-19 vaccination and how disturbances of circadian rhythms will affect the immunogenicity of the vaccine in shift workers. Studies on the relationship between sleep time and the immunogenicity of vaccines for influenza and hepatitis have demonstrated that less sleep time and sleep deprivation tended to adversely affect immunogenicity. In some studies, there were even sex differences in these effects. When comparing shift workers with disturbances in their circadian rhythms and those who only worked during the day, one study found less antibody formation in shift workers; however, further studies on the relationship between shift work and the immunogenicity of vaccines are needed. Studies on the relationship between vaccine administration time and immunogenicity have shown different results according to age and sex. Therefore, future studies on vaccine administration time and immunogenicity may require an individualized approach for each vaccine and each population to be vaccinated. There is accumulating evidence on the effects of sleep and vaccine administration time on the immunogenicity of vaccines. However, further studies are needed to determine whether the association between immunogenicity and circadian rhythms and vaccine administration time can be used as a basis to increase the immunogenicity for individual vaccines.","PeriodicalId":53015,"journal":{"name":"Kosin Medical Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48260133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0